Y. Alnouti

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Tissue distribution and ontogeny of sulfotransferase enzymes in mice.

C. Klaassen, Y. Alnouti, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950–Metabolites in Frozen Human Plasma[S]

Matej Oresic, Oliver Fiehn, Edward A. Dennis, 2017, Journal of Lipid Research.

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals

H. Gendelman, J. McMillan, N. Gautam, 2018, Nanomedicine.

Species differences in bile acids I. Plasma and urine bile acid composition

A. D. Rodrigues, N. Gautam, Y. Alnouti, 2018, Journal of applied toxicology : JAT.

Simultaneous determination of zidovudine and lamivudine from rat plasma, amniotic fluid and tissues by HPLC.

Y. Alnouti, M. Bartlett, C. White, 2004, Biomedical chromatography : BMC.

Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

H. Gendelman, J. McMillan, Samuel M. Cohen, 2021, Nature Communications.

Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.

C. Klaassen, Y. Alnouti, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Praziquantel analogs with activity against juvenile Schistosoma mansoni.

J. Keiser, J. Chollet, Y. Alnouti, 2010, Bioorganic & medicinal chemistry letters.

Quantification of the transporter substrate fexofenadine in cell lysates by LC-MS/MS

G. Reed, Y. Alnouti, C. Flynn, 2014 .

Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry.

G. Reed, Y. Alnouti, C. Flynn, 2011, Rapid communications in mass spectrometry : RCM.

Creation of a Long-Acting Nanoformulated 2′,3′-Dideoxy-3′-Thiacytidine

H. Gendelman, J. McMillan, T. Bronich, 2016, Journal of acquired immune deficiency syndromes.

Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS.

C. Klaassen, Y. Alnouti, I. Csanaky, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth

P. Singh, Asserewou Etekpo, N. Gautam, 2020, Current developments in nutrition.

Method for internal standard introduction for quantitative analysis using on-line solid-phase extraction LC-MS/MS.

Y. Alnouti, A. Gusev, C. Hop, 2006, Analytical chemistry.

Regulation of Sulfotransferase Enzymes by Prototypical Microsomal Enzyme Inducers in Mice

C. Klaassen, Y. Alnouti, 2008, Journal of Pharmacology and Experimental Therapeutics.

Simultaneous determination of zidovudine and lamivudine from rat tissues by liquid chromatography/tandem mass spectrometry.

Y. Alnouti, M. Bartlett, C. White, 2005, Rapid communications in mass spectrometry : RCM.

Determination of lamivudine in plasma, amniotic fluid, and rat tissues by liquid chromatography.

Y. Alnouti, M. Bartlett, C. White, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS.

M. Nunn, Y. Alnouti, D. R. Cerutis, 2011, Journal of pharmaceutical and biomedical analysis.

Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

Y. Alnouti, Hong Lu, Devendra Kumar, 2022, Lipids in health and disease.

Hepatocyte nuclear factor 4a and glucocorticoid receptor coordinately regulate lipid metabolism in mice fed a high-fat-high-sugar diet

Y. Alnouti, Hong Lu, Devendra Kumar, 2021, bioRxiv.

Targeting the NF-κB and mTOR Pathways with a Quinoxaline Urea Analog That Inhibits IKKβ for Pancreas Cancer Therapy

M. Hollingsworth, S. Lele, A. Natarajan, 2013, Clinical Cancer Research.

Simultaneous LC-MS/MS analysis of eicosanoids and related metabolites in human serum, sputum and BALF.

R. Casaburi, B. Make, G. Criner, 2018, Biomedical chromatography : BMC.

Pharmacokinetic and biodistribution studies of N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model.

Y. Alnouti, Dong Wang, Fang Yuan, 2010, Molecular pharmaceutics.

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

J. Chiang, Xinwen Wang, A. Patterson, 2022, Hepatology communications.

The profile of bile acids and their sulfate metabolites in human urine and serum.

Y. Alnouti, S. Mukherjee, M. Olivera, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids.

M. Haimerl, Y. Alnouti, A. Hofmann, 2014, Journal of hepatology.

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS.

A. Natarajan, N. Gautam, Y. Alnouti, 2013, Biomedical chromatography : BMC.

Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy

D. Oleynikov, Rohit Kohli, Y. Alnouti, 2018, Surgical Endoscopy.

Quantitative analysis of endogenous compounds.

N. Gautam, Y. Alnouti, Rhishikesh Thakare, 2016, Journal of pharmaceutical and biomedical analysis.

Head-to-head comparative pharmacokinetic and biodistribution (PK/BD) study of two dexamethasone Prodrug Nanomedicines on lupus-prone NZB/WF1 mice.

J. O'dell, T. Bronich, Sushil Kumar, 2020, Nanomedicine : nanotechnology, biology, and medicine.

A combination of Omega-3 PUFAs and COX inhibitors: A novel strategy to manage obesity-linked dyslipidemia and adipose tissue inflammation.

V. Saraswathi, C. Desouza, Y. Alnouti, 2019, Journal of diabetes and its complications.

Urinary bile acids as biomarkers for liver diseases I. Stability of the baseline profile in healthy subjects.

J. Meza, N. Gautam, Y. Alnouti, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques

H. Gendelman, J. McMillan, H. Fox, 2019, AIDS.

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice

Samuel M. Cohen, A. Kabanov, T. Bronich, 2012, International journal of nanomedicine.

Analyte recovery in LC-MS/MS bioanalysis: An old issue revisited.

N. Gautam, Y. Alnouti, Devendra Kumar, 2022, Analytica chimica acta.

Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS.

Y. Alnouti, Jiangeng Huang, I. Csanaky, 2011, Journal of pharmaceutical and biomedical analysis.

Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth

Ayrianne J. Crawford, G. Borgstahl, M. Hollingsworth, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Bile Acid sulfation: a pathway of bile acid elimination and detoxification.

Y. Alnouti, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC

D. Coulter, Rakesh K. Singh, Joseph A. Vetro, 2021, Non-coding RNA.

Direct and indirect quantification of phosphate metabolites of nucleoside analogs in biological samples.

Sushil Kumar, N. Gautam, Y. Alnouti, 2020, Journal of pharmaceutical and biomedical analysis.

Simultaneous quantification of intracellular lamivudine and abacavir triphosphate metabolites by LC–MS/MS

H. Gendelman, J. McMillan, N. Gautam, 2018, Journal of pharmaceutical and biomedical analysis.

A long acting nanoformulated lamivudine ProTide.

H. Gendelman, J. McMillan, N. Gautam, 2019, Biomaterials.

ProTide generated long-acting abacavir nanoformulations† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8cc04708a

H. Gendelman, J. McMillan, N. Gautam, 2018, Chemical communications.

The application of liquid chromatography and mass spectrometry for the determination of nucleoside analogues in biological matrices

Y. Alnouti, 2004 .

Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection

A. Epstein, H. Gendelman, R. High, 2013, Journal of Neuroimmune Pharmacology.

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators.

C. Hopkins, Sushil Kumar, N. Gautam, 2019, Bioorganic & medicinal chemistry letters.

Irreversible binding of an anticancer compound (BI-94) to plasma proteins

Sandeep Rana, A. Natarajan, N. Gautam, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma.

Olga Kavetskaia, Y. Alnouti, A. Gusev, 2005, Journal of chromatography. A.

Urinary BA Indices as Prognostic Biomarkers for Complications Associated with Liver Diseases

N. Gautam, Y. Alnouti, Devendra Kumar, 2022, International journal of hepatology.

Species differences in bile acids II. Bile acid metabolism

A. D. Rodrigues, N. Gautam, Y. Alnouti, 2018, Journal of applied toxicology : JAT.

Increase of the LC-MS/MS sensitivity and detection limits using on-line sample preparation with large volume plasma injection.

Y. Alnouti, A. Gusev, Rachael Leverence, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Intramuscular and subcutaneous administration of antiretroviral drugs, compared with oral, enhances delivery to lymphoid tissues in BALB/c mice.

C. Fletcher, Sushil Kumar, N. Gautam, 2021, The Journal of antimicrobial chemotherapy.

A Year-Long Extended Release Nanoformulated Cabotegravir Prodrug

J. Meza, H. Gendelman, J. McMillan, 2020, Nature Materials.

Creation of a long-acting rilpivirine prodrug nanoformulation.

H. Gendelman, J. McMillan, H. Fox, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

H. Gendelman, J. McMillan, N. Gautam, 2019, International journal of nanomedicine.

Synthesis of a long acting nanoformulated emtricitabine ProTide.

H. Gendelman, J. McMillan, N. Gautam, 2019, Biomaterials.

Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir

H. Gendelman, J. McMillan, N. Gautam, 2021, Nature Communications.

Preclinical Pharmacokinetics and Tissue Distribution of Long-Acting Nanoformulated Antiretroviral Therapy

H. Gendelman, J. McMillan, H. Fox, 2013, Antimicrobial Agents and Chemotherapy.

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

H. Gendelman, J. McMillan, H. Fox, 2017, Biomaterials.

Creation of a long-acting nanoformulated dolutegravir

H. Gendelman, J. McMillan, P. Dash, 2018, Nature Communications.

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

H. Gendelman, J. McMillan, H. Gelbard, 2017, The Journal of clinical investigation.

Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry.

A. Epstein, H. Gendelman, M. Boska, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

D. Brenner, D. Fouts, M. Downes, 2018, Hepatology.

Urinary bile acids as biomarkers for liver diseases II. Signature profiles in patients.

J. Meza, N. Gautam, Y. Alnouti, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

TISSUE DISTRIBUTION AND ONTOGENY OF ORGANIC CATION TRANSPORTERS IN MICE

J. Petrick, C. Klaassen, Y. Alnouti, 2006, Drug Metabolism and Disposition.

A Major Human Oral Lysophosphatidic Acid Species, LPA 18:1, Regulates Novel Genes in Human Gingival Fibroblasts.

M. Nunn, M. D. Weston, Y. Alnouti, 2015, Journal of periodontology.

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model.

S. Goldring, Y. Alnouti, K. Garvin, 2017, Molecular pharmaceutics.

Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders

A. Dunaevsky, R. Padmashri, N. Gautam, 2015, Brain, Behavior, and Immunity.

Nanoimaging for Molecular Pharmaceutics of Alzheimer ’ s and other Neurodegenerative Disorders

H. Mansour, Y. Alnouti, P. Reigan, 2013 .

UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues.

H. Gendelman, J. McMillan, N. Gautam, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation

H. Gendelman, J. McMillan, A. Dahan, 2022, Nature Communications.

Creation of a long-acting nanoformulated dolutegravir

H. Gendelman, J. McMillan, P. Dash, 2018, Nature Communications.

Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1)

Y. Alnouti, Jing Tong, B. Hagenbuch, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice.

C. Fletcher, N. Gautam, Y. Alnouti, 2019, The Journal of antimicrobial chemotherapy.

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

Ju-Seog Lee, Y. Alnouti, M. Finegold, 2020, bioRxiv.

Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults)

C. Klaassen, Y. Alnouti, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

A. D. Rodrigues, G. S. Walker, L. Tremaine, 2017, Drug Metabolism and Disposition.

Synthesis and Evaluation of a Well-defined HPMA Copolymer–Dexamethasone Conjugate for Effective Treatment of Rheumatoid Arthritis

K. Fu, G. Thiele, Y. Alnouti, 2008, Pharmaceutical Research.

Preliminary preclinical study of Chol-DsiRNA Polyplexes formed with PLL[30]-PEG[5 K] for the RNAi-based therapy of breast Cancer.

Vishakha V. Ambardekar, D. Coulter, Rakesh K. Singh, 2021, Nanomedicine : nanotechnology, biology, and medicine.

Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.

J. Meza, H. Gendelman, J. McMillan, 2012, The Journal of infectious diseases.

Development and characterization of a long-acting nanoformulated abacavir prodrug.

H. Gendelman, J. McMillan, Dhirender Singh, 2016, Nanomedicine.

Pharmacokinetics, Biodistribution, and Toxicity of Folic Acid-Coated Antiretroviral Nanoformulations

H. Gendelman, J. McMillan, H. Fox, 2014, Antimicrobial Agents and Chemotherapy.

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

H. Gendelman, J. McMillan, H. Gelbard, 2012, AIDS.

Synthesis and Characterization of Long Acting Darunavir Prodrugs.

H. Gendelman, J. McMillan, N. Gautam, 2019, Molecular pharmaceutics.

Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques

H. Gendelman, J. McMillan, H. Fox, 2017, Antimicrobial Agents and Chemotherapy.

Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities.

Yan Liu, Jialin C. Zheng, Zhen Qiao, 2016, European journal of medicinal chemistry.

Buspirone, fexofenadine, and omeprazole: quantification of probe drugs and their metabolites in human plasma.

G. Reed, Y. Alnouti, P. Gor, 2011, Journal of pharmaceutical and biomedical analysis.

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers

J. Meza, N. Gautam, Y. Alnouti, 2021, World journal of hepatology.

A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice.

V. Saraswathi, M. Ganesan, C. Desouza, 2017, The Journal of nutritional biochemistry.

Discovery, synthesis and biological characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.

C. Hopkins, Sushil Kumar, N. Gautam, 2021, RSC medicinal chemistry.

KVA-D-88, a novel preferable phosphodiesterase 4B inhibitor, decreases cocaine-mediated reward properties in vivo.

C. Hopkins, K. Miczek, S. Buch, 2020, ACS chemical neuroscience.

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

H. Gendelman, J. McMillan, A. Kabanov, 2012, International journal of nanomedicine.

The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice.

E. Cable, N. Gautam, Y. Alnouti, 2020, Translational research : the journal of laboratory and clinical medicine.

Synthesis and SAR Studies of 1H-Pyrrolo[2,3-b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors.

C. Hopkins, T. Kielian, Sushil Kumar, 2020, ACS medicinal chemistry letters.

Bile acid indices as biomarkers for liver diseases II: The bile acid score survival prognostic model

J. Meza, N. Gautam, Y. Alnouti, 2021, World journal of hepatology.

Metabolite profiling of praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple quadrupole linear ion trap mass spectrometer.

Y. Alnouti, Jiangeng Huang, S. Bathena, 2010, Drug metabolism and pharmacokinetics.

Pathways for Dolutegravir Transformation from a Daily Oral to a Once-a-Year Parenteral Medicine

H. Gendelman, J. McMillan, A. Dahan, 2022 .