H. Suzuki

发表

Molecular cloning of the nemA gene encoding N-ethylmaleimide reductase from Escherichia coli.

T. Hishinuma, M. Mizugaki, K. Miura, 1997, Biological & pharmaceutical bulletin.

Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data.

Y. Sugiyama, H. Suzuki, T Iwatsubo, 1997, The Journal of pharmacology and experimental therapeutics.

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.

Y. Sugiyama, H. Suzuki, H Suzuki, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Distributed model analysis of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine distribution in brain tissue and cerebrospinal fluid.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1997, The Journal of pharmacology and experimental therapeutics.

Functional Analysis of a Canalicular Multispecific Organic Anion Transporter Cloned from Rat Liver*

Y. Sugiyama, Takao Shimizu, K. Kume, 1998, The Journal of Biological Chemistry.

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

Y. Sugiyama, C. Tyson, H. Suzuki, 1998, FEBS letters.

Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.

T. Tsuruo, H. Kusuhara, Y. Sugiyama, 1998, The Journal of pharmacology and experimental therapeutics.

High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4).

T. Tsuruo, H. Kusuhara, Y. Sugiyama, 1999, The Journal of pharmacology and experimental therapeutics.

Transporters for bile acids and organic anions.

Y. Sugiyama, H. Suzuki, H. Suzuki, 1999, Pharmaceutical biotechnology.

Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).

Y. Sugiyama, H. Suzuki, K. Konno, 1997, The Journal of pharmacology and experimental therapeutics.

Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.

Y. Sugiyama, H. Suzuki, K. Ito, 2001, Molecular pharmacology.

Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): species differences among rats, monkeys and humans.

Y. Sugiyama, T. Kuwabara, S. Kobayashi, 1994, The Journal of pharmacology and experimental therapeutics.

Prediction of in vivo nonlinear first-pass hepatic metabolism of YM796 from in vitro metabolic data.

Y. Sugiyama, H. Suzuki, A. Hisaka, 1998, The Journal of pharmacology and experimental therapeutics.

Applications and prospects for physiologically based pharmacokinetic (PB-PK) models involving pharmaceutical agents.

Y. Sugiyama, H. Suzuki, T. Iwatsubo, 1995, Toxicology letters.

Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1998, The Journal of pharmacology and experimental therapeutics.

Kinetic analysis of the disposition of MRK16, an anti-P-glycoprotein monoclonal antibody, in tumors: comparison between in vitro and in vivo disposition.

T. Tsuruo, Y. Sugiyama, M. Naito, 1997, The Journal of pharmacology and experimental therapeutics.

Comparative hepatic transport of desglycylated and cyclic metabolites of rilmazafone in rats: Analysis by multiple indicator dilution method

Y. Sugiyama, S. Miyauchi, H. Suzuki, 1993, Biopharmaceutics & drug disposition.

Prediction of the pharmacokinetics of cefodizime and cefotetan in humans from pharmacokinetic parameters in animals.

Y. Sawada, T. Iga, H. Suzuki, 1990, Journal of pharmacobio-dynamics.

Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain.

H. Kusuhara, Y. Sugiyama, H. Suzuki, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.

Y. Sugiyama, H. Suzuki, M. Hanano, 1999, The Journal of pharmacology and experimental therapeutics.

Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion.

Y. Sugiyama, H. Suzuki, M. Hanano, 1993, Biological & pharmaceutical bulletin.

Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1997, Journal of Pharmacology and Experimental Therapeutics.

Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes.

Y. Sugiyama, H. Suzuki, K. Ito, 1999, The Journal of pharmacology and experimental therapeutics.

Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes.

Y. Sugiyama, H. Suzuki, K. Ito, 1998, The Journal of pharmacology and experimental therapeutics.

Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats.

Y. Sugiyama, H. Suzuki, T. Horie, 1995, The Journal of pharmacology and experimental therapeutics.

Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.

T. Abe, H. Kusuhara, Y. Sugiyama, 2001, The Journal of pharmacology and experimental therapeutics.

Excretion of GSSG and Glutathione Conjugates Mediated by MRP1 and CM0AT/MRP2

Y. Sugiyama, H. Suzuki, H. Suzuki, 1998, Seminars in liver disease.

Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.

Y. Sugiyama, Takao Shimizu, K. Kume, 1997, The American journal of physiology.

Carrier-mediated hepatic uptake of peptidic endothelin antagonists in rats.

Y. Sugiyama, P. Meier, Y. Kato, 1999, The Journal of pharmacology and experimental therapeutics.

Transport of Drugs Across the Hepatic Sinusoidal Membrane: Sinusoidal Drug Influx and Efflux in the Liver

Y. Sugiyama, H. Suzuki, H. Suzuki, 2000, Seminars in liver disease.

Primary active transport of organic anions on bile canalicular membrane in humans.

Y. Sugiyama, Y. Kato, C. Tyson, 1999, The American journal of physiology.

Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds.

Y. Sugiyama, H. Suzuki, M. Hanano, 1994, The Journal of pharmacology and experimental therapeutics.

Biliary excretion of 17beta-estradiol 17beta-D-glucuronide is predominantly mediated by cMOAT/MRP2.

Y. Sugiyama, A. Morikawa, H. Suzuki, 2000, Pharmaceutical research.

Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

Y. Sugiyama, Y. Kato, H. Suzuki, 1997, Cancer research.

Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2).

Y. Sugiyama, X. Chu, I. Tamai, 2000, The Journal of pharmacology and experimental therapeutics.

P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.

H. Kusuhara, Y. Sugiyama, T. Terasaki, 1997, The Journal of pharmacology and experimental therapeutics.

Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.

Y. Sugiyama, H. Takikawa, H. Akita, 2001, Biochimica et biophysica acta.

Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats.

Y. Sugiyama, H. Suzuki, R. Kawai, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.

Y. Sugiyama, Y. Kato, H. Suzuki, 1997, The Journal of pharmacology and experimental therapeutics.

Effect of benzylpenicillin on the disposition of cefodizime in rats: no net effect on total clearance due to decreased hepatobiliary clearance and increased renal clearance.

Y. Sawada, T. Iga, H. Suzuki, 1992, The Journal of pharmacology and experimental therapeutics.

Dose-dependent effects of PSC 833 on its tissue distribution and on the biliary excretion of endogenous substrates in rats.

Y. Sugiyama, H. Suzuki, C. Tanaka, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Characterization of inducible nature of MRP3 in rat liver.

Y. Sugiyama, T. Ishikawa, P. Meier, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Characterization of 5'-flanking region of human MRP3.

Y. Sugiyama, H. Suzuki, T. Takada, 2000, Biochemical and biophysical research communications.

Different relationships between cellular ATP and hepatic uptake among taurocholate, cholate, and organic anions.

Y. Sugiyama, H. Suzuki, M. Yamazaki, 1993, The American journal of physiology.

Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1998, The Journal of pharmacology and experimental therapeutics.

Utilization of ATP-depleted cells in the analysis of taurocholate uptake by isolated rat hepatocytes.

T. Iga, H. Suzuki, M. Yamazaki, 1992, Journal of hepatology.

Evaluation of the efficiency of targeting of antitumor drugs: simulation analysis based on pharmacokinetic/pharmacodynamic considerations.

Y. Sugiyama, E. Fuse, H. Suzuki, 1996, Journal of drug targeting.

Identification of tissues responsible for the conjugative metabolism of liquiritigenin in rats: an analysis based on metabolite kinetics.

Y. Sugiyama, H. Suzuki, M. Hanano, 1993, Biological & pharmaceutical bulletin.

Immunocytochemical localization of Δ3, Δ2-enoyl-CoA isomerase and NADPH-dependent-2,4-dienoyl-CoA reductase in rat kidney

M. Mizugaki, Y. Tomioka, H. Suzuki, 1993, Histochemistry.

Characterization of the transport properties of organic anion transporting polypeptide 1 (oatp1) and Na(+)/taurocholate cotransporting polypeptide (Ntcp): comparative studies on the inhibitory effect of their possible substrates in hepatocytes and cDNA-transfected COS-7 cells.

Y. Sugiyama, P. Meier, B. Stieger, 2000, The Journal of pharmacology and experimental therapeutics.

Epidermal growth factor as a regulatory hormone maintaining a low pH microclimate in the rat small intestine.

T. Iga, H. Suzuki, M. Yamazaki, 1989, Journal of pharmaceutical sciences.

Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: phenylarsine oxide-sensitive and -insensitive pathways.

Y. Sawada, Y. Kato, H. Suzuki, 1992, Proceedings of the National Academy of Sciences of the United States of America.

In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1997, The Journal of pharmacology and experimental therapeutics.

Transport of cefodizime, a novel third generation cephalosporin antibiotic, in isolated rat choroid plexus.

Y. Sawada, T. Iga, H. Suzuki, 1989, The Journal of pharmacology and experimental therapeutics.

Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation.

Y. Sawada, H. Suzuki, Y. Sugiyama, 1994, The American journal of physiology.

Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats.

T. Tsuruo, Y. Sugiyama, Y. Sawada, 1995, Journal of hepatology.

Carrier-mediated active transport of the glucuronide and sulfate of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) into rat liver: quantitative comparison of permeability in isolated hepatocytes, perfused liver and liver in vivo.

Y. Sugiyama, H. Suzuki, T. Horie, 1997, The Journal of pharmacology and experimental therapeutics.

Transport of cimetidine by the rat choroid plexus in vitro.

Y. Sawada, T. Iga, H. Suzuki, 1986, The Journal of pharmacology and experimental therapeutics.

Subcellular distribution of rat liver NADPH-2,4-dienoyl-CoA reductase.

M. Mizugaki, K. Miura, Y. Tomioka, 1996, Biological & pharmaceutical bulletin.

Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate.

Y. Sugiyama, H. Suzuki, K. Ito, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Effects of phenothiazine derivatives on the microclimate-pH in the rat jejunum.

T. Iga, H. Suzuki, T. Iwatsubo, 1988, Journal of pharmaceutical sciences.

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

Y. Sugiyama, Kiyomi Ito, T. Iwatsubo, 1998, Pharmacological reviews.

Vitamin K deficiency in male rats fed diets containing butylated hydroxytoluene (BHT).

H. Suzuki, T. Nakao, K. Hiraga, 1979, Toxicology and applied pharmacology.

Transport of digoxin into brain microvessels and choroid plexuses isolated from guinea pig.

Y. Sawada, T. Iga, H. Suzuki, 1988, Journal of pharmaceutical sciences.

The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs.

H. Kusuhara, Y. Sugiyama, H. Suzuki, 1998, Journal of pharmaceutical sciences.

Saturable transport of cimetidine from cerebrospinal fluid to blood in rats.

Y. Sawada, T. Iga, H. Suzuki, 1985, Journal of pharmacobio-dynamics.

Reduced folate derivatives are endogenous substrates for cMOAT in rats.

H. Kusuhara, Y. Sugiyama, Y. H. Han, 1998, The American journal of physiology.

Effect of peroxisome proliferator-activated receptor gamma on thromboxane A(2) and prostaglandin E(2) production in macrophage cell lines.

T. Hishinuma, M. Mizugaki, Y. Tomioka, 2002, Prostaglandins, leukotrienes, and essential fatty acids.

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.

T Ishizaki, K Chiba, Y. Sugiyama, 1997, Pharmacology & therapeutics.

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

Y. Sugiyama, K. Kume, H. Suzuki, 1998, Molecular pharmacology.

Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.

Y. Sugiyama, H. Suzuki, M. Yamazaki, 1993, The American journal of physiology.

Uptake of organic anions by isolated rat hepatocytes. A classification in terms of ATP-dependency.

T. Iga, H. Suzuki, M. Yamazaki, 1992, Journal of hepatology.

Active efflux of CPT-11 and its metabolites in human KB-derived cell lines.

Y. Sugiyama, X. Chu, S. Akiyama, 1999, The Journal of pharmacology and experimental therapeutics.

Facilitated transport of benzylpenicillin through the blood-brain barrier in rats.

Y. Sawada, T. Iga, H. Suzuki, 1989, Journal of pharmacobio-dynamics.

Positron emission tomography (PET) study of the alterations in brain distribution of [11C]methamphetamine in methamphetamine sensitized dog.

T. Hishinuma, M. Itoh, M. Mizugaki, 1995, Nuclear medicine and biology.

Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats.

Y. Sugiyama, Y. Kato, H. Suzuki, 2000, The Journal of pharmacology and experimental therapeutics.

Species differences in the transport activity for organic anions across the bile canalicular membrane.

Y. Sugiyama, Kumiko Konno, H. Suzuki, 1999, The Journal of pharmacology and experimental therapeutics.

Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats.

Y. Sugiyama, H. Suzuki, M. Hanano, 1993, The Journal of pharmacology and experimental therapeutics.

Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters.

Y. Sugiyama, X. Chu, Y. Kato, 1998, Cancer research.

Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes.

Y. Sugiyama, T. Kamataki, C. Tyson, 1997, The Journal of pharmacology and experimental therapeutics.

Anion exchanger mediates benzylpenicillin transport in rat choroid plexus.

Y. Sawada, T. Iga, H. Suzuki, 1987, The Journal of pharmacology and experimental therapeutics.

A new method of quantifying human muscle sympathetic nerve activity for frequency domain analysis.

T Mano, S Iwase, Y. Sugiyama, 1996, Electroencephalography and clinical neurophysiology.

Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide.

Y. Sugiyama, P. Meier, B. Stieger, 1998, The Journal of pharmacology and experimental therapeutics.

Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1996, The Journal of pharmacology and experimental therapeutics.

Multiple transport systems for organic anions across the bile canalicular membrane.

Y. Sugiyama, H. Suzuki, T. Yamada, 1994, The Journal of pharmacology and experimental therapeutics.

Disposition and metabolism of [3H]gliclazide in rats

H. Suzuki, S. Arakawa, H. Miyazaki, 1983, European journal of drug metabolism and pharmacokinetics.

Facilitated transport of cefodizime into the rat central nervous system.

Y. Sawada, T. Iga, H. Suzuki, 1991, The Journal of pharmacology and experimental therapeutics.

Transport of benzylpenicillin by the rat choroid plexus in vitro.

Y. Sawada, T. Iga, H. Suzuki, 1987, The Journal of pharmacology and experimental therapeutics.

Pharmacokinetic study of 4-methylumbelliferone in mice.

Y. Sawada, T. Iga, H. Suzuki, 1987, Journal of pharmacobio-dynamics.

Ascorbate-dependent elevation of mRNA levels for cytochrome P450s induced by polychlorinated biphenyls.

H. Suzuki, N. Tsukagoshi, K. Hitomi, 1993, Biochemical pharmacology.

Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.

Y. Sugiyama, Kiyomi Ito, Y. Kato, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Uptake of propranolol by microvessels isolated from bovine brain.

Y. Sawada, T. Iga, H. Suzuki, 1987, Journal of pharmaceutical sciences.

Nonlinear relationship between benzodiazepine receptor occupancy and glucose metabolic response in the conscious mouse brain in vivo.

Y. Sawada, T. Iga, H. Suzuki, 1989, The Journal of pharmacology and experimental therapeutics.

Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system.

Y. Sawada, T. Iga, H. Suzuki, 1989, The Journal of pharmacology and experimental therapeutics.