B. Santoro

发表

The HCN Gene Family: Molecular Basis of the Hyperpolarization‐Activated Pacemaker Channels

B. Santoro, G. Tibbs, 1999, Annals of the New York Academy of Sciences.

Molecular mechanism of cAMP modulation of HCN pacemaker channels

S. Siegelbaum, B. Wainger, B. Santoro, 2001, Nature.

Molecular and Functional Heterogeneity of Hyperpolarization-Activated Pacemaker Channels in the Mouse CNS

S. Siegelbaum, P. Pavlidis, A. Lüthi, 2000, The Journal of Neuroscience.

HCN1 Channels Control Resting and Active Integrative Properties of Stellate Cells from Layer II of the Entorhinal Cortex

M. Nolan, P. D. Dodson, J. Dudman, 2007, The Journal of Neuroscience.

The Hyperpolarization-Activated HCN1 Channel Is Important for Motor Learning and Neuronal Integration by Cerebellar Purkinje Cells

Matthew F. Nolan, Eric R. Kandel, Richard F. Thompson, 2003, Cell.

TRIP8b Regulates HCN1 Channel Trafficking and Gating through Two Distinct C-Terminal Interaction Sites

S. Siegelbaum, Lei Hu, B. Santoro, 2011, The Journal of Neuroscience.

Explorer HCN 1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex

M. Nolan, P. D. Dodson, J. Dudman, 2017 .

Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain

Eric R Kandel, Dusan Bartsch, E. Kandel, 1998, Cell.

Representation of Three-Dimensional Space in the Hippocampus of Flying Bats

Bruce L. McNaughton, Howard Eichenbaum, Michael E. Hasselmo, 2013 .

Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel

K. Hamacher, G. Thiel, B. Santoro, 2018, The Journal of Biological Chemistry.

Gating movements and ion permeation in HCN4 pacemaker channels

M. Bolognesi, S. Siegelbaum, K. Hamacher, 2020, Molecular cell.

Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

S. Siegelbaum, Lei Hu, B. Santoro, 2013, The Journal of general physiology.

Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift

B. Santoro, E. C. Young, Zarina Madden, 2009, Pflügers Archiv - European Journal of Physiology.

Frequency-Dependent Synaptic Dynamics Differentially Tune CA1 and CA2 Pyramidal Neuron Responses to Cortical Input

David H. Brann, S. Siegelbaum, D. Nicholson, 2021, The Journal of Neuroscience.

Binding of TRIP8b to the cyclic nucleotide binding domain (CNBD) of mammalian HCN

C. Donadoni, L. Banci, G. Thiel, 2022 .

A Behavioral Role for Dendritic Integration HCN1 Channels Constrain Spatial Memory and Plasticity at Inputs to Dendrites of CA1 Pyramidal Neurons

E. Kandel, G. Buzsáki, D. Buhl, 2005, Cell.

Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy

H. Scharfman, S. Siegelbaum, B. Santoro, 2022, bioRxiv.

The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons

Tobias Bock, S. Siegelbaum, F. Leroy, 2022, bioRxiv.

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy

H. Scharfman, S. Siegelbaum, J. Lafrancois, 2022, Neuron.

Regulation of HCN Channel Surface Expression by a Novel C-Terminal Protein-Protein Interaction

S. Siegelbaum, B. Wainger, B. Santoro, 2004, The Journal of Neuroscience.

A Behavioral Role for Dendritic Integration HCN1 Channels Constrain Spatial Memory and Plasticity at Inputs to Distal Dendrites of CA1 Pyramidal Neurons

Matthew F. Nolan, György Buzsáki, Eric R. Kandel, 2004, Cell.

Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1–4 suggests evolving roles in the developing rat hippocampus

M. Biel, T. Baram, F. Hofmann, 2001, Neuroscience.

TRIP8b Splice Forms Act in Concert to Regulate the Localization and Expression of HCN1 Channels in CA1 Pyramidal Neurons

S. Siegelbaum, B. Santoro, R. Piskorowski, 2011, Neuron.

TRIP8b Splice Variants Form a Family of Auxiliary Subunits that Regulate Gating and Trafficking of HCN Channels in the Brain

S. Siegelbaum, Lei Hu, B. Santoro, 2009, Neuron.

The multiple personalities of h-channels

T. Baram, B. Santoro, 2003, Trends in Neurosciences.

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

K. Hamacher, G. Thiel, B. Santoro, 2019, eLife.

Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy.

Lauren E Bleakley, I. Scheffer, C. Reid, 2021, Brain : a journal of neurology.

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

E. Kandel, D. Bartsch, S. Grant, 1997, Proceedings of the National Academy of Sciences of the United States of America.

HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond

K. Hamacher, C. Mercer, P. Striano, 2018, Brain : a journal of neurology.

The Dendrites of CA2 and CA1 Pyramidal Neurons Differentially Regulate Information Flow in the Cortico-Hippocampal Circuit

S. Siegelbaum, D. Nicholson, Hiroto Takahashi, 2017, The Journal of Neuroscience.

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

C. Donadoni, L. Banci, D. DiFrancesco, 2018, eLife.

Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels

C. Donadoni, L. Banci, G. Thiel, 2018, bioRxiv.

HCN2 Overexpression in Newborn and Adult Ventricular Myocytes: Distinct Effects on Gating and Excitability

R B Robinson, R. Robinson, B. Santoro, 2001, Circulation research.

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

Tobias Bock, S. Siegelbaum, F. Leroy, 2021, bioRxiv.

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders.

M. Shah, B. Santoro, 2020, Annual review of pharmacology and toxicology.

Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function

C. Donadoni, L. Banci, Lei Hu, 2014, Proceedings of the National Academy of Sciences.

Increased seizure severity and seizure‐related death in mice lacking HCN1 channels

S. Siegelbaum, H. Blumenfeld, D. Englot, 2010, Epilepsia.

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure generation in a mouse model of temporal lobe epilepsy

H. Scharfman, S. Siegelbaum, J. Lafrancois, 2022, bioRxiv.

ADENOSINE PREVENTS KINDLED SEIZURES—AN EFFECT AS SMOOTH AS SILK

G. Buzsáki, D. Buhl, K. Wilcox, 2010 .