T. Large

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Screening Strategies for Ion Channel Targets

T. Large, Martin Smith, 2001 .

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.

D. Schoepp, T. Large, M. Baez, 2003, Journal of medicinal chemistry.

Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists.

E. Nisenbaum, T. Large, M. Baez, 2004, Biochemical Society transactions.

Neuronal receptors that regulate axon growth.

L. Reichardt, S. Carbonetto, B. Bossy, 1990, Cold Spring Harbor symposia on quantitative biology.

Neuronal properties and trophic activities of immortalized hippocampal cells from embryonic and young adult mice

D. A. Brown, B. Wainer, T. Large, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Generation of the truncated form of the nerve growth factor receptor by rat Schwann cells. Evidence for post-translational processing.

R. A. Murphy, P. Barker, F. Miller, 1991, The Journal of biological chemistry.

Neural differentiation promoted by truncated trkC receptors in collaboration with p75(NTR).

T. Large, F. Lefcort, K. Boeshore, 1998, Developmental biology.

trkC-mediated NT-3 signaling is required for the early development of a subpopulation of neurogenic neural crest cells.

T. Large, A. Garner, J. A. Weston, 1995, Developmental biology.

Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation

Scott P. Brown, L. Hardy, L. Pollegioni, 2014, Bioscience reports.

Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.

E. Su, T. Large, P. Eacho, 2005, Biochemical and biophysical research communications.

Expression of Full-Length trkB Receptors by Reactive Astrocytes after Chronic CNS Injury

J. Silver, T. Large, R. Mckeon, 1997, Experimental Neurology.

Two molecular weight forms of muscarinic acetylcholine receptors in the avian central nervous system: switch in predominant form during differentiation of synapses.

W. Klein, T. Large, J. Rauh, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro

D. Bleakman, T. Large, A. Alt, 2004, Neuropharmacology.

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo

T. Large, U. Campbell, M. Varney, 2013, Pharmacology research & perspectives.

In vivo phenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

Liming Shao, Kerry L. Spear, N. Powell, 2016 .

Molecular alteration of a muscarinic acetylcholine receptor system during synaptogenesis.

W. Klein, T. Large, N. Cho, 1985, The Journal of biological chemistry.

Pharmacodynamic Effects of a d-Amino Acid Oxidase Inhibitor Indicate a Spinal Site of Action in Rat Models of Neuropathic Pain

F. Zhao, T. Large, M. Varney, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.

S. Oliet, M. Nardini, L. Hardy, 2013, Journal of medicinal chemistry.

Data Standardization for Results Management

J. Weidner, B. Eastwood, T. Large, 2012 .

TrkB Isoforms with Distinct Neurotrophin Specificities Are Expressed in Predominantly Nonoverlapping Populations of Avian Dorsal Root Ganglion Neurons

T. Large, R. Zigmond, R. Zigmond, 1999, The Journal of Neuroscience.

Autonomous control of phosphatidylinositol turnover by histamine and acetylcholine receptors in the N1E-115 neuron-like cell line

W. Klein, M. Lambert, T. Large, 1986, Neuroscience Letters.

Muscle sensory neurons require neurotrophin-3 from peripheral tissues during the period of normal cell death.

E. Frank, T. Large, A. Garner, 1995, Development.

Expression of TrkB receptor isoforms in the developing avian visual system

T. Large, X. Xie, Ashley L. Garner, 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Expression of neurotrophins and the low-affinity NGF receptor in septal and hippocampal reaggregate cultures: local physiologic effects of NGF synthesized in the septal region.

B. Wainer, T. Large, U. Otten, 1992, Brain research. Developmental brain research.

The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo.

R. Oppenheim, R. Tucker, T. Large, 1996, Development.

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

E. Shooter, G. Weskamp, M. Radeke, 1989, Neuron.

Immortalized young adult neurons from the septal region: generation and characterization.

B. Wainer, Henry J. Lee, T. Large, 1990, Brain research. Developmental brain research.

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action

N. Dedic, R. Lew, T. Large, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Parallel Postnatal Development of Choline Acetyltransferase Activity and Muscarinic Acetylcholine Receptors in the Rat Olfactory Bulb

W. Klein, M. Lambert, T. Large, 1986, Journal of neurochemistry.

Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen

J. W. Tawil, L. Reichardt, S. Carbonetto, 1990, The Journal of cell biology.

Nerve growth factor gene expression in the developing rat brain.

G. Weskamp, D. Clegg, L. Reichardt, 1986, Science.

Regulation of nerve growth factor mRNA levels in developing rat heart ventricle is not altered by sympathectomy.

D. Clegg, L. Reichardt, S. Bodary, 1989, Developmental biology.

Nerve growth factor expression in the developing hippocampus isolated in vitro.

B. Wainer, T. Large, U. Otten, 1990, Developmental biology.