J. Sedgwick

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Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis.

J. Forrester, A. Dick, C. Broderick, 2002, The American journal of pathology.

DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.

B. Blom, L. Lanier, A. Cerwenka, 2000, Immunity.

Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen

J. Cyster, M. Cooper, J. Browning, 2022 .

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

J. Cyster, M. Cooper, J. Browning, 1999, The Journal of experimental medicine.

Interactions Between Hemopoietically Derived TNF and Central Nervous System-Resident Glial Chemokines Underlie Initiation of Autoimmune Inflammation in the Brain1

S. Lira, R. Hoek, J. Sedgwick, 2002, The Journal of Immunology.

Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models.

J. Sedgwick, S. Ruuls, 1999, American journal of human genetics.

IMMUNOGENETICS '99 Unlinking Tumor Necrosis Factor Biology from the Major Histocompatibility Complex: Lessons from Human Genetics and Animal Models

J. Sedgwick, S. Ruuls, 1999 .

Chemokines and B-cell homing to follicles.

J. Cyster, K. Ansel, V. Ngo, 1999, Current topics in microbiology and immunology.

Regulation of microglial cell responses in murine Toxoplasma encephalitis by CD200/CD200 receptor interaction

M. Deckert, J. Sedgwick, D. Schlüter, 2006, Acta Neuropathologica.

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

A. Barclay, J. Sedgwick, A. Didierlaurent, 2008, Nature Immunology.

Differential Requirements by CD4+ and CD8+ T Cells for Soluble and Membrane TNF in Control of Francisella tularensis Live Vaccine Strain Intramacrophage Growth

J. Sedgwick, K. Elkins, S. Cowley, 2007, The Journal of Immunology.

Vaccine Strain Intramacrophage Growth Live Francisella tularensis Control of T Cells for Soluble and Membrane TNF in + and CD 8 + Differential Requirements by CD 4

J. Sedgwick, K. Elkins, S. Cowley, 2007 .

Membrane tumor necrosis factor confers partial protection to Listeria infection.

B. Ryffel, David Torres, S. Grivennikov, 2005, The American journal of pathology.

TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis1

M. Deckert, K. Foulds, J. Sedgwick, 2006, The Journal of Immunology.

An Essential Role for Tumor Necrosis Factor in the Formation of Experimental Murine Staphylococcus aureus-Induced Brain Abscess and Clearance

M. Deckert, W. Stenzel, H. Miletic, 2005, Journal of neuropathology and experimental neurology.

Tumor Necrosis Factor–dependent Segmental Control of MIG Expression by High Endothelial Venules in Inflamed Lymph Nodes Regulates Monocyte Recruitment

J. Sedgwick, S. Hudak, L. Mcevoy, 2001, The Journal of experimental medicine.

Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts.

J. Sedgwick, A. Ford, E. Foulcher, 1998, Journal of immunology.

Interaction with Tissue-Infiltrating T Cell Blasts Activation and Proliferation Follows Direct Central Nervous System Microglial Cell

J. Sedgwick, A. Ford, E. Foulcher, 1998 .

Regulation of Myeloid Cell Function through the CD200 Receptor1

J. Phillips, H. Cherwinski, M. Jenmalm, 2006, The Journal of Immunology.

Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system

G. Chaudhri, J. Sedgwick, H. Körner, 1997, European journal of immunology.

Tumor Necrosis Factor Sustains the Generalized Lymphoproliferative Disorder ( gld ) Phenotype

M. Smyth, E. Cretney, M. Röllinghoff, 2000, The Journal of experimental medicine.

Novel concepts of tumor necrosis factor action in autoimmune pathology.

J. Sedgwick, D. Riminton, 2000, Current directions in autoimmunity.

Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin.

J. Sedgwick, H. Körner, D. Riminton, 1999, Journal of immunology.

Increased Thymic B Cells but Maintenance of Thymic Structure, T Cell Differentiation and Negative Selection in Lymphotoxin-α and TNF Gene-Targeted Mice

D. Godfrey, J. Sedgwick, D. Riminton, 2000, Developmental immunology.

Pronounced Th2 Switch in Response to in CD200-Deficient Mice Correlates with a Enhanced Tolerance to Autoimmune Uveitis

J. Sedgwick, C. Calder, Karen McConnachie, 2017 .

Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis.

A. Dick, J. Phillips, H. Cherwinski, 2007, The American journal of pathology.

Enhanced Tolerance to Autoimmune Uveitis in CD200-Deficient Mice Correlates with a Pronounced Th2 Switch in Response to Antigen Challenge1

A. Dick, J. Liversidge, J. Sedgwick, 2005, The Journal of Immunology.

Antigen Challenge Pronounced Th 2 Switch in Response to in CD 200-Deficient Mice Correlates with a Enhanced Tolerance to Autoimmune Uveitis

A. Dick, J. Liversidge, J. Sedgwick, 2004 .

Microglia induce CD4 T lymphocyte final effector function and death

J. Sedgwick, F. Lemckert, A. Ford, 1996, The Journal of experimental medicine.

T-lymphocyte activation and regulation in the central nervous system.

J. Sedgwick, 1997, Biochemical Society transactions.

Tumor necrosis factor: a master-regulator of leukocyte movement.

J. Cyster, J. Sedgwick, H. Körner, 2000, Immunology today.

Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting

J. Pollard, J. Sedgwick, H. Körner, 1997, The Journal of experimental medicine.

Molecular Mechanisms of CD200 Inhibition of Mast Cell Activation

J. Phillips, H. Cherwinski, J. Sedgwick, 2004, The Journal of Immunology.

Antigen presentation in brain: brain endothelial cells are poor stimulators of T-cell proliferation.

G. Pryce, J. Sedgwick, D. Male, 1989, Immunology.

Brain Initiation of Autoimmune Inflammation in System-Resident Glial Chemokines Underlie Derived TNF and Central Nervous Interactions Between Hemopoietically

S. Lira, R. Hoek, J. Sedgwick, 2002 .

J Am Soc Nephrol 14: 1785–1793, 2003 Intrinsic Renal Cells Are the Major Source of Tumor Necrosis Factor Contributing to Renal Injury in Murine Crescentic

P. Tipping, S. Holdsworth, J. Sedgwick, 2022 .

TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus.

A. Tarkowski, J. Sedgwick, H. Körner, 1998, Journal of immunology.

Mortality in Response to Resist Septic Arthritis but Display Increased Double-Mutant Mice α TNF / Lymphotoxin -

J. Sedgwick, H. Körner, H. Eugster, 1998 .

Cytokine‐directed therapies in multiple sclerosis and experimental autoimmune encephalomyelitis

J. Sedgwick, S. Ruuls, 1998, Immunology and cell biology.

Molecular Mechanisms of CD 200 Inhibition of Mast Cell Activation

J. Phillips, H. Cherwinski, J. Sedgwick, 2004 .

of Mast Cell Activation Molecular Mechanisms of CD200 Inhibition

H. Cherwinski, J. Sedgwick, 2004 .

The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation [Current Opinion in Immunology 2006, 18:670–675]

K. Kikly, J. Sedgwick, S. Na, 2007 .

Mechanism of airway inflammation in asthma.

W. Busse, J. Sedgwick, W. Calhoun, 1993, The American review of respiratory disease.

Transgenic Expression of the CC Chemokine of the Thyroid Gland Generated by A Novel Model for Lymphocytic Infiltration

P. Frenette, J. Sedgwick, G. Vassileva, 2013 .

A Novel Model for Lymphocytic Infiltration of the Thyroid Gland Generated by Transgenic Expression of the CC Chemokine CCL211

P. Frenette, S. Lira, J. Sedgwick, 2004, The Journal of Immunology.

Relationship of plasma epinephrine and circulating eosinophils to nocturnal asthma.

W. Busse, M. Bates, N. Jarjour, 1994, American journal of respiratory and critical care medicine.

Membrane lymphotoxin contributes to anti‐leishmanial immunity by controlling structural integrity of lymphoid organs

R. Hoek, J. Sedgwick, H. Körner, 2002, European journal of immunology.

Cutting Edge: Organogenesis of Nasal-Associated Lymphoid Tissue (NALT) Occurs Independently of Lymphotoxin-α (LTα) and Retinoic Acid Receptor-Related Orphan Receptor-γ, but the Organization of NALT Is LTα Dependent1

D. Littman, T. Randall, Yongwon Choi, 2002, The Journal of Immunology.

Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles

M. Cook, A. Basten, M. Röllinghoff, 2001, Immunology and cell biology.

Generation of Splenic Follicular Structure and B Cell Movement in Tumor Necrosis Factor–deficient Mice

P. Hodgkin, J. Cyster, M. Cook, 1998, The Journal of experimental medicine.

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF1

M. Tsai, S. Galli, S. Nakae, 2006, The Journal of Immunology.

Immune surveillance and autoantigen recognition in the central nervous system.

J. Sedgwick, 1995, Australian and New Zealand journal of medicine.

The immune system response to viral infection of the CNS

J. Sedgwick, R. Dörries, 1991, Seminars in Neuroscience.

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system

D. Mason, J. Sedgwick, S. Brostoff, 1987, The Journal of experimental medicine.

Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase Cθ-Deficient Mice

Seng-Lai Tan, Jian Wang, J. Sedgwick, 2006, The Journal of Immunology.

Challenging Cytokine Redundancy: Inflammatory Cell Movement and Clinical Course of Experimental Autoimmune Encephalomyelitis Are Normal in Lymphotoxin-deficient, but Not Tumor Necrosis Factor–deficient, Mice

J. Pollard, J. Sedgwick, H. Körner, 1998, The Journal of experimental medicine.

Allele-specific PCR analysis for detection of the gld Fas-ligand point mutation.

R. Hoek, J. Sedgwick, M. Kortekaas, 1997, Journal of immunological methods.

Infection Mycobacterium tuberculosis Control of and Provide Acute, but Not Long-Term, Cell Migration and Granuloma Formation Transmembrane TNF Is Sufficient to Initiate

W. Britton, B. Saunders, J. Sedgwick, 2005 .

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

W. Hickey, J. Sedgwick, A. Ford, 1995, Journal of immunology.

Interactions with CD200 Family in Mice and Humans and Their Characterization of the CD200 Receptor

T. Mcclanahan, J. Phillips, A. Barclay, 2003 .

Delayed kinetics of tumor necrosis factor‐mediated bystander lysis by peptide‐specific CD8+ cytotoxic T lymphocytes

M. Smyth, J. Sedgwick, 1998, European journal of immunology.

Augmentation of major histocompatibility complex class I and ICAM‐1 expression on glial cells following measles virus infection: Evidence for the role of type‐1 interferon

M. Miyasaka, J. Sedgwick, S. Schneider‐Schaulies, 1992, European journal of immunology.

Lymphocyte-myelin sheath interactions in acute experimental allergic encephalomyelitis

W. Blakemore, J. Sedgwick, B. Summers, 1989, Journal of Neuroimmunology.

The mechanism of inhibition of experimental allergic encephalomyelitis in the rat by monoclonal antibody against CD4

D. Mason, J. Sedgwick, 1986, Journal of Neuroimmunology.

Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses

I. Waizenegger, N. Kraut, L. Frego, 2022, Oncoimmunology.

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

R. Kastelein, S. Lira, J. Sedgwick, 2003, Nature.

Loss of TNF Signaling Facilitates the Development of a Novel Ly-6Clow Macrophage Population Permissive for Leishmania major Infection

M. Mack, J. Sedgwick, H. Körner, 2012, The Journal of Immunology.

Leishmania major Macrophage Population Permissive for lowDevelopment of a Novel Ly-6 C Loss of TNF Signaling Facilitates

M. Mack, J. Sedgwick, H. Körner, 2012 .

This information is current as Molecules and Secreted TNF Importance of Mast Cell Costimulatory Mast Cells Enhance T Cell Activation :

M. Tsai, S. Galli, S. Nakae, 2006 .

Long‐term depletion of cd8+ t cells in vivo in the rat: no observed role for cd8+ (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis

J. Sedgwick, 1988, European journal of immunology.

Immune down‐regulation and peripheral deletion of CD8 T cells does not require TNF receptor‐ligand interactions nor CD95 (Fas, APO‐1)

H. Pircher, J. Sedgwick, H. Körner, 2000, European journal of immunology.

Down-regulation of the macrophage lineage through interaction with OX2 (CD200).

B. Blom, W. Streit, A. Barclay, 2000, Science.

A chemokine-driven positive feedback loop organizes lymphoid follicles

Jason G. Cyster, Reinhold Förster, K. Mark Ansel, 2000, Nature.

Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection.

J. McKerrow, J. Sedgwick, K. Lim, 2004, International journal for parasitology.

CCL27–CCR10 interactions regulate T cell–mediated skin inflammation

H. Soto, A. Zlotnik, T. Ruzicka, 2002, Nature Medicine.

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

T. Mcclanahan, R. Kastelein, J. Sedgwick, 2003, The Journal of experimental medicine.

Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.

A. Barclay, A. Willis, R. Hoek, 2000, Immunity.

Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina

J. Forrester, A. Dick, B. Scallon, 1996, European journal of immunology.

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

J. Karras, P. Hertzog, B. Jenkins, 2008, Journal of Clinical Investigation.

Tumour necrosis factor and lymphotoxin: Molecular aspects and role in tissue‐specific autoimmunity

J. Sedgwick, H. Korner, HEINRICH KORNER, 1996, Immunology and cell biology.

An Essential Role for Tumor Necrosis Factor in Natural Killer Cell–mediated Tumor Rejection in the Peritoneum

M. Smyth, J. Sedgwick, H. Körner, 1998, The Journal of experimental medicine.

Mast Cell-Associated TNF Promotes Dendritic Cell Migration1

M. Tsai, S. Galli, S. Nakae, 2006, The Journal of Immunology.

Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues.

A. Sheil, J. Sedgwick, G. Bishop, 1996, Journal of immunology.

Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases

S. Shchegrova, M. Fassan, H. Sethi, 2021, JCO precision oncology.

Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200 1

Joseph H. Phillips, T. Mcclanahan, J. Phillips, 2003, The Journal of Immunology.

ELISPOT assay: a personal retrospective.

J. Sedgwick, 2005, Methods in molecular biology.

Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

M. Tsai, S. Galli, S. Nakae, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Distinct roles for lymphotoxin‐α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

M. Cook, R. Hoek, J. Sedgwick, 1997 .

Transmembrane TNF Is Sufficient to Initiate Cell Migration and Granuloma Formation and Provide Acute, but Not Long-Term, Control of Mycobacterium tuberculosis Infection1

W. Britton, B. Saunders, J. Sedgwick, 2005, The Journal of Immunology.

Enhanced Tolerance to Autoimmune Uveitis in CD200-Deficient Mice Correlates with a Pronounced Th2 Switch in Response to Antigen Challenge.

A. Dick, J. Liversidge, J. Sedgwick, 2005, The Journal of Immunology.

The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

D. Baeten, J. Sedgwick, S. Na, 2018, Front. Immunol..

TNF modulates susceptibility to UVB‐induced systemic immunomodulation in mice by effects on dermal mast cell prevalence

P. Hart, J. Finlay-Jones, J. Sedgwick, 1998, European journal of immunology.

Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist

T. Zichner, S. Carotta, H. Nar, 2020 .

Tissue digestion with dispase substantially reduces lymphocyte and macrophage cell-surface antigen expression.

J. Sedgwick, E. Foulcher, A. Goodsall, 1996, Journal of immunological methods.

The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.

K. Kikly, J. Sedgwick, S. Na, 2006, Current opinion in immunology.

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

J. Cyster, V. Ngo, R. Hoek, 2001, Immunity.

Microglia induce CD4 T lymphocyte final effector function and death

J. Sedgwick, F. Lemckert, E. Foulcher, 1996, The Journal of experimental medicine.

Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy.

J. Kirby, A. Burt, D. Jones, 2000, Liver.

CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts

Juan Ke, J. Sedgwick, W. Cui, 2007, Proceedings of the National Academy of Sciences.

Direct ex vivo flow cytometric analysis of human microglial cell CD4 expression: examination of central nervous system biopsy specimens from HIV‐seropositive patients and patients with other neurological disease

A. Dick, B. Brew, J. Sedgwick, 1997, AIDS.

Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent.

D. Littman, T. Randall, Yongwon Choi, 2002, Journal of Immunology.

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

V. ter meulen, J. Sedgwick, J. Sedgwick, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.

J. Sedgwick, A. Bean, W. Britton, 1999, Journal of immunology.

Isolation of encephalitogenic CD4+ T cell clones in the rat. Cloning methodology and interferon-gamma secretion.

J. Sedgwick, I. Macphee, J. Sedgwick, 1989, Journal of immunological methods.

Detection of cell-surface molecules, secreted products of single cells and cellular proliferation by enzyme immunoassay.

J. Sedgwick, C. Czerkinsky, J. Sedgwick, 1992, Journal of immunological methods.

Gene targeting in C57BL/6 ES cells. Successful germ line transmission using recipient BALB/c blastocysts developmentally matured in vitro.

J. Sedgwick, J. Sedgwick, H. Körner, 1997, Nucleic acids research.

Gene knock-out technology: a methodological overview for the interested novice.

J. Sedgwick, S. Wood, J. Sedgwick, 1995, Journal of immunological methods.

Delayed kinetics of tumor necrosis factor‐mediated bystander lysis by peptide‐specific CD8+ cytotoxic T lymphocytes

M. Smyth, J. Sedgwick, 1998, European journal of immunology.

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

J. Karras, P. Hertzog, B. Jenkins, 2008, The Journal of clinical investigation.

Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting

J. Pollard, J. Sedgwick, H. Körner, 1997, The Journal of experimental medicine.

Lymphotoxin a / b and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

J. Cyster, M. Cooper, J. Browning, 1999 .

Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation.

P. Holt, J. Sedgwick, J. Sedgwick, 1985, Cellular immunology.

Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens.

P. Holt, J. Sedgwick, J. Sedgwick, 1987, Immunology today.