C. Pifl

发表

Thalamic noradrenaline in Parkinson's disease: Deficits suggest role in motor and non‐motor symptoms

S. Kish, O. Hornykiewicz, C. Pifl, 2012, Movement disorders : official journal of the Movement Disorder Society.

Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey

O. Hornykiewicz, C. Pifl, G. Schingnitz, 1991, Neuroscience.

Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

H. Sitte, M. Freissmuth, C. Pifl, 2021, bioRxiv.

Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

H. Sitte, M. Freissmuth, C. Pifl, 2021, eLife.

Solving the trade-off by differences in handling of intracellular K+: why substrate translocation by the dopamine transporter but not by the serotonin transporter is voltage-dependent

H. Sitte, M. Freissmuth, C. Pifl, 2020, bioRxiv.

Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain

G. Sperk, A. Reiner, C. Pifl, 2019, Journal of neurochemistry.

Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants

L. Groop, T. Hökfelt, J. Mulder, 2019, The EMBO journal.

Molecular pharmacology of amantadine and related drugs in cells heterologously expressing human transporters and receptors

C. Pifl, C. Sommerauer, Diplomstudium Molekulare Biologie, 2010 .

Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter.

O. Hornykiewicz, C. Pifl, E. Singer, 1995, Molecular pharmacology.

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium

M. Caron, B. Giros, C. Pifl, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Zn2+ modulates currents generated by the dopamine transporter: parallel effects on amphetamine-induced charge transfer and release

C. Pifl, P. Rebernik, H. Reither, 2004, Neuropharmacology.

Pharmacological Characterization of Ecstasy Synthesis Byproducts with Recombinant Human Monoamine Transporters

G. Nagy, C. Pifl, S. Antus, 2005, Journal of Pharmacology and Experimental Therapeutics.

JPET #84426 1 Pharmacological characterization of ecstasy synthesis by-products with recombinant human monoamine transporters

C. Pifl, Sándor, H. Reither, 2005 .

Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of facilitated exchange diffusion.

C. Pifl, E. Singer, E. A. Singer, 1999, Molecular pharmacology.

Functional sensitization of striatal dopamine D1 receptors in the 6-hydroxydopamine-lesioned rat

O. Hornykiewicz, C. Pifl, H. Reither, 1992, Brain Research.

The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine

C. Nanoff, C. Pifl, P. Rebernik, 2012, Neuropharmacology.

Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter

M. Caron, O. Hornykiewicz, J. Zezula, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Apoptosis‐inducing factor in nigral dopamine neurons: Higher levels in primates than in mice

C. Pifl, J. Bauer, T. Peneder, 2016, Movement disorders : official journal of the Movement Disorder Society.

Disturbed neurotransmitter homeostasis in ether lipid deficiency

D. Pollak, C. Wiesinger, C. Pifl, 2019, Human molecular genetics.

Striatal and non-striatal neurotransmitter changes in MPTP-parkinsonism in rhesus monkey: The symptomatic versus the asymptomatic condition

O. Hornykiewicz, C. Pifl, G. Schingnitz, 1992, Neurochemistry International.

Cellular effects of dopamine--beyond oxidative mechanisms.

O. Hornykiewicz, C. Pifl, H. Reither, 2002, Parkinsonism & related disorders.

Induction of apoptosis in vitro and in vivo by the cholinergic neurotoxin ethylcholine aziridinium

H. Lassmann, C. Pifl, W. Rinner, 1997, Neuroscience.

A Pex7 Deficient Mouse Series Correlates Biochemical and Neurobehavioral Markers to Genotype Severity—Implications for the Disease Spectrum of Rhizomelic Chondrodysplasia Punctata Type 1

A. Moser, N. Braverman, C. Pifl, 2022, Frontiers in Cell and Developmental Biology.

Lower efficacy of the dopamine D1 agonist, SKF 38393, to stimulate adenylyl cyclase activity in primate than in rodent striatum.

O. Hornykiewicz, C. Pifl, H. Reither, 1991, European journal of pharmacology.

A mechanism of uncompetitive inhibition of the serotonin transporter

T. Hummel, M. Freissmuth, C. Pifl, 2022, bioRxiv.

Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion.

H. Sitte, C. Pifl, P. Scholze, 2001, Molecular pharmacology.

Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter.

H. Sitte, C. Pifl, P. Scholze, 2000, The Journal of pharmacology and experimental therapeutics.

Characterization of Carrier‐Mediated Efflux in Human Embryonic Kidney 293 Cells Stably Expressing the Rat Serotonin Transporter: A Superfusion Study

H. Sitte, C. Pifl, P. Schloss, 2000, Journal of neurochemistry.

The psychostimulant (±)-cis-4,4′-dimethylaminorex (4,4′-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters

H. Sitte, M. Liechti, C. Pifl, 2018, Neuropharmacology.

Effects of NMDA receptor modulators on a blood–brain barrier in vitro model

C. Noe, M. Wirth, C. Pifl, 2011, Brain Research.

The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter.

O. Hornykiewicz, C. Pifl, H. Reither, 2015, European journal of pharmacology.

Early Paradoxical Increase of Dopamine: A Neurochemical Study of Olfactory Bulb in Asymptomatic and Symptomatic MPTP Treated Monkeys

C. Cavada, J. Obeso, J. Blesa, 2017, Front. Neuroanat..

Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D-1 receptor stimulation.

O. Hornykiewicz, C. Pifl, 1988, European journal of pharmacology.

The dopamine autoreceptor agonist, B-HT 920, preferentially reduces brain dopamine release in vivo: biochemical indices of brain dopamine, noradrenaline and serotonin in ventriculocisternal perfusates in the cat.

O. Hornykiewicz, C. Pifl, L. Pichler, 1988, European journal of pharmacology.

Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus

G. Sperk, C. Pifl, H. Hörtnagl, 1991, Neuroscience.

Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues

M. Zehl, G. Lubec, C. Pifl, 2021, Amino Acids.

Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues

M. Zehl, G. Lubec, M. Wieder, 2021, Amino acids.

Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

C. Cavada, J. Obeso, O. Hornykiewicz, 2014, The Journal of Neuroscience.

Hepatic encephalopathy in thioacetamide‐induced acute liver failure in rats: Characterization of an improved model and study of amino acid‐ergic neurotransmission

H. Lassmann, C. Yurdaydın, P. Ferenci, 1989, Hepatology.

Dopamine and noradrenaline, but not serotonin, in the human claustrum are greatly reduced in patients with Parkinson's disease: possible functional implications

H. Sitte, S. Kish, O. Hornykiewicz, 2017, The European journal of neuroscience.

Increased Serotoninergic and Noradrenergic Activity in an Experimental Model of Hepatic Encephalopathy in Rats

P. Ferenci, C. Pifl, E. Singer, 1989 .

Correlation between calmodulin-dependent increase in the rate of calcium transport and calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Characterization of calmodulin-dependent phosphorylation.

J. Suko, B. Plank, W. Wyskovsky, 1983, European journal of biochemistry.

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

S. Linnarsson, G. Fisone, T. Harkany, 2017, Nature Biotechnology.

Central control of fever and female body temperature by RANKL/RANK

A. Haeseler, S. Narumiya, J. Penninger, 2009, Nature.

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

M. Caron, B. Giros, Yan-min Wang, 1994, The Journal of biological chemistry.

Carrier‐Mediated Release, Transport Rates, and Charge Transfer Induced by Amphetamine, Tyramine, and Dopamine in Mammalian Cells Transfected with the Human Dopamine Transporter

H. Sitte, C. Pifl, E. Singer, 1998, Journal of neurochemistry.

Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter.

M. Caron, B. Giros, O. Hornykiewicz, 1996, The Journal of pharmacology and experimental therapeutics.

The Dopamine Transporter: Molecular Biology, Pharmacology and Genetics

M. Caron, C. Pifl, 2002 .

Striatal biopterin and tyrosine hydroxylase protein reduction in dopa-responsive dystonia

S J Kish, J. Haycock, S. Kish, 1999, Neurology.

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment.

O. Hornykiewicz, C. Pifl, G. Schingnitz, 1986, European journal of pharmacology.

Dopamine inhibits cell growth and cell cycle by blocking ribonucleotide reductase

O. Hornykiewicz, C. Pifl, H. Reither, 2005, Neuropharmacology.

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

Steven P Gygi, Joshua E Elias, Joshua E. Elias, 2005, Human molecular genetics.

Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition

M. Pistis, H. Sitte, M. Zehl, 2021, Molecular Psychiatry.

Organic cation transporter mRNA and function in the rat superior cervical ganglion

C. Pifl, S. Huck, D. Kristufek, 2002, The Journal of physiology.

Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thioacetamide—induced acute liver failure

C. Yurdaydın, P. Ferenci, C. Pifl, 1990, Hepatology.

Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress

T. Hökfelt, M. Palkovits, A. Alpár, 2018, The EMBO journal.

Overlapping and Distinct Features of Cardiac Pathology in Inherited Human and Murine Ether Lipid Deficiency

T. Helbich, N. Braverman, C. Pifl, 2023, International journal of molecular sciences.

Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice

E. Richfield, O. Hornykiewicz, C. Pifl, 2011, Neuroscience.

Reduced noradrenaline, but not dopamine and serotonin in motor thalamus of the MPTP primate: relation to severity of Parkinsonism

C. Cavada, J. Obeso, O. Hornykiewicz, 2013, Journal of neurochemistry.

Sensitization of Dopamine‐Stimulated Adenylyl Cyclase in the Striatum of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Treated Rhesus Monkeys and Patients with Idiopathic Parkinson's Disease

O. Hornykiewicz, W. Schütz, C. Nanoff, 1992, Journal of neurochemistry.

The dopamine autoreceptor agonist B-HT 920 inhibits in vivo dopamine release into the cerebroventricular system of cats.

O. Hornykiewicz, C. Pifl, L. Pichler, 1987, European journal of pharmacology.

α-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter

O. Hornykiewicz, C. Pifl, J. Hardy, 2004, Neuroscience Letters.

Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding

J. Salamone, M. Correa, G. Lubec, 2020, Psychopharmacology.

Alteration of Acylphosphate Formation of Cardiac Sarcoplasmic Reticulum ATPase by Calmodulin-Dependent Phosphorylation

J. Suko, B. Plank, W. Wyskovsky, 1984, Zeitschrift fur Naturforschung. Section C, Biosciences.

Amphetamine reverses or blocks the operation of the human noradrenaline transporter depending on its concentration: superfusion studies on transfected cells

H. Sitte, C. Pifl, E. Singer, 1999, Neuropharmacology.

Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease

S. Fahn, D. Sulzer, R. Fariello, 2021, npj Parkinson's Disease.

Induction by low Na+ or Cl− of cocaine sensitive carrier‐mediated efflux of amines from cells transfected with the cloned human catecholamine transporters †

C. Pifl, E. Singer, H. Reither, 1997, British journal of pharmacology.

The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: A PET, histological and biochemical study

I. Peñuelas, J. A. Obeso, C. Cavada, 2012, Neurobiology of Disease.

Globus pallidus dopamine and Parkinson motor subtypes

O. Hornykiewicz, A. Rajput, A. Rajput, 2008, Neurology.

Calmodulin X (Ca2+)4 is the active calmodulin-calcium species activating the calcium-, calmodulin-dependent protein kinase of cardiac sarcoplasmic reticulum in the regulation of the calcium pump.

J. Suko, B. Plank, O. Bertel, 1984, Biochimica et biophysica acta.

Extrastriatal dopamine in symptomatic and asymptomatic rhesus monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

O. Hornykiewicz, O. Bertel, C. Pifl, 1990, Neurochemistry International.

Differential changes in neurochemical markers of striatal dopamine nerve terminals in idiopathic Parkinson's disease

A. Levey, S. Kish, K. Shannak, 1996, Neurology.

Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys

O. Hornykiewicz, C. Pifl, 2006, Neurochemistry International.

Glutamate decarboxylase67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients

G. Sperk, C. Baumgartner, E. Trinka, 2012, Hippocampus.

Human brain dopamine metabolism in levodopa-induced dyskinesia and wearing-off.

O. Hornykiewicz, A. Rajput, T. Di Paolo, 2004, Parkinsonism & related disorders.

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

T. Harkany, R. Konrat, G. Douglas, 2023, bioRxiv.

Problems with traffic ahead: Synaptic vesicles in Parkinson's disease

C. Pifl, 2016, Movement disorders : official journal of the Movement Disorder Society.

The dopamine transporter. The cloned target site of parkinsonism-inducing toxins and of drugs of abuse.

M. Caron, B. Giros, C. Pifl, 1996, Advances in neurology.

Locomotor Behaviour of Selective Dopamine Agonists in Mice: Is Endogenous Dopamine the Only Catecholamine Involved?

C. Pifl, L. Pichler, 1989, The Journal of pharmacy and pharmacology.

Structure Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters.

H. Sitte, M. Zehl, T. Langer, 2019, Journal of medicinal chemistry.

Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson

J. Attems, L. Zecca, C. Pifl, 2023, NPJ Parkinson's disease.

The time delay between in vivo imaging and postmortem data poses a caveat on “no link” findings

C. Pifl, 2019, Movement disorders : official journal of the Movement Disorder Society.

The neurotoxin MPTP does not reproduce in the rhesus monkey the interregional pattern of striatal dopamine loss typical of human idiopathic Parkinson's disease

O. Hornykiewicz, C. Pifl, G. Schingnitz, 1988, Neuroscience Letters.