K. Wafford

发表

Modelling maintenance of wakefulness in rats: comparing potential non‐invasive sleep‐restriction methods and their effects on sleep and attentional performance

G. Gilmour, B. Eastwood, A. McCarthy, 2017, Journal of sleep research.

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

B. Orser, J. Macdonald, J. Lambert, 2004 .

Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice

D. Dijk, G. Gilmour, K. Wafford, 2022, The Journal of Neuroscience.

REM sleep’s unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice

C. Möller-Levet, D. Dijk, K. Malki, 2019, Proceedings of the National Academy of Sciences.

REM sleep: unique associations with behavior, corticosterone regulation and apoptotic pathways in chronic stress in mice

C. Möller-Levet, D. Dijk, K. Malki, 2018 .

Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer’s disease and schizophrenia: Insights from studies in patient populations and animal models

Gary Gilmour, Raphaelle Winsky-Sommerer, Derk-Jan Dijk, 2019, Neuroscience & Biobehavioral Reviews.

Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration

B. Eastwood, A. McCarthy, K. Wafford, 2020, Alzheimer's Research & Therapy.

New directions in kinetic high information content assays.

K. Wafford, Keith A Wafford, Peter B Simpson, 2006, Drug discovery today.

NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.

Menghang Xia, Bohumil Bednar, Kenneth D Anderson, 2004, Journal of medicinal chemistry.

Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.

J. Kemp, P. Whiting, B. le Bourdellès, 1995, Molecular pharmacology.

N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a Novel Metabotropic Glutamate 2 Potentiator with Potential Anxiolytic/Antidepressant Properties: In Vivo Profiling Suggests a Link between Behavioral and Central Nervous System Neu

G. Marek, K. Perry, J. Witkin, 2011, Journal of Pharmacology and Experimental Therapeutics.

Development and pharmacological characterization of a model of sleep disruption‐induced hypersensitivity in the rat

R. Treede, G. Gilmour, K. Wafford, 2015, European journal of pain.

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor α5 Subtype-Selective Inverse Agonist

A. D. Rodrigues, K. Gingrich, G. Dawson, 2009, Journal of Pharmacology and Experimental Therapeutics.

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-

A. D. Rodrigues, K. Gingrich, G. Dawson, 2009 .

Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers

Desmond O'Connor, G. Dawson, J. Atack, 2004 .

The proconvulsant effects of the GABAA α5 subtype-selective compound RY-080 may not be α5-mediated

G. Dawson, R. Mckernan, J. Atack, 2006 .

The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present.

R. Mckernan, P. Whiting, C. Ragan, 1995, Journal of receptor and signal transduction research.

THE PHARMACOLOGY OF THE BENZODIAZEPINE SITE OF SUBUNIT PRESENT. THE GABA-A RECEPTOR IS DEPENDENT ON THE TYPE OF y-

R. Mckernan, K. Wafford, K. Quirk, 1995 .

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

J. F. Soriano, P. Ornstein, M. Blanco, 2016, Bioorganic & medicinal chemistry letters.

The GABAA receptor: An important target for the general anaesthetic etomidate

J. Lambert, T. Rosahl, K. Wafford, 2005 .

γ-Aminobutyric Acid Type A Receptor β2 Subunit Mediates the Hypothermic Effect of Etomidate in Mice

T. Rosahl, K. Wafford, G. O'Meara, 2004 .

Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides

D. Sattelle, S. Lummis, K. Wafford, 1989, Proceedings of the Royal Society of London. B. Biological Sciences.

Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro

Stuart D. Greenhill, A. Burgess, I. Stanford, 2017, Neuropharmacology.

Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist

Sandra M. Sanabria-Bohórquez, G. Bormans, K. Van Laere, 2011, Journal of psychopharmacology.

The M1/M4 agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain

A. Schwarz, D. McKinzie, A. Gozzi, 2020, bioRxiv.

Cloning and expression of a cDNA encoding the human GABA-A receptor alpha 5 subunit.

J. Kemp, P. Whiting, C. Ragan, 1992, Biochemical Society transactions.

Loss of the Major GABAA Receptor Subtype in the Brain Is Not Lethal in Mice

G. Dawson, R. Mckernan, P. Whiting, 2001, The Journal of Neuroscience.

Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration

B. Eastwood, A. McCarthy, K. Wafford, 2020, Alzheimer's Research & Therapy.

Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist.

N. Hanley, G. Gilmour, B. Eastwood, 2019, Sleep.

Differential contribution of GABAA receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands

G. Dawson, P. Whiting, J. Atack, 2007, Journal of psychopharmacology.

Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

S. Tye, A. Pike, J. Atack, 2006 .

A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-d-aspartate type 2B receptor

P. Whiting, R. Heavens, T. Rosahl, 2006, Molecular and Cellular Neuroscience.

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

G. Dawson, S. Tye, R. Mckernan, 2006, Journal of Pharmacology and Experimental Therapeutics.

Noncompetitive inhibition of GABA receptors in insect and vertebrate CNS by endrin and lindane

D. Sattelle, K. Wafford, A. Eldefrawi, 1989 .

γ‐Aminobutyric Acid‐Activated 36Cl‐ Influx: A Functional In Vitro Assay for CNS γ‐Aminobutyric Acid Receptors of Insects

D. Sattelle, K. Wafford, A. Eldefrawi, 1987, Journal of neurochemistry.

N‐Methyl‐d‐aspartate receptor subtype‐selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors

K. Wafford, S. Grimwood, P. Hutson, 2002, Journal of neurochemistry.

The role of K2P channels in anaesthesia and sleep

N. Franks, W. Wisden, S. Brickley, 2014, Pflügers Archiv - European Journal of Physiology.

Mechanism of α-subunit selectivity of benzodiazepine pharmacology at γ-aminobutyric acid type A receptors

P. Whiting, P. Safo, S. Thompson, 2002 .

Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors.

P. Whiting, P. Safo, S. Thompson, 2002, European journal of pharmacology.

Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat.

Andreas Bender, Georgios Drakakis, Suzanne C Brewerton, 2017, ACS chemical biology.

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

G. Dawson, R. Mckernan, A. Pike, 2004, Journal of medicinal chemistry.

Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABAA receptors

J. Kemp, U. Kristiansen, P. Krogsgaard‐Larsen, 1997 .

Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors.

J. Kemp, P. Whiting, K. Wafford, 1993, Molecular pharmacology.

Benzodiazepine receptor agonists and insomnia: Is subtype selectivity lost in translation?

K. Wafford, B. Ebert, 2006 .

Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.

P. Whiting, R. Heavens, D. Sirinathsinghji, 1996, Molecular pharmacology.

Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.

J. Kemp, P. Whiting, K. Wafford, 1993, Molecular pharmacology.

u, a novel g-aminobutyric acid type A receptor subunit

R. Mckernan, P. Whiting, R. Heavens, 1999 .

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.

Karen S. Curley, R. Mckernan, J. Atack, 2004, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.

A. Pike, J. Atack, K. Wafford, 2006, Bioorganic & medicinal chemistry letters.

Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus

J. Lambert, K. Wafford, Q. Ma, 2009, Neuropharmacology.

Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution

K. Wafford, 2021, Cerebral circulation - cognition and behavior.

Structure and pharmacology of vertebrate GABAA receptor subtypes.

R. Mckernan, P. Whiting, K. Wafford, 1995, International review of neurobiology.

The expression of GABAAβ subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells

G. Homanics, J. Lambert, T. Rosahl, 2008, The Journal of physiology.

Extrasynaptic GABAA Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics

J. Lambert, T. Rosahl, K. Wafford, 2005, The Journal of Neuroscience.

Selective Enhancement of Tonic GABAergic Inhibition in Murine Hippocampal Neurons by Low Concentrations of the Volatile Anesthetic Isoflurane

B. Orser, J. Macdonald, T. Rosahl, 2004, The Journal of Neuroscience.

Anxiogenic properties of an inverse agonist selective for α3 subunit‐containing GABAA receptors

G. Dawson, R. Mckernan, J. Atack, 2005 .

GABA receptors on the cell-body membrane of an identified insect motor neuron

D. Sattelle, K. Wafford, J. A. David, 1988, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.

B. Orser, J. Macdonald, J. Lambert, 2004, Proceedings of the National Academy of Sciences of the United States of America.

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

G. Dawson, P. Leeson, R. Mckernan, 2004 .

3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

G. Dawson, P. Leeson, R. Mckernan, 2004, Journal of medicinal chemistry.

Imidazo[1,2-a]pyrimidines as Functionally Selective and Orally Bioavailable GABAAα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders

Joanna Stanley, A. Pike, J. Atack, 2006 .

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.

R. Mckernan, J. Atack, K. Wafford, 2005, Journal of medicinal chemistry.

Tracazolate Reveals a Novel Type of Allosteric Interaction with Recombinant γ-Aminobutyric AcidA Receptors

P. Whiting, K. Wafford, Keith A. Wafford, 2002 .

6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.

G. Dawson, J. Atack, H. Broughton, 2002, Journal of medicinal chemistry.

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.

K. Wafford, S. Grimwood, F. Murray, 2003, Bioorganic & medicinal chemistry letters.

Pyrazolopyridinones as functionally selective GABAA ligands.

R. Mckernan, J. Atack, K. Wafford, 2005, Bioorganic & medicinal chemistry letters.

Metabotropic Glutamate Receptor

J. F. Soriano, P. Ornstein, S. Atwell, 2016 .

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo‐oligomeric GABA receptor from Drosophila melanogaster

D. Sattelle, E. Williamson, C. Priestley, 2003, British journal of pharmacology.

Assembly of N-methyl-D-aspartate (NMDA) receptors.

P. Whiting, K. Wafford, R. Mcilhinney, 2003, Biochemical Society transactions.

The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function.

K. Wafford, C. Connolly, Christopher N. Connolly, 2004, Biochemical Society transactions.

GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

K. Wafford, 2005, Current opinion in pharmacology.

A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy.

R. Harris, S. Mihic, P. Whiting, 1994, The Journal of biological chemistry.

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.

V. Warren, Y. S. Tang, K. Wafford, 2004, Biochemistry.

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism

J. Isaac, D. Bredt, E. Nisenbaum, 2016, Nature Medicine.

The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain

A. Schwarz, D. McKinzie, A. Gozzi, 2020, Neuropsychopharmacology.

Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.

J. Sikela, P. Whiting, K. Wafford, 1996, Molecular pharmacology.

Growth factors regulate the survival and fate of cells derived from human neurospheres

Scott Pollack, Clive N. Svendsen, C. Svendsen, 2001, Nature Biotechnology.

Actions of the insecticide 2 (nitromethylene) tetrahydro-1, 3-thiazine on insect and vertebrate nicotinic acetylcholine receptors

D. Sattelle, T. E. May, K. Wafford, 1989, Proceedings of the Royal Society of London. B. Biological Sciences.

Ethanol sensitivity of the GABAA receptor expressed in xenopus oocytes requires 8 amino acids contained in the γ2L subunit

J. Sikela, T. Dunwiddie, P. Kofuji, 1991, Neuron.

Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-d-aspartate Receptors*

K. Wafford, R. Mcilhinney, S. Grimwood, 2001, The Journal of Biological Chemistry.

Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.

R. Mckernan, J. Schaeffer, K. Wafford, 2000, The Journal of pharmacology and experimental therapeutics.

Allosteric modulators affect the efficacy of partial agonists for recombinant GABAA receptors

G. Maksay, K. Wafford, S. Thompson, 2000, British journal of pharmacology.

Molecular and Functional Diversity of the Expanding GABA‐A Receptor Gene Family

R. Mckernan, P. Whiting, M. Rigby, 1999, Annals of the New York Academy of Sciences.

Sedatives and Hypnotics

P. Whiting, K. Wafford, 2007 .

Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms

G. Dawson, T. Iwatsubo, I. Nishimoto, 2003, The Journal of Neuroscience.

Effects of amino acid neurotransmitter candidates on an identified insect motoneurone

D. Sattelle, K. Wafford, 1986, Neuroscience Letters.

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones

G. Homanics, J. Lambert, J. Fritschy, 2008, The Journal of physiology.

Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors.

J Kerby, P. Whiting, T. Bonnert, 2002, British journal of pharmacology.

theta, a novel gamma-aminobutyric acid type A receptor subunit.

R. Mckernan, P. Whiting, M. Rigby, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Distinct activities of GABA agonists at synaptic‐ and extrasynaptic‐type GABAA receptors

T. Smart, K. Wafford, M. Mortensen, 2010, The Journal of physiology.

Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines

G. Dawson, R. Dias, S. Tye, 2005, The Journal of Neuroscience.

An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

N Collinson, B. Everitt, J. Atack, 2006, Journal of Pharmacology and Experimental Therapeutics.

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.

G. Dawson, R. Mckernan, A. Pike, 2005, Journal of medicinal chemistry.

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression

E. Robinson, D. Lodge, A. McCarthy, 2018, Neuropharmacology.

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders

Hong Wang, Charles R. Yang, M. O'Neill, 2018, Neuropharmacology.

Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors

S. Mitchell, G. Gilmour, J. Witkin, 2017, Neuropharmacology.

Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression.

P. Ornstein, V. Tolstikov, S. Mitchell, 2017, The Journal of Pharmacology and Experimental Therapeutics.

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

G. Dawson, R. Mohs, C. Harmer, 2016, Neuropsychopharmacology.

REM sleep homeostasis in the absence of REM sleep: Effects of antidepressants

D. Dijk, D. Edgar, A. McCarthy, 2016, Neuropharmacology.

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

G. Dawson, R. Mohs, C. Harmer, 2016, Neuropsychopharmacology.

In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat

Janice W. Smith, M. Tricklebank, F. Gastambide, 2013, Neuropharmacology.

Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia

Matt W. Jones, M. O'Neill, M. Tricklebank, 2012, Neuropharmacology.

Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABAA Receptor Subunit Conferring Atypical Functional Properties

P. Whiting, D. Vassilatis, M. Rigby, 1997, The Journal of Neuroscience.

Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.

P. Whiting, K. Wafford, G. Marshall, 1999, Molecular pharmacology.

Functional Characterization of GABAA Receptor Ligands In Vitro

S. Thompson, K. Wafford, Signe í Stórustovu, 2004 .

The Interactions of Hexachlorocyclohexane Isomers with Human γ-Aminobutyric AcidA Receptors Expressed inXenopus Oocytes

L. King, K. Wafford, I. Bermúdez, 1997 .

The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes.

L. King, K. Wafford, I. Bermúdez, 1997, The Journal of pharmacology and experimental therapeutics.

A Pyridazine Series of α2/α3 Subtype Selective GABAA Agonists for the Treatment of Anxiety

S. Tye, A. Pike, J. Atack, 2006 .

Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.

S. Tye, A. Pike, J. Atack, 2006, Journal of medicinal chemistry.

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

J. F. Soriano, P. Ornstein, S. Atwell, 2016, Journal of medicinal chemistry.

Decoupling of Sleep-Dependent Cortical and Hippocampal Interactions in a Neurodevelopmental Model of Schizophrenia

Mark D. Tricklebank, Keith G. Phillips, Dale M. Edgar, 2012, Neuron.

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

J. Sikela, J. Kemp, C. Ragan, 1993, Molecular pharmacology.

Gaboxadol--a new awakening in sleep.

K. Wafford, B. Ebert, Keith A Wafford, 2006, Current opinion in pharmacology.

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.

P. Whiting, J. A. Peters, J. Lambert, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.

P. Whiting, K. Wafford, C. Bain, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A novel allosteric modulatory site on the GABAA receptor β subunit

J. Kemp, R. Mckernan, P. Whiting, 1994, Neuron.

The role of GABAAβ2 subunit‐containing receptors in mediating the anticonvulsant and sedative effects of loreclezole

A. Pike, T. Rosahl, K. Wafford, 2006, The European journal of neuroscience.

Key Amino Acids in the γ Subunit of the γ-Aminobutyric AcidA Receptor that Determine Ligand Binding and Modulation at the Benzodiazepine Site

P. Whiting, K. Wafford, P. Wingrove, 1997 .

Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.

J. Kemp, P. Whiting, P. Krogsgaard‐Larsen, 1994, Molecular pharmacology.

The modulatory action of loreclezole at the y-aminobutyric acid type A receptor is determined by a single amino acid in the P 2 and f 3 subunit

P. Whiting, K. Wafford, C. Bain, 2004 .

beta-Carboline gamma-aminobutyric acidA receptor inverse agonists modulate gamma-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site.

P. Whiting, K. Wafford, P. Wingrove, 1995, Molecular pharmacology.

A novel allosteric modulatory site on the GABAA receptor beta subunit.

J. Kemp, R. Mckernan, P. Whiting, 1994, Neuron.

Activity of chlormethiazole at human recombinant GABAA and NMDA receptors

P. Whiting, K. Wafford, S. Thompson, 2003, British journal of pharmacology.

The pharmacology of spontaneously open α1β3ε GABAA receptor–ionophores

G. Maksay, S. Thompson, K. Wafford, 2003, Neuropharmacology.

Pharmacology of GABA(A) receptors exhibiting different levels of spontaneous activity.

K. Wafford, M. Mortensen, B. Ebert, 2003, European journal of pharmacology.

Cellular / Molecular 5 GABAA Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

Loren J. Martin, J. Roder, B. Orser, 2006 .

The in vivo properties of pagoclone in rat are most likely mediated by 5′-hydroxy pagoclone

G. Dawson, R. Mckernan, J. Atack, 2006, Neuropharmacology.

REM sleep : unique associations with corticosterone regulation , 2 apoptotic pathways and behavior in chronic stress in mice 3

C. Möller-Levet, D. Dijk, K. Malki, 2019 .

Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour

G. Dawson, J. Atack, C. McCabe, 2004, Neuropharmacology.

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

A. Pike, J. Atack, K. Wafford, 2006 .

2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists

J. Atack, K. Wafford, L. Street, 2006 .

Imidazo[1,2-a]pyrazin-8-ones, Imidazo[1,2-d][1,2,4]triazin-8-ones and Imidazo[2,1-f][1,2,4]triazine-8-ones as α2/α3 Subtype Selective GABAA Agonists for the Treatment of Anxiety.

A. Pike, J. Atack, K. Wafford, 2006 .

Treating insomnia: Current and investigational pharmacological approaches.

K. Wafford, S. Deacon, Stephen Deacon, 2006, Pharmacology & therapeutics.

Effect of α Subunit on Allosteric Modulation of Ion Channel Function in Stably Expressed Human Recombinant γ-Aminobutyric AcidA Receptors Determined Using36Cl Ion Flux

C. Adkins, R. Mckernan, J. Atack, 2001 .

Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux.

C. Adkins, R. Mckernan, K. Wafford, 2001, Molecular pharmacology.

L-GLUTAMATE RECEPTORS ON THE CELL BODY MEMBRANE OF AN IDENTIFIED INSECT MOTOR NEURONE

D. Sattelle, K. Wafford, 1989 .

L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors

G. Dawson, R. Mckernan, J. Atack, 2006, Neuropharmacology.

The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers

K. Biglan, C. Brittain, A. McCarthy, 2021, The Journal of Pharmacology and Experimental Therapeutics.

The dopamine D1 receptor positive allosteric modulator mevidalen (LY3154207) enhances wakefulness in the humanized D1 mouse and in sleep deprived healthy volunteers

B. Eastwood, K. Biglan, C. Brittain, 2021 .

The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol

R. Harris, J. Lambert, K. Wafford, 2006, Journal of Pharmacology and Experimental Therapeutics.

3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels

G. Dawson, R. Mckernan, A. Pike, 2002 .

Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors.

G. Dawson, R. Mckernan, J. Atack, 2005, British journal of pharmacology.

Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time

K. Wafford, B. Ebert, 2008, Nature Reviews Drug Discovery.

Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice

V. Vyazovskiy, S. Peirson, R. Foster, 2018, The Journal of Neuroscience.

Expression and pharmacology of human GABAA receptors containing γ3 subunits

P. Whiting, S. Thompson, K. Wafford, 1995 .

The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

R. Harris, J. Lambert, K. Wafford, 2006, The Journal of pharmacology and experimental therapeutics.

Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour

G. Collingridge, E. Robinson, B. Conway-Campbell, 2017, Neuropharmacology.

Preferential co-assembly of recombinant NMDA receptors composed of three different subunits.

J. Kemp, P. Whiting, K. Wafford, 1993, Neuroreport.

GABAA Receptor Subtypes: Novel Targets for Novel Medicines

J. Atack, K. Wafford, N. Mirza, 2012, Advances in pharmacological sciences.

A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

S. Tye, A. Pike, J. Atack, 2006, Journal of Medicinal Chemistry.

Orally efficacious NR2B-selective NMDA receptor antagonists.

Kenneth D Anderson, R. Freidinger, N. Liverton, 2003, Bioorganic & medicinal chemistry letters.

The role of K2P channels in anaesthesia and sleep

N. Franks, W. Wisden, S. Brickley, 2014, Pflügers Archiv - European Journal of Physiology.

α5GABAA Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

Loren J. Martin, J. Roder, B. Orser, 2006, The Journal of Neuroscience.

Mutation at the putative GABAA ion‐channel gate reveals changes in allosteric modulation

P. Whiting, K. Wafford, P. Wingrove, 1999, British journal of pharmacology.

Functional characteristics of recombinant human GABAA receptors containing the ϵ-subunit

P. Whiting, T. Bonnert, K. Wafford, 1998 .

gamma-Aminobutyric acid-A (GABA-A) receptor/ion channel complex.

R. Mckernan, P. Whiting, C. Ragan, 1993, Biochemical Society Transactions.

Overexpression of the GABAA receptor ε subunit results in insensitivity to anaesthetics

P. Whiting, T. Bonnert, K. Wafford, 2002, Neuropharmacology.

The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers S

K. Biglan, C. Brittain, A. McCarthy, 2022 .

The Pharmacology of Extrasynaptic GABAA Receptors

K. Wafford, 2014 .

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

R. Mckernan, P. Whiting, J. Atack, 2000, Nature Neuroscience.

P. Ornstein, S. Mitchell, G. Gilmour, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors

P. Whiting, T. Bonnert, K. Wafford, 2002 .

Functional modulation of cloned GABAA receptors expressed in Xenopus oocytes.

J. Kemp, P. Whiting, K. Wafford, 1992, Advances in biochemical psychopharmacology.

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors

J. Lambert, K. Wafford, D. Belelli, 2013, British journal of pharmacology.

Cloning, Functional Coexpression, and Pharmacological Characterisation of Human cDNAs Encoding NMDA Receptor NR1 and NR2A Subunits

K. Wafford, C. Bain, B. Bourdellès, 1994, Journal of neurochemistry.

TaiNi: Maximizing research output whilst improving animals’ welfare in neurophysiology experiments

Esther Rodriguez-Villegas, Stuart A. Bowyer, Zhou Jiang, 2017, Scientific Reports.

Orexin A induced increases in rat locus coeruleus neuronal activity are attenuated by systemic administration of OX1R and OX2R antagonists

G. Gilmour, K. Wafford, C. Holton, 2020 .

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.

Desmond O'Connor, Robert Maxey, J. Atack, 2006, Bioorganic & medicinal chemistry letters.

Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-d-aspartate Receptors*

K. Wafford, S. Grimwood, P. Whiting, 2001, The Journal of Biological Chemistry.

Pharmacology of putative glutamate receptors from insect skeletal muscles, insect central nervous system and rat brain.

D. Sattelle, K. Wafford, A. Eldefrawi, 1987, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

P. Whiting, K. Wafford, S. Thompson, 1996, British journal of pharmacology.

Anticonvulsant and Adverse Effects of Avermectin Analogs in Mice Are Mediated through the g -Aminobutyric Acid A Receptor

R. Mckernan, K. Wafford, P. Bayley, 2000 .

Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site.

P. Whiting, K. Wafford, P. Wingrove, 1997, Molecular pharmacology.