M. Nesterova

发表

A rapid method for microarray cross platform comparisons using gene expression signatures.

K. Becker, C. Cheadle, K. Barnes, 2007, Molecular and cellular probes.

Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells

K. Becker, C. Cheadle, K. Barnes, 2008, BMC Medical Genomics.

A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex

E. Remmers, J. Bertherat, C. Stratakis, 2008, European Journal of Human Genetics.

Investigation of a patient with a partial trisomy 16q including the fat mass and obesity associated gene (FTO): Fine mapping and FTO gene expression study

B. Ylstra, P. Heutink, C. Stratakis, 2010, American journal of medical genetics. Part A.

Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?

P. Rustin, N. Patronas, M. de la Luz Sierra, 2012, The Journal of clinical endocrinology and metabolism.

Is IGSF1 involved in human pituitary tumor formation?

F. Faucz, E. Oldfield, C. Stratakis, 2015, Endocrine-related cancer.

Antisense-protein kinase A: a single-gene-based therapeutic approach.

Y. Cho‐Chung, S. Pepe, R. Srivastava, 1997, Antisense & nucleic acid drug development.

A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

Y. Cho‐Chung, M. Nesterova, 1995, Nature Medicine.

Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition.

M. Greene, E. Remmers, F. Faucz, 2013, The Journal of clinical endocrinology and metabolism.

An Intronic Mutation is Associated with Prolactinoma in a Young Boy, Decreased Penetrance in his Large Family, and Variable Effects on MEN1 mRNA and Protein

C. Stratakis, V. Mericq, A. Horvath, 2009, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Acute vs chronic exposure to high fat diet leads to distinct regulation of PKA.

C. Stratakis, M. Nesterova, E. London, 2017, Journal of molecular endocrinology.

Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type IIα.

C. Stratakis, O. Gavrilova, M. Nesterova, 2014, Endocrinology.

Through Cyclic Amp-dependent Protein Kinase of Bcl2 Phosphorylation and Apoptosis Involvement of Microtubules in the Regulation

R. K Srivastava, Y. Cho‐Chung, M. Nesterova, 1998 .

Does somatostatin have a role in the regulation of cortisol secretion in primary pigmented nodular adrenocortical disease (ppnad)? a clinical and in vitro investigation.

C. Stratakis, P. Xekouki, L. Hofland, 2014, The Journal of clinical endocrinology and metabolism.

Comparison of Aldosterone Production Among Human Adrenocortical Cell Lines

W. Rainey, M. Nesterova, J. Rowland, 2012, Hormone and Metabolic Research.

Erratum: Autoantibody cancer biomarker: Extracellular protein kinase A (Cancer Research (September 15, 2006) 66 (8971-8974))

S. Bates, C. Cheadle, C. Stratakis, 2006 .

Killing the messenger: antisense DNA and siRNA.

Y. Cho‐Chung, M. Nesterova, 2004, Current drug targets.

Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.

F. Faucz, J. Bertherat, X. Bertagna, 2011, The Journal of clinical endocrinology and metabolism.

Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects

C. Stratakis, N. Bhattacharyya, S. Leikin, 2017, Molecular and Cellular Endocrinology.

8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.

I. Bossis, C. Stratakis, M. Nesterova, 2009, The Journal of clinical endocrinology and metabolism.

Subcellular distribution of the R‐subunits of cAMP‐dependent protein kinase in LS‐174T human colon carcinoma cells

Y. Cho‐Chung, M. Nesterova, A. Kondrashin, 1998, Biochemistry and molecular biology international.

Brain histone kinase: the structure, the substrate specificity and the mechanism of action.

M. Nesterova, S. V. Shlyapnikov, E. Severin, 1976, Advances in enzyme regulation.

Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors.

M. Greene, E. Remmers, F. Faucz, 2009, Cancer research.

Functional Phosphodiesterase 11 A Mutations May Modify the Risk of Familial and Bilateral Testicular Germ Cell Tumors

M. Greene, E. Remmers, F. Faucz, 2009 .

Clinical Studies in Patients with Solid Tumors using a Second‐Generation Antisense Oligonucleotide (GEM®231) Targeted against Protein Kinase A Type I

G. Tortora, R. Zhang, Y. Cho‐Chung, 2003, Annals of the New York Academy of Sciences.

Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors.

C. Stratakis, A. Lacroix, M. Nesterova, 2009, The Journal of clinical endocrinology and metabolism.

The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes

V. Bours, C. Stratakis, A. Horvath, 2010, Clinical genetics.

Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.

F. Faucz, C. Stratakis, S. Leikin, 2015, Human molecular genetics.

Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells.

C. Stratakis, S. Stojilkovic, M. Nesterova, 2011, American journal of physiology. Endocrinology and metabolism.

Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.

H. Yokozaki, Y. Cho‐Chung, M. Nesterova, 1996, European Journal of Biochemistry.

Isolation of the regulatory subunit of pig‐brain histone kinase by affinity chromatography on cyclic‐AMP‐containing adsorbent

M. Nesterova, S. Kochetkov, E. Severin, 1974, FEBS letters.

Effect of cyclic AMP-dependent protein kinases on gene expression.

M. Nesterova, E. Severin, 1982, Advances in enzyme regulation.

Influence of a specific histone kinase on the physico-chemical properties of chromatin In situ

A. Zelenin, V. A. Kolesnikov, M. Nesterova, 1975, Molecular Biology Reports.

[Sulfhydryl groups of cyclic AMP-dependent histone kinase from pig brain].

M. Nesterova, S. Kochetkov, E. Severin, 1976, Biokhimiia.

Studies of mice with cyclic AMP-dependent protein kinase (PKA) defects reveal the critical role of PKA’s catalytic subunits in anxiety

C. Stratakis, M. Nesterova, G. Briassoulis, 2016, Behavioural Brain Research.

Anxiety phenotype in mice that overexpress protein kinase A

C. Stratakis, M. Nesterova, G. Briassoulis, 2012, Psychoneuroendocrinology.

Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer.

F. Faucz, R. B. Alexandre, J. Bertherat, 2010, The Journal of clinical endocrinology and metabolism.

Dissecting the Circuitry of Protein Kinase A and cAMP Signaling in Cancer Genesis

K. Becker, C. Cheadle, Y. Cho‐Chung, 2002, Annals of the New York Academy of Sciences.

cAMP-dependent protein kinase: role in normal and malignant growth.

Y. Cho‐Chung, S. Pepe, A. Budillon, 1995, Critical reviews in oncology/hematology.

Significance of Protein Kinase A in Cancer

Y. Cho‐Chung, M. Nesterova, 2006 .

Protein Kinase A: Regulation and Receptor‐Mediated Delivery of Antisense Oligonucleotides and Cytotoxic Drugs

M. Nesterova, E. Severin, I. D. Grozdova, 2002, Annals of the New York Academy of Sciences.

Identification of novel genetic variants in phosphodiesterase 8B ( PDE8B ), a cAMP‐specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours

F. Faucz, J. Bertherat, C. Stratakis, 2012, Clinical endocrinology.

Investigation of the adenosine 3', 5'-cyclic phosphate binding site of pig brain histone kinase with the aid of some analogues of adenosine 3', 5'-cyclic phosphate.

M. Nesterova, L. P. Sashchenko, E. Severin, 1975, Biochimica et biophysica acta.

Antisense Protein Kinase A RIα Inhibits 7,12-Dimethylbenz(a)anthracene-Induction of Mammary Cancer

Y. Cho‐Chung, M. Nesterova, 2004, Clinical Cancer Research.

Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.

Y. Cho‐Chung, M. Nesterova, 2004, Clinical cancer research : an official journal of the American Association for Cancer Research.

Oligonucleotide sequence-specific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIalpha subunit.

Y. Cho‐Chung, M. Nesterova, 2000, Antisense & nucleic acid drug development.

Compensatory Stabilization of RIIβ Protein, Cell Cycle Deregulation, and Growth Arrest in Colon and Prostate Carcinoma Cells by Antisense-directed Down-Regulation of Protein Kinase A RIα Protein

Y. Cho‐Chung, M. Nesterova, K. Noguchi, 2000 .

CpG Immunomer DNA Enhances Antisense Protein Kinase A RIα Inhibition of Multidrug-Resistant Colon Carcinoma Growth in Nude Mice: Molecular Basis for Combinatorial Therapy

Y. Cho‐Chung, S. Abrams, M. Nesterova, 2005, Clinical Cancer Research.

An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of overexpression of the wild-type Allele and other protein kinase A subunits.

I. Bossis, C. Stratakis, A. Horvath, 2008, The Journal of clinical endocrinology and metabolism.

Differences in adiposity in Cushing syndrome caused by PRKAR1A mutations: clues for the role of cyclic AMP signaling in obesity and diagnostic implications.

M. de la Luz Sierra, C. Stratakis, M. Lodish, 2014, The Journal of clinical endocrinology and metabolism.

In vitro studies of novel PRKAR1A mutants that extend the predicted RIα protein sequence into the 3'-untranslated open reading frame: proteasomal degradation leads to RIα haploinsufficiency and Carney complex.

C. Stratakis, A. Horvath, M. Nesterova, 2012, The Journal of clinical endocrinology and metabolism.

A large family with Carney complex caused by the S147G PRKAR1A mutation shows a unique spectrum of disease including adrenocortical cancer.

C. Stratakis, A. Horvath, J. Carney, 2012, The Journal of clinical endocrinology and metabolism.

Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions.

C. Cheadle, C. Stratakis, A. Horvath, 2011, The Journal of clinical endocrinology and metabolism.

Protein Kinase A: The Enzyme and Cyclic AMP Signaling

C. Stratakis, M. Nesterova, 2011 .

Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.

C. Cheadle, I. Bossis, C. Stratakis, 2010, Human molecular genetics.

Association of the M1V PRKAR1A mutation with primary pigmented nodular adrenocortical disease in two large families.

J. Romijn, C. Stratakis, A. Horvath, 2010, The Journal of clinical endocrinology and metabolism.

Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes.

C. Stratakis, M. Nesterova, E. Bimpaki, 2009, European journal of endocrinology.

MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.

D. Iliopoulos, C. Stratakis, M. Nesterova, 2009, Cancer research.

In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay

I. Bossis, C. Stratakis, A. Horvath, 2008, Human mutation.

Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.

M. Mavrakis, I. Bossis, J. Bertherat, 2008, Cancer research.

Large Deletions of the PRKAR1A Gene in Carney Complex

E. Remmers, I. Bossis, J. Bertherat, 2008, Clinical Cancer Research.

Large Deletions of the PRKAR1AGene in Carney Complex

E. Remmers, I. Bossis, C. Stratakis, 2008 .

cAMP and protein kinase A in endocrine (and other) tumors

C. Stratakis, M. Nesterova, 2007, Expert review of endocrinology & metabolism.

Autoantibody cancer biomarker: extracellular protein kinase A.

S. Bates, C. Cheadle, C. Stratakis, 2006, Cancer research.

Tumor Reversion: Protein Kinase A Isozyme Switching

Y. Cho‐Chung, M. Nesterova, YOON S. CHO‐CHUNG, 2005, Annals of the New York Academy of Sciences.

Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase

S. Korsmeyer, D. Longo, R. K Srivastava, 1998, Molecular and Cellular Biology.

Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.

C. Stratakis, N. Krett, M. Nesterova, 2008, The Journal of clinical endocrinology and metabolism.

Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.

R. K Srivastava, Y. Cho‐Chung, S. Pepe, 1999, Frontiers in bioscience : a journal and virtual library.

Effect of the regulatory subunit of cAMP-dependent protein kinase on the genetic activity of eukaryotic cells

A. Glukhov, M. Nesterova, E. Severin, 1982, Molecular and Cellular Biochemistry.

Cyclic adenosine 3':5'-monophosphate-dependent protein kinase on the external surface of LS-174T human colon carcinoma cells.

Y. Cho‐Chung, M. Nesterova, A. Kondrashin, 1999, Biochemistry.

Autoantibody biomarker opens a new gateway for cancer diagnosis.

C. Cheadle, Y. Cho‐Chung, M. Nesterova, 2006, Biochimica et biophysica acta.

Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations.

C. Cheadle, C. Stratakis, A. Horvath, 2012, The Journal of clinical endocrinology and metabolism.

Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.

C. Cheadle, C. Stratakis, J. Grivel, 2011, Human molecular genetics.

Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone

C. Cheadle, C. Stratakis, M. Collins, 2010, Proceedings of the National Academy of Sciences.

Overexpresson of RIIβ, Regulatory Subunit of Protein Kinase A in Human Colon Carcinoma Cell Induces Growth Arrest and Phenotypic Changes that are Abolished by Site‐Directed Mutation of RIIβ

Y. Cho‐Chung, M. Nesterova, E. McDuffie, 1996 .

Drug Intolerance: Age Related Aspects

M. Nesterova, O. Rychkova, M. Grakhova, 2021, Russian Journal of Allergy.

Dual Blockade of Cyclic AMP Response Element- (CRE) and AP-1-directed Transcription by CRE-transcription Factor Decoy Oligonucleotide

S. Agrawal, Y. Cho‐Chung, M. Nesterova, 1999, The Journal of Biological Chemistry.

Germline AIP, MEN1, PRKAR1A, CDKN1B (p27Kip1) and CDKN2C (p18INK4c) gene mutations in a large cohort of pediatric patients with pituitary adenomas occurring in isolation or with associated syndromic features

V. Bours, C. Stratakis, A. Horvath, 2008 .

Bilateral Adrenal Hyperplasia as a Possible Mechanism for Hyperandrogenism in Women With Polycystic Ovary Syndrome.

E. Turkbey, A. Dobs, M. de la Luz Sierra, 2016, The Journal of clinical endocrinology and metabolism.

Comprehensive Analysis of LC/MS Data Using Pseudocolor Plots

C. Stratakis, A. Yergey, M. Nesterova, 2013, Journal of The American Society for Mass Spectrometry.

Threat bias in mice with inactivating mutations of Prkar1a

C. Stratakis, M. Nesterova, G. Briassoulis, 2013, Neuroscience.

CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth

Y. Cho‐Chung, Y. Cho, M. Nesterova, 2000, Molecular and Cellular Biochemistry.

The autophosphorylation reaction in the mechanism of activation of pig brain cyclic AMP-dependent protein kinase.

M. Nesterova, S. V. Shlyapnikov, K. Ulmasov, 1981, Biochimica et biophysica acta.

Study of the influence of fungicidal substituted dithiocarbamates on the system of second messengers and the proliferative activity of mammalian cells

T. Halaši, M. Nesterova, E. Severin, 1993, Pharmaceutical Chemistry Journal.

Comparison of the Effects of PRKAR1A and PRKAR2B Depletion on Signaling Pathways, Cell Growth, and Cell Cycle Control of Adrenocortical Cells

J. Bertherat, C. Stratakis, F. Cormier, 2014, Hormone and Metabolic Research.

Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts.

G. Merlo, A. Cereseto, Y. Cho‐Chung, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion

K. Becker, C. Cheadle, Y. Cho‐Chung, 2004, Oncogene.

The Mechanism of Action of Brain Cyclic AMP-dependent Protein Kinase: Structure of Active Site, Mechanism of Dissociation of the Holoenzyme, and Possible Biological Role of Its Subunits

I. Grozdova, M. Nesterova, A. Gabibov, 1981 .

STRUCTURE AND FUNCTIONS OF PROTEIN KINASES

S. Kochetkov, M. Nesterova, L. P. Sashchenko, 1980 .

Not All Glucocorticoid-Induced Obesity is the Same: Differences in Adiposity Among Various Diagnostic Groups of Cushing Syndrome

M. de la Luz Sierra, C. Stratakis, M. Lodish, 2014, Hormone and Metabolic Research.

Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation

F. Faucz, C. Stratakis, M. Abu-Asab, 2020, Molecular and Cellular Endocrinology.

Identification of novel genetic variants in phosphodiesterase 8B ( PDE8B ), a cAMP‐specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours

F. Faucz, J. Bertherat, C. Stratakis, 2012, Clinical endocrinology.

Bilateral Adrenal Hyperplasia as a Possible Mechanism for Hyperandrogenism in Women With Polycystic Ovary Syndrome.

E. Turkbey, A. Dobs, M. de la Luz Sierra, 2016, Journal of Clinical Endocrinology and Metabolism.

A cyclic adenosine 3',5'-monophosphate-dependent histone kinase from pig brain. Purification and some properties of the enzyme.

M. Nesterova, L. P. Sashchenko, E. Severin, 1975, Biochimica et biophysica acta.

Investigation of the sites phosphorylated in lysine‐rich histones by protein kinase from pig brain

S. N. Kurochkin, M. Nesterova, L. P. Sashchenko, 1975, FEBS letters.

The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes

V. Bours, C. Stratakis, A. Horvath, 2010, Clinical genetics.

PRKAR1A gene analysis and protein kinase A activity in endometrial tumors.

C. Stratakis, A. Horvath, M. Nesterova, 2012, Endocrine-related cancer.