J. Smolders

发表

Phenotyping primary human microglia: Tight regulation of LPS responsiveness

K. Schuurman, R. Hoek, N. Koning, 2012, Glia.

Vitamin D as an immune modulator in multiple sclerosis, a review

P. Menheere, J. Damoiseaux, J. Smolders, 2008, Journal of Neuroimmunology.

Vitamin D in the healthy and inflamed central nervous system: access and function

T. Holmøy, J. Damoiseaux, I. Huitinga, 2011, Journal of the Neurological Sciences.

Tissue-resident memory T cells populate the human brain

E. Remmerswaal, I. T. Ten Berge, R. V. van Lier, 2018, Nature Communications.

Vitamin D in multiple sclerosis: implications for assessment and treatment

T. Holmøy, J. Smolders, M. Kampman, 2012, Expert review of neurotherapeutics.

The association of Epstein‐Barr virus infection with CXCR3+ B‐cell development in multiple sclerosis: impact of immunotherapies

M. V. van Zelm, J. Smolders, J. Samijn, 2020, European journal of immunology.

Vitamin D3 supplementation and neurofilament light chain in multiple sclerosis

J. Kuhle, J. V. D. van den Ouweland, J. Damoiseaux, 2020, Acta neurologica Scandinavica.

An Update on Vitamin D and Disease Activity in Multiple Sclerosis

T. Holmøy, W. Camu, J. Smolders, 2019, CNS Drugs.

Characteristics of differentiated CD8+ and CD4+ T cells present in the human brain

E. Remmerswaal, K. Schuurman, I. Huitinga, 2013, Acta Neuropathologica.

White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue‐resident memory T cells

I. Huitinga, J. Smolders, J. Hamann, 2020, European journal of immunology.

Vitamin D as a T-cell modulator in multiple sclerosis.

J. Damoiseaux, J. Smolders, 2011, Vitamins and hormones.

The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells

H. Harbo, E. Celius, T. Holmøy, 2016, Genes and Immunity.

G. Poelmans, J. V. D. van den Ouweland, J. Damoiseaux, 2021, PloS one.

Vitamin D3 supplementation and the IL-2/IL-2R pathway in multiple sclerosis: Attenuation of progressive disturbances?

J. Damoiseaux, J. Smolders, R. Hupperts, 2018, Journal of Neuroimmunology.

Immune regulatory effects of high dose vitamin D3 supplementation in a randomized controlled trial in relapsing remitting multiple sclerosis patients receiving IFNβ; the SOLARIUM study

J. Damoiseaux, J. Smolders, R. Hupperts, 2016, Journal of Neuroimmunology.

Shedding Light on Vitamin D and Multiple Sclerosis

J. Damoiseaux, J. Smolders, R. Hupperts, 2016 .

Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis

P. Menheere, J. Damoiseaux, J. Smolders, 2014, Multiple sclerosis.

multiple sclerosis Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in

P. Menheere, J. Damoiseaux, J. Smolders, 2014 .

Monitoring in vivo immune modulation by vitamin D in multiple sclerosis

J. Damoiseaux, J. Smolders, Anne-Hilde Muris, 2013 .

Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue.

E. Hol, C. V. van Eden, K. Schuurman, 2013, Journal of neuropathology and experimental neurology.

Complementary and Alternative Medicine in Alopecia Areata

J. Jansen, J. Smolders, F. V. D. Biggelaar, 2010, American Journal of Clinical Dermatology.

Stress-Axis Regulation by Vitamin D3 in Multiple Sclerosis

J. V. D. van den Ouweland, J. Damoiseaux, I. Huitinga, 2018, Front. Neurol..

P. Menheere, J. Damoiseaux, J. Smolders, 2011, Journal of Neuroimmunology.

Exploring the effect of vitamin D3 supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis

R. D. Du Pasquier, J. Kuhle, G. Disanto, 2017, Multiple sclerosis.

cacy of vitamin D 3 as add-on therapy in patients with relapsing – remitting multiple sclerosis receiving subcutaneous interferon beta-1 a : A Phase II , multicenter , double-blind , randomized , placebo-controlled trial

F. Barkhof, L. Grimaldi, T. Holmøy, 2011 .

Correlation of different cellular assays to analyze T cell‐related cytokine profiles in vitamin D3‐supplemented patients with multiple sclerosis

J. V. D. van den Ouweland, J. Damoiseaux, J. Smolders, 2019, Molecular immunology.

Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis.

J. Damoiseaux, J. Smolders, R. Hupperts, 2015, Molecular immunology.

Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

P. Menheere, J. Damoiseaux, J. Smolders, 2013, Journal of Neuroimmunology.

The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis.

P. Menheere, J. Damoiseaux, J. Smolders, 2009, Autoimmunity reviews.

On the ethics of not supplementing low 25-hydroxyvitamin D levels in a controlled study in relapsing remitting multiple sclerosis

J. Damoiseaux, J. Smolders, R. Hupperts, 2017, Journal of the Neurological Sciences.

Effect of vitamin D3 supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis

J. Damoiseaux, J. Smolders, R. Hupperts, 2011, Multiple sclerosis.

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

P. Menheere, J. Damoiseaux, J. Smolders, 2011, Journal of Neuroimmunology.

Distinct Effector Programs of Brain-Homing CD8+ T Cells in Multiple Sclerosis

J. Smolders, M. M. van Luijn, M. Melief, 2022, Cells.

NK/T cell ratios associate with interleukin-2 receptor alpha chain expression and shedding in multiple sclerosis

G. Poelmans, J. Damoiseaux, J. Smolders, 2021, Journal of Neuroimmunology.

Prognostic value of natural killer cell/T cell ratios for disease activity in multiple sclerosis

J. Kuhle, J. Damoiseaux, J. Smolders, 2020, European journal of neurology.

Brain-homing CD4+ T cells display glucocorticoid-resistant features in MS

H. D. de Vries, G. Verjans, E. Lubberts, 2020, Neurology: Neuroimmunology & Neuroinflammation.

Editorial: Vitamin D in Neurological Diseases: From Pathophysiology to Therapy

W. Camu, J. Smolders, A. Hiller, 2021, Frontiers in Neurology.

Hypercalcaemia rather than high dose vitamin D3 supplements could exacerbate multiple sclerosis.

J. Damoiseaux, J. Smolders, R. Hupperts, 2019, Brain : a journal of neurology.

High dose cholecalciferol (vitamin D3) oil as add-on therapy in subjects with relapsing-remitting multiple sclerosis (RRMS) receiving subcutaneous interferon β-1a (scIFNβ-1a) (S44.005)

F. Barkhof, L. Grimaldi, T. Holmøy, 2017 .

Letter to the Editor: Vitamin D deficiency in COVID-19: Mixing up cause and consequence

P. Pickkers, M. Kox, J. V. D. van den Ouweland, 2020, Metabolism.

Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis

P. Menheere, J. Damoiseaux, J. Smolders, 2010, The Journal of Steroid Biochemistry and Molecular Biology.

Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis

A. Kessels, P. Menheere, J. Damoiseaux, 2008, Multiple sclerosis.

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions.

T. Kuhlmann, E. Remmerswaal, I. Huitinga, 2020, Brain : a journal of neurology.

Programmed Cell Death Protein 1–Positive CD8+ T Cells in Multiple Sclerosis

J. Smolders, J. Hamann, 2022, Neurology: Neuroimmunology & Neuroinflammation.

Naive B cells in neuromyelitis optica spectrum disorders: impact of steroid use and relapses

J. Smolders, M. M. van Luijn, M. Melief, 2020, Brain communications.

Vitamin D supplementation and antibodies against the Epstein-Barr virus in multiple sclerosis patients

G. Giovannoni, G. Disanto, A. Handel, 2013, Multiple sclerosis.

Improving Glucocorticoid Sensitivity of Brain-Homing CD4+ T Helper Cells by Steroid Hormone Crosstalk

W. Dik, E. Lubberts, J. Smolders, 2022, Frontiers in Immunology.

Pediatric MS patients with a primary progressive-like disease may still have relevant inflammatory activity and may benefit from regular MS treatment

J. Smolders, A. Bruijstens, R. Neuteboom, 2020, Multiple sclerosis.

Intracellular IL-10 detection in T cells by flowcytometry: the use of protein transport inhibitors revisited.

J. C. Cohen Tervaert, J. Damoiseaux, J. Smolders, 2012, Journal of immunological methods.

Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis

M. Mingueneau, P. Moerland, Baohong Zhang, 2022, iScience.

B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers

J. Smolders, M. M. van Luijn, Jamie van Langelaar, 2020, Frontiers in Immunology.

Pregnancy-induced effects on memory B-cell development in multiple sclerosis

C. D. de Groot, J. Smolders, M. M. van Luijn, 2021, Scientific Reports.

Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis.

I. Huitinga, J. Smolders, J. Hamann, 2020, Expert review of neurotherapeutics.

Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up

J. Damoiseaux, J. Smolders, R. Hupperts, 2016, PloS one.

Fluctuations of MS births and UV‐light exposure

G. Comi, J. Lechner-Scott, M. Slee, 2013, Acta neurologica Scandinavica.

Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse

P. Menheere, J. Damoiseaux, J. Smolders, 2011, Journal of Neuroimmunology.

Vitamin D status in patients with MS is negatively correlated with depression, but not with fatigue

J. Damoiseaux, J. Smolders, R. Hupperts, 2011, Acta neurologica Scandinavica.

Safety and T Cell Modulating Effects of High Dose Vitamin D3 Supplementation in Multiple Sclerosis

P. Menheere, J. C. Cohen Tervaert, J. Damoiseaux, 2010, PloS one.

Vitamin D Status Is Positively Correlated with Regulatory T Cell Function in Patients with Multiple Sclerosis

P. Menheere, J. C. Cohen Tervaert, J. Damoiseaux, 2009, PloS one.

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

K. Schuurman, I. Huitinga, J. Melief, 2017, Acta neuropathologica communications.

Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients

J. Damoiseaux, J. Smolders, R. Hupperts, 2021, Journal of Neuroimmunology.

Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis

P. Menheere, J. Damoiseaux, J. Smolders, 2009, Journal of Neuroimmunology.

Network of nuclear receptor ligands in multiple sclerosis: Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules.

J. Damoiseaux, I. Huitinga, J. Smolders, 2016, Autoimmunity reviews.

Post‐mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms

E. Remmerswaal, J. Crusius, I. Huitinga, 2019, Brain pathology.

Effects of vitamin D on the peripheral adaptive immune system: a review.

J. Damoiseaux, J. Smolders, R. Hupperts, 2011, Autoimmunity reviews.

Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed

K. Schuurman, I. Huitinga, J. Melief, 2013, Glia.

Randomized trial of daily high-dose vitamin D3 in patients with RRMS receiving subcutaneous interferon β-1a

F. Barkhof, L. Grimaldi, T. Holmøy, 2019, Neurology.

Benefits of sphingosine-1-phosphate receptor modulators in relapsing MS estimated with a treatment sequence model

M. Versteegh, J. Smolders, I. Smets, 2022, medRxiv.

Association Study on Two Vitamin D Receptor Gene Polymorphisms and Vitamin D Metabolites in Multiple Sclerosis

P. Menheere, J. Damoiseaux, J. Smolders, 2009, Annals of the New York Academy of Sciences.

The Engagement Between Vitamin D and the Immune System: Is Consolidation by a Marriage to Be Expected?

J. Damoiseaux, J. Smolders, 2018, EBioMedicine.

Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage

C. Teunissen, I. Huitinga, J. Smolders, 2022, Neurology: Neuroimmunology & Neuroinflammation.

Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib

U. Boschert, J. Rip, O. Corneth, 2022, JCI insight.

T-cell surveillance of the human brain in health and multiple sclerosis

J. Smolders, J. Hamann, M. M. van Luijn, 2022, Seminars in Immunopathology.

GM-CSF production by CD4+ T cells in MS patients: Regulation by regulatory T cells and vitamin D

J. Damoiseaux, J. Smolders, R. Hupperts, 2015, Journal of Neuroimmunology.

Efficacy of vitamin D3 as add-on therapy in patients with relapsing–remitting multiple sclerosis receiving subcutaneous interferon beta-1a: A Phase II, multicenter, double-blind, randomized, placebo-controlled trial

F. Barkhof, L. Grimaldi, T. Holmøy, 2011, Journal of the Neurological Sciences.

GPCRomics of Homeostatic and Disease-Associated Human Microglia

R. Sankowski, M. Prinz, I. Huitinga, 2021, Frontiers in Immunology.

Selective emergence of antibody-secreting cells in the multiple sclerosis brain

J. Smolders, J. Hamann, M. M. van Luijn, 2023, EBioMedicine.

Editorial: Environmental factors influencing the immune functions during multiple sclerosis

A. Steelman, J. Smolders, M. Inoue, 2023, Frontiers in Immunology.

Absence of B Cells in Brainstem and White Matter Lesions Associates With Less Severe Disease and Absence of Oligoclonal Bands in MS

T. Kuhlmann, I. Huitinga, J. Smolders, 2021, Neurology: Neuroimmunology & Neuroinflammation.

A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis

J. Damoiseaux, J. Smolders, R. Hupperts, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

Should anti-CD20 be used as an immune reconstitution therapy?

J. Smolders, I. Smets, B. Wokke, 2022, Multiple sclerosis.

Natural killer cells in multiple sclerosis: a review.

J. Damoiseaux, J. Smolders, R. Hupperts, 2020, Immunology letters.

3D-to-2D Transition of Anion Mobility in CsPbBr3 under Pressure

A. Walker, J. Smolders, M. Wolf, 2021 .

Effector T Helper Cells Are Selectively Controlled During Pregnancy and Related to a Postpartum Relapse in Multiple Sclerosis

W. Dik, J. Smolders, M. M. van Luijn, 2021, Frontiers in Immunology.

Vitamin D3 supplementation in multiple sclerosis: Symptoms and biomarkers of depression

J. Damoiseaux, J. Smolders, R. Hupperts, 2017, Journal of the Neurological Sciences.

Chapter 8 - The Way Forward With Vitamin D in Multiple Sclerosis

J. Damoiseaux, J. Smolders, R. Hupperts, 2018 .

Identification of neuropathology-based subgroups in multiple sclerosis using a data-driven approach

I. Holtman, I. Huitinga, J. Smolders, 2023, medRxiv.

Fatigue and heat sensitivity in patients with multiple sclerosis

A. Duits, J. Smolders, R. Hupperts, 2012, Acta neurologica Scandinavica.

T cell composition and polygenic multiple sclerosis risk: A population‐based study in children

T. White, M. V. van Zelm, H. Moll, 2021, European journal of neurology.

Immunomodulation by vitamin D in multiple sclerosis: More than IL-17

J. Damoiseaux, J. Smolders, A. Muris, 2016, Journal of Neuroimmunology.

Vitamin D and Multiple Sclerosis: Correlation, Causality, and Controversy

J. Smolders, 2010, Autoimmune diseases.

Multiple sclerosis: why we should focus on both sides of the (auto) antibody

J. Smolders, J. den Dunnen, W. Hoepel, 2021, Neural regeneration research.

Epstein-Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases.

J. Rip, J. Smolders, Laurens Bogers, 2023, Immunology letters.

Multiple sclerosis risk variants influence the peripheral B‐cell compartment early in life in the general population

T. White, M. V. van Zelm, H. Moll, 2022, European journal of neurology.

Locus for severity implicates CNS resilience in progression of multiple sclerosis

Till F. M. Andlauer, K. Stefánsson, M. Pericak-Vance, 2023, Nature.

Comment on the article by Allen et al. ‘A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers’

J. Damoiseaux, J. Smolders, A. Muris, 2013, Multiple sclerosis.

Health-economic benefits of anti-CD20 treatments in relapsing multiple sclerosis estimated using a treatment-sequence model

M. Versteegh, J. Smolders, I. Smets, 2023, Multiple sclerosis journal - experimental, translational and clinical.

Effectiveness and Cost-Effectiveness of 360 Disease-Modifying Treatment Escalation Sequences in Multiple Sclerosis.

M. Versteegh, J. Smolders, S. Huygens, 2021, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

The Diagnostic Sensitivity for Ulnar Neuropathy at the Elbow Is Not Increased by Addition of Needle EMG of ADM and FDI When Nerve Conduction Studies Are Normal

J. Meulstee, W. Verhagen, F. Nijhuis, 2019, Front. Neurol..

Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation

P. Moerland, A. Jongejan, I. Huitinga, 2023, bioRxiv.

Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation

Maarten H. P. Kole, K. Nave, W. Möbius, 2022, Annals of neurology.

Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed

K. Schuurman, I. Huitinga, J. Melief, 2013, Glia.

Response: relationship between vitamin D and depression in multiple sclerosis

J. Damoiseaux, J. Smolders, S. Knippenberg, 2012 .

Vitamin D status in patients with MS is negatively correlated with depression, but not with fatigue

J. Smolders, S. Knippenberg, J. Damoiseaux, 2011, Acta neurologica Scandinavica.

Differential Runx3, Eomes, and T‐bet expression subdivides MS‐associated CD4+ T cells with brain‐homing capacity

J. Rip, N. Hellings, P. Stinissen, 2023, European journal of immunology.

Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis

P. Menheere, J. Damoiseaux, J. Smolders, 2009, Journal of Neuroimmunology.

Real‐world challenges in the diagnosis of primary progressive multiple sclerosis

J. van Rosmalen, J. Smolders, J. D. de Beukelaar, 2023, European journal of neurology.

Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions

I. Holtman, J. Smolders, N. Fransen, 2024, Acta neuropathologica.

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

K. Schuurman, I. Huitinga, J. Melief, 2017, Acta Neuropathologica Communications.