I. V. van Vlijmen-Willems

发表

The identification of CCL18 as biomarker of disease activity in localized scleroderma.

E. Hoppenreijs, W. Marut, E. D. De Jong, 2019, Journal of autoimmunity.

A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis.

L. Joosten, M. Netea, J. Schalkwijk, 2010, The Journal of investigative dermatology.

Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families.

Tomasz Stokowy, Torunn Fiskerstrand, Fan Yang, 2017, American journal of human genetics.

Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

M. Peppelman, P. Jansen, H. Venselaar, 2018, Genetics in Medicine.

A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification.

J. Schalkwijk, P. Zeeuwen, I. V. van Vlijmen-Willems, 2002, Human molecular genetics.

Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions

J. Schalkwijk, D. Rodijk‐Olthuis, P. Zeeuwen, 2012, Experimental dermatology.

Expression profile of cornified envelope structural proteins and keratinocyte differentiation‐regulating proteins during skin barrier repair

A. Ishida-Yamamoto, J. Schalkwijk, M. Simon, 2012, The British journal of dermatology.

Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.

A. Ishida-Yamamoto, P. Jansen, M. Narita, 2011, The American journal of pathology.

Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis

P. van Erp, T. Feuth, J. Schalkwijk, 2010, The British journal of dermatology.

Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin.

M. Kleerebezem, S. Kežić, S. V. van Hijum, 2017, The Journal of allergy and clinical immunology.

Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia.

R. Pfundt, F. Ruissen, J. Fransen, 1996, The Journal of clinical investigation.

Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase.

F. Ruissen, J. Meis, J. Janssen, 2001, The Journal of investigative dermatology.

Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice.

H. O. D. op den Camp, J. Schalkwijk, K. Hitomi, 2004, Human molecular genetics.

Demonstration of skin‐derived antileukoproteinase (skalp) and its target enzyme human leukocyte elastase in squamous cell carcinoma

P. V. D. van de Kerkhof, J. Schalkwijk, I. V. van Vlijmen-Willems, 1994, The Journal of pathology.

In situ demonstration of phosphorylated c‐jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin

R. Pfundt, J. Schalkwijk, I. V. van Vlijmen-Willems, 2001, The Journal of pathology.

Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of human hair follicle and nail.

J. Schalkwijk, K. Hitomi, P. Zeeuwen, 2009, The Journal of investigative dermatology.

Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation.

A. Ishida-Yamamoto, H. Iizuka, J. Schalkwijk, 2007, The Journal of investigative dermatology.

Identification of Lesional CD4+ CD25+ Foxp3+ Regulatory T Cells in Psoriasis

P. V. D. van de Kerkhof, I. V. van Vlijmen-Willems, H. Bovenschen, 2006, Dermatology.

STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling.

M. Peppelman, J. Schalkwijk, H. Niehues, 2019, The Journal of allergy and clinical immunology.

Cystatin M / E expression in inflammatory and neoplastic skin disorders

H. Egami, J. Schalkwijk, P. Zeeuwen, 2002, The British journal of dermatology.

Development and application of monoclonal antibodies against SKALP/elafin and other trappin family members

J. Geysen, M. Vandermeeren, J. Schalkwijk, 2001, Archives of Dermatological Research.

Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology.

R. Mecham, J. Schalkwijk, P. Steijlen, 2004, The Journal of investigative dermatology.

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis

J. Schalkwijk, H. Niehues, D. Rodijk‐Olthuis, 2021, JID innovations : skin science from molecules to population health.

Epidermal expression of host response genes upon skin barrier disruption in normal skin and uninvolved skin of psoriasis and atopic dermatitis patients.

J. Schalkwijk, D. Rodijk‐Olthuis, P. Zeeuwen, 2011, The Journal of investigative dermatology.

Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes.

J. Meis, J. Schalkwijk, P. Zeeuwen, 1998, The Journal of investigative dermatology.

Proliferation is the main epidermal target in the treatment of psoriatic plaques with once daily application of tacalcitol ointment.

P. Van Erp, P. V. D. van de Kerkhof, I. V. van Vlijmen-Willems, 1999, Acta dermato-venereologica.

Oral retinoic acid metabolism blocking agent RambazoleTM for plaque psoriasis: an immunohistochemical study

A. Langewouters, P. V. D. van de Kerkhof, M. Seyger, 2007, The British journal of dermatology.

SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes.

M. Ponec, P. V. D. van de Kerkhof, J. Schalkwijk, 1994, Journal of cell science.

Pharmacological Effects of a Specific Leukotriene B4 Receptor Antagonist (VML 295) on Blood Leukocytes, Cutaneous Inflammation and Epidermal Proliferation

P. Van Erp, P. V. D. van de Kerkhof, I. V. van Vlijmen-Willems, 2000, Skin Pharmacology and Physiology.

Localized and systemic scleroderma show different histological responses to methotrexate therapy

F. V. D. van den Hoogen, P. V. D. van de Kerkhof, M. Seyger, 2001, The Journal of pathology.

Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins

G. Rikken, J. Smits, I. V. van Vlijmen-Willems, 2022, International journal of molecular sciences.

Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice

J. Schalkwijk, I. V. van Vlijmen-Willems, D. van Rens, 2008, Cell and Tissue Research.

Tenascin expression in human dermis is related to epidermal proliferation.

J. Schalkwijk, P. Steijlen, I. V. van Vlijmen-Willems, 1991, American Journal of Pathology.

Absent in Melanoma 2 is predominantly present in primary melanoma and primary squamous cell carcinoma, but largely absent in metastases of both tumors.

J. Schalkwijk, P. Zeeuwen, I. V. van Vlijmen-Willems, 2014, Journal of the American Academy of Dermatology.

Differential expression of SKALP/Elafin in human epidermal tumors.

J. Schalkwijk, I. V. van Vlijmen-Willems, H. Molhuizen, 1993, The American journal of pathology.

Wound Healing in Tenascin-X Deficient Mice Suggests that Tenascin-X is Involved in Matrix Maturation Rather than Matrix Deposition

J. Schalkwijk, I. V. van Vlijmen-Willems, D. Egging, 2007, Connective tissue research.

Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.

P. Jansen, J. Schalkwijk, D. Rodijk‐Olthuis, 2009, The Journal of investigative dermatology.

Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders.

G. Perdew, I. Murray, G. Rikken, 2022, Biochemical pharmacology.

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.

J. Schalkwijk, I. Joosten, P. Zeeuwen, 2013, The Journal of clinical investigation.

Normal human skin demonstrates marked site-variation of tenascin expression, not correlated to epidermal proliferation (Ki-67 binding).

P. V. D. van de Kerkhof, J. Schalkwijk, I. V. van Vlijmen-Willems, 1993, Journal of dermatological science.

CYSRT1: an antimicrobial epidermal protein that can interact with late cornified envelope (LCE) proteins.

F. Kersten, J. Schalkwijk, H. Niehues, 2023, The Journal of investigative dermatology.

β-Defensin-2 Protein Is a Serum Biomarker for Disease Activity in Psoriasis and Reaches Biologically Relevant Concentrations in Lesional Skin

Andrea W. M. Evers, Edward J. Hollox, Martin den Heijer, 2009, PloS one.

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models

J. Schalkwijk, H. Niehues, G. Rikken, 2017, Scientific Reports.

Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site That Is Distinct from the Legumain-binding Site

T. Reinheckel, J. Schalkwijk, K. Hitomi, 2006, Journal of Biological Chemistry.

TARgeting the cutaneous microbiota in atopic dermatitis by coal tar via AHR-dependent induction of antimicrobial peptides.

S. V. van Hijum, J. Schalkwijk, J. Boekhorst, 2019, The Journal of investigative dermatology.

The epidermal phenotype during initiation of the psoriatic lesion in the symptomless margin of relapsing psoriasis.

P. V. D. van de Kerkhof, I. V. van Vlijmen-Willems, F A Castelijns, 1999, Journal of the American Academy of Dermatology.

Cathepsin B as a potential cystatin M/E target in the mouse hair follicle

T. Reinheckel, F. Kersten, S. Verbeek, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression of endoglin in the transition between psoriatic uninvolved and involved skin.

P. V. D. van de Kerkhof, J. van Pelt, E. D. De Jong, 1998, Acta dermato-venereologica.

Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function.

J. Schalkwijk, J. Brandner, H. Niehues, 2017, The Journal of allergy and clinical immunology.

Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease.

P. Jansen, J. Schalkwijk, F. Rutjes, 2013, ACS chemical biology.

Vesicular hand eczema transcriptome analysis provides insights into its pathophysiology

H. Niehues, P. Zeeuwen, I. V. van Vlijmen-Willems, 2021, Experimental dermatology.

Investigations into the filaggrin null phenotype: showcasing the methodology for CRISPR/Cas9 editing of human keratinocytes.

J. Schalkwijk, H. Niehues, J. Smits, 2023, The Journal of investigative dermatology.

The Response of Uninvolved Skin of Patients with Psoriasis to Single and Repeated Applications of Dithranol Cream: An Immunohistochemical Assessment

P. C. van de Kerkhof, I. V. van Vlijmen-Willems, M. Prins, 2002, Skin Pharmacology and Physiology.

The immunohistochemical effect of a hydrocolloid occlusive dressing (DuoDERM E) in psoriasis vulgaris.

P. V. D. van de Kerkhof, I. V. van Vlijmen-Willems, J. Boezeman, 1993, Dermatology.

Advanced methodology for bacterial colonization of 3D organotypic epidermal models: a gateway to long-term host-microbe interaction and intervention studies

J. Schalkwijk, B. Homey, H. Niehues, 2023, bioRxiv.

Rho kinase inhibitor Y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development, and facilitates lentiviral transduction.

P. Jansen, J. Schalkwijk, I. Joosten, 2012, Tissue engineering. Part A.

Weekly treatment of psoriasis with a hydrocolloid dressing in combination with triamcinolone acetonide. A controlled comparative study.

P. C. van de Kerkhof, I. V. van Vlijmen-Willems, J. Boezeman, 1994, Acta dermato-venereologica.

The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis.

K. Stephens, J. Schalkwijk, P. Zeeuwen, 2003, The Journal of investigative dermatology.

The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

S. V. van Heeringen, Huiqing Zhou, J. Schalkwijk, 2023, bioRxiv.

Epidermal Cell Kinetics by Combining In Situ Hybridization and Immunohistochemistry

Janine Ezendam, P. V. D. van de Kerkhof, P. Zeeuwen, 1998, The Histochemical Journal.

The effect of tacalcitol (1,24(OH)2D3) on cutaneous inflammation, epidermal proliferation and keratinization in psoriasis: a placebo-controlled, double-blind study.

P. V. D. van de Kerkhof, I. V. van Vlijmen-Willems, J. Boezeman, 1994, The British journal of dermatology.

An Immunohistochemical Assessment of the Response of the Psoriatic Lesion to Single and Repeated Applications of High-Dose Dithranol Cream

P. C. van de Kerkhof, I. V. van Vlijmen-Willems, M. Prins, 2002, Skin Pharmacology and Physiology.

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models

J. Schalkwijk, H. Niehues, G. Rikken, 2017, Scientific Reports.

β-Defensin-2 Protein Is a Serum Biomarker for Disease Activity in Psoriasis and Reaches Biologically Relevant Concentrations in Lesional Skin

P. Jansen, M. den Heijer, E. D. De Jong, 2009, PloS one.

Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families.

J. Szustakowski, R. Bruccoleri, B. Linghu, 2017, American journal of human genetics.

Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models

J. Schalkwijk, H. Niehues, G. Rikken, 2023, Microbiome.

Gram-positive anaerobic cocci guard skin homeostasis by regulating host-defense mechanisms.

J. Schalkwijk, G. Rikken, P. Zeeuwen, 2023, iScience.

Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin.

M. Kleerebezem, S. Kežić, S. V. van Hijum, 2017, The Journal of allergy and clinical immunology.