D. Beers

发表

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

S. Mckercher, S. Appel, D. Beers, 2006, Proceedings of the National Academy of Sciences.

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

S. Appel, D. Beers, J. Henkel, 2012, Experimental Neurology.

Dissociation of data-based and expectancy-based memory following hippocampal lesions in rats.

R. Kesner, D. Beers, 1988, Behavioral and neural biology.

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis

S. Appel, D. Beers, Weihua Zhao, 2020, Scientific Reports.

The Microglial-Motoneuron dialogue in ALS

S. Appel, D. Beers, J. Henkel, 2011, Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology.

Altered calcium homeostasis in ALS as a target for therapy.

S. Appel, D. Beers, R. G. Smith, 2000, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

T. Siddique, T. Pan, S. Appel, 2004, Annals of neurology.

Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

H. Heslop, U. Popat, S. Appel, 2008, Neurology.

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

S. Appel, D. Beers, Weihua Zhao, 2015, Experimental Neurology.

A robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy.

R. Başar, K. Rezvani, E. Shpall, 2016, Cytotherapy.

Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation

S. Appel, D. Beers, Weihua Zhao, 2022, Frontiers in Immunology.

Role of Potassium Channels in Amyloid‐Induced Cell Death

L. Colom, S. Appel, M. Diaz, 1998, Journal of neurochemistry.

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

S. Appel, D. Beers, J. Henkel, 2010, Trends in immunology.

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

S. Appel, D. Beers, 2019, The Lancet Neurology.

Reactive oxygen and nitrogen species - A driving force in amyotrophic lateral sclerosis

S. Appel, D. Beers, J. Henkel, 2012 .

PARP Expression Is Increased in Astrocytes but Decreased in Motor Neurons in the Spinal Cord of Sporadic ALS Patients

S. Appel, D. Beers, J. Henkel, 2003, Journal of neuropathology and experimental neurology.

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity.

E. Shpall, S. Appel, D. Beers, 2017, JCI insight.

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

S. Powell, S. Appel, D. Beers, 2012, EMBO molecular medicine.

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

S. Appel, D. Beers, J. Henkel, 2011, Brain, Behavior, and Immunity.

Mutant SOD1G93A microglia are more neurotoxic relative to wild‐type microglia

S. Appel, D. Beers, J. Henkel, 2007, Journal of neurochemistry.

The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS

S. Appel, D. Beers, J. Henkel, 2006, Molecular and Cellular Neuroscience.

Protective effects of an anti‐inflammatory cytokine, interleukin‐4, on motoneuron toxicity induced by activated microglia

S. Appel, D. Beers, Qin Xiao, 2006, Journal of neurochemistry.

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

S. Appel, D. Beers, J. Henkel, 2008, Proceedings of the National Academy of Sciences.

Novel therapeutic targets in neurodegenerative diseases: Lessons from amyotrophic lateral sclerosis

S. Appel, D. Beers, J. Henkel, 2008, Current neurology and neuroscience reports.

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

S. Appel, D. Beers, J. Henkel, 2012, Neurobiology of Disease.

The Role of Regulatory T Lymphocytes in Amyotrophic Lateral Sclerosis.

S. Appel, D. Beers, Weihua Zhao, 2018, JAMA neurology.

Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis

S. Paganoni, M. Cudkowicz, S. Appel, 2022, Neurology: Neuroimmunology & Neuroinflammation.

HFE mutations are not strongly associated with sporadic ALS

S. Appel, D. Beers, J. Henkel, 2004, Neurology.

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

Robert H. Brown, D. Schoenfeld, J. Glass, 2018, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Peripheral nerve inflammation in ALS mice: cause or consequence

S. Appel, D. Beers, J. Henkel, 2012, Neurology.

Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS

S. Appel, D. Beers, Weihua Zhao, 2022, Annals of neurology.

Serum programmed cell death proteins in amyotrophic lateral sclerosis

S. Appel, D. Beers, Weihua Zhao, 2021, Brain, behavior, & immunity - health.

Expanded autologous regulatory T-lymphocyte infusions in ALS

M. Cudkowicz, J. Berry, S. Appel, 2018, Neurology: Neuroimmunology & Neuroinflammation.

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease

J. Masdeu, Hong Zhao, S. Appel, 2022, Acta Neuropathologica Communications.

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain

J. Masdeu, M. Veronese, P. Zanotti-Fregonara, 2019, European Journal of Nuclear Medicine and Molecular Imaging.

Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration

S. Appel, D. Beers, Weihua Zhao, 2021, Current opinion in neurology.

Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis

M. Schwartz, E. Yoles, O. Butovsky, 2011, PloS one.

Cloning and restriction endonuclease mapping of herpes simplex virus type-1 strains H129 and +GC

T. Kienzle, D. Beers, J. Henkel, 1995, Archives of Virology.

Serial position curves for item (spatial location) information: role of the dorsal hippocampal formation and medial septum

Raymond P. Kesner, R. Kesner, D. Beers, 1988, Brain Research.

SCIENTIFIC PUBLICATIONS OF THE INSTITUTE OF BIOPHYSICS OF THE HUNGARIAN ACADEMY OF SCIENCES 2009 LABORATORY OF MEMBRANE BIOENERGETICS

L. Zou, S. Appel, D. Beers, 2010 .

Parvalbumin overexpression alters immune‐mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis

S. Appel, D. Beers, L. Siklós, 2001, Journal of neurochemistry.

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls

C. Svendsen, L. Ornelas, H. Goodridge, 2020, iScience.

Functional alterations of myeloid cells during the course of Alzheimer’s disease

J. Masdeu, B. Pascual, S. Appel, 2018, Molecular Neurodegeneration.

Restoring regulatory T-cell dysfunction in Alzheimer’s disease through ex vivo expansion

J. Masdeu, B. Pascual, S. Appel, 2020, Brain communications.

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease

S. Appel, E. Lai, D. Beers, 2021, NPJ Parkinson's disease.

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

S. Appel, D. Beers, J. Henkel, 2011, Brain : a journal of neurology.

Neuroinflammation is highest in areas of disease progression in semantic dementia.

J. Masdeu, M. Veronese, P. Zanotti-Fregonara, 2021, Brain : a journal of neurology.

Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury

J. Julien, S. Appel, D. Beers, 2010, Glia.

Microglia in ALS: The Good, The Bad, and The Resting

Weihua Zhao, S. Appel, D. Beers, 2009, Journal of Neuroimmune Pharmacology.

Head-to-Head Comparison of 11C-PBR28 and 18F-GE180 for Quantification of the Translocator Protein in the Human Brain

J. Masdeu, P. Zanotti-Fregonara, B. Pascual, 2018, The Journal of Nuclear Medicine.

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

Shanker Kalyana-Sundaram, G. P. Livi, D. Sieglaff, 2017, JAMA neurology.

Immunoglobulin Fcγ receptor promotes immunoglobulin uptake, immunoglobulin‐mediated calcium increase, and neurotransmitter release in motor neurons

L. Zou, S. Appel, D. Beers, 2002, Journal of neuroscience research.

Activated Microglia Initiate Motor Neuron Injury by a Nitric Oxide and Glutamate‐Mediated Mechanism

W. Le, S. Appel, D. Beers, 2004, Journal of neuropathology and experimental neurology.

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

S. Appel, D. Beers, Weihua Zhao, 2015, Neurotherapeutics.

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

S. Appel, D. Beers, Weihua Zhao, 2013, Journal of Neuroimmune Pharmacology.

Functional alterations of myeloid cells during the course of Alzheimer’s disease

J. Masdeu, B. Pascual, S. Appel, 2018, Molecular Neurodegeneration.

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

R. Bowser, S. Appel, D. Beers, 2009, Neurology.

Calcium: the Darth Vader of ALS

S. Appel, D. Beers, L. Siklós, 2001, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

Neuropathology of Herpes Simplex Virus Encephalitis in a Rat Seizure Model

D. Beers, J. Henkel, J. Rose, 1993, Journal of neuropathology and experimental neurology.

Erratum: Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival [EMBO Mol Med 5, 1] DOI: 10.1002/emmm.201201544

S. Powell, S. Appel, D. Beers, 2013 .

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

S. Appel, D. Beers, Weihua Zhao, 2015, Neurotherapeutics.

Neuroimmunology of Amyotrophic Lateral Sclerosis

S. Appel, D. Beers, J. Henkel, 2014 .

Spatial recognition memory deficits without notable CNS pathology in rats following herpes simplex encephalitis

R. Kesner, D. Beers, J. Henkel, 1995, Journal of the Neurological Sciences.

The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis

S. Appel, D. Beers, Weihua Zhao, 2015 .