A. Ebneth

发表

Ion channel screening technologies: will they revolutionize drug discovery?

A. Ebneth, 2002, Drug discovery today.

Fragment-based discovery of BACE1 inhibitors using functional assays.

R. Godemann, T. Hesterkamp, A. Cesura, 2009, Biochemistry.

Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease

E. Mandelkow, S. Illenberger, K. Stamer, 1998, The Journal of cell biology.

MAPs, MARKs and microtubule dynamics.

G. Drewes, E. Mandelkow, A. Ebneth, 1998, Trends in biochemical sciences.

Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition

Andreas Ebneth, Gerhard Trube, G. Trube, 2005, Journal of biomolecular screening.

Screening lead compounds for QT interval prolongation.

O. Pongs, A. Ebneth, O Pongs, 2001, Drug discovery today.

Using electrophysiology and in silico three-dimensional modeling to reduce human Ether-à-go-go related gene K(+) channel inhibition in a histamine H3 receptor antagonist program.

Michael P. Mazanetz, A. Heifetz, R. Law, 2010, Assay and drug development technologies.

Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease.

A. Ramírez, O. Brüstle, A. Ebneth, 2021, Stem cell research.

Scalable expansion of iPSC and their derivatives across multiple lineages.

C. Verfaillie, H. Zimmermann, A. Ebneth, 2022, Reproductive toxicology.

The EBiSC iPSC bank for disease studies.

H. Zimmermann, A. Ebneth, Rachel Steeg, 2020, Stem cell research.

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

J. Reumers, R. de Hoogt, A. Buist, 2018, Stem cell reports.

Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus.

U. Mau-Holzmann, A. Ebneth, Rachel Steeg, 2021, Stem cell research.

Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.

Juan D. Pita-Almenar, P. Shih, A. Ebneth, 2021, Stem cell research.

Morpholine containing CB2 selective agonists.

Sabine Löbbe, A. Ebneth, M. Gemkow, 2009, Bioorganic & medicinal chemistry letters.

Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.

B. Dymock, Sabine Löbbe, M. Brewer, 2008, Bioorganic & medicinal chemistry letters.

Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders.

J. Bartolomé-Nebreda, F. Delgado, Carlos M Martínez-Viturro, 2020, Journal of medicinal chemistry.

Tau Protein: Role in Intracellular Traffic and Development of Cell Polarity

E. Mandelkow, E. Mandelkow, K. Stamer, 2000 .

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

Amaia M. Arranz, J. Hardy, B. Strooper, 2017, Neuron.

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System

C. Verfaillie, V. Broccoli, G. Bultynck, 2021, Stem Cell Reviews and Reports.

Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles.

E. Mandelkow, E. Mandelkow, B. Trinczek, 1999, Journal of cell science.

MARK4 Is a Novel Microtubule-associated Proteins/Microtubule Affinity-regulating Kinase That Binds to the Cellular Microtubule Network and to Centrosomes*

Miro Brajenovic, G. Drewes, B. Trinczek, 2004, Journal of Biological Chemistry.

The Structure of Mammalian Serine Racemase

V. Mack, I. Moraes, A. Cesura, 2010, The Journal of Biological Chemistry.

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

G. Drewes, E. Mandelkow, E. Mandelkow, 1997, Cell.

Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.

G. Drewes, E. Mandelkow, A. Ebneth, 1999, Cell motility and the cytoskeleton.

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

T. Nero, M. Parker, M. Rives, 2019, iScience.

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

S. Kwak, A. Ebneth, G. Yohrling, 2015, PloS one.

Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models

Nicolas Moindrot, G. Nabel, Yaming Wang, 2018, Glia.

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics

G. Breithardt, W. Haverkamp, M. Borggrefe, 2002, Journal of Molecular Medicine.

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.

Tony Burdett, Helen Parkinson, Heiko Zimmermann, 2017, Stem cell research.

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

J. Wityak, H. Lashuel, C. Scheich, 2021, Scientific Reports.

Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format

A. Buist, A. Ebneth, A. Verheyen, 2016, Journal of biomolecular screening.

Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration

B. Strooper, C. Verfaillie, A. Sierksma, 2018, Alzheimer's & Dementia.

HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery.

Andreas Ebneth, A. Ebneth, R. Netzer, 2003, Current opinion in drug discovery & development.

The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease

L. Mrzljak, C. Dominguez, D. Winkler, 2016, Experimental Neurology.

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.

U. Mau-Holzmann, A. Ebneth, Ravi S Muddashetty, 2019, Stem cell research.

Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.

Andreas Ebneth, Sabine Schaertl, Andreas Scheel, 2012, Journal of medicinal chemistry.

IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau.

J. Bartolomé-Nebreda, L. Dillen, A. Ebneth, 2023, Journal of proteome research.

Deploying human pluripotent stem cells to treat central nervous system disorders: facts, challenges and realising the potential.

A. Ebneth, T. Allsopp, A. Cabrera-Socorro, 2019, Stem cell research.

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET ligand.

J. Wityak, C. Halldin, L. Mrzljak, 2020, Journal of medicinal chemistry.

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

J. Reumers, R. de Hoogt, A. Buist, 2019, Stem cell reports.

Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO)

C. Dominguez, D. Winkler, M. Beconi, 2013, Journal of biomolecular screening.

Deploying human pluripotent stem cells to treat central nervous system disorders: facts, challenges and realising the potential.

A. Ebneth, T. Allsopp, A. Cabrera-Socorro, 2019, Stem cell research.

SliceMap: an algorithm for automated brain region annotation

Michaël Barbier, Astrid Bottelbergs, Rony Nuydens, 2018, Bioinform..

The Structure of Mammalian Serine Racemase

V. Mack, I. Moraes, A. Cesura, 2010, The Journal of Biological Chemistry.