C. O'Callaghan

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Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

S. Watson, S. Lombard, A. Pollitt, 2018, Platelets.

A genetics-led approach defines the drug target landscape of 30 immune-related traits

Hinrich W. H. Göhlmann, David R. Damerell, J. Knight, 2019, Nature Genetics.

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

F. Hobbs, J. Hirst, D. Lasserson, 2016, PloS one.

Classical and Nonclassical Class I Major Histocompatibility Complex Molecules Exhibit Subtle Conformational Differences That Affect Binding to CD8αα*

David I. Stuart, Bent K. Jakobsen, Christopher A. O'Callaghan, 2000, The Journal of Biological Chemistry.

Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.

P. Bjorkman, L. Lanier, A. Cerwenka, 2001, Immunity.

Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Christian Gieger, Jason Carey, Steven Wiltshire, 2016 .

Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.

C. O'Callaghan, A. A. Watson, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HIP

Benjamin Bishop, A. Radu Aricescu, Karl Harlos, 2009, Nature Structural &Molecular Biology.

Expression, purification and crystallization of the human UL16-binding protein ULBP1.

C. O'Callaghan, A. A. Watson, Charita M. Christou, 2011, Protein expression and purification.

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

J. Bell, G. Ogg, A. McMichael, 1998, Nature.

Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding

Kyle J. Gaulton, A. Morris, E. Soilleux, 2015, PLoS genetics.

Structure of the fungal β‐glucan‐binding immune receptor dectin‐1: Implications for function

S. Gordon, E. Jones, James Brown, 2007, Protein science : a publication of the Protein Society.

Renal cells activate the platelet receptor CLEC-2 through podoplanin.

S. Watson, D. Jackson, A. R. Mistry, 2008, The Biochemical journal.

HLA-Ebindstonatural killer cell receptors CD 94 / NKG 2 A , BandC

J. Bell, G. Ogg, A. McMichael, 2022 .

Chronic kidney disease: a large-scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting

D. Lasserson, C. O'Callaghan, B. Shine, 2011, BMJ Open.

Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.

G. Ogg, V. Cerundolo, M. Colonna, 1998, Journal of immunology.

Crystal structure of rhodocytin, a ligand for the platelet‐activating receptor CLEC‐2

C. O'Callaghan, A. A. Watson, J. Eble, 2008, Protein science : a publication of the Protein Society.

Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS).

C. O'Callaghan, J. Henry, H. Davies, 1994, Journal of neurology, neurosurgery, and psychiatry.

Long-term health outcomes of people with reduced kidney function in the UK: A modelling study using population health data

R. Perera, R. Stevens, F. Hobbs, 2020, PLoS medicine.

Requirement for cystatin C testing in chronic kidney disease: a retrospective population-based study.

D. Lasserson, C. O'Callaghan, B. Shine, 2017, The British journal of general practice : the journal of the Royal College of General Practitioners.

Characteristics and outcome of membranous nephropathy in older patients

H. Doll, C. O'Callaghan, J. Cameron, 2004, International Urology and Nephrology.

Prevention of nosocomial respiratory syncytial virus infection

C. O'Callaghan, P. Madge, J. Paton, 1993, The Lancet.

Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure.

A. McMichael, P. Bowness, C. O'Callaghan, 1999, Journal of immunology.

The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus

C. O'Callaghan, L. Davison, B. Catchpole, 2017, Journal of veterinary internal medicine.

Effective use of cyclosporin in sarcoidosis: a treatment strategy based on computed tomography scanning.

D. Hansell, A. Lalvani, C. O'Callaghan, 1994, The European respiratory journal.

Functional characterization of HLA‐F and binding of HLA‐F tetramers to ILT2 and ILT4 receptors

J. Bell, A. McMichael, D. Mason, 2000, European journal of immunology.

Molecular Analysis of the Interaction of the Snake Venom Rhodocytin with the Platelet Receptor CLEC-2

C. O'Callaghan, A. A. Watson, 2011, Toxins.

Renal manifestations of systemic autoimmune disease: diagnosis and therapy.

C. O'Callaghan, 2004, Best practice & research. Clinical rheumatology.

Kupffer cell staining by an HFE‐specific monoclonal antibody: implications for hereditary haemochromatosis

D. Mason, C. O'Callaghan, Margaret Jones, 1998, British journal of haematology.

University of Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults

R. Perera, J. Aronson, S. Fleming, 2019 .

A lucky fall? Case report.

I. Roberts, D. Cranston, C. O'Callaghan, 2010, Transplantation proceedings.

Structure of Nonclassical MHC I (HLA-E, HLA-F, HLA-G, and Orthologs)

C. O'Callaghan, 2016 .

Tetrameric complexes of HLA-E, HLA-F, and HLA-G.

A. McMichael, E. Lepin, C. O'Callaghan, 2002, Journal of immunological methods.

Direct visualisation of cytomegalovirus-specific CD8+ T cells in renal transplant recipients.

R. Hargreaves, C. O'Callaghan, R. Hilton, 2002, Transplantation proceedings.

Recombinant modified vaccinia virus Ankara efficiently restimulates human cytotoxic T lymphocytes in vitro.

G. Smith, W. Britton, C. O'Callaghan, 2000, Vaccine.

Intragenic transcriptional interference regulates the human immune ligand MICA

C. O'Callaghan, Da Lin, T. K. Hiron, 2018, The EMBO journal.

NF-κB Regulates MICA Gene Transcription in Endothelial Cell through a Genetically Inhibitable Control Site*

E. Soilleux, H. Lavender, C. O'Callaghan, 2011, The Journal of Biological Chemistry.

Renal Transplant Immunosuppression Impairs Natural Killer Cell Function In Vitro and In Vivo

C. O'Callaghan, R. Cornall, A. Chakera, 2010, PloS one.

Renal disease and use of topical non-steroidal: anti-inflammatory drugs

C. O'Callaghan, P. Andrews, C. Ogg, 1994, BMJ.

Prolonged QT syndrome presenting as epilepsy

C. O'Callaghan, D. Trump, 1993, The Lancet.

MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner

G. Moncayo, C. O'Callaghan, M. McCarthy, 2017, Front. Immunol..

Cutting Edge: The Minor Histocompatibility Antigen H60 Peptide Interacts with Both H-2Kb and NKG2D1

L. Lanier, A. Cerwenka, D. Roopenian, 2002, The Journal of Immunology.

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.

S. Watson, S. Kunapuli, A. Herr, 2015, The Biochemical journal.

CLEC-2 activates Syk through dimerization.

J. Hartwig, S. Watson, K. Fütterer, 2010, Blood.

University of Birmingham CLEC-2 activates Syk through dimerization

J. Hartwig, S. Watson, K. Fütterer, 2010 .

Production of soluble αβ T‐cell receptor heterodimers suitable for biophysical analysis of ligand binding

G. Gao, J. Bell, J. Boulter, 2008, Protein science : a publication of the Protein Society.

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)*

S. Watson, C. Hughes, C. O'Callaghan, 2012, The Journal of Biological Chemistry.

The platelet receptor CLEC-2 is active as a dimer.

R. Gilbert, G. Moncayo, A. R. Mistry, 2009, Biochemistry.

A New Look at T Cells

A. McMichael, C. O'Callaghan, 1998, The Journal of experimental medicine.

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.

P. Easterbrook, A. Oxenius, R. Phillips, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Defining the T cell antigen proteome of wasp venom

G. Ogg, D. Warrell, C. O'Callaghan, 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Differential Narrow Focusing of Immunodominant Human Immunodeficiency Virus Gag-Specific Cytotoxic T-Lymphocyte Responses in Infected African and Caucasoid Adults and Children

E. Rosenberg, M. Altfeld, B. Walker, 2000, Journal of Virology.

Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.

P. Easterbrook, R. Phillips, C. O'Callaghan, 1999, Clinical science.

Trends in kidney function testing in UK primary care since the introduction of the quality and outcomes framework: a retrospective cohort study using CPRD

R. Perera, J. Aronson, R. Stevens, 2019, BMJ Open.

BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation.

J. Bell, A. McMichael, B. Jakobsen, 1999, Analytical biochemistry.

Combined structural and immunological refinement of HIV‐1 HLA‐B8‐restricted cytotoxic T lymphocyte epitopes

R. Phillips, P. Goulder, A. McMichael, 1997, European journal of immunology.

Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

D. Stuart, P. Klenerman, J. Bell, 1996, The Journal of experimental medicine.

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.

P. Moss, C. O'Callaghan, Ayman Antoun, 2010, Human immunology.

Functionally Inert HIV-Specific Cytotoxic T Lymphocytes Do Not Play a Major Role in Chronically Infected Adults and Children

E. Rosenberg, M. Altfeld, B. Walker, 2000, The Journal of experimental medicine.

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

G. Ogg, A. McMichael, A. Rickinson, 1998, The Journal of experimental medicine.

Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific

S. Rowland-Jones, P. Goulder, G. Ogg, 1998, The Journal of experimental medicine.

Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in children.

D. Nixon, W. Borkowsky, G. Ogg, 1999, The Journal of infectious diseases.

Analysis of Ebola Virus Entry Into Macrophages

G. Herrler, W. Jahnen-Dechent, S. Becker, 2015, The Journal of infectious diseases.

Assembly and crystallization of the complex between the human T cell coreceptor CD8α homodimer and HLA‐A2

G. Gao, J. Bell, U. Gerth, 1998, Protein science : a publication of the Protein Society.

Molecular basis of human natural killer cell recognition of HLA-E (human leucocyte antigen-E) and its relevance to clearance of pathogen-infected and tumour cells.

C. O'Callaghan, 2000, Clinical science.

Natural killer cell surveillance of intracellular antigen processing pathways mediated by recognition of HLA-E and Qa-1b by CD94/NKG2 receptors.

C. O'Callaghan, 2000, Microbes and infection.

Structure and function of the human MHC class Ib molecules HLA‐E, HLA‐F and HLA‐G

J. Bell, C. O'Callaghan, 1998, Immunological reviews.

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.

D. Stuart, J. Bell, A. McMichael, 1998, Molecular cell.

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

L. Rasmussen, H. Wandall, C. Wheelock, 2020, Frontiers in Immunology.

Systematic Review and Metaanalysis Comparing the Bias and Accuracy of the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration Equations in Community-Based Populations.

R. Stevens, J. Hirst, D. Lasserson, 2018, Clinical chemistry.

Chronic kidney disease--assessing the impact.

C. O'Callaghan, 2009, QJM : monthly journal of the Association of Physicians.

Purine nucleotide metabolism regulates expression of the human immune ligand MICA

T. Soga, C. O'Callaghan, M. McCarthy, 2017, The Journal of Biological Chemistry.

A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.

S. Rowland-Jones, P. Hansasuta, A. McMichael, 1999, Journal of immunology.

Carriers Cells Specific for EBV in Healthy Virus T + A Re-Evaluation of the Frequency of CD 8

S. Rowland-Jones, A. McMichael, A. Rickinson, 1999 .

Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide

J. Bell, A. McMichael, B. Jakobsen, 1997, European journal of immunology.

Homodimer Structure-Microglobulin-Free Heavy Chain 2 β Cutting Edge : HLA-B 27 Can Form a Novel McMichael

A. McMichael, P. Bowness, C. O'Callaghan, 1999 .

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

L. Picker, A. McMichael, P. Borrow, 2018, Nature Communications.

Antigen‐specific T cell responses to BK polyomavirus antigens identify functional anti‐viral immunity and may help to guide immunosuppression following renal transplantation

C. O'Callaghan, R. Cornall, O Morteau, 2011, Clinical and experimental immunology.

Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression

T. Soga, C. O'Callaghan, M. McCarthy, 2019, European journal of immunology.

Thrombomodulation via CLEC-2 targeting.

C. O'Callaghan, 2009, Current opinion in pharmacology.

The Crystal Structure and Mutational Binding Analysis of the Extracellular Domain of the Platelet-activating Receptor CLEC-2*

Christopher A O'Callaghan, Karl Harlos, James Brown, 2007, Journal of Biological Chemistry.

Crystallization and X-ray diffraction analysis of human CLEC-2.

C. O'Callaghan, A. A. Watson, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Prevention of organ rejection in renal and liver transplantation with extended release tacrolimus

C. O'Callaghan, M. Reschen, 2014 .

Reversible renal impairment caused by thyroid disease

C. O'Callaghan, A. Chakera, Hans Paul, 2010, Scandinavian Journal of Urology and Nephrology.

Early prediction of treatment outcome in idiopathic membranous nephropathy.

C. O'Callaghan, J. Cameron, S. Sacks, 1995, QJM : monthly journal of the Association of Physicians.

Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis

A. Banerjee, R. Perera, J. Aronson, 2019, BMJ Open.

Impact of the COVID-19 pandemic on emergency department attendances and acute medical admissions

D. Lasserson, C. O'Callaghan, M. Giles, 2021, BMC Emergency Medicine.

Kidney transplantation--the long term view.

C. O'Callaghan, C. A. O'callaghan, 2008, QJM : monthly journal of the Association of Physicians.

Long-term monitoring in primary care for chronic kidney disease and chronic heart failure: a multi-method research programme

A. Banerjee, R. Perera, J. Aronson, 2021, Programme Grants for Applied Research.

Structural Flexibility of the Macrophage Dengue Virus Receptor CLEC5A

G. Screaton, G. Murshudov, A. Vagin, 2011, The Journal of Biological Chemistry.

Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study

F. Hobbs, J. Hirst, D. Lasserson, 2020, The British journal of general practice : the journal of the Royal College of General Practitioners.

The role of primary care in managing chronic kidney disease

C. O'Callaghan, Alison J Maycock, 2016 .

Floating–Harbor syndrome and polycystic kidneys associated with SRCAP mutation

J. Hurst, K. Boycott, U. Kini, 2012, American journal of medical genetics. Part A.

Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1

A. Chalisey, E. Soilleux, C. O'Callaghan, 2016, Atherosclerosis.

Hierarchical Modular DNA Assembly Using MetClo.

Da Lin, Christopher A O'Callaghan, C. O'Callaghan, 2020, Methods in molecular biology.

Process of care and activity in a clinically inclusive ambulatory emergency care unit: progressive effect over time on clinical outcomes and acute medical admissions

D. Lasserson, C. O'Callaghan, M. Giles, 2020, Future healthcare journal.

A retrospective analysis of outcomes in low- and intermediate–high-risk pulmonary embolism patients managed on an ambulatory medical unit in the UK

D. Lasserson, C. O'Callaghan, J. Raby, 2019, ERJ Open Research.

What is the relationship between renal function and visit-to-visit blood pressure variability in primary care? Retrospective cohort study from routinely collected healthcare data

J. Wetzels, D. Lasserson, C. O'Callaghan, 2016, BMJ Open.

Impact on cardiovascular risk follow-up from a shift to the CKD-EPI formula for eGFR reporting: a cross-sectional population-based primary care study

J. Wetzels, D. Lasserson, C. O'Callaghan, 2013, BMJ Open.

Prevalence and factors associated with multimorbidity among primary care patients with decreased renal function

F. Hobbs, J. Hirst, C. O'Callaghan, 2021, PloS one.

PeaKDEck: a kernel density estimator-based peak calling program for DNaseI-seq data

Michael T. McCarthy, Christopher A. O'Callaghan, C. O'Callaghan, 2014, Bioinform..

OxMaR: Open Source Free Software for Online Minimization and Randomization for Clinical Trials

Christopher A. O’Callaghan, C. O'Callaghan, 2014, PloS one.

Production, crystallization, and preliminary X‐ray analysis of the human MHC class Ib molecule HLA‐E

D. Stuart, J. Bell, A. McMichael, 1998, Protein science : a publication of the Protein Society.

Reduced kidney function at presentation in unselected acute emergency medical admissions: incidence, outcome and associated factors.

A. Chalisey, D. Lasserson, C. O'Callaghan, 2019, Acute medicine.

Acute renal failure associated with NSAIDS

C. O'Callaghan, 1994, British medical journal.

Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Tanya M. Teslovich, Kyle J. Gaulton, Sara M. Willems, 2015, Nature Genetics.

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

L. Picker, A. McMichael, P. Borrow, 2018, Nature Communications.

The Oxford Renal (OxRen) cross-sectional study of chronic kidney disease in the UK

F. Hobbs, C. Pugh, D. Lasserson, 2013, BMJ Open.

NSAIDS in the postoperative period. Many factors threaten renal function.

C. O'Callaghan, C. Ogg, P. Andrews, 1993, BMJ.

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis

S. Watson, S. Lombard, A. Pollitt, 2018, Platelets.

Antigen‐specific T cell responses to BK polyomavirus antigens identify functional anti‐viral immunity and may help to guide immunosuppression following renal transplantation

C. O'Callaghan, R. Cornall, S. Lawrence, 2011, Clinical and experimental immunology.

MetClo: methylase-assisted hierarchical DNA assembly using a single type IIS restriction enzyme

Da Lin, C. O'Callaghan, Christopher A O’Callaghan, 2018, Nucleic acids research.

Renal cells activate the platelet receptor CLEC-2 through podoplanin.

S. Watson, D. Jackson, A. R. Mistry, 2008, The Biochemical journal.

Structural and energetic aspects of multispecific immune recognition by NKG2D.

C. O'Callaghan, E. Jones, 2003, Structure.

University of Birmingham Critical role for an acidic amino acid region in platelet signaling by the hemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2)

S. Watson, C. Hughes, C. O'Callaghan, 2013 .