G. Tibbs

发表

The HCN Gene Family: Molecular Basis of the Hyperpolarization‐Activated Pacemaker Channels

B. Santoro, G. Tibbs, 1999, Annals of the New York Academy of Sciences.

Molecular mechanism of cAMP modulation of HCN pacemaker channels

S. Siegelbaum, B. Wainger, B. Santoro, 2001, Nature.

Molecular and Functional Heterogeneity of Hyperpolarization-Activated Pacemaker Channels in the Mouse CNS

S. Siegelbaum, P. Pavlidis, A. Lüthi, 2000, The Journal of Neuroscience.

cAMP Control of HCN2 Channel Mg2+ Block Reveals Loose Coupling between the Cyclic Nucleotide-Gating Ring and the Pore

G. Tibbs, P. A. Goldstein, Alex K Lyashchenko, 2014, PloS one.

Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain

Eric R Kandel, Dusan Bartsch, E. Kandel, 1998, Cell.

A State-independent Interaction between Ligand and a Conserved Arginine Residue in Cyclic Nucleotide-gated Channels Reveals a Functional Polarity of the Cyclic Nucleotide Binding Site*

S. Siegelbaum, G. Tibbs, B. Leypold, 1998, The Journal of Biological Chemistry.

Subunit Stoichiometry of Cyclic Nucleotide-Gated Channels and Effects of Subunit Order on Channel Function

S. Siegelbaum, G. Tibbs, David T Liu, 1996, Neuron.

Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core

G. Tibbs, J. Yang, Alex K Lyashchenko, 2007, The Journal of physiology.

HCN1 Channels as Targets for Anesthetic and Nonanesthetic Propofol Analogs in the Amelioration of Mechanical and Thermal Hyperalgesia in a Mouse Model of Neuropathic Pain

A. Proekt, P. Flood, O. Andersen, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Microsoft Word-56830684-file00.docx

A. Proekt, P. Flood, O. Andersen, 2013 .

HCN 1 channels as targets for anesthetic and non-anesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain

A. Proekt, P. Flood, O. Andersen, 2013 .

Dendrotoxin, 4‐Aminopyridine, and β‐Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+‐Dependent Release of Glutamate from Guinea‐Pig Cerebrocortical Synaptosomes

D. Nicholls, J. Dolly, G. Tibbs, 1989, Journal of neurochemistry.

Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?

G. Tibbs, P. A. Goldstein, Gareth R Tibbs, 2016, Trends in pharmacological sciences.

PIP2-Mediated HCN3 Channel Gating Is Crucial for Rhythmic Burst Firing in Thalamic Intergeniculate Leaflet Neurons

F. Hofmann, S. Ying, A. Picollo, 2011, The Journal of Neuroscience.

Repetitive Action Potentials in Isolated Nerve Terminals in the Presence of 4‐Aminopyridine: Effects on Cytosolic Free Ca2+ and Glutamate Release

D. Nicholls, H. McMahon, F. Mieghem, 1989, Journal of neurochemistry.

Alkylphenol inverse agonists of HCN1 gating: H‐bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency

R. Eckenhoff, D. Barman, G. Tibbs, 2019, Biochemical pharmacology.

Molecular mechanism of cyclic-nucleotide-gated channel activation

S. Siegelbaum, G. Tibbs, Evan H. Goulding, 1994, Nature.

Constraining Ligand-Binding Site Stoichiometry Suggests that a Cyclic Nucleotide–Gated Channel Is Composed of Two Functional Dimers

S. Siegelbaum, P. Paoletti, G. Tibbs, 1998, Neuron.

Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels

S. Siegelbaum, G. Tibbs, David T. Liu, 1993, Nature.

HCN Pacemaker Channel Activation Is Controlled by Acidic Lipids Downstream of Diacylglycerol Kinase and Phospholipase A2

K. J. Fogle, G. Tibbs, Alex K Lyashchenko, 2007, The Journal of Neuroscience.

Impairment of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Intravenous General Anesthetic Propofol

N. Harrison, N. Topf, G. Abbott, 2005, Journal of Pharmacology and Experimental Therapeutics.

A simple method for recording single-channel activity from synaptic plasma membranes

W. R. Lieb, N. Franks, J. Dolly, 1993, Journal of Neuroscience Methods.

Dendrotoxin and charybdotoxin increase the cytosolic concentration of free Ca2+ in cerebrocortical synaptosomes: An effect not shared by apamin

D. Nicholls, J. Dolly, G. Tibbs, 1989, FEBS letters.

Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels

S. Siegelbaum, G. Tibbs, Evan H. Goulding, 1997, Nature.

HCN and K2P Channels in Anesthetic Mechanisms Research.

G. Tibbs, P. A. Goldstein, P. Riegelhaupt, 2018, Methods in enzymology.

Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination

S. Siegelbaum, D. Bell, Lei Zhou, 2009, Pflügers Archiv - European Journal of Physiology.

Mechanisms of Glutamate Exocytosis from Isolated Nerve Terminals

D. Nicholls, H. McMahon, G. Tibbs, 1989 .

Homologues of a K+ channel blocker α-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration

D. Nicholls, J. Dolly, P. Bougis, 1990, Neurochemistry International.

Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.

K. J. Fogle, G. Tibbs, N. Olivier, 2009, Biochimica et biophysica acta.

Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain

O. Andersen, Guoan Zhang, K. Aromolaran, 2023, Neurobiology of Pain.

Evidence for the Induction of Repetitive Action Potentials in Synaptosomes by K+‐Channel Inhibitors: An Analysis of Plasma Membrane Ion Fluxes

D. Nicholls, J. Dolly, G. Tibbs, 1996, Journal of neurochemistry.

An anchor-tether 'hindered' HCN1 inhibitor is antihyperalgesic in a rat spared nerve injury neuropathic pain model.

Helgi I. Ingólfsson, W. Mellado, Delin Sun, 2023, British journal of anaesthesia.

Perturbation of HCN1 response to small molecule modulation.

Elizabeth D. Kim, G. Tibbs, P. A. Goldstein, 2023, Biophysical Journal.

Ion binding in the Open HCN Pacemaker Channel Pore: Fast Mechanisms to Shape “Slow” Channels

G. Tibbs, Alex K Lyashchenko, 2008, The Journal of general physiology.