A. Peijnenburg

发表

Omics-Based Testing for Direct Immunotoxicity

H. Loveren, P. Hendriksen, O. Volger, 2014 .

Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach.

Marjoke Heneweer, Chris Maliepaard, R. Houtman, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models

A. Boorsma, H. Loveren, M. Luijten, 2014, Archives of Toxicology.

Quantitative in vitro-to-in vivo extrapolation (QIVIVE) of estrogenic and anti-androgenic potencies of BPA and BADGE analogues

A. Peijnenburg, A. Gerssen, R. Hoogenboom, 2019, Archives of Toxicology.

Gene expression profiling in Caco-2 human colon cells exposed to TCDD, benzo[a]pyrene, and natural Ah receptor agonists from cruciferous vegetables and citrus fruits.

F. V. van Schooten, T. D. de Kok, A. Peijnenburg, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes

Marlon J. A. Jetten, J. Kleinjans, M. Jetten, 2015, Archives of Toxicology.

Endocrine-disrupting effects of thioxanthone photoinitiators.

P. Hendriksen, M. Reitsma, A. Peijnenburg, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO)

J. Pennings, J. Kleinjans, A. Osman, 2009 .

A new highly androgen specific yeast biosensor, enabling optimisation of (Q)SAR model approaches

M. Nielen, A. Peijnenburg, J. Lommerse, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

A 155-plex high-throughput in vitro coregulator binding assay for (anti-)estrogenicity testing evaluated with 23 reference compounds.

R. Houtman, I. Rietjens, A. Peijnenburg, 2013, ALTEX.

Towards an integrated in vitro strategy for estrogenicity testing

I. Rietjens, D. Argyriou, A. Peijnenburg, 2014, Journal of applied toxicology : JAT.

SERMs and SARMs: Detection of their activities with yeast based bioassays

M. Nielen, M. Thevis, A. Peijnenburg, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

A low-density DNA microchip for the detection of (anti-)estrogenic compounds and their relative potencies.

I. Rietjens, A. Peijnenburg, T. Bovee, 2013, Analytical biochemistry.

Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities

A. Peijnenburg, W. Schoonen, T. Bovee, 2008, Analytical and bioanalytical chemistry.

ethinylestradiol and zearalenone using a systems biology approach

R. Houtman, C. Maliepaard, M. Heneweer, 2007 .

Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.

R. Houtman, A. Brouwer, I. Rietjens, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Ah receptor agonist activity in frequently consumed food items

F. V. van Schooten, T. D. de Kok, A. Peijnenburg, 2008, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

Risk assessment of paracetamol-induced liver toxicity based on human in vitro data.

J. Kleinjans, N. Vermeulen, J. Proost, 2014 .

Influence of TCDD and natural Ah receptor agonists on benzo[a]pyrene-DNA adduct formation in the Caco-2 human colon cell line.

F. V. van Schooten, T. D. de Kok, A. Peijnenburg, 2007, Mutagenesis.

Model Steatogenic Compounds (Amiodarone, Valproic Acid, and Tetracycline) Alter Lipid Metabolism by Different Mechanisms in Mouse Liver Slices

B. van der Burg, P. Hendriksen, A. Peijnenburg, 2014, PLoS ONE.

Phenolic compounds of Triplaris gardneriana can protect cells against oxidative stress and restore oxidative balance.

A. Boligon, A. Peijnenburg, D. Farias, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment–AWorkshop Report

D. Schrenk, G. Lin, S. Pfuhler, 2021 .

Subacute effects of hexabromocyclododecane (HBCD) on hepatic gene expression profiles in rats.

A. Piersma, M. van den Berg, M. Heneweer, 2008, Toxicology and applied pharmacology.

Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants

H. Loveren, P. Hendriksen, O. Volger, 2015, Archives of Toxicology.

Transcriptome-based functional classifiers for direct immunotoxicity

H. Loveren, P. Hendriksen, O. Volger, 2013, Archives of Toxicology.

Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro

H. Loveren, P. Hendriksen, O. Volger, 2015, Journal of applied toxicology : JAT.

Subchronic Effects of Hexabromocyclododecane ( HBCDD ) on Hepatic Gene Expression Profiles in Rats

M. Heneweer, A. Peijnenburg, R. F. Cantón, 2006 .

Providing Biological Plausibility for Exposure–Health Relationships for the Mycotoxins Deoxynivalenol (DON) and Fumonisin B1 (FB1) in Humans Using the AOP Framework

H. Dirven, A. Brantsæter, A. Peijnenburg, 2022, Toxins.

Evaluation of immunomodulation by Lactobacillus casei Shirota: immune function, autoimmunity and gene expression.

J. Pennings, H. van Loveren, K. Baken, 2006, International journal of food microbiology.

Transcriptome-based functional classifiers for direct immunotoxicity

H. Loveren, P. Hendriksen, O. Volger, 2014, Archives of Toxicology.

Polyphenol Composition, Antioxidant Activity and Cytotoxicity of Seeds from Two Underexploited Wild Licania Species: L. rigida and L. tomentosa

A. Peijnenburg, J. J. Lopes Neto, Aline Augusti Boligon, 2016, Molecules.

Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.

Arjen Lommen, Ad A C M Peijnenburg, A. Peijnenburg, 2012, Chemical research in toxicology.

Simple and rapid in vitro assay for detecting human thyroid peroxidase disruption.

I. Rietjens, A. Peijnenburg, T. Bovee, 2015, ALTEX.

In vitro pituitary and thyroid cell proliferation assays and their relevance as alternatives to animal testing.

Ivonne M C M Rietjens, Ad A C M Peijnenburg, Albertinka J Murk, 2013, ALTEX.

A 28-day repeat dose toxicity study of steroidal glycoalkaloids, alpha-solanine and alpha-chaconine in the Syrian Golden hamster.

O. Meyer, W. Slob, M. Poulsen, 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights.

H. van Loveren, M. Katika, P. Hendriksen, 2012, Toxicology and applied pharmacology.

Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test.

A. Piersma, I. Rietjens, A. Peijnenburg, 2014, ALTEX.

Protein expression profiling of mouse thymoma cells upon exposure to the trichothecene deoxynivalenol (DON): Implications for its mechanism of action

J. Pennings, H. van Loveren, A. Osman, 2010, Journal of immunotoxicology.

Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models

A. Boorsma, H. Loveren, M. Luijten, 2014, Archives of Toxicology.

The effects of tributyltin oxide and deoxynivalenol on the transcriptome of the mouse thymoma cell line EL-4

H. Loveren, P. Hendriksen, A. Peijnenburg, 2014 .

H. van Loveren, M. Katika, P. Hendriksen, 2014, Toxicology letters.

Toxicogenomics-based identification of mechanisms for direct immunotoxicity.

H. van Loveren, M. Katika, P. Hendriksen, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics.

H. van Loveren, P. Hendriksen, O. Volger, 2013, Toxicology letters.

Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis.

H. van Loveren, M. Katika, P. Hendriksen, 2011, Toxicology and applied pharmacology.

The effects of deoxynivalenol on gene expression in the murine thymus.

H. van Loveren, P. Hendriksen, A. Peijnenburg, 2011, Toxicology and applied pharmacology.

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Jos Kleinjans, Danyel Jennen, Joost van Delft, 2011, BMC Systems Biology.

Whole genome mRNA transcriptomics analysis reveals different modes of action of the diarrheic shellfish poisons okadaic acid and dinophysis toxin-1 versus azaspiracid-1 in Caco-2 cells.

P. Hendriksen, A. Peijnenburg, R. Hoogenboom, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

A foresight study on emerging technologies: State of the art of Omics technologies and potential applications in food and feed safety

Peter J. M. Hendriksen, A. Pielaat, Ad A. C. M. Peijnenburg, 2013 .

New approach methodologies: A quantitative in vitro to in vivo extrapolation case study with PFASs

A. Piersma, B. Bokkers, M. Luijten, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Protein phosphorylation profiling identifies potential mechanisms for direct immunotoxicity

H. van Loveren, P. Hendriksen, O. Volger, 2016, Journal of immunotoxicology.

Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells.

H. van Loveren, N. D. de Ruijter, M. Katika, 2012, Toxicology letters.

Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO).

H. van Loveren, P. Hendriksen, A. Peijnenburg, 2012, Toxicology.

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Arjen Lommen, Jos Kleinjans, Ainhoa Ruiz-Aracama, 2011, BMC Genomics.

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Marlon J. A. Jetten, R. Stierum, S. Gaj, 2012, Toxicology and applied pharmacology.

Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.

J. Pennings, J. V. van Delft, J. Bessems, 2011, Toxicology and applied pharmacology.

Bovine liver slices: A multifunctional in vitro model to study the prohormone dehydroepiandrosterone (DHEA).

M. Nielen, I. Rietjens, A. Peijnenburg, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine.

F. V. van Schooten, T. D. de Kok, A. Peijnenburg, 2008, Chemico-biological interactions.

Tailored microarray platform for the detection of marine toxins.

M. Nielen, C. Elliott, P. Hendriksen, 2011, Environmental science & technology.

Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells

A. Piersma, B. Bokkers, M. Luijten, 2023, Archives of Toxicology.

Mode of action of Organotins in Immune cells

H. Loveren, P. Hendriksen, A. Peijnenburg, 2015 .

Proliferation assays for estrogenicity testing with high predictive value for the in vivo uterotrophic effect

I. Rietjens, A. Peijnenburg, Toine F.H. Bovee, 2012, The Journal of Steroid Biochemistry and Molecular Biology.

Quantitative in vitro-to-in vivo extrapolation (QIVIVE) of estrogenic and anti-androgenic potencies of BPA and BADGE analogues

A. Peijnenburg, A. Gerssen, R. Hoogenboom, 2019, Archives of Toxicology.

Analysis of dietary supplements for hormonal activity.

M. Nielen, C. Peteghem, A. Peijnenburg, 2007 .

Induction of the cholesterol biosynthesis pathway in differentiated Caco-2 cells by the potato glycoalkaloid alpha-chaconine.

H. Kuiper, C. Garza, A. Peijnenburg, 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Differential gene expression in intestinal epithelial cells induced by single and mixtures of potato glycoalkaloids.

H. Kuiper, C. Garza, A. Peijnenburg, 2007, Journal of agricultural and food chemistry.

Evidence of the indirect hormonal activity of prohormones using liver S9 metabolic bioactivation and an androgen bioassay

M. Nielen, A. Peijnenburg, M. Groot, 2008, Analytical and Bioanalytical Chemistry.

Bovine liver slices combined with an androgen transcriptional activation assay: an in-vitro model to study the metabolism and bioactivity of steroids

A. Peijnenburg, S. V. van Kuijk, T. Bovee, 2010, Analytical and bioanalytical chemistry.

Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants

H. Loveren, P. Hendriksen, O. Volger, 2016, Archives of Toxicology.

DNA microarray technology reveals similar gene expression patterns in rats with vitamin a deficiency and chemically induced colitis.

R. Reifen, H. Noteborn, A. Peijnenburg, 2002, The Journal of nutrition.

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes

J. Kleinjans, M. Jetten, J. V. van Delft, 2015, Archives of Toxicology.

Bioassay directed identification of natural aryl hydrocarbon-receptor agonists in marmalade.

Patrick Mulder, A. Peijnenburg, R. Hoogenboom, 2008, Analytica chimica acta.

The application of DNA microarrays in gene expression analysis.

E. Kok, A. Aharoni, J. Keijer, 2000, Journal of biotechnology.

Assessment of the safety of foods derived from genetically modified (GM) crops.

I Kimber, R W R Crevel, U Hammerling, 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells

E. Danen, B. van de Water, Louise von Stechow, 2013, PloS one.

Effect of oxygen concentration and selected protocol factors on viability and gene expression of mouse liver slices.

P. Hendriksen, A. Peijnenburg, M. Groot, 2013, Toxicology in vitro : an international journal published in association with BIBRA.