A. Slitt

发表

Lack of multidrug-resistance associated protein 4 prolongs partial hepatectomy-induced hepatic steatosis.

Ji-Young Lee, J. Schuetz, Ajay C Donepudi, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Regulation of hepatic transporters by xenobiotic receptors.

C. Klaassen, A. Slitt, 2005, Current drug metabolism.

Bromobenzene-induced hepatotoxicity at the transcriptome level.

Ben van Ommen, Wilbert H M Heijne, R. Stierum, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding.

Masayuki Yamamoto, J. Luyendyk, A. Slitt, 2013, Free radical biology & medicine.

Keap 1 knockdown increases markers of metabolic syndrome after long-term fat diet feeding

Masayuki Yamamoto, J. Luyendyk, A. Slitt, 2013 .

Retinoid X Receptor α Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-Glutathione Conjugation in Mouse Liver

C. Klaassen, A. Slitt, Angela L Slitt, 2005, Molecular Pharmacology.

Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

Masayuki Yamamoto, C. Klaassen, J. Chan, 2007, Hepatology.

The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding.

Steven D. Cohen, A. Slitt, J. Manautou, 2004, Toxicology.

Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro

N. Seeram, Meenakshi Sharma, H. Aisa, 2014, Journal of natural products.

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

Jonathan P. Jackson, D. Moore, C. Klaassen, 2008, Drug Metabolism and Disposition.

Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice

P. Thomas, A. Slitt, X. Wen, 2012, Comparative hepatology.

Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by 19F NMR.

G. Bothun, A. Slitt, Michael Fedorenko, 2021, Chemosphere.

Reverse Pharmacognosy: A Tool to Accelerate the Discovery of New Bioactive Food Ingredients

N. Seeram, A. Slitt, T. Peppard, 2014 .

Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease

D. Besselsen, A. Slitt, J. Manautou, 2007, Drug Metabolism and Disposition.

PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway.

A. Slitt, Jialin Xu, Prajakta C. Shimpi, 2016, Toxicology and applied pharmacology.

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

D. Moore, C. Klaassen, A. Slitt, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Constitutive activation of nuclear factor‐E2‐related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte‐specific deletion of Kelch‐like ECH‐associated protein 1

Masayuki Yamamoto, A. Slitt, J. Manautou, 2011, Journal of biochemical and molecular toxicology.

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.

C. Klaassen, J. Chan, A. Slitt, 2008, Toxicology and applied pharmacology.

Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.

C. Klaassen, T. Leazer, A. Slitt, 2004, Biochemical and biophysical research communications.

Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers

D. Dolinoy, A. Slitt, L. Aleksunes, 2016, Drug Metabolism and Disposition.

TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE

Xingguo Cheng, C. Klaassen, A. Slitt, 2005, Drug Metabolism and Disposition.

Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes.

G. Bothun, Marisa Pfohl, A. Slitt, 2022, Toxicology and applied pharmacology.

Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations.

N. Seeram, A. Slitt, Pragati P. Nahar, 2014, Journal of medicinal food.

Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin‐deficient mice

T. Chatterjee, Ajay C Donepudi, A. Slitt, 2015, Obesity.

Perfluorooctanesulfonic acid (PFOS) thwarts the beneficial effects of calorie restriction and Metformin.

Wei Wei, A. Slitt, Pragati P. Nahar, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice

A. Slitt, Vijay R More, 2011, Drug Metabolism and Disposition.

DMD049676 1148..1155

Z. Lu, Ajay C Donepudi, A. Slitt, 2013 .

Alcohol Cirrhosis Alters Nuclear Receptor and Drug Transporter Expression in Human Liver

Z. Lu, Ajay C Donepudi, A. Slitt, 2013, Drug Metabolism and Disposition.

Antidiabetic ellagitannins from pomegranate flowers: inhibition of α-glucosidase and lipogenic gene expression.

N. Seeram, D. Ferreira, A. Slitt, 2012, Organic letters.

INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER

Curtis D. Klaassen, Xingguo Cheng, Xingguo Cheng, 2005, Drug Metabolism and Disposition.

Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression

Z. Lu, Ajay C Donepudi, A. Slitt, 2016, Drug Metabolism and Disposition.

Effect of Caloric Restriction and AMPK Activation on Hepatic Nuclear Receptor, Biotransformation Enzyme, and Transporter Expression in Lean and Obese Mice

Wei Wei, Ajay C Donepudi, A. Slitt, 2013, Pharmaceutical Research.

Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor-α, Interleukin-1β, Interleukin-6, and Nuclear Factor-κB in Two Models of Cholestasis

M. Karin, A. Slitt, N. Cherrington, 2007, Drug Metabolism and Disposition.

DMD #12138 DIFFERENTIAL REGULATION OF HEPATIC TRANSPORTERS IN THE ABSENCE OF TNF-α, IL-1β, IL-6 AND NF-κB IN TWO MODELS OF CHOLESTASIS

Cherrington, M. Karin, A. Slitt, 2006 .

Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.

C. Klaassen, A. Slitt, N. Cherrington, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Per- and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes.

Wei Wei, A. Slitt, N. DaSilva, 2021, Toxicology.

trans-Stilbene Oxide Induces Expression of Genes Involved in Metabolism and Transport in Mouse Liver via CAR and Nrf2 Transcription Factors

D. Moore, C. Klaassen, G. Scheffer, 2006, Molecular Pharmacology.

Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6.

C. Klaassen, A. Slitt, N. Cherrington, 2006, Life sciences.

Induction of drug metabolism enzymes and transporters by oltipraz in rats

A. Slitt, N. Cherrington, Matthew D. Merrell, 2008, Journal of biochemical and molecular toxicology.

Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis.

M. Karin, A. Slitt, N. Cherrington, 2007, Drug metabolism and disposition: the biological fate of chemicals.

Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels.

C. Klaassen, T. Leazer, A. Slitt, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease

D. Dolinoy, B. Rubin, Ajay C Donepudi, 2017, Environmental health perspectives.

Early growth response factor-1 is critical for cholestatic liver injury.

B. Copple, N. Kim, A. Slitt, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.

C. Klaassen, A. Slitt, J. Manautou, 2007, Toxicology.

Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro

N. Seeram, N. Zawia, A. Eid, 2017, Nutritional neuroscience.

The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure.

Wei Wei, Marisa Pfohl, A. Slitt, 2021, Toxicology.

Increased toxicity and retention of Perflourooctane Sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a High-Fat Diet (HFD).

Marisa Pfohl, A. Slitt, W. S. Baldwin, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

Ajay C Donepudi, A. Slitt, Vijay R More, 2012, Diabetes.

Enhanced Nrf 2 Activity Worsens Insulin Resistance , Impairs Lipid Accumulation in Adipose Tissue , and Increases Hepatic Steatosis in Leptin-De fi cient Mice

Ajay C Donepudi, A. Slitt, Vijay R More, 2012 .

Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats.

C. Klaassen, G. Scheffer, A. Slitt, 2005, Biochemical pharmacology.

Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease

Z. Lu, A. Slitt, J. Manautou, 2013, Drug Metabolism and Disposition.

DMD048439 554..561

A. Slitt, J. Manautou, April D. Lake, 2013 .

Bisphenol A sulfonation is impaired in metabolic and liver disease.

A. Slitt, E. Yalçın, R. King, 2016, Toxicology and applied pharmacology.

The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit), decreases liver inflammation, injury and fibrosis during cholestasis

N. Seeram, Ajay C Donepudi, A. Slitt, 2012, Liver international : official journal of the International Association for the Study of the Liver.

Regulation of Hepatic Phase II Metabolism in Pregnant Mice

P. Thomas, Ajay C Donepudi, A. Slitt, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Perfluorooctanesulfonic Acid and Perfluorohexanesulfonic Acid Alter the Blood Lipidome and the Hepatic Proteome in a Murine Model of Diet-Induced Obesity

Marisa Pfohl, A. Slitt, R. Jamwal, 2020 .

Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2

C. Klaassen, L. Lehman-Mckeeman, A. Slitt, 2007, Drug Metabolism and Disposition.

Critical new insights into the binding of poly- and perfluoroalkyl substances (PFAS) to albumin protein.

G. Bothun, A. Slitt, Jessica Alesio, 2021, Chemosphere.

A PDK-1 allosteric agonist improves spatial learning and memory in a βAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer's disease

H. Querfurth, A. Slitt, Nathan O. Surles, 2022, Behavioural Brain Research.

Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression

Ajay C Donepudi, A. Slitt, L. Aleksunes, 2013, Journal of biochemical and molecular toxicology.

Phenolic mediated anti-inflammatory properties of a maple syrup extract in RAW 264.7 murine macrophages

N. Seeram, A. Slitt, Liya Li, 2014 .

Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes.

N. Seeram, A. Slitt, Hang Ma, 2020, Journal of natural products.

Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion.

Steven D. Cohen, A. Slitt, J. Roberts, 2005, Basic & clinical pharmacology & toxicology.

Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.

G. Scheffer, A. Slitt, J. Manautou, 2008, Molecular pharmaceutics.

Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats.

Ning Li, C. Klaassen, A. Slitt, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Per- and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters.

A. Calafat, A. Caban-Martinez, J. Botelho, 2021, Epigenomics.

Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting

A. Slitt, E. Morgan, T. Lamb, 2018, Drug Metabolism and Disposition.

Red Blood Cell Folate Modifies the Association between Serum Per- and Polyfluoroalkyl Substances and Antibody Concentrations in U.S. Adolescents.

B. Coull, Yang Sun, V. Mustieles, 2023, Environmental science & technology.

Enhanced acetaminophen toxicity by activation of the pregnane X receptor.

S. Kliewer, J. Ward, C. Nicol, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.

D. Besselsen, A. Slitt, N. Cherrington, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.

Xingguo Cheng, F. Gonzalez, C. Klaassen, 2006, Biochemical pharmacology.

Standard of care may not protect against acetaminophen-induced nephrotoxicity.

Steven D. Cohen, A. Slitt, J. Roberts, 2004, Basic & clinical pharmacology & toxicology.

An 'Omics Approach to Unraveling the Paradoxical Effect of Diet on Perfluorooctanesulfonic Acid (PFOS) and Perfluorononanoic Acid (PFNA)-Induced Hepatic Steatosis.

F. Akhlaghi, Marisa Pfohl, A. Slitt, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity.

Marisa Pfohl, A. Slitt, R. Jamwal, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Phospholipid Levels Predict the Tissue Distribution of Poly- and Perfluoroalkyl Substances in a Marine Mammal.

Marisa Pfohl, A. Slitt, E. Sunderland, 2019, Environmental science & technology letters.

Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice.

F. Akhlaghi, Marisa Pfohl, A. Slitt, 2020, Toxicology and applied pharmacology.

UDP-Glucuronosyltransferase Expression in Mouse Liver Is Increased in Obesity- and Fasting-Induced Steatosis

A. Slitt, Liya Li, Jialin Xu, 2012, Drug Metabolism and Disposition.

Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human.

Xiaoling Li, DelindaA . Johnson, Jeffrey A. Johnson, 2014, Antioxidants & redox signaling.

Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice

N. Seeram, Marisa Pfohl, A. Slitt, 2020, International journal of food sciences and nutrition.

Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways

A. Slitt, E. Heart, Xiaomei Liang, 2017, PloS one.

Challenges in Evaluating Safety and Efficacy in Drug Development for Rare Diseases: A Review for Pharmacists

A. Slitt, S. Kogut, Kanya K. Shah, 2020, Journal of pharmacy practice.

Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis

C. Klaassen, J. Chan, A. Slitt, 2006, Cell stress & chaperones.

Caloric Restriction-Mediated Induction of Lipid Metabolism Gene Expression in Liver is Enhanced by Keap1-Knockdown

A. Slitt, Laura E. Armstrong, Supriya R Kulkarni, 2013, Pharmaceutical Research.

In vitro metabolism of HMTD and blood stability and toxicity of peroxide explosives (TATP and HMTD) in canines and humans

James L. Smith, J. Oxley, Lindsay McLennan, 2021, Xenobiotica; the fate of foreign compounds in biological systems.

Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers

Z. Lu, A. Slitt, N. Cherrington, 2013, Drug Metabolism and Disposition.

Downregulation of Sulfotransferase Expression and Activity in Diseased Human Livers s

Z. Lu, A. Slitt, N. Cherrington, 2013 .

Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria

M. Varma, A. Slitt, H. Eng, 2021, European Journal of Drug Metabolism and Pharmacokinetics.

Effects of a Standardized Phenolic-Enriched Maple Syrup Extract on β-Amyloid Aggregation, Neuroinflammation in Microglial and Neuronal Cells, and β-Amyloid Induced Neurotoxicity in Caenorhabditis elegans

N. Seeram, A. Slitt, N. DaSilva, 2016, Neurochemical Research.

Chemical Compositional, Biological, and Safety Studies of a Novel Maple Syrup Derived Extract for Nutraceutical Applications

N. Seeram, A. Slitt, Liya Li, 2014, Journal of agricultural and food chemistry.

Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis.

C. Klaassen, A. Slitt, J. Manautou, 2007, Biochimica et biophysica acta.

Pregnancy Represses Induction of Efflux Transporters in Livers of Type I Diabetic Mice

A. Slitt, X. Wen, L. Aleksunes, 2013, Pharmaceutical Research.

Folate concentrations and serum perfluoroalkyl and polyfluoroalkyl substance concentrations in adolescents and adults in the USA (National Health and Nutrition Examination Study 2003-16): an observational study.

Yang Sun, V. Mustieles, A. Slitt, 2023, The Lancet. Planetary health.

Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats

A. Slitt, N. Cherrington, L. Aleksunes, 2008, Journal of biochemical and molecular toxicology.

Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice.

Swetha Rudraiah, Ajay C Donepudi, A. Slitt, 2014, Toxicology.

Differential Fmo 3 gene expression in various liver injury models involving hepatic oxidative stress in mice

Aleksunes, Swetha Rudraiah, Ajay C Donepudi, 2019 .

Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue

Ajay C Donepudi, A. Slitt, Jialin Xu, 2013, PloS one.

INDUCTION OF GENES FOR METABOLISM AND TRANSPORT BY TRANS-STILBENE OXIDE IN LIVERS OF SPRAGUE-DAWLEY AND WISTAR-KYOTO RATS

M. Negishi, C. Klaassen, A. Slitt, 2006, Drug Metabolism and Disposition.

N. Seeram, A. Slitt, N. DaSilva, 2016, Neurochemical Research.

Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma

Yurong Lai, Y. Lai, A. Slitt, 2013, Hepatology.

INDUCTION OF DRUG-METABOLIZING ENZYMES BY GARLIC AND ALLYL SULFIDE COMPOUNDS VIA ACTIVATION OF CAR AND NRF 2

C. Klaassen, L. Lehman-Mckeeman, A. Slitt, 2007 .

2,2′,4,4′,5‐Pentabromodiphenyl ether induces lipid accumulation throughout differentiation in 3T3‐L1 and human preadipocytes in vitro

A. Slitt, Laura E. Armstrong, S. Akinbo, 2020, Journal of biochemical and molecular toxicology.

Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin‐deficient mice

T. Chatterjee, Ajay C Donepudi, A. Slitt, 2015, Obesity.

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

D. Moore, C. Klaassen, A. Slitt, 2008, Drug Metabolism and Disposition.

Regulation of Hepatic Phase II Metabolism in Pregnant Mice

P. Thomas, Ajay C Donepudi, A. Slitt, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease

D. Besselsen, A. Slitt, J. Manautou, 2007, Drug Metabolism and Disposition.

Retinoid X Receptor α Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-Glutathione Conjugation in Mouse Liver

C. Klaassen, A. Slitt, M. Gyamfi, 2005, Molecular Pharmacology.

Pregnancy Represses Induction of Efflux Transporters in Livers of Type I Diabetic Mice

A. Slitt, Michael J Goedken, X. Wen, 2013, Pharmaceutical Research.

Perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity.

Marisa Pfohl, A. Slitt, R. Jamwal, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development.

S. W. Bihaqi, A. Slitt, I. Hmila, 2024, Ecotoxicology and environmental safety.