K. Lee

发表

Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators.

Li Huang, Katherine Jung, Chin-Ho Chen, 2012, ACS medicinal chemistry letters.

New developments in the chemistry and biology of the bioactive constituents of tanshen

K. Lee, Xihong Wang, S. Morris-Natschke, 2007, Medicinal research reviews.

Plant-derived natural product research aimed at new drug discovery

K. Lee, S. Morris-Natschke, H. Itokawa, 2008, Journal of Natural Medicines.

Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, European journal of medicinal chemistry.

Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus

Li Huang, Chin-Ho Chen, K. Lee, 2017, Bioorganic & medicinal chemistry letters.

Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, European journal of medicinal chemistry.

Asian Herbal Products: The Basis for Development of High-Quality Dietary Supplements and New Medicines

M. Kozuka, K. Lee, H. Itokawa, 2005 .

Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).

Hong Lu, Shibo Jiang, Keduo Qian, 2008, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds.

K. Lee, Lei Yan, Fang-fang Lai, 2017, Bioorganic & medicinal chemistry letters.

Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon (神農本草經 Shén Nóng Běn Cǎo Jīng)

Yizhou Dong, Keduo Qian, K. Lee, 2012, Journal of traditional and complementary medicine.

Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.

K. Lee, S. Morris-Natschke, H. Itokawa, 2007, Bioorganic & medicinal chemistry.

Development of anti‐influenza agents from natural products

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2020, Medicinal research reviews.

Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

Li Huang, Chin-Ho Chen, Z. Dang, 2012, Bioorganic & medicinal chemistry letters.

Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.

A. Brossi, M. Hung, Yizhou Dong, 2010, Bioorganic & medicinal chemistry.

Anticancer Principles from Medicinal Piper (胡椒 Hú Jiāo) Plants

K. Lee, S. Morris-Natschke, Chun-lin Long, 2014, Journal of traditional and complementary medicine.

Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.

Li Huang, Chin-Ho Chen, K. Lee, 2015, MedChemComm.

Lignans in treatment of cancer and other diseases†

K. Lee, Zhiyan Xiao, 2004, Phytochemistry Reviews.

Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.

K. Lee, Chao-Lin Chang, Hui-Chi Huang, 2010, Journal of natural products.

Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursors.

T. Hwang, K. Lee, H. Hung, 2015, Bioorganic & medicinal chemistry letters.

Antitumor Agents. Part 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids.

A. Tropsha, A. Brossi, A. McPhail, 1998 .

Antitumor Agents. 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids

A. Brossi, A. Tropsha, A. McPhail, 1998 .

Cancer Preventive Agents. Part 6: Chemopreventive Potential of Furanocoumarins and Related Compounds

Harukuni Tokuda, H. Nishino, M. Kozuka, 2006 .

Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata.

Yukiko Kobayashi, H. Tokuda, K. Lee, 2016, Journal of natural products.

Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents†

H. Tokuda, K. Lee, A. Iida, 2012, Pharmaceutical biology.

Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

Y. Nobukuni, H. Nishino, M. Kozuka, 2003, Bioorganic & medicinal chemistry.

Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.

A. Brossi, M. Hung, J. Hsu, 2010, Journal of medicinal chemistry.

Design, synthesis, crystal structure, bioactivity, and molecular docking studies of novel sulfonylamidine-derived neonicotinoid analogs

Huan Li, Keduo Qian, K. Lee, 2014, Medicinal Chemistry Research.

Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions.

K. Lee, S. Morris-Natschke, Xiao-bo Zhao, 2014, European journal of medicinal chemistry.

Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS.

K. Lee, S. Morris-Natschke, Qiang Zhang, 2018, Journal of ethnopharmacology.

Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia.

K. Lee, P. Kuo, Tian-Shung Wu, 2004, Bioorganic & medicinal chemistry.

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

E. De Clercq, Dongwei Kang, Boshi Huang, 2018, European journal of medicinal chemistry.

Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors.

Li Huang, Chin-Ho Chen, Keduo Qian, 2012, Bioorganic & medicinal chemistry letters.

Isolation of rhododaurichromanic acid B and the anti-HIV principles rhododaurichromanic acid A and rhododaurichromenic acid from Rhododendron dauricum

K. Lee, S. Morris-Natschke, T. Fujioka, 2001 .

Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin.

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2014, Bioorganic & medicinal chemistry.

Podophyllotoxins and analogs

K. Lee, Zhiyan Xiao, 2005 .

5 Podophyllotoxins and Analogs 1

K. Lee, Zhiyan Xiao, 2005 .

Biology of quinoline and quinazoline alkaloids.

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2022, The Alkaloids. Chemistry and biology.

SAR study on N2,N4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents

K. Lee, Zhiyan Xiao, M. Goto, 2018, RSC advances.

Biologically active quinoline and quinazoline alkaloids part I

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2018, Medicinal research reviews.

Synthesis and proteasome inhibition of lithocholic acid derivatives.

Dominique N. Soroka, Li Huang, Chin-Ho Chen, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.

Li Huang, Chin-Ho Chen, K. Lee, 2012, Bioorganic & medicinal chemistry letters.

New betulinic acid derivatives as potent proteasome inhibitors.

Li Huang, Chin-Ho Chen, Keduo Qian, 2011, Bioorganic & medicinal chemistry letters.

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

G. Mustata, J. Lazo, K. Lee, 2010, PLoS neglected tropical diseases.

Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2010, Bioorganic & medicinal chemistry.

Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.

Y. Wu, F. Chang, K. Lee, 2009, Journal of natural products.

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.

Guan-Jhong Huang, K. Lee, S. Morris-Natschke, 2017, Bioorganic & medicinal chemistry letters.

Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways.

Hsuan-Yu Chen, Sung-Liang Yu, Pan‐Chyr Yang, 2009, Journal of medicinal chemistry.

Anticancer Drug Design Based on Plant-Derived Natural Products1

K. Lee, 1999, Journal of Biomedical Science.

Synthesis and in vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin

K. Lee, Lei Zhao, S. Morris-Natschke, 2020, Journal of Asian natural products research.

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

C. Teng, S. Pan, K. Lee, 2015, Oncotarget.

DYZ‐2‐90, a Novel Neo‐tanshinlactone Ring‐Opened Compound, Induces ERK‐Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells

C. Teng, S. Pan, Yizhou Dong, 2012, Chembiochem : a European journal of chemical biology.

New Seco-DSP derivatives as potent chemosensitizers.

K. Lee, S. Morris-Natschke, Q. Wan, 2020, European journal of medicinal chemistry.

Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anticancer effects.

Pan‐Chyr Yang, C. Teng, S. Pan, 2013, Carcinogenesis.

Anti-HBV and cytotoxic activities of pyranocoumarin derivatives.

Po-Cheng Chiang, K. Lee, S. Yeh, 2009, Bioorganic & medicinal chemistry.

Recent advances in the investigation of curcuminoids

K. Lee, S. Morris-Natschke, H. Itokawa, 2008, Chinese medicine.

Bioactivity inspired C19-diterpenoid alkaloids for overcoming multidrug-resistant cancer

H. Yamashita, K. Lee, M. Goto, 2022, Journal of Natural Medicines.

Structure–activity relationships and evaluation of esterified diterpenoid alkaloid derivatives as antiproliferative agents

H. Yamashita, K. Lee, M. Goto, 2019, Journal of Natural Medicines.

Molecular mechanism of the inhibitory effect of KS-5 on bFGF-induced angiogenesis in vitro and in vivo.

C. Teng, S. Pan, Chieh-Yu Peng, 2007, Cancer letters.

Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

K. Lee, L. Shyur, Kyoko Nakagawa-Goto, 2017, Front. Pharmacol..

New developments in natural products‐based anti‐AIDS research

K. Lee, S. Morris-Natschke, Donglei Yu, 2007, Medicinal research reviews.

Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation.

Keduo Qian, K. Lee, Tian-Shung Wu, 2011, Bioorganic & medicinal chemistry.

Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein.

C. Chou, K. Lee, S. Morris-Natschke, 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells.

K. Lee, S. Morris-Natschke, J. Wang, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris.

K. Lee, S. Morris-Natschke, Yu Zhang, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Biologically active quinoline and quinazoline alkaloids part II

Jiyu Zhang, K. Lee, S. Morris-Natschke, 2018, Medicinal research reviews.

Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines.

Chi-Hung Huang, S. Kuo, Li‐Jiau Huang, 2015, European journal of medicinal chemistry.

2-(3-Methoxyphenyl)-5-methyl-1,8-naphthyridin-4(1H)-one (HKL-1) induces G2/M arrest and mitotic catastrophe in human leukemia HL-60 cells.

S. Kuo, Li‐Jiau Huang, K. Lee, 2012, Toxicology and applied pharmacology.

CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo

S. Kuo, C. Teng, S. Pan, 2008, Molecular Cancer Therapeutics.

Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs.

S. Kuo, Li‐Jiau Huang, K. Lee, 2011, European journal of medicinal chemistry.

Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu.

Ming Zhao, Shiqi Peng, Keduo Qian, 2008, Bioorganic & medicinal chemistry.

Evaluation of tea polyphenols as anti-HIV agents

T. Nohara, K. Lee, Y. Kashiwada, 1996 .

Induction of reversible protein-linked DNA breaks in human osteogenic sarcoma cells by novel cytocidal colchicine derivatives which inhibit DNA topoisomerase II in vitro: Absence of cross-resistance in a colchicine-resistant sub-clone

K. Lee, H. Tatematsu, B. Goz, 1993 .

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.

Chin‐Chung Wu, Y. Wu, F. Chang, 2007, Journal of medicinal chemistry.

New dammarane-type saponins from the galls of Sapindus mukorossi.

F. Chang, Y. Hsu, K. Lee, 2005, Journal of agricultural and food chemistry.

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Li Huang, 2010, Journal of medicinal chemistry.

Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy.

K. Lee, Ting Zhou, K. Bastow, 2012, Bioorganic & medicinal chemistry letters.

Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2011, Bioorganic & medicinal chemistry letters.

Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids.

H. Tokuda, K. Lee, K. Bastow, 2004, Bioorganic & medicinal chemistry.

Chinese Materia Medica: Chemistry, Pharmacology and Applications By You-Ping Zhu (China−Netherlands Medical and Pharmaceutical Centre, Groningen, The Netherlands). Harwood Academic Publishers, Amsterdam, Netherlands. 1998. vii + 706 pp. 17 × 24.5 cm. $120.00. ISBN 90-5702-285-0.

K. Lee, 1999 .

A N-propionylsulfonamide prodrug of K-5a2 provided improved aqueous solubility and hERG inhibition

Dongwei Kang, C. Pannecouque, P. Zhan, 2020 .

In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens.

Guan-Jhong Huang, T. Hwang, K. Lee, 2014, Bioorganic & medicinal chemistry letters.

Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Chin-Ho Chen, 2009, Bioorganic & medicinal chemistry letters.

Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues.

Alexander Sedykh, Hao Zhu, K. Lee, 2010, Journal of medicinal chemistry.

Kaurane and abietane diterpenoids from Tripterygium doianum (Celastraceae).

K. Lee, Y. Takaishi, K. Bastow, 2004, Phytochemistry.

Seco-4-methyl-DCK derivatives as potent chemosensitizers.

K. Lee, S. Morris-Natschke, Ke Wang, 2019, Bioorganic & medicinal chemistry letters.

Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy.

Yong Ling, K. Lee, Jianqiang Qian, 2020, European journal of medicinal chemistry.

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

Yu Cao, Zhi-hua Xing, Q. Xia, 2017, Free radical biology & medicine.

Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin.

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2019, European journal of medicinal chemistry.

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death

K. Lee, L. Shyur, Kyoko Nakagawa-Goto, 2017, Oncotarget.

Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.

Chieh-Yu Peng, K. Lee, A. Nyarko, 2007, Bioorganic & medicinal chemistry letters.

Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.

Chin‐Chung Wu, K. Lee, J. Wu, 2005, Bioorganic & medicinal chemistry.

Phytotoxic cis-clerodane diterpenoids from the Chinese liverwort Scapania stephanii.

Bin Sun, H. Lou, K. Lee, 2014, Phytochemistry.

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2009, Bioorganic & medicinal chemistry letters.

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

Jai-Sing Yang, Y. Wu, S. Kuo, 2014, Journal of medicinal chemistry.

Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.

M. Hung, D. Newman, G. Cragg, 2010, Journal of natural products.

Role of Human Immunodeficiency Virus (HIV) Type 1 Envelope in the Anti-HIV Activity of the Betulinic Acid Derivative IC9564

Lei Jin, T. Matthews, Chin-Ho Chen, 2001, Antimicrobial Agents and Chemotherapy.

Inhibition of the Epstein-Barr virus lytic cycle by moronic acid.

Li-Kwan Chang, F. Chang, Y. Wu, 2010, Antiviral research.

Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.

Li Huang, Chin-Ho Chen, Keduo Qian, 2009, Journal of medicinal chemistry.

Phenolic diterpenoid derivatives as anti-influenza a virus agents.

Li Huang, Katherine Jung, Chin-Ho Chen, 2015, ACS medicinal chemistry letters.

Identification and synthesis of quinolizidines with anti-influenza a virus activity.

Li Huang, Katherine Jung, Chin-Ho Chen, 2014, ACS medicinal chemistry letters.

Plant‐Derived Natural Products Research in Drug Discovery

K. Lee, S. Morris-Natschke, H. Itokawa, 2012 .

Plant-Derived Natural Products Research: Recent Progress in Drug Discovery

K. Lee, S. Morris-Natschke, H. Itokawa, 2008 .

New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.

Han-Dong Sun, K. Lee, Xihong Wang, 2004, Journal of natural products.

The application of NCTS (N-cyano-N-phenyl-p-toluenesulfonamide) in palladium-catalyzed cyanation of arenediazonium tetrafluoroborates and aryl halides

K. Lee, Jizhen Li, Wenbin Xu, 2016 .

Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs.

Chieh-Yu Peng, K. Lee, J. Wu, 2007, Journal of medicinal chemistry.

Antiviral activity of dammarane saponins against herpes simplex virus i

K. Lee, K. Bastow, T. Ohba, 1995 .

Prodrug design, synthesis and pharmacokinetic evaluation of (3' R, 4' R)-3-hydroxymethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone.

Xiao‐Feng Wang, Keduo Qian, K. Lee, 2012, Acta pharmaceutica Sinica. B.

Cytotoxic diterpenoid alkaloid from Aconitum japonicum subsp. subcuneatum

H. Yamashita, K. Lee, M. Goto, 2019, Journal of Natural Medicines.

Four new C19-diterpenoid alkaloids from Delphinium elatum.

H. Yamashita, K. Lee, M. Goto, 2015, Phytochemistry letters.

Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the H erbs belonging to The Divine Husbandman’s Herbal Foundation Canon ( 神農本草經 Shén Nóng Běn Jīng)

Yizhou Dong, Keduo Qian, K. Lee, 2012 .

Chinese Herbal Medicine-Derived Products for Prevention or Treatment of Diseases Affecting Quality of Life

K. Lee, S. Morris-Natschke, Yu Zhao, 2016 .

Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents.

K. Lee, W. Chiou, K. Bastow, 2008, Bioorganic & medicinal chemistry.

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents.

K. Lee, S. Morris-Natschke, M. Goto, 2015, Bioorganic & medicinal chemistry letters.

Structure and stereochemistry of thalicsiline, a new antiinflammatory C20-diterpenoid alkaloid from Thalictrum sessile

A. McPhail, K. Lee, Y. Hirata, 1988 .

Structure and stereochemistry of corytensine, a new phthalideisoquinoline alkaloid from Corydalis ochotensis

A. McPhail, K. Lee, D. McPhail, 1988 .

Diterpenoids from the stems of Tripterygium hypoglaucum (Celastraceae) and cytotoxic evaluation

K. Lee, Hong Mei Li, Rong-Tao Li, 2015 .

Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2012, Journal of natural products.

Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2014, Medicinal Chemistry Research.

Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2013, Bioorganic & medicinal chemistry.

Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.

Wei Li, Li Huang, Chin-Ho Chen, 2018, ACS medicinal chemistry letters.

Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives.

T. Hwang, Keduo Qian, K. Lee, 2011, Bioorganic & medicinal chemistry.

MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex

P. Gean, S. Kuo, Wei-Ting Liu, 2014, Neuropharmacology.

Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents.

K. Lee, S. Morris-Natschke, K. Bastow, 2011, Medicinal chemistry.

Notolutesins A–J, Dolabrane-Type Diterpenoids from the Chinese Liverwort Notoscyphus lutescens

Huiqing Yuan, H. Lou, Rongxiu Zhu, 2014, Journal of natural products.

Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7.

E. De Clercq, Dongwei Kang, Boshi Huang, 2020, Bioorganic & Medicinal Chemistry Letters.

Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi.

K. Lee, S. Morris-Natschke, Jichao Liang, 2018, Fitoterapia.

ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.

B. Keppler, K. Lee, Xihong Wang, 2011, Bioorganic & medicinal chemistry letters.

Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.

C. Liaw, Chin‐Chung Wu, Y. Wu, 2005, Bioorganic & medicinal chemistry.

Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents.

Po-Cheng Chiang, K. Lee, P. Kuo, 2007, Journal of natural products.

Discovery of C20-Diterpenoid Alkaloid Kobusine Derivatives Exhibiting Sub-G1 Inducing Activity

K. Lee, M. Goto, K. Wada, 2022, ACS omega.

Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line.

K. Lee, S. Morris-Natschke, K. Wada, 2012, Bioorganic & medicinal chemistry letters.

Antiplatelet and Anti-HIV Constituents from Euchresta Formosana

Chin‐Chung Wu, Y. Wu, F. Chang, 2003, Natural product research.

Identification of Novel 4′-O-Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II

Hua Sun, K. Lee, Zhiyan Xiao, 2022, Molecules.

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.

Po-Cheng Chiang, J. Guh, K. Lee, 2011, Biochemical pharmacology.

The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.

Jai-Sing Yang, Jing-Gung Chung, C. Liaw, 2012, Oncology reports.

Clerodane diterpenes: sources, structures, and biological activities.

K. Lee, S. Morris-Natschke, Rongtao Li, 2016, Natural product reports.

Biologically active indolizidine alkaloids

K. Lee, S. Morris-Natschke, Junmin Zhang, 2020, Medicinal research reviews.

Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa.

K. Lee, X. Hao, S. Morris-Natschke, 2017, Organic letters.

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.

D. Newman, K. Lee, B. O’Keefe, 2017, Journal of natural products.

Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities.

Yong Ling, K. Lee, S. Morris-Natschke, 2018, European journal of medicinal chemistry.

Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.

Shiow-Ju Lee, K. Lee, P. Wu, 2004, Chemical & pharmaceutical bulletin.

Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents.

K. Lee, S. Morris-Natschke, Dan Wu, 2014, Bioorganic & medicinal chemistry.

Anti-inflammatory neolignans from the roots of Magnolia officinalis.

Qiong Gu, T. Hwang, K. Lee, 2016, Bioorganic & medicinal chemistry.

Indole alkaloid glycosides from the aerial parts of Strobilanthes cusia.

K. Lee, X. Hao, S. Morris-Natschke, 2014, Journal of natural products.

Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds.

T. Hwang, Keduo Qian, K. Lee, 2011, Journal of natural products.

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Journal of medicinal chemistry.

Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.

K. Lee, J. Ishida, M. Nagai, 2002, Bioorganic & medicinal chemistry.

Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids.

Chawnshang Chang, K. Lee, Zhiyan Xiao, 2003, Bioorganic & medicinal chemistry.

Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.

Chawnshang Chang, K. Lee, J. Ishida, 2002, Journal of medicinal chemistry.

A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis.

Keduo Qian, K. Lee, S. Li, 2010, Journal of pharmaceutical and biomedical analysis.

Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents.

Y. Wu, F. Chang, T. Hwang, 2010, Bioorganic & medicinal chemistry letters.

A high yield preparation of 2-fluoropodophyllotoxin☆

K. Lee, D. VanVliet, 1999 .

Cancer Preventive Agents. Part 5. Anti-tumor-Promoting Effects of Coumarins and Related Compounds on Epstein-Barr Virus Activation and Two-stage Mouse Skin Carcinogenesis

Harukuni Tokuda, H. Nishino, M. Kozuka, 2006 .

Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents.

S. Kuo, Li‐Jiau Huang, T. Yamori, 2005, Bioorganic & medicinal chemistry.

Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

K. Lee, 2010, Journal of natural products.

Discovery of novel andrographolide derivatives as cytotoxic agents.

K. Lee, H. Hua, Zhiyan Xiao, 2013, Bioorganic & medicinal chemistry letters.

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Keduo Qian, K. Lee, S. Morris-Natschke, 2009, Natural product reports.

Cardiac glycosides from Antiaris toxicaria with potent cardiotonic activity.

S. Kuo, Han-Dong Sun, K. Lee, 2010, Journal of natural products.

Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors.

Chin-Ho Chen, K. Lee, S. Morris-Natschke, 2021, European journal of medicinal chemistry.

Recent advances in natural anti‐HIV triterpenoids and analogs

K. Lee, Xu-dong Xu, S. Morris-Natschke, 2020, Medicinal research reviews.

Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.

Xiaoqin Tong, Pan‐Chyr Yang, Yan-li Liu, 2019, Journal of natural products.

Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.

Wei Li, K. Koike, Li Huang, 2019, Journal of medicinal chemistry.

Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.

Qiong Gu, Chin-Ho Chen, K. Lee, 2016, Journal of medicinal chemistry.

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

Zhiyan Xiao, Susan L Morris-Natschke, Kuo-Hsiung Lee, 2016, Medicinal research reviews.

Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.

Chin-Ho Chen, Keduo Qian, K. Lee, 2012, Bioorganic & medicinal chemistry letters.

Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds.

Midori Takasaki, Kenji Mizutani, Harukuni Tokuda, 2009, Bioorganic & medicinal chemistry.

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.

Keduo Qian, K. Lee, K. Bastow, 2012, European journal of medicinal chemistry.

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Liying Zhang, Hao Zhu, K. Lee, 2011, Journal of medicinal chemistry.

Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.

C. Liaw, Y. Wu, F. Chang, 2003, Journal of medicinal chemistry.

Structure and stereochemistry of (−)-odorinol, an antileukemic diamide from Aglaia odorata☆

N. Hayashi, A. McPhail, K. Lee, 1982 .

Structure and stereochemistry of microlenin, a novel antitumour dimeric sesquiterpene lactone from Helenium microcephalum; X-ray crystal structure

K. Lee, Y. Imakura, D. Sims, 1976 .

Structure and absolute stereochemistry of dihydroflorilenalin, a new sesquiterpene lactone from Florida Helenium autumnale L.

A. McPhail, M. Kozuka, K. Lee, 1975 .

Structure and stereochemistry of carolenalone, a new sesquiterpene lactone from north carolina helenium autumnale L.

A. McPhail, K. Lee, H. Furukawa, 1975 .

Crystal structure of carolenalin monoacetate: revision of the stereochemistry of carolenalin and carolenin

C. Piantadosi, A. McPhail, K. Lee, 1973 .

Ochrocephalamines B-D, Three Alkaloids from Oxytropis ochrocephala Bunge.

K. Lee, Yue-Hu Wang, Wen Tian, 2019, Organic letters.

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge.

K. Lee, S. Morris-Natschke, M. Goto, 2016, Tetrahedron letters.

(+)‐(14β)‐14‐Ethylmatridin‐15‐one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

K. Lee, S. Morris-Natschke, M. Goto, 2016 .

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.

K. Lee, S. Morris-Natschke, M. Goto, 2016, Bioorganic & medicinal chemistry letters.

Recent progress in the development of coumarin derivatives as potent anti‐HIV agents

K. Lee, S. Morris-Natschke, Lan Xie, 2003, Medicinal research reviews.

Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza.

M. Don, Yun-Lian Lin, K. Lee, 2004, Journal of medicinal chemistry.

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation.

Z. Yao, K. Lee, Yan Li, 2013, Journal of medicinal chemistry.

ELECANACIN, A NOVEL NEW NAPHTHOQUINONE FROM THE BULB OF ELEUTHERINE AMERICANA

K. Lee, Y. Imakura, K. Bastow, 1997 .

Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.

A. Brossi, A. McPhail, K. Lee, 2002, Bioorganic & Medicinal Chemistry Letters.

Antitumor Agents. Part 184. Syntheses and antitubulin activity of compounds derived from reaction of thiocolchicone with amines: Lactams, alcohols, and ester analogs of allothiocolchicinoids†‡

A. Brossi, A. McPhail, K. Lee, 1998 .

Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.

Hui-Yi Lin, Chi-Hung Huang, S. Kuo, 2010, Journal of medicinal chemistry.

Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.

S. Kuo, Li‐Jiau Huang, Keduo Qian, 2009, Journal of medicinal chemistry.

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2011, Bioorganic & medicinal chemistry letters.

Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents.

Yi Xia, Chin-Ho Chen, Keduo Qian, 2010, Bioorganic & medicinal chemistry.

Design, synthesis, crystal structure, bioactivity, and molecular docking studies of novel sulfonylamidine-derived neonicotinoid analogs

Huan Li, Keduo Qian, K. Lee, 2014, Medicinal Chemistry Research.

Fluorinated Modification of Neo-Tanshinlactone and Antiproliferative Activity Evaluation

K. Lee, M. Goto, Kaixin Zhang, 2022, Chemistry of Natural Compounds.

Selectfluor-Enabled C(sp3)-H Alkoxylation of 3-Methylfuranocoumarins.

K. Lee, M. Goto, Kaixin Zhang, 2021, The Journal of organic chemistry.

Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives.

Qiong Gu, Jun Xu, K. Lee, 2015, Organic & biomolecular chemistry.

New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis.

Jai-Sing Yang, T. Hwang, Keduo Qian, 2011, Bioorganic & medicinal chemistry.

Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2011, Natural product reports.

Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2011, Bioorganic & medicinal chemistry letters.

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2010, Bioorganic & medicinal chemistry letters.

Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents.

Yizhou Dong, K. Lee, X. Wang, 2009, Journal of medicinal chemistry.

Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata.

K. Lee, P. Kuo, K. Bastow, 2006, Organic letters.

Antitumor Agents. Part 239. Isolation, Structure Elucidation, Total Synthesis, and anti-Breast Cancer Activity of Neo-tanshinlactone from Salvia miltiorrhiza.

M. Don, Yun-Lian Lin, K. Lee, 2005 .

Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.

Li Huang, Chin-Ho Chen, K. Lee, 2012, European journal of medicinal chemistry.

Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.

Hao Zhu, Li Huang, Chin-Ho Chen, 2010, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells.

Yi-Chien Lin, S. Kuo, Li‐Jiau Huang, 2016, European journal of medicinal chemistry.

Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity.

Po-Cheng Chiang, K. Lee, S. Morris-Natschke, 2008, Bioorganic & medicinal chemistry.

Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata.

H. Nozaki, F. Chang, A. McPhail, 2004, Journal of natural products.

Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents

K. Lee, S. Morris-Natschke, Hui-Kang Wang, 1997, Medicinal research reviews.

Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos.

K. Lee, Xihong Wang, Y. Yi, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies of novel 6,7,8‐substituted 4‐substituted benzyloxyquinolin‐2(1H)‐one derivatives for anticancer activity

Hui-Yi Lin, Yi-Chien Lin, S. Kuo, 2015, British journal of pharmacology.

Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.

Yi Xia, Hong-shan Liu, Chin-Ho Chen, 2011, Bioorganic & medicinal chemistry letters.

Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.

Yi Xia, Keduo Qian, K. Lee, 2010, Bioorganic & medicinal chemistry.

Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs.

Q. Zhang, Yi Xia, K. Lee, 2004, Bioorganic & medicinal chemistry.

Synthesis of rutaecarpine and cytotoxic analogues

Chieh-fu Chen, K. Lee, L. Yang, 1995 .

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction.

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2015, Bioorganic & medicinal chemistry letters.

Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids.

K. Lee, Donglei Yu, Y. Takaishi, 2006, Journal of natural products.

Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents.

M. Don, Yun-Lian Lin, K. Lee, 2006, Journal of medicinal chemistry.

Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents.

Yi Xia, Hong-shan Liu, Keduo Qian, 2012, European journal of medicinal chemistry.

Current developments in the discovery and design of new drug candidates from plant natural product leads.

K. Lee, 2004, Journal of natural products.

Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium.

K. Lee, S. Ahmed, Y. Takaishi, 2005, Organic letters.

The Cytotoxic Properties of Natural Coumarins Isolated from Roots of Ferulago campestris (Apiaceae) and of Synthetic Ester Derivatives of Aegelinol

K. Lee, S. Rosselli, S. Morris-Natschke, 2009, Natural product communications.

Antitumour triterpenes of Maytenus diversifolia

H. Nozaki, R. Kasai, K. Lee, 1986 .

Schizarin B, C, D, and E, Four New Lignans from Kadsura matsudai and Their Antihepatitis Activities

K. Lee, Shyh-Yuan Li, M. Wu, 2001 .

Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita.

Chin-Ho Chen, K. Lee, S. Morris-Natschke, 2018, Journal of natural products.

One-step templated synthesis of chiral organometallic salicyloxazoline complexes

K. Lee, S. Morris-Natschke, Mei Luo, 2019, BMC Chemistry.

Progress in the Recent Discovery and Development of Promising Anticancer and Anti-HIV Agents from Natural Products in the United States†

K. Lee, S. Morris-Natschke, J. Wu, 2003 .

Antitumor Agents. Part 204. Synthesis and Biological Evaluation of Substituted 2‐Aryl Quinazolinones.

K. Lee, 2001 .

Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R-disubstituted-2',2'-dimethyldihydropyrano[2,3-f]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance.

K. Lee, Ting Zhou, K. Bastow, 2010, Journal of medicinal chemistry.

Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.

Susan L Morris-Natschke, M. Itoigawa, K. Lee, 2005, Bioorganic & medicinal chemistry.

Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents.

A. Brossi, Chin-Ho Chen, K. Lee, 2004, Journal of medicinal chemistry.

Novel antitumor agents from higher plants

K. Lee, 1999, Medicinal research reviews.

Isolation and cytotoxicity of rhinacanthin-A and -B, two; naphthoquinones, from Rhinacanthus nasutus

H. Tien, K. Lee, M. Yeh, 1988 .

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis.

D. Newman, K. Lee, B. O’Keefe, 2019, Journal of natural products.

Acetophenone Monomers from Acronychia trifoliolata.

D. Newman, K. Lee, B. O’Keefe, 2016, Journal of natural products.

Antitumor Agents 225. Acrofoliones A and B, Two Novel Cytotoxic Acetophenone Dimers from Acronychia Trifoliolata

Y. Shirataki, G. Cragg, K. Lee, 2003 .

Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents.

Chi-Hung Huang, Shih-Ming Huang, S. Kuo, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.

Chi-Hung Huang, Shih-Ming Huang, S. Kuo, 2010, Journal of medicinal chemistry.

Design, Synthesis and Structure-Activity Relationships of (±)-Isochaihulactone Derivatives.

H. Harn, K. Lee, S. Morris-Natschke, 2017, MedChemComm.

Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway.

Shuwen Liu, K. Lee, S. Morris-Natschke, 2014, Bioorganic & Medicinal Chemistry.

Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization

A. Oda, K. Lee, X. Hao, 2019, Molecules.

Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata.

K. Lee, P. Kuo, K. Bastow, 2007, Journal of natural products.

Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides.

K. Lee, I. Chen, M. Cheng, 2005, Bioorganic & medicinal chemistry.

Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters.

Harukuni Tokuda, Sheng-Chu Kuo, S. Kuo, 2005, Bioorganic & medicinal chemistry.

Structural analogs of tylophora alkaloids may not be functional analogs.

C. Leung, A. Fürstner, K. Lee, 2008, Bioorganic & medicinal chemistry letters.

Antitumor agents. 274. A new synthetic strategy for E-ring SAR study of antofine and cryptopleurine analogues.

K. Lee, Xiao-ming Yang, K. Bastow, 2010, Organic letters.

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

A. Brossi, C. Teng, S. Pan, 2007, Journal of medicinal chemistry.

Molecular modeling, design, synthesis, and biological evaluation of novel 3',4'-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents.

K. Lee, Lan Xie, Ting Zhou, 2005, Bioorganic & medicinal chemistry.

ANTI-AIDS AGENTS 65: INVESTIGATION OF THE IN VITRO OXIDATIVE METABOLISM OF 3′,4′-DI-O-(–)-CAMPHANOYL-(+)-CIS-KHELLACTONE DERIVATIVES AS POTENT ANTI-HIV AGENTS

David E. Martin, J. Swenberg, K. Lee, 2005, Drug Metabolism and Disposition.

Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent.

A. Brossi, K. Lee, N. Kilgore, 2003, Bioorganic & medicinal chemistry letters.

Elecanacin, a Novel New Naphthoquinone from the Bulb of Eleutherine americana.

K. Lee, Y. Imakura, K. Bastow, 1998 .

Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers.

Guan-Jhong Huang, T. Hwang, K. Lee, 2012, Phytochemistry.

Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria.

S. Kuo, Han-Dong Sun, K. Lee, 2014, Bioorganic & medicinal chemistry.

Cytotoxic geranylflavonoids from Bonannia graeca.

M. Safder, K. Lee, S. Rosselli, 2011, Phytochemistry.

Cytotoxic isoprenylated flavonoids from the roots of sophora flavescens.

K. Lee, Xihong Wang, A. Nyarko, 2004 .

Kalshiolin A, new lignan from Kalimeris shimadai

G. Wang, N. Zhang, K. Lee, 2019, Journal of Asian natural products research.

Total Synthesis of (+)-Medicarpin.

K. Lee, Ch H. Cheng, Xiao-ming Yang, 2017, Journal of natural products.

Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry.

Chin-Ho Chen, Keduo Qian, K. Lee, 2012, Tetrahedron letters.

Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.

K. Lee, Zhiyan Xiao, K. Bastow, 2004, Journal of medicinal chemistry.

Antitumor agents. 16. Steroidal alpha-methylene-gamma-lactones.

E. Huang, K. Lee, I. Hall, 1975, Journal of medicinal chemistry.

Recent Progress on C‐4‐Modified Podophyllotoxin Analogs as Potent Antitumor Agents

Keduo Qian, K. Lee, S. Morris-Natschke, 2015, Medicinal research reviews.

Synthesis of novel spin-labeled podophyllotoxin derivatives as potential antineoplastic agents: Part XXV

K. Lee, Wen-Qun Li, Xiao-bo Zhao, 2014, Medicinal Chemistry Research.

Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents.

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2013, Bioorganic & medicinal chemistry.

Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.

Chieh-Hung Huang, K. Lee, Li-Shian Shi, 2003, Journal of natural products.

Anti-AIDS agents 68. The first total synthesis of a unique potent anti-HIV chalcone from genus Desmos

K. Lee, Kyoko Nakagawa-Goto, 2006 .

Homoharringtonine and related compounds

K. Lee, Xihong Wang, H. Itokawa, 2005 .

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

S. Fukuyoshi, D. Newman, K. Lee, 2019, Molecules.

Synthesis of novel spin-labeled podophyllotoxin derivatives as potential antineoplastic agents: Part XXV

Zhi‐Jun Zhang, K. Lee, Wen-Qun Li, 2014, Medicinal Chemistry Research.

SYNTHESIS OF ARYLTETRALIN TYPE 2-AZALIGNANS USING SCHÖLLKOPF'S BISLACTIM-ETHER METHODOLOGY

K. Lee, Y. Usami, K. Bastow, 2009 .

Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives.

K. Lee, Zhiyan Xiao, L. Cosentino, 2004, Bioorganic & medicinal chemistry.

Antitumor Agents. Part 232. Synthesis of Cyclosulfite Podophyllotoxin Analogues as Novel Prototype Antitumor Agents.

K. Lee, Zhiyan Xiao, Shiqing Han, 2004 .

Antitumor agents. Part 227: Studies on novel 4'-O-demethyl-epipodophyllotoxins as antitumor agents targeting topoisomerase II.

K. Lee, Zhiyan Xiao, K. Bastow, 2004, Bioorganic & medicinal chemistry.

Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.

A. Brossi, K. Lee, Zhiyan Xiao, 2004, Bioorganic & medicinal chemistry.

Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.

K. Lee, Zhiyan Xiao, Shiqing Han, 2004, Bioorganic & medicinal chemistry letters.

Characterization of human lung cancer cells resistant to 4′-O-demethyl-4β-(2′′-nitro-4′′-fluoroanilino)-4-desoxypodophyllotoxin, a unique compound in the epipodophyllotoxin antitumor class

K. Lee, K. Bastow, Y. Tachibana, 2000, Anti-cancer drugs.

CHM-1, a New Vascular Targeting Agent, Induces Apoptosis of Human Umbilical Vein Endothelial Cells via p53-mediated Death Receptor 5 Up-regulation*

Hui-Lung Sun, S. Kuo, C. Teng, 2009, The Journal of Biological Chemistry.

Novel sesquiterpene lactone analogues as potent anti‐breast cancer agents

K. Lee, Yohei Saito, L. Shyur, 2016, Molecular oncology.

Cytotoxic germacranolides of Elephantopus carolinianus and the structure and stereochemistry of isodeoxyelephantopin

A. McPhail, K. Lee, M. Haruna, 1986 .

Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.

Pan‐Chyr Yang, C. Teng, S. Pan, 2012, Journal of medicinal chemistry.

Total Synthesis of Taxoids

K. Lee, Zhiyan Xiao, H. Itokawa, 2004 .

Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.

Sung-Liang Yu, Pan‐Chyr Yang, C. Teng, 2011, Journal of medicinal chemistry.

Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.

Pan‐Chyr Yang, K. Lee, Guiyu Zhao, 2009, Journal of medicinal chemistry.

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2015, Bioorganic & medicinal chemistry.

N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin.

Xiao‐Feng Wang, Keduo Qian, K. Lee, 2013, European journal of medicinal chemistry.

Antitumor Agents. 192. Antitubulin Effect and Cytotoxicity of C(7)-Oxygenated Allocolchicinoids

A. Brossi, A. McPhail, K. Lee, 1999 .

Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents.

A. Brossi, K. Lee, E. Hamel, 2010, Bioorganic & medicinal chemistry letters.

Antitumor agents 238. anti-tubulin and in vitro cytotoxic effects of N-substituted allocolchicinoids

A. Brossi, Chin‐Chung Wu, K. Lee, 2005 .

Structures of tetra-O-demethylcolchicine, -isocolchicine, and 10-O-demethylcolchicine derivatives

K. Lee, Y. Kashiwada, H. Tatematsu, 1993 .

Antitumor Agents. Part 215. Antitubulin Effects of Cytotoxic B‐Ring Modified Allocolchicinoids.

A. Brossi, A. McPhail, K. Lee, 2003 .

Highlights of Research on Plant-Derived Natural Products and Their Analogs with Antitumor, Anti-HIV, and Antifungal Activity

K. Lee, 1999 .

Antitumor Agents. Part 184. Syntheses and Antitubulin Activity of Compounds Derived from Reaction of Thiocolchicone with Amines: Lactams, Alcohols, and Ester Analogues of Allothiocolchicinoids.

A. Brossi, A. McPhail, K. Lee, 1998 .

Structure and synthesis of clausenaquinone-a. A novel carbazolequinone alkaloid and bioactive principle from Clausena excavata

K. Lee, S. Huang, P. Wu, 1994 .

Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus.

Weifan Zheng, Shibo Jiang, Na Liu, 2016, Journal of medicinal chemistry.

Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.

C. Liaw, Y. Wu, F. Chang, 2003, Planta medica.

Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.

Chin‐Chung Wu, K. Lee, A. Nyarko, 2006, Journal of medicinal chemistry.

THREE NEW QUASSINOID DERIVATIVES AND RELATED COMPOUNDS AS ANTITUMOR PROMOTERS FROM BRUCEA JAVANICA

H. Nishino, K. Tagahara, H. Tokuda, 1999 .

Correction to: One-step templated synthesis of chiral organometallic salicyloxazoline complexes

K. Lee, S. Morris-Natschke, Mei Luo, 2019, BMC Chemistry.

Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.

H. Nozaki, C. Liaw, Chin‐Chung Wu, 2004, Planta medica.

Biologically active isoquinoline alkaloids covering 2014–2018

Xiao Guo, Jiyu Zhang, K. Lee, 2020, Medicinal research reviews.

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2009, Bioorganic & medicinal chemistry letters.

Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents.

K. Lee, K. Bastow, F. Lee, 2003, Bioorganic & medicinal chemistry.

Palladium (II), platinum (II) and silver (I) complexes with oxazolines: Their synthesis, characterization, DFT calculation, molecular docking and antitumour effects.

K. Lee, S. Morris-Natschke, Lan Xie, 2022, Journal of inorganic biochemistry.

Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs.

Harukuni Tokuda, H. Tokuda, K. Lee, 2005, Bioorganic & medicinal chemistry letters.

New sesquiterpenes from Capsicum annuum.

K. Kawazoe, K. Lee, Y. Takaishi, 2004, Journal of natural products.

Antineoplastic Alkaloids From Chinese Medicinal Plants and Their Analogs

K. Lee, Li Sun, Hui-Kang Wang, 1994 .

Cytotoxic antileukemic anthraquinones from Morinda parvifolia

K. Lee, Kuo Hsiung Lee, Pong Chang, 1984 .

Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents.

Qian Shi, Susan L Morris-Natschke, A. Brossi, 2006, Bioorganic & medicinal chemistry.

Honokiol Dimers and Magnolol Derivatives with New Carbon Skeletons from the Roots of Magnolia officinalis and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

T. Hwang, K. Lee, P. Kuo, 2013, PloS one.

Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

Keduo Qian, K. Lee, S. Morris-Natschke, 2014, Journal of medicinal chemistry.

Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine

K. Lee, S. Morris-Natschke, H. Itokawa, 2012, Journal of traditional and complementary medicine.

Effect of Helenalin and Bis(helenalinyl)malonate on Nucleic Acid and Protein Synthesis in Human KB Carcinoma Cells

S. Chaney, K. Lee, A. Grippo, 1987, Pharmaceutical Research.

Antitumor agents XXX: Evaluation of α-methylene-γ-lactone-containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis

K. Lee, M. Haruna, I. Hall, 1978 .

Plant-derived terpenoids and analogues as anti-HIV agents.

K. Lee, S. Morris-Natschke, Y. Kashiwada, 2003, Current topics in medicinal chemistry.

Recent discovery of plant-derived anti-diabetic natural products.

Keduo Qian, K. Lee, S. Morris-Natschke, 2012, Natural product reports.

Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia.

Qiong Gu, Jun Xu, K. Lee, 2017, Journal of natural products.

Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica.

Hui-Chi Huang, K. Lee, Yao-Haur Kuo, 2010, Journal of natural products.

Cytotoxic and anti‐HIV Principles from the Rhizomes of Begonia nantoensis.

Shiow-Ju Lee, K. Lee, P. Wu, 2004 .

Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi.

H. Tokuda, K. Lee, S. Morris-Natschke, 2006, Journal of natural products.

Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum: A new class of potent anti-HIV agents

K. Lee, Y. Takaishi, H. Duan, 1999 .

THREE NEW QUASSINOID DERIVATIVES AND RELATED COMPOUNDS AS ANTITUMOR PROMOTERS FROM BRUCEA JAVANICA

H. Nishino, K. Tagahara, H. Tokuda, 1999 .

Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents.

H. Lou, H. Tokuda, K. Lee, 2014, Tetrahedron letters.

The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes.

K. Lee, T. Akiyama, L. Oberoi, 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis.

Wei Li, K. Koike, Li Huang, 2021, Journal of natural products.

Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.

C. Liaw, K. Lee, Y. Yi, 2003, Journal of natural products.

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors.

Li Huang, Chin-Ho Chen, Z. Dang, 2016, ACS medicinal chemistry letters.

Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.

Kazuo Koike, K. Koike, T. Nikaido, 2004, Bioorganic & medicinal chemistry letters.

Structure and synthesis of murrapanine, a novel skeletal indole-naphthoquinone alkaloid and cytotoxic principal from Murraya paniculata var. omphalocarpa

A. McPhail, K. Lee, Tian-Shung Wu, 1989 .

Eremophilane sesquiterpenes from Ligularia macrophylla.

Susan L Morris-Natschke, K. Lee, S. Morris-Natschke, 2007, Journal of natural products.

Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

Chin-Ho Chen, K. Lee, S. Morris-Natschke, 2019, Molecules.

Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron

D. Tsuji, Chin-Ho Chen, K. Lee, 2021, Journal of Natural Medicines.

Sesquiterpene lactones of artemisia constituents of A. ludoviciana SSP. mexicana

K. Lee, T. A. Geissman, 1970 .

Acid degradation products of qinghaosu and their structure-activity relationships

W. Milhous, K. Lee, Y. Imakura, 1990 .

New cembranolide analogues from the formosan soft coral Sinularia flexibilis and their cytotoxicity

Y. Wu, F. Chang, A. McPhail, 2003, Natural product research.

A sesquiterpene ester from Celastrus Hindsii

Chieh-fu Chen, K. Lee, C. Chou, 1996 .

Genkwadaphnin, a potent antileukemic diterpene from Daphne genkwa

K. Lee, H. Huang, Ryoji Kasal, 1981 .

Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents.

C. Leung, Shin-Young Park, Hao Zhu, 2012, Bioorganic & medicinal chemistry.

Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.

M. Hung, Shao-Chun Wang, B. Spohn, 2007, Bioorganic & medicinal chemistry letters.

Structure and stereochemistry of eupaformosanin, a new antileukemic and antisarcoma germacranolide from Eupatorium formosanum

A. McPhail, K. Lee, M. Haruna, 1977 .

Beta Unsubstituted Cyclopentenone, a Structural Requirement for Antimicrobial and Cytotoxic Activities

K. Lee, T. Ibuka, R. Wu, 1974 .

Structure and stereochemistry of the epoxide of phantomolin, a novel cytotoxic sesquiterpene lactone from Elephantopus mollis

A. McPhail, M. Kozuka, K. Lee, 1974 .

Reaction of helenalin with hydrogen chloride.

C. Piantadosi, K. Lee, S. H. Kim, 1973, Journal of pharmaceutical sciences.

Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.

Li Huang, Chin-Ho Chen, Keduo Qian, 2008, Bioorganic & Medicinal Chemistry.

Antioxidant lignans and chromone glycosides from Eurya japonica.

K. Lee, S. Morris-Natschke, H. Ho, 2013, Journal of natural products.

Prenylated benzophenones and xanthones from Hypericum scabrum.

Michiho Ito, K. Lee, Y. Takeda, 2004, Journal of natural products.

Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.

K. Lee, S. Morris-Natschke, Wei Liu, 2017, Journal of natural products.

The cytotoxic principles of Hyptis capitata and the structures of the new triterpenes hyptatic acid-A and -B☆

A. McPhail, K. Lee, T. Yamagishi, 1988 .

Constituents from the stems of Hibiscus taiwanensis.

K. Lee, P. Wu, Tian-Shung Wu, 2005, Chemical & pharmaceutical bulletin.

Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta

K. Lee, S. Morris-Natschke, Z. Liao, 2013, Molecules.

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.

K. Lee, N. Kilgore, Dao-feng Chen, 2006, Journal of natural products.

Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.

C. Liaw, X. Yao, K. Lee, 2005, Journal of natural products.

The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV

David E. Martin, Chin-Ho Chen, K. Lee, 2005, Expert opinion on investigational drugs.

HIV and reverse transcriptase inhibition by tannins

R. Kilkuskie, K. Lee, Y. Kashiwada, 1992 .

Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwa Guided by UPLC-MSn.

Chin-Ho Chen, K. Lee, S. Morris-Natschke, 2019, Journal of natural products.

Desmosdumotin C, a Novel Cytotoxic Principle from Desmos dumosus.

A. McPhail, K. Lee, J. Wu, 2002 .

New labdane diterpenoids from Leonurus japonicus and their anti-inflammatory activity

K. Lee, Hong Mei Li, Rong-Tao Li, 2014 .

Perspectives on Biologically Active Camptothecin Derivatives

Susan L Morris-Natschke, Liu Yang, Keduo Qian, 2015, Medicinal research reviews.

Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

Li Huang, Chin-Ho Chen, Keduo Qian, 2010, Journal of medicinal chemistry.

Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation

T. Hwang, Keduo Qian, K. Lee, 2010 .

Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.

Chin-Ho Chen, K. Lee, Y. Kashiwada, 2002, Journal of medicinal chemistry.

Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives.

Jin-Ying Tian, Keduo Qian, K. Lee, 2013, Bioorganic & medicinal chemistry.

Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication.

Yan Wang, Qian Wang, Hui Cui, 2015, Journal of natural products.

Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root

K. Lee, S. Morris-Natschke, Shu‐Ming Li, 2018, Chemistry & biodiversity.

5–Methoxyaristololactam I, the First Natural 5–Substituted Aristololactam from Asarum ichangense

K. Lee, K. Komatsu, S. Cai, 2011, Natural product communications.

Antitumor agents 248. Chemistry and antitumor activity of tylophorinerelated alkaloids

A. Brossi, K. Lee, S. Morris-Natschke, 2008 .

Salviatalin A (I) and Salvitrijudin A (II), Two Diterpenes with Novel Skeletons from Roots of Salvia digitaloides and Antiinflammatory Evaluation.

T. Hwang, Keduo Qian, K. Lee, 2010 .

Computational Studies and Drug Design for HIV-1 Reverse Transcriptase Inhibitors of 3′,4′-di-O-(S)-camphanoyl-(+)-cis-Khellactone (DCK) Analogs

Haifeng Chen, Ting Zhou, Chenyang Zhao, 2005, J. Comput. Aided Mol. Des..

Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds.

Harukuni Tokuda, H. Nishino, M. Kozuka, 2005, Bioorganic & medicinal chemistry.

Cytotoxic Phenylpropanoids and a New Triterpene, Turformosinic Acid, from Turpinia formosana Nakai

K. Lee, I. Chen, Chao-Lin Chang, 2012, Molecules.

5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix

Keduo Qian, K. Lee, S. Morris-Natschke, 2008, Journal of Natural Medicines.

Secondary metabolites from the Chinese liverwort Cephaloziella kiaeri.

H. Lou, Rongxiu Zhu, K. Lee, 2013, Journal of natural products.

Antitumor agents. Part 212. Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras.

H. Nozaki, G. Cragg, K. Lee, 2002, Bioorganic & medicinal chemistry letters.

New lignans and cytotoxic constituents from Wikstroemia lanceolata.

K. Lee, C. Duh, I. Chen, 2004, Planta medica.

(+)-Arctigenin, a lignan from Wikstroemia indica

K. Lee, M. Haruna, Kazuo Itô, 1982 .

Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odora.

Wei Li, K. Koike, Chin-Ho Chen, 2019, Organic letters.

Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.

Wei Li, K. Koike, Chin-Ho Chen, 2011, Organic letters.

Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

Wei Li, K. Koike, Li Huang, 2020, Journal of natural products.

Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

Jai-Sing Yang, Hui-Yi Lin, S. Kuo, 2020, Molecules.

Bauhinin, a new nitrile glucoside from Bauhinia championii

A. McPhail, K. Lee, C. Chen, 1985 .

A novel bridged stilbenoid trimer and four highly condensed stilbenoid oligomers in Vatica rassak

Tetsuro Ito, M. Iinuma, H. Naganawa, 2001 .

Conversion of tetrahydroberberine into pavinane-type alkaloids

K. Lee, Kazuo Itô, H. Furukawa, 1975 .

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata.

S. Fukuyoshi, D. Newman, K. Lee, 2019, Journal of natural products.

Terpenoids from Juniperus polycarpus var. seravschanica.

K. Lee, Y. Kashiwada, Y. Takaishi, 2006, Phytochemistry.

Efficient 1H nuclear magnetic resonance method for improved quality control analyses of Ginkgo constituents.

K. Lee, Tian-Shung Wu, Chia-Ying Li, 2004, Journal of agricultural and food chemistry.

Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.

Y. Nobukuni, H. Nishino, M. Kozuka, 2002, Journal of natural products.

Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid.

Stephen J. Capuzzi, K. Lee, Ling-Chu Chang, 2019, Bioorganic & medicinal chemistry.

Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.

Li Huang, Chin-Ho Chen, K. Lee, 2016, Bioorganic & medicinal chemistry letters.

New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.

Li Huang, Chin-Ho Chen, Z. Dang, 2013, Journal of medicinal chemistry.

HIV entry inhibitors and their potential in HIV therapy

Keduo Qian, K. Lee, S. Morris-Natschke, 2009, Medicinal research reviews.

Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents 1

Yoshiki, F. Chang, Li Huang, 2008 .

Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

F. Chang, Li Huang, Chin-Ho Chen, 2006, Journal of medicinal chemistry.

Bioactive chemical constituents from the root bark of Morus australis.

Guan-Jhong Huang, K. Lee, P. Kuo, 2017, Bioorganic & medicinal chemistry letters.

Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum.

Yu-Jen Kuo, Ming-Der Wu, K. Lee, 2010, Journal of natural products.

The Pharmacology of Chinese Herbs, Second Edition By K. C. Huang (University of Louisville). CRC Press, Inc., Boca Raton, FL. 1998. xxi + 512 pp. 17.5 × 25 cm. $129.00. ISBN 0-8493-1665-0

K. Lee, 1998 .

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

G. Wang, Gang Wang, K. Lee, 2018, Molecules.

Tigliane-Type Diterpene Esters from the Fruits of Shirakiopsis indica and Their Anti-HIV Activity.

Chin-Ho Chen, K. Lee, Y. Kashiwada, 2022, Journal of natural products.

Secoiridoid dilactones from Fraxinus uhdei

K. Lee, Ya‐Ching Shen, Chung-Hsiung Chen, 1993 .

Anti-AIDS agents. 291. Anti-HIV activity of modified podophyllotoxin derivatives

K. Lee, Hong Hu, S. Morris-Natschke, 1997 .

Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae.

G. Wang, N. Zhang, Gang Wang, 2019, Journal of natural products.

Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis.

K. Lee, K. Bastow, P. Wu, 2006, Organic letters.

ANTI-HIV ACTIVITY OF QUASSINOIDS

M. Cosentino, K. Tagahara, K. Lee, 1996 .

SESQUITERPENE ANTITUMOR AGENTS- INHIBITORS OF CELLULAR METABOLISM

T. G. Waddell, K. Lee, I. Hall, 1977 .

Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.

H. Nozaki, C. Liaw, Y. Wu, 2003, Journal of natural products.

Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus Talaromyces sp.

Mengting Teng, Nan Jiang, Bo Yuan, 2020, Journal of natural products.

Fungal Metabolites as Potent Protein Kinase Inhibitors: Identification of a Novel Metabolite and Novel Activities of Known Metabolites

R. Jones, E. Garvey, Zhihong Xu, 2004 .

Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum

Bo Yuan, K. Lee, S. Morris-Natschke, 2015, Journal of Asian natural products research.

Altaicalarins A-D, cytotoxic bisabolane sesquiterpenes from Ligularia altaica.

K. Lee, Kuo-Hsiung Lee, Dao-feng Chen, 2010, Journal of natural products.

Annoquinone-A, an antimicrobial and cytotoxic principle from Annona montana

H. Tien, K. Lee, H. Furukawa, 1987 .

Dyscusins A-C, three new steroids from the leaves of Dysoxylum cumingianum.

K. Lee, S. Morris-Natschke, Y. Kashiwada, 2011, Chemical & pharmaceutical bulletin.

Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents.

Y. Wu, T. Hwang, K. Lee, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV‐1 RNase H inhibitors

Peng Zhan, Jacob Kongsted, Luis Menéndez-Arias, 2019, Chemical biology & drug design.

Structure-Activity Relationships of Curcumin and Its Analogs with Different Biological Activities††Antitumor Agents 241.

K. Lee, Li Lin, 2006 .

Efficient synthesis and biological evaluation of epiceanothic acid and related compounds.

Luyong Zhang, Keduo Qian, K. Lee, 2011, Bioorganic & medicinal chemistry letters.

Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.

K. Lee, H. Itokawa, K. Bastow, 2006, Journal of natural products.

New Phorbol Ester Derivatives as Potent Anti-HIV Agents.

Chin-Ho Chen, K. Lee, Lei Zhao, 2021, Bioorganic & medicinal chemistry letters.

Dantaxusins C and D, two novel taxoids from Taxus yunnanensis.

K. Tagahara, K. Lee, T. Nehira, 2002, Journal of natural products.

R. Kilkuskie, K. Lee, Y. Kashiwada, 1992 .

Novel N-(3-carboxyl-9-benzyl-beta-carboline-1-yl)ethylamino acids: synthesis, anti-tumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation.

Ming Zhao, Shiqi Peng, Keduo Qian, 2009, European journal of medicinal chemistry.

A new resveratrol octamer, vateriaphenol A, in Vateria indica

Tetsuro Ito, M. Iinuma, H. Naganawa, 2001 .

Antitumor Agents. 125. New 4β-Benzoylamino Derivatives of 4′-O-Demethyl-4-desoxypodophyllotoxin and 4β-Benzoyl Derivatives of 4′-O-Demethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

K. Lee, Yung‐chi Cheng, Xiaoming Zhou, 1993, Pharmaceutical Research.

Chapter 13:From Natural Product to Clinical Trials: Bevirimat, a Plant-Derived Anti-AIDS Drug

Keduo Qian, K. Lee, G. Allaway, 2009 .

Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.

Harukuni Tokuda, Masahiko Taniguchi, H. Tokuda, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.

Li Huang, Chin-Ho Chen, K. Lee, 2006, Bioorganic & medicinal chemistry.

Cancer Preventive Agents 3. Antitumor Promoting Effects of Agaricus blazei.

H. Nishino, M. Kozuka, H. Tokuda, 2005 .

Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.

K. Lee, M. Goto, K. Bastow, 2012, Journal of medicinal chemistry.

Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors.

Zhijun Li, Li Huang, Chin-Ho Chen, 2020, Current medicinal chemistry.

The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells.

Jai-Sing Yang, Yi-Chien Lin, S. Kuo, 2013, International journal of oncology.

Desmosdumotin C, a novel cytotoxic principle from Desmos dumosus

A. McPhail, K. Lee, J. Wu, 2002 .

Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.

Weidong Hu, Chin-Ho Chen, Keduo Qian, 2011, European journal of medicinal chemistry.

Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs.

Chin-Ho Chen, Keduo Qian, K. Lee, 2010, Bioorganic & medicinal chemistry letters.

Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.

Yanli Wang, Chin-Ho Chen, K. Lee, 2020, ACS medicinal chemistry letters.

Synthesis and anti‐HIV Activity of 2′‐Deoxy‐2′‐fluoro‐4′‐C‐ethynyl Nucleoside Analogues.

Chin-Ho Chen, Keduo Qian, K. Lee, 2010 .

Condensed as‐triazines. Synthesis of 7‐aryl‐8H‐[1,4]thiazino[2,3‐e]‐1,2,4‐triazin‐3(2H)‐one

C. Tzeng, Yeh-long Chen, K. Lee, 1993 .

Condensed as‐Triazines. Synthesis of 7‐Aryl‐8H(1,4)thiazino(2,3‐e)‐1,2, 4‐triazin‐3(2H)‐one.

C. Tzeng, Yeh-long Chen, K. Lee, 1993 .

Cytotoxic Principles from Saussurea Lappa and Corydalis Turtshaninovii f. Yanhusuo

K. Lee, Y. Leu, Tian-Shung Wu, 1997 .

Lewis acid‐mediated defluorinative [3+2] cycloaddition/aromatization cascade of 2,2‐difluoroethanol systems with nitriles

S. Kuo, K. Lee, Min-Tsang Hsieh, 2018 .

Conjugates of betulin derivatives with AZT as potent anti-HIV agents.

Chin-Ho Chen, Keduo Qian, K. Lee, 2010, Bioorganic & medicinal chemistry.

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

M. Lai, Ying-Jung Chen, J. Hung, 2015, Oncotarget.

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

A. Oda, K. Lee, E. Hamel, 2016, Bioorganic & medicinal chemistry.

Antitumor Agents. Part 209. Pheophorbide-a Derivatives as Photo-Independent Cytotoxic Agents.

A. Brossi, K. Lee, P. Wongsinkongman, 2002 .

Geranyl Derivatives of Isoquinoline Alkaloids Show Increased Biological Activities

S. Takeuchi, Hye-Sook Kim, Y. Wataya, 2010 .

Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii.

N. Seeram, Dane Huang, Qiong Gu, 2016, Organic letters.

Research and Discovery Trends of Chinese Medicine in the New Century

K. Lee, 2004 .

Hepatoprotective triterpenes from Sedum sarmentosum

K. Lee, Mingshi Wang, Decheng Zhang, 1998 .

Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis.

K. Tagahara, K. Lee, Kuo-Hsiung Lee, 2002, Bioorganic & medicinal chemistry letters.

Structure and stereochemistry of taxuchin A, a new 11(15 → 1)abeo-taxane type diterpene from Taxus chinensis

Ke Chen, A. McPhail, K. Lee, 1994 .

NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells

Szu-Ying Wu, C. Teng, S. Pan, 2014, PloS one.

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa.

K. Lee, X. Hao, S. Morris-Natschke, 2018, Journal of natural products.

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa.

S. Fukuyoshi, D. Newman, K. Lee, 2017, Journal of natural products.

The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.

Jai-Sing Yang, Hui-Yi Lin, S. Tsai, 2011, International journal of oncology.

Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus.

Keduo Qian, K. Lee, Y. Leu, 2010, Journal of natural products.

Antitumor agents 171. Cytotoxicities of lobatosides B, C, D, and E, cyclic bisdesmosides isolated from Actinostemma lobatum maxim

K. Lee, T. Fujioka, Y. Kashiwada, 1996 .

Structure and stereochemistry of pseudolarolide E, a novel triterpene dilactone from Pseudolarix kaempferi

A. McPhail, K. Lee, Ke Chen, 1990 .

Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens

K. Lee, Dao-feng Chen, Yan Lu, 2013, Pharmaceutical biology.

QS‐ZYX‐1‐61 induces apoptosis through topoisomerase II in human non‐small‐cell lung cancer A549 cells

Qian Shi, Zhiyan Xiao, C. Teng, 2012, Cancer science.

CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.

M. Hung, Jing-Gung Chung, Chi-Hung Huang, 2011, European journal of pharmacology.

Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study

Jai-Sing Yang, F. Tsai, S. Kuo, 2017, International journal of oncology.

Structure-activity relationships of quassinoids for eukaryotic protein synthesis.

J. Pelletier, K. Lee, I. Harvey, 2005, Cancer letters.

Catalytic Hydrogenation of Dehydro Quassinoids and Cytotoxic Antitumor Activity of the Hydrogenation Products

K. Tagahara, K. Lee, N. Fukamiya, 1992 .

CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.

S. Kuo, C. Teng, S. Pan, 2007, Cancer letters.

Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives.

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.

N. Zhang, K. Lee, S. Morris-Natschke, 2017, Bioorganic & medicinal chemistry letters.

Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents.

K. Lee, S. Morris-Natschke, Dan Wu, 2014, Bioorganic & medicinal chemistry letters.

Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents.

K. Lee, S. Morris-Natschke, Wei Dai, 2012, Bioorganic & medicinal chemistry letters.

Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity.

K. Lee, S. Morris-Natschke, K. Bastow, 2008, Journal of medicinal chemistry.

Tannins as selective inhibitors of protein kinase C

W. Janzen, K. Lee, Y. Kashiwada, 1992 .

Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.

Li Huang, Chin-Ho Chen, K. Lee, 2019, European journal of medicinal chemistry.

Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells

K. Lee, S. Morris-Natschke, Chin-Chuan Hung, 2019, Scientific Reports.

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues.

K. Lee, S. Morris-Natschke, Chun-lin Long, 2014, Bioorganic & medicinal chemistry letters.

Dehydrocostuslactone Suppresses Angiogenesis In Vitro and In Vivo through Inhibition of Akt/GSK-3β and mTOR Signaling Pathways

C. Teng, S. Pan, Chieh-Yu Peng, 2012, PloS one.

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity.

K. Lee, M. Goto, Kyoko Nakagawa-Goto, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.

P. Zhan, Xinyong Liu, Chin-Ho Chen, 2020, European journal of medicinal chemistry.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Peng Zhan, Jian Zhang, F. J. Luque, 2019, Journal of medicinal chemistry.

Philinopsides A and B, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadrangularis

C. Liaw, Jian Ding, Y. Tong, 2006 .

Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.

Jai-Sing Yang, Hui-Yi Lin, S. Kuo, 2013, Bioorganic & medicinal chemistry letters.

Mechanistic Studies on Regioselective Dephosphorylation of Phosphate Prodrugs during a Facile Synthesis of Antitumor Phosphorylated 2-Phenyl-6,7-methylenedioxy-1H-quinolin-4-one

Chi-Hung Huang, S. Kuo, Li‐Jiau Huang, 2013, Molecules.

Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters.

A. Brossi, Yi Xia, K. Lee, 2003, Bioorganic & medicinal chemistry letters.

A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice

K. Lee, L. Shyur, Kyoko Nakagawa-Goto, 2016, Molecular Cancer Therapeutics.

3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents

Li Huang, K. Lee, Y. Kashiwada, 1994 .

Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.

Wei Li, K. Koike, Li Huang, 2018, European journal of medicinal chemistry.

Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

Wei Li, K. Koike, Chin-Ho Chen, 2013, Journal of natural products.

Picomolar Dichotomous Activity of Gnidimacrin Against HIV-1

Jie Yu, Li Huang, Chin-Ho Chen, 2011, PloS one.

Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents

K. Lee, Ying Wang, Shao-Ru Chen, 2017, Bioorganic & Medicinal Chemistry.

Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF).

K. Lee, H. Itokawa, M. Shibano, 2007, Journal of natural products.

Plant-derived anticancer agents and their analogs currently in clinical use or in clinical trials

K. Lee, Hui Kang Wang, 1997 .

Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β.

Wei Li, G. Ferrari, Cliburn Chan, 2015, Journal of medicinal chemistry.

Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer.

Leaf Huang, Nasha Qiu, K. Lee, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.

R. Kasai, K. Lee, S. Morris-Natschke, 2008, Journal of natural products.

The synthesis of 5-substituted camptothecins as potential inhibitors of DNA topoisomerase I

Suyun Lin, A. McPhail, K. Lee, 1995 .

Novel water-solutle (7-(acylhydrazono)-formyl camptothecins as potent inhibitors of DNA topoisomerase I

K. Lee, K. Hwang, Hui Kang Wang, 1994 .

Novel lignan derivatives as selective inhibitors of DNA topoisomerase II

K. Lee, Y. Kashiwada, K. Bastow, 1995 .

Antitumor Agents 126. Novel 4β-Substituted Anilino Derivatives of 3′,4′ -O, O-Didemethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II

K. Lee, Jang-Yang Chang, Ya‐Ching Shen, 1993, Pharmaceutical Research.

Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.

K. Lee, Zhiyan Xiao, Shiqing Han, 2004, Bioorganic & medicinal chemistry letters.

Antitumor agents. 1771. Design, syntheses, and biological evaluation of novel etoposide analogs bearing pyrrolecarboxamidino group as DNA topoisomerase II inhibitors

K. Lee, S. Cho, K. Bastow, 1997 .

Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2019, Natural product research.

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives.

Lanlan Li, K. Lee, S. Morris-Natschke, 2016, European journal of medicinal chemistry.

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties.

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2017, Bioorganic & medicinal chemistry letters.

Antineoplastic Agents and Their Analogues from Chinese Traditional Medicine

K. Lee, 1993 .

Synthesis and evaluation of novel podophyllotoxin analogs.

Shipeng Zhang, K. Lee, H. Hua, 2012, Bioorganic & medicinal chemistry letters.

Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.

Keduo Qian, K. Lee, Y. Leu, 2011, Bioorganic & medicinal chemistry.

A concise regiospecific synthesis of 8,8-dimethyl-2H, 8H-pyrano[6, 5-h]quinolin-2-oneand related compounds

A. Brossi, Yi Xia, K. Lee, 1999 .

An intermolecular Michael addition of benzene

C. Tzeng, K. Lee, Tai‐Chi Wang, 1996 .

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.

Pan‐Chyr Yang, S. Kuo, Jen-Yi Lee, 2015, Bioorganic & medicinal chemistry.

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens.

K. Lee, S. Morris-Natschke, M. Goto, 2012, Bioorganic & medicinal chemistry.

Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method.

Alexander Golbraikh, Alexander Tropsha, Zhiyan Xiao, 2002, Journal of medicinal chemistry.

Chemopreventive potential of cyclic diarylheptanoids.

Harukuni Tokuda, Junko Ishida, H. Nishino, 2002, Bioorganic & medicinal chemistry.

Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents.

K. Lee, Q. Shi, C. Shih, 2006, Bioorganic & medicinal chemistry.

Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents

H. Tokuda, K. Lee, J. Tatsuzaki, 2010, Journal of Asian natural products research.

Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.

Bingjie Qin, Lan Xie, Li Huang, 2012, Journal of medicinal chemistry.

In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents.

K. Lee, S. Morris-Natschke, E. Hamel, 2017, Journal of medicinal chemistry.

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo.

Hui-Yi Lin, S. Kuo, Chang-Hai Tsai, 2017, European journal of medicinal chemistry.

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.

Qiong Gu, Jun Xu, Chin-Ho Chen, 2016, Journal of natural products.

Structure and stereochemistry of maytenfolic acid and maytenfoliol, two new antileukemic triterpenes from maytenus diversifolia: X-ray crystal structures

H. Nozaki, A. McPhail, K. Lee, 1982 .

Recent Advances in the Discovery and Development of Plant-derived Chemotherapeutic Agents

K. Lee, 2005 .

In Silico De Novo Curcuminoid Derivatives From the Compound Library of Natural Products Research Laboratories Inhibit COVID-19 3CLpro Activity

Jai-Sing Yang, F. Tsai, S. Tsai, 2020 .

Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine

K. Lee, W. Lam, E. Gullen, 2012, PloS one.

Molecular Hybridization Used to Design and Synthesize Neo-tanshinlactone Derivatives as PD-1/PD-L1 Inhibitors

K. Lee, S. Morris-Natschke, Yue Wang, 2021, Bioorganic & Medicinal Chemistry.

[A new aristolochic acid derivative from Asarum himalaicum].

K. Lee, S. Cai, M. Shang, 2011, Yao xue xue bao = Acta pharmaceutica Sinica.

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

H. Yamashita, Shota Suzuki, K. Lee, 2017, Journal of Natural Medicines.

Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke.

Kui Yu, K. Lee, Junhua Zhang, 2020, European journal of medicinal chemistry.

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

Yu Cao, Q. Xia, Yanrong Lu, 2016, Scientific Reports.

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring.

A. Oda, K. Lee, E. Hamel, 2015, Journal of medicinal chemistry.

New Dammarane-Type Saponins from Gynostemma pentaphyllum

K. Lee, Yu-Chi Lin, S. Morris-Natschke, 2019, Molecules.

Napalolides A-D, four new sesquiterpene lactones from Carpesium nepalense

Y. Kuo, Yun-Lian Lin, K. Lee, 1996 .

Cytotoxic activity of some natural and synthetic guaianolides.

K. Lee, S. Rosselli, A. Maggio, 2005, Journal of natural products.

Cytotoxic activity of some natural and synthetic ent-kauranes.

K. Lee, S. Rosselli, A. Maggio, 2007, Journal of natural products.

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus.

K. Lee, Dao-feng Chen, K. Bastow, 2007, Journal of natural products.

Current perspectives on Chinese medicines and dietary supplements in China, Japan and the United States

K. Lee, Hui Kang Wang, Hideji Itokawa, 2020 .

Triterpenes and a triterpene glucoside from Dysoxylum cumingianum.

K. Lee, Y. Kashiwada, Y. Takaishi, 2011, Phytochemistry.

Anti-tumor agents. 136. Cumingianosides A-F, potent antileukemic new triterpene glucosides, and cumindysosides A and B, trisnor- and tetranortriterpene glucosides with a 14,18-cycloapoeuphane-type skeleton from Dysoxylum cumingianum

K. Lee, T. Fujioka, Y. Kashiwada, 1992 .

3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease.

Qiong Gu, Jun Xu, K. Lee, 2015, Journal of natural products.

Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells.

Hui-Yi Lin, S. Kuo, Li‐Jiau Huang, 2018, Bioorganic & medicinal chemistry.

Paliasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14-oxabicyclo[3.2.1]octane Unit from Melochia umbellata var. deglabrata.

S. Fukuyoshi, Chin-Ho Chen, K. Lee, 2020, Journal of natural products.

Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

Keduo Qian, K. Lee, N. Kilgore, 2007, Bioorganic & medicinal chemistry letters.

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Bioorganic & medicinal chemistry.

Oxidation Products of Phenolic Thiocolchicines: Ring a Quinones and Dienones

A. Brossi, K. Lee, J. Guan, 1998 .

Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues.

Yi Xia, K. Lee, N. Kilgore, 2004, Bioorganic & medicinal chemistry letters.

Structure and absolute stereochemistry of tomenphantopin-A and -B two cytotoxic sesquiterpene lactones from elephantopus tomentosus ☆

Toshimitsu Hayashi, A. McPhail, K. Lee, 1987 .

Molephantin, a novel cytotoxic germacranolide from Elephantopus mollis. X-Ray crystal structure

A. McPhail, M. Kozuka, K. Lee, 1973 .

Antitumor Agents VIII: Synthesis and Cytotoxic Activity of O,O′-Bis(acrylyl)-α, ω-alkanediols

C. Piantadosi, E. Huang, K. Lee, 1974 .

Cytotoxicity of Sesquiterpene Lactones 1

C. Piantadosi, E. Huang, J. Pagano, 2006 .

Rational selection of training and test sets for the development of validated QSAR models

Alexander Golbraikh, Min Shen, Alexander Tropsha, 2003, J. Comput. Aided Mol. Des..

Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

Li Huang, Chin-Ho Chen, Keduo Qian, 2012, Journal of medicinal chemistry.

Scaffold Hopping-Driven Optimization of 4-(Quinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-ones as Novel Tubulin Inhibitors.

K. Lee, S. Morris-Natschke, L. Jiang, 2019, ACS Medicinal Chemistry Letters.

Structure and stereochemistry of radermasinin, a novel cytotoxic triterpene lactone from Radermachia sinica. X-Ray crystal structure of radermasinin monohydrate

Toshimitsu Hayashi, A. McPhail, K. Lee, 1986 .

Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.

Li Huang, Chin-Ho Chen, Z. Dang, 2009, Journal of medicinal chemistry.

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation

C. Aiken, C. Lundquist, B. Forshey, 2004, Journal of Virology.

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity.

K. Rahman, T. Han, L. Qin, 2017, Journal of ethnopharmacology.

Anti-HIV Potential of Beesioside I Derivatives as Maturation Inhibitors: Synthesis, 3D-QSAR, Molecular Docking and Molecular Dynamics Simulations

K. Lee, Xu-dong Xu, S. Morris-Natschke, 2023, International journal of molecular sciences.

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, RSC advances.

Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.

Chin-Ho Chen, K. Lee, Dao-feng Chen, 2019, Journal of natural products.

Flavonoids Isolated from Heat-Processed Epimedium koreanum and Their Anti-HIV-1 Activities

Chin-Ho Chen, K. Lee, Cheng Zhou, 2015 .

Four New Triterpenoids from the Bark of Euonymus alatus forma ciliato-dentatus.

H. Yamashita, K. Lee, T. Shibata, 2019, Phytochemistry letters.

New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III

Yun-fang Zhao, K. Lee, S. Morris-Natschke, 2018, Natural product research.

A New Triterpene Lactone, Maytenfolone, and a New Sesquiterpene Pyridine Alkaloid, Emarginatine H, from the Leaves of Maytenus diversifolia.

Y. Kuo, K. Lee, J. Ou, 1996 .

Maytensifolin-C, a friedelane alcohol fromMaytenus diversifolia

H. Nozaki, R. Kasai, K. Lee, 1991 .

Goniodilactone and gonioheptenolactone,two novel cytotoxic styryllactones from the leaves of Goniothalamus cheliensis

K. Lee, Donglei Yu, Q. Zheng, 2012 .

Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK.

Yi Xia, K. Lee, N. Kilgore, 2007, Bioorganic & medicinal chemistry letters.

Cancer Preventive Agents. 7. Antitumor-Promoting Effects of Seven Active Flavonolignans from Milk Thistle (Silybum marianum.) on Epstein-Barr Virus Activation

Harukuni Tokuda, H. Tokuda, K. Lee, 2007 .

Cucurbitane-Type Triterpenoids from the Vines of Momordica charantia and Their Anti-inflammatory Activities.

K. Lee, Yu-Chi Lin, S. Morris-Natschke, 2020, Journal of Natural Products.

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum.

Chin‐Chung Wu, Y. Wu, F. Chang, 2008, Phytochemistry.

Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation

Wei Li, K. Koike, Minami Tsuji, 2021, Journal of natural medicines.

Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana.

C. Liaw, Y. Wu, F. Chang, 2004, Journal of natural products.

Anti-HIV tigliane diterpenoids from Reutealis trisperma.

Chin-Ho Chen, K. Lee, S. Morris-Natschke, 2020, Phytochemistry.

Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.

Wei Li, K. Koike, Minami Tsuji, 2020, Journal of natural products.

Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme.

Chin-Ho Chen, K. Lee, Dao-feng Chen, 2015, Journal of natural products.

Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.

A. Brossi, K. Lee, P. Wongsinkongman, 2002, Bioorganic & medicinal chemistry.

Taxus, the genus Taxus.

K. Lee, H. Itokawa, 2003 .

Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.

Yi Xia, K. Lee, S. Morris-Natschke, 2003, Bioorganic & medicinal chemistry.

Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action.

K. Lee, Jing Zhou, S. Morris-Natschke, 2020, Journal of Natural Products.

Asymmetric synthesis of 3′,4′-Di-O-(-)-camphanoyl-(+)-Cis-khellactone (DCK), a potent anti-HIV agent

K. Lee, M. Crimmins, Lan Xie, 1995 .

Anti-aids agents 33.1 Synthesis and anti-HIV activity of mono-methyl substituted 3′,4′-di-O-(−)-camphanoyl-(+)-cis-khellactone (DCK) analogues

K. Lee, L. Cosentino, Lan Xie, 1998 .

Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia

C. Teng, K. Lee, T. Nagao, 1997 .

Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives.

K. Lee, G. Allaway, C. Wild, 2004, Journal of medicinal chemistry.

Antitumor Agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents

Alexander Tropsha, Weifan Zheng, Shuxing Zhang, 2007, J. Comput. Aided Mol. Des..

Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice

Yu-Chih Yang, P. Hsiao, K. Lee, 2021, International Journal of Molecular Sciences.

Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis.

C. Liaw, F. Chang, K. Lee, 2003, Bioorganic & Medicinal Chemistry Letters.

Antitumor Agents. Part 218. Cappamensin A, a New in vitro Anticancer Principle, from Capparis sikkimensis

C. Liaw, F. Chang, K. Lee, 2003 .

Insect Antifeedant and Growth Inhibitory Activity of Forty-Six Quassinoids on Two Species of Agricultural Pests

K. D. Wing, K. Lee, H. Kiyokawa, 1987 .

Cytotoxic and Anti-HIV Phenanthroindolizidine Alkaloids from Cryptocarya chinensis†

K. Lee, Tian-Shung Wu, Chung-Ren Su, 2012, Natural Product Communications.

Glucuronidation of Anti-HIV Drug Candidate Bevirimat: Identification of Human UDP-glucuronosyltransferases and Species Differences

David E. Martin, K. Lee, P. Bullock, 2007, Drug Metabolism and Disposition.

Structure and stereochemistry of emarginatine-A, a novel cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata: X-ray crystal structure of emarginatine-a monohydrate

A. McPhail, K. Lee, I. Chen, 1989 .

Antimalarial artemisinin analogs : synthesis of 2,3-desethano-12-deoxoartemisinin-related compounds

K. Lee, J. Sakakibara, Y. Imakura, 1990 .

Synthesis of desethanoqinghaosu, a novel analogue of the antimalarial qinghaosu

A. McPhail, J. Koyama, K. Lee, 1988 .

Antitumor agents. 43. Conversion of bruceoside-A into bruceantin

K. Lee, M. Okano, 1981 .

Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2013, Bioorganic & medicinal chemistry.

Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.

W. Janzen, M. Hour, Xiao‐Feng Wang, 2012, Bioorganic & medicinal chemistry letters.

The Antitumor Agent PBT-1 Directly Targets HSP90 and hnRNP A2/B1 and Inhibits Lung Adenocarcinoma Growth and Metastasis

Jau-Chen Lin, Chi-Yuan Chen, Pan‐Chyr Yang, 2014, Journal of medicinal chemistry.

Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

Lu Lu, Bingjie Qin, Lan Xie, 2014, Bioorganic & medicinal chemistry letters.

Optimization of the Antiviral Potency and Lipophilicity of Halogenated 2,6‐Diarylpyridinamines as a Novel Class of HIV‐1 NNRTIS

Bingjie Qin, Lan Xie, Shibo Jiang, 2014, ChemMedChem.

Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Xiao‐Feng Wang, 2010, Journal of medicinal chemistry.

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.

Fangfang Zhang, Peng Zhan, Ye Tian, 2018, European journal of medicinal chemistry.

Cell differentiation enhancement by hydrophilic derivatives of 4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-diones in HL-60 leukemia cells.

S. Kuo, Li‐Jiau Huang, K. Lee, 2007, Bioorganic & medicinal chemistry letters.

Effects of CpG methylation to double stranded DNA breaks by Cu(II)-podophyllotoxin derivative complexes

K. Lee, R. Tawa, M. Takami, 1997 .

Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers

Hao Zhu, Qian Shi, Liying Zhang, 2014, Journal of Computer-Aided Molecular Design.

Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors.

K. Lee, Xiaoguang Chen, Zhiyan Xiao, 2021, European journal of medicinal chemistry.

Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents.

Yizhou Dong, K. Lee, S. Morris-Natschke, 2011, Natural product reports.

Antitumor Agents. Part 212. Bucidarasins A—C, Three New Cytotoxic Clerodane Diterpenes from Bucida buceras.

H. Nozaki, G. Cragg, K. Lee, 2002 .

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

S. Fukuyoshi, D. Newman, K. Lee, 2018, The Journal of organic chemistry.

Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.

Masahiko Taniguchi, Gordon M Cragg, G. Cragg, 2006, Journal of natural products.

Structural Elucidation and Chemical Conversion of Amorphispironone, a Novel Spironone form Amorpha fruticosa, to Rotenoids

T. Konoshima, M. Kozuka, K. Lee, 1993 .

Structure and stereochemistry of amorphispironone, a novel cytotoxic spironone type rotenoid from Amorpha fruticosa

J. Estes, A. McPhail, T. Konoshima, 1991 .

Synthesis of unsymmetrical biphenyls as potent cytotoxic agents.

K. Lee, S. Morris-Natschke, Lan Xie, 2008, Bioorganic & medicinal chemistry letters.

Antitumor Agents. Part 236. Synthesis of Water-Soluble Colchicine Derivatives

A. Brossi, Chin‐Chung Wu, K. Lee, 2005 .

SYNTHESIS AND ANTI-HIV ACTIVITY OF DIBENZYLBUTYROLACTONE LIGNANS

K. Lee, Shwu-Jiuan Lin, L. Yang, 1996 .

LC/TIS-MS fingerprint profiling of Cimicifuga species and analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa commercial products.

K. Lee, C. Shih, Hui-Kang Wang, 2005, Journal of agricultural and food chemistry.

One-step templated synthesis of chiral organometallic salicyloxazoline complexes

K. Lee, S. Morris-Natschke, Mei Luo, 2019, BMC Chemistry.

Cytotoxic Alangium alkaloids from Alangium longiflorum.

G. Cragg, K. Lee, N. Sakurai, 2006, Phytochemistry.

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

D. Newman, K. Lee, B. O’Keefe, 2018, Journal of natural products.

Antifeedant and Insecticidal Activity of Quassinoids against the Diamondback Moth (Plutella xylostella) and Structure—Activity Relationships

K. Tagahara, K. Lee, H. Yamazaki, 1995 .

Two New Quassinoids, Ailantinols C and D, from Ailanthus Altissima

K. Tagahara, K. Lee, N. Fukamiya, 1996 .

Two New Quassinoids, Ailantinols C and D, from Ailanthus altissima.

K. Tagahara, K. Lee, N. Fukamiya, 1997 .

Antitumor agents. 33. Isolation and structural elucidation of bruceoside -A and -B, novel antileukemic quassinoid glycosides, and brucein -D and -E from Brucea javanica

K. Lee, I. Hall, Y. Imakura, 1979 .

Cytotoxic aporphinoid alkaloids from thalictrum sessile

K. Lee, Y. Wu, S. Lu, 1988 .

Research and future trends in the pharmaceutical development of medicinal herbs from Chinese medicine

K. Lee, K. Lee, 2000, Public Health Nutrition.

Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.

K. Lee, M. Kozuka, K. Lee, 1998, Journal of natural products.

Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.

A. Tropsha, A. Brossi, S. Kuo, 2000, Journal of medicinal chemistry.

New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris.

C. Teng, K. Lee, K. Lee, 2001, Bioorganic & medicinal chemistry.

First Total Synthesis of Desmosdumotin C

K. Lee, J. Wu, Kyoko Nakagawa-Goto, 2005 .

Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.

M. Itoigawa, K. Lee, K. Lee, 2000, Journal of natural products.

Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents.

Yi Xia, K. Lee, K. Lee, 1998, Advances in experimental medicine and biology.

Structure and stereochemistry of eupaformonin, a novel cytotoxic sesquiterpene lactone from eupatorium formosanum hay.

A. McPhail, K. Lee, T. Ibuka, 1974 .

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds.

S. Kuo, C. Teng, K. Lee, 1998, Bioorganic & medicinal chemistry.

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.

S. Kuo, Li‐Jiau Huang, C. Teng, 1997, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 6 , 7 , 2 ′ , 3 ′ , 4 ′-Substituted-1 , 2 , 3 , 4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents

S. Kuo, Yi Xia, K. Lee, 1998 .

Tannins as potent inhibitors of DNA topoisomerase II in vitro.

K. Lee, K. Lee, Y. Kashiwada, 1993, Journal of pharmaceutical sciences.

Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents.

K. Lee, K. Lee, Y. Kashiwada, 1992, Journal of natural products.

A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra.

Y. Wu, F. Chang, T. Hwang, 2004, Journal of natural products.

Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.

M. Cosentino, K. Lee, K. Lee, 2001, Journal of natural products.

Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents.

K. Lee, K. Lee, D. Li, 2000, Journal of natural products.

Anti-AIDS agents, 18. Sodium and potassium salts of caffeic acid tetramers from Arnebia euchroma as anti-HIV agents.

K. Lee, K. Lee, T. Tanaka, 1995, Journal of natural products.

Cucurbitacin F derivatives, anti-HIV principles from cowania mexicana

T. Konoshima, M. Kozuka, K. Lee, 1994 .

Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.

W. Janzen, R. Kilkuskie, K. Lee, 1994, Journal of natural products.

Anti-AIDS agents, 9. Suberosol, a new C31 lanostane-type triterpene and anti-HIV principle from Polyalthia suberosa.

K. Lee, K. Lee, Y. Kashiwada, 1993, Journal of natural products.

Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba.

K. Lee, K. Lee, L. Cosentino, 1999, Journal of natural products.

Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

Y. Cheng, R. Kilkuskie, K. Lee, 1994, Journal of natural products.

Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.

R. Kilkuskie, K. Lee, K. Lee, 1992, Journal of natural products.

Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

Yi Xia, K. Lee, K. Bastow, 2000 .

Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.

Yi Xia, K. Lee, K. Lee, 2000, Bioorganic & medicinal chemistry letters.

Lewis Acid Catalyzed Reaction of Cinnamanilides: Competition of Intramolecular and Intermolecular Friedel-Crafts Reaction

C. Tzeng, K. Lee, Tai‐Chi Wang, 1997 .

Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives.

K. Lee, Ying-Qian Liu, Liu Yang, 2012, Bioorganic & medicinal chemistry letters.

Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant

K. Lee, M. Goto, K. Wada, 2021, Journal of Natural Medicines.

Six new norditerpenoid alkaloids from Delphinium elatum

H. Yamashita, K. Lee, M. Goto, 2015 .

Sesquiterpene antitumor agents: inhibitors of cellular metabolism.

T. G. Waddell, K. Lee, K. Lee, 1977, Science.

Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.

K. Lee, K. Lee, L. Cosentino, 1999, Journal of medicinal chemistry.

Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs.

A. McPhail, K. Lee, Li Huang, 1994, Journal of medicinal chemistry.

First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents

Chin‐Chung Wu, Y. Wu, F. Chang, 2007 .

Two New Sesquiterpenoids and anti‐HIV Principles from the Root Bark of Zanthoxylum Ailanthoides.

K. Lee, I. Chen, M. Cheng, 2006 .

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2016, Bioorganic & medicinal chemistry.

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.

S. Kuo, M. Hour, Yi Xia, 2001, Bioorganic & medicinal chemistry letters.

Recent progress in the development of tubulin inhibitors as antimitotic antitumor agents.

K. Lee, K. Lee, S. Morris-Natschke, 1970, Current pharmaceutical design.

Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.

K. Lee, K. Lee, L. Cosentino, 1998, Bioorganic & medicinal chemistry letters.

Bioactive components from the heartwood of Pterocarpus santalinus.

Chin‐Chung Wu, Y. Wu, F. Chang, 2011, Bioorganic & medicinal chemistry letters.

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

Yu Cao, Q. Xia, K. Lee, 2017, Free radical biology & medicine.

miRNA-mediated Mitochondrial Dysfunction is Involved in the Anti-triple-negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones.

K. Lee, L. Shyur, Kyoko Nakagawa-Goto, 2022, Antioxidants & redox signaling.

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Li Huang, 2010, Journal of medicinal chemistry.

Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors.

Li Huang, Chin-Ho Chen, Keduo Qian, 2012, Bioorganic & Medicinal Chemistry Letters.

Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Hong Lu, Shibo Jiang, Xiao‐Feng Wang, 2010, Journal of medicinal chemistry.

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

K. Lee, S. Morris-Natschke, Zhiyan Xiao, 2016, Medicinal research reviews.

Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways.

Hsuan-Yu Chen, Sung-Liang Yu, Pan‐Chyr Yang, 2009, Journal of medicinal chemistry.

Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives.

K. Lee, S. Morris-Natschke, Donglei Yu, 2007, Bioorganic & medicinal chemistry.

Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers.

Guan-Jhong Huang, T. Hwang, K. Lee, 2012, Phytochemistry.

FOUR NEW GERMACRANOLIDES FROM EUPATORIUM LINDLEYANUM DC.

K. Lee, M. Haruna, Kazuo Itô, 1979 .

Apigenin-7-O-β-D-glucopyranoside, an anti-HIV principle from Kummerowia striata☆

M. Cosentino, K. Lee, Ke Chen, 1994 .

Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis.

Y. Wu, F. Chang, K. Lee, 2008, Bioorganic & medicinal chemistry letters.

2-(1-Hydroxethyl)-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione (BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells.

S. Kuo, Li‐Jiau Huang, K. Lee, 2009, Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis.

(BTP-11) enhances the ATRA-induced differentiation in human leukemia HL-60 cells

S. Kuo, Li‐Jiau Huang, K. Lee, 2009 .

Cytotoxic activity of some natural and synthetic sesquiterpene lactones.

Chin‐Chung Wu, K. Lee, S. Rosselli, 2005, Planta medica.

Cytotoxicity of sesquiterpene lactones.

C. Piantadosi, E. Huang, K. Lee, 1971, Cancer research.

Characterization of a novel inhibitor of human DNA polymerases: 3,4,5-tri-O-galloylquinic acid.

Y. Cheng, K. Lee, M. Fisher, 1989, Biochemical pharmacology.

Inhibition of Sardine Flesh Lipoxygenase by a New Antioxidant from Aspergillus terreus

K. Lee, Tadayoshi Ito, Y. Ishikawa, 1996 .

The Isolation and Structural Elucidation of Three New Neolignans, Puberulins A, B, and C, as Platelet Activating Factor Receptor Antagonists from Piper puberulum

A. McPhail, K. Lee, Ke Chen, 1995 .

Structures and stereochemistry of melicophyllone A and hypocholesterolemic melicophyllone B, novel sesquiterpene lactones from Melicope triphylla

A. McPhail, K. Lee, Tian-Shung Wu, 1988 .

Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.

K. Lee, K. Lee, Y. Kashiwada, 2000, Journal of natural products.

New Dammarane-Type Saponins from Gynostemma pentaphyllum

K. Lee, Yu-Chi Lin, S. Morris-Natschke, 2019, Molecules.

Identification and synthesis of quinolizidines with anti-influenza a virus activity.

Li Huang, Katherine Jung, Chin-Ho Chen, 2014, ACS medicinal chemistry letters.