M. Middleton

C. Sirlin, M. Hellerstein, R. Loomba, 2018, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Reproducibility of MRI‐determined proton density fat fraction across two different MR scanner platforms

A. Gamst, C. Sirlin, M. Shiehmorteza, 2011, Journal of magnetic resonance imaging : JMRI.

Bone marrow fat content is correlated with hepatic fat content in paediatric non-alcoholic fatty liver disease.

A. Gamst, C. Sirlin, T. Wolfson, 2017, Clinical radiology.

MR imaging of extracapsular silicone from breast implants: diagnostic pitfalls.

M. Soo, G. Pennello, W. Berg, 2002, AJR. American journal of roentgenology.

Evaluation of Quantitative Imaging Biomarkers for Early Phase Clinical Trials of Steatohepatitis in Adolescents.

C. Sirlin, J. Schwimmer, M. Middleton, 2019, Journal of pediatric gastroenterology and nutrition.

Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2, 3, and 4 Observations Detected at CT and MR Imaging.

A. Gamst, C. Sirlin, Y. Kono, 2016, Radiology.

accuracy of M r imaging- estimated Proton Density Fat Fraction for classification of Dichotomized histologic s teatosis grades in nonalcoholic

A. Gamst, C. Sirlin, M. Peterson, 2015 .

Assessment of liver fat quantification in the presence of iron.

A. Gamst, C. Sirlin, M. Shiehmorteza, 2010, Magnetic resonance imaging.

Nephrogenic systemic fibrosis in liver disease: A systematic review

C. Sirlin, M. Shiehmorteza, S. Mazhar, 2009, Journal of magnetic resonance imaging : JMRI.

Bias , and Precision of hepatic Proton Density Fat Fraction Measurements by Using Mr imaging : A Meta-Analysis 1

N. Obuchowski, S. Reeder, C. Sirlin, 2018 .

Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial

C. Sirlin, C. McCracken, C. Travers, 2019, JAMA.

Breast Implant Classification with MR Imaging Correlation

M. Middleton, M. P. McNamara, 2000 .

Progression of Fatty Liver Disease in Children Receiving Standard of Care Lifestyle Advice.

Kathryn J Fowler, O. Cummings, C. Sirlin, 2020, Gastroenterology.

Liver metastases: detection by phase-contrast MR imaging.

J. Wittenberg, D. Stark, J. Ferrucci, 1986, Radiology.

Prospective comparison of longitudinal change in hepatic proton density fat fraction (PDFF) estimated by magnitude-based MRI (MRI-M) and complex-based MRI (MRI-C)

Kathryn J Fowler, A. Gamst, L. Funk, 2020, European Radiology.

Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial

V. Wong, J. Trotter, M. Shiffman, 2020, Hepatology.

Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib.

C. Sirlin, Z. Goodman, K. Kowdley, 2019, Journal of hepatology.

MRI proton density fat fraction is robust across the biologically plausible range of triglyceride spectra in adults with nonalcoholic steatohepatitis

S. Reeder, C. Sirlin, T. Wolfson, 2018, Journal of magnetic resonance imaging : JMRI.

Accuracy of magnitude- and complex-reconstruction chemical-shift-encoded magnetic resonance imaging proton density fat fraction for diagnosis of hepatic steatosis in subjects with severe obesity using histology as reference

Alexandra N. Schlein, S. Horgan, A. Gamst, 2018 .

Cross‐sectional correlation between hepatic R2* and proton density fat fraction (PDFF) in children with hepatic steatosis

Alexandra N. Schlein, A. Gamst, C. Sirlin, 2018, Journal of magnetic resonance imaging : JMRI.

Accuracy of PDFF estimation by magnitude‐based and complex‐based MRI in children with MR spectroscopy as a reference

Alexandra N. Schlein, S. Reeder, C. Sirlin, 2017, Journal of magnetic resonance imaging : JMRI.

Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage.

Christopher J. N. Kigongo, Kathryn J Fowler, O. Cummings, 2019, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

C. Sirlin, R. Xu, M. Valasek, 2018, Gastroenterology.

MR elastography in nonalcoholic fatty liver disease: inter-center and inter-analysis-method measurement reproducibility and accuracy at 3T

Alexandra N. Schlein, A. Gamst, C. Sirlin, 2021, European Radiology.

Multicenter Validation of Association Between Decline in MRI‐PDFF and Histologic Response in NASH

B. Neuschwander‐Tetri, C. Sirlin, N. Chalasani, 2020, Hepatology.

nonalcoholic Fatty liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis 1

A. Gamst, C. Sirlin, T. Wolfson, 2013 .

GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.

R. Loomba, M. Noureddin, M. Middleton, 2018, Gastroenterology.

Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults

A. Gamst, C. Sirlin, T. Wolfson, 2015, Abdominal Imaging.

Inter‐examination precision of magnitude‐based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects

A. Gamst, C. Sirlin, T. Wolfson, 2014, Journal of magnetic resonance imaging : JMRI.

Agreement between region-of-interest- and parametric map-based hepatic proton density fat fraction estimation in adults with chronic liver disease

Alexandra N. Schlein, A. Gamst, C. Sirlin, 2017, Abdominal Radiology.

Prevalence of Nonalcoholic Fatty Liver Disease in Children with Obesity.

C. Sirlin, J. Schwimmer, M. Middleton, 2019, The Journal of pediatrics.

In vivo breath‐hold 1H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi‐TR, multi‐TE sequence

C. Sirlin, G. Hamilton, M. Allison, 2015, Journal of magnetic resonance imaging : JMRI.

MR evaluation of breast implants.

M. Middleton, 2014, Radiologic clinics of North America.

Acetyl-CoA carboxylase (ACC) inhibitor GS-0976 leads to suppression of hepatic de novo lipogenesis and significant improvements in MRI-PDFF, MRE, and markers of fibrosis after 12 weeks of therapy in patients with NASH

C. Sirlin, M. Hellerstein, M. Middleton, 2017 .

Effect of Fat Spectral Model Parameters on Hepatic Fat Quantification by Multi-Echo Gradient-Echo Magnetic Resonance Imaging

C. Sirlin, M. Bydder, G. Hamilton, 2009 .

Prevalence of rupture of silicone gel breast implants revealed on MR imaging in a population of women in Birmingham, Alabama.

M. Soo, G. Pennello, W. Berg, 2000, AJR. American journal of roentgenology.

Magnetic resonance evaluation of breast implants and soft-tissue silicone.

M. Middleton, 1998, Topics in magnetic resonance imaging : TMRI.

The Importance of Documenting the Appearance and Status of Breast Implants at Time of Explantation

N. Hardt, M. Middleton, M. P. McNamara, 2000, Modern Pathology.

Inclusion criteria for trial recruitment Parameter Criterion Bone marrow function Haemoglobin Neutrophil count Platelet count Renal function Urea Creatinine Hepatic function Prothrombin time APPT time Total bilirubin AST

R. Phillips, M. Middleton, R. Ritchie, 2012 .

Optimal Threshold of Controlled Attenuation Parameter for Detection of HIV-Associated NAFLD With Magnetic Resonance Imaging as the Reference Standard.

C. Sirlin, G. Hamilton, R. Loomba, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Changes in abdominal adipose tissue depots accessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis.

Kathryn J Fowler, B. Neuschwander‐Tetri, A. Gamst, 2022, Journal of hepatology.

Fat-suppression contrast-enhanced MRI in the failed back surgery syndrome: a prospective study

J. Hesselink, B. Georgy, M. Middleton, 2004, Neuroradiology.

Clinical Impact of Breast Implant Magnetic Resonance Imaging

M. Middleton, M. Dobke, 1994, Annals of plastic surgery.

SAT-352-A combination of the ACC inhibitor GS-0976 and the nonsteroidal FXR agonist GS-9674 improves hepatic steatosis, biochemistry, and stiffness in patients with non-alcoholic steatohepatitis

P. Kwo, M. Hellerstein, E. Gane, 2019, Journal of Hepatology.

Can gadopentetate dimeglumine be safely administered more rapidly than the FDA-approved injection rate for liver imaging?

M. Shiehmorteza, M. Middleton, R. Hanna, 2007, AJR. American journal of roentgenology.

MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials.

Alfredo E Farjat, C. Sirlin, C. Moylan, 2022, Radiology.

SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease.

G. Norman, C. Sirlin, N. Kerkar, 2010, Gastroenterology.

Pediatric Nonalcoholic Fatty Liver Disease: A Critical Appraisal of Current Data and Implications for Future Research

C. Sirlin, J. Schwimmer, J. Lavine, 2006, Journal of pediatric gastroenterology and nutrition.

Accuracy of common proton density fat fraction thresholds for magnitude- and complex-based chemical shift-encoded MRI for assessing hepatic steatosis in patients with obesity

Alexandra N. Schlein, S. Horgan, A. Gamst, 2019, Abdominal Radiology.

Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women.

M. Soo, G. Pennello, W. Berg, 2001, The Journal of rheumatology.

Quantitative analysis of signal intensities and contrast after fat suppression in contrast-enhanced magnetic resonance imaging of the spine.

J. Hesselink, B. Georgy, M. Middleton, 1996, Academic radiology.

Randomised clinical trial: a leucine‐metformin‐sildenafil combination (NS‐0200) vs placebo in patients with non‐alcoholic fatty liver disease

C. Sirlin, N. Chalasani, R. Gil-Redondo, 2018, Alimentary pharmacology & therapeutics.

Spatial distribution of MRI‐determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease

A. Gamst, C. Sirlin, T. Wolfson, 2014, Journal of magnetic resonance imaging : JMRI.

Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease.

A. Gamst, C. Sirlin, M. Peterson, 2015, Radiology.

Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis.

A. Gamst, C. Sirlin, T. Wolfson, 2013, Radiology.

Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease

C. Sirlin, G. Hamilton, M. V. Van Natta, 2018, Hepatology.

Linearity, Bias, and Precision of Hepatic Proton Density Fat Fraction Measurements by Using MR Imaging: A Meta-Analysis.

N. Obuchowski, S. Reeder, C. Sirlin, 2017, Radiology.

Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.

Rohit Loomba, Mustafa R Bashir, Claude B Sirlin, 2017, Gastroenterology.

Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease

A. Gamst, C. Sirlin, T. Wolfson, 2015, Abdominal Imaging.

The efficacy of breast MRI in predicting breast conservation therapy

T. Wolfson, A. Wallace, J. Mortimer, 2006, Journal of surgical oncology.

Accuracy of multiecho magnitude‐based MRI (M‐MRI) for estimation of hepatic proton density fat fraction (PDFF) in children

A. Gamst, C. Sirlin, T. Wolfson, 2015, Journal of magnetic resonance imaging : JMRI.

Non-invasive Quantitative Magnetic Resonance Imaging and Spectroscopic Biomarkers in Nonalcoholic Fatty Liver Disease and Other Cardiometabolic Diseases Associated with Ectopic Fat Deposition

C. Sirlin, G. Hamilton, E. Heba, 2019, Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease.

Imaging Techniques for the Assessment of Ectopic Fat in Liver and Skeletal Muscle

C. Sirlin, G. Hamilton, E. Heba, 2015 .

Ultrasound of Breast Implants and Soft Tissue Silicone

M. Middleton, M. P. McNamara, 2011 .

Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children.

Alexandra N. Schlein, C. Sirlin, J. Nichols, 2021, The Journal of pediatrics.

Effect of echo‐sampling strategy on the accuracy of out‐of‐phase and in‐phase multiecho gradient‐Echo MRI hepatic fat fraction estimation

Rohit Loomba, Tanya Wolfson, Claude B Sirlin, 2014, Journal of magnetic resonance imaging : JMRI.

Repeatability and reproducibility of 2D and 3D hepatic MR elastography with rigid and flexible drivers at end-expiration and end-inspiration in healthy volunteers

Richard L Ehman, Tanya Wolfson, Meng Yin, 2017, Abdominal Radiology.

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

Rohit Loomba, Claude Sirlin, Jessica Lam, 2013, Hepatology.

Linearity and Bias of Proton Density Fat Fraction as a Quantitative Imaging Biomarker: A Multicenter, Multiplatform, Multivendor Phantom Study.

Jean A. Tkach, N. Obuchowski, S. Reeder, 2021, Radiology.

Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease

Kathryn J Fowler, A. Gamst, C. Sirlin, 2018, Journal of magnetic resonance imaging : JMRI.

Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data‐based, T1‐independent, T2*‐corrected, spectrum‐modeled MRI

Scott Reeder, Rohit Loomba, Tanya Wolfson, 2014, Journal of magnetic resonance imaging : JMRI.

Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging

Sabrina Fox‐Bosetti, C. Sirlin, N. Shire, 2013, Journal of magnetic resonance imaging : JMRI.

Effects of intravenous gadolinium administration and flip angle on the assessment of liver fat signal fraction with opposed‐phase and in‐phase imaging

C. Sirlin, M. Bydder, T. Yokoo, 2008, Journal of magnetic resonance imaging : JMRI.

Automated CT and MRI Liver Segmentation and Biometry Using a Generalized Convolutional Neural Network.

Claude B. Sirlin, Kyle Hasenstab, Naeim Bahrami, 2019, Radiology. Artificial intelligence.

Automated CNN-Based Analysis Versus Manual Analysis for MR Elastography in Nonalcoholic Fatty Liver Disease: Inter-method Agreement and Fibrosis Stage Discriminative Performance.

Kathryn J Fowler, C. Sirlin, R. Loomba, 2022, AJR. American journal of roentgenology.

Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis.

C. Sirlin, M. Bydder, G. Hamilton, 2009, Radiographics : a review publication of the Radiological Society of North America, Inc.

Effect of intravenous gadoxetate disodium and flip angle on hepatic proton density fat fraction estimation with six-echo, gradient-recalled-echo, magnitude-based MR imaging at 3T

A. Gamst, C. Sirlin, T. Wolfson, 2017, Abdominal Radiology.

A Pilot Genome‐Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH

Christopher J. N. Kigongo, Kathryn J Fowler, O. Cummings, 2019, Hepatology communications.

Accuracy and the effect of possible subject‐based confounders of magnitude‐based MRI for estimating hepatic proton density fat fraction in adults, using MR spectroscopy as reference

Alexandra N. Schlein, A. Gamst, C. Sirlin, 2016, Journal of magnetic resonance imaging : JMRI.

Counterfactual Thinking and Quality of Life Among Women with Silicone Breast Implants

J. Kulik, P. Parker, M. Middleton, 2002, Journal of Behavioral Medicine.

Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease

C. Sirlin, G. Hamilton, J. Schwimmer, 2015, Hepatology.

Diagnosis of fatty liver with MR imaging

C. Compton, A. Tanimoto, D. Stark, 1992, Journal of magnetic resonance imaging : JMRI.

Detection of hepatic metastases: analysis of pulse sequence performance in MR imaging.

R R Edelman, T J Brady, S Saini, 1986, Radiology.

Scientific Paper Abstracts Presented at the Society of Abdominal Radiology 2016 Annual Scientific Meeting and Educational Course March 13–18, 2016, Waikoloa, Hawaii

C. Sirlin, T. Wolfson, G. Hamilton, 2016, Abdominal Radiology.

Intravenous Gadoxetate Disodium Administration Reduces Breath-holding Capacity in the Hepatic Arterial Phase: A Multi-Center Randomized Placebo-controlled Trial.

Utaroh Motosugi, Scott B Reeder, Tracy A Jaffe, 2017, Radiology.

Title Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2 , 3 , and 4 Observations Detected at CT and MR Imaging Permalink

A. Gamst, Y. Kono, C. Santillan, 2016 .

GASTROINTESTINAL IMAGING : Imaging Outcomes of Liver Imaging Reporting and Data System Observations

A. Gamst, C. Sirlin, Y. Kono, 2016 .

Magnetic resonance elastography measured shear stiffness as a biomarker of fibrosis in pediatric nonalcoholic fatty liver disease

Alexandra N. Schlein, A. Gamst, C. Sirlin, 2017, Hepatology.

Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T

Claude B. Sirlin, Michael R. Peterson, Tanya Wolfson, 2015, BioMed research international.

The relationship between liver triglyceride composition and proton density fat fraction as assessed by 1H MRS

Alexandra N. Schlein, Kathryn J Fowler, C. Sirlin, 2020, NMR in biomedicine.

CLINICAL—LIVER, PANCREAS, AND BILIARY TRACT SAFETY Study: Alanine Aminotransferase Cutoff Values Are Set Too High for Reliable Detection of Pediatric Chronic Liver Disease

G. Norman, C. Sirlin, N. Kerkar, 2010 .

imaging Outcomes of liver imaging r eporting and Data s ystem Version 2014 category 2

A. Gamst, C. Sirlin, Y. Kono, 2016 .

Repeatability and accuracy of various region-of-interest sampling strategies for hepatic MRI proton density fat fraction quantification

Alexandra N. Schlein, Kathryn J Fowler, A. Gamst, 2021, Abdominal Radiology.

Association of Hepatic Steatosis with Adipose and Muscle Mass and Distribution in Children.

C. Sirlin, J. Schwimmer, M. Middleton, 2023, Metabolic syndrome and related disorders.

In vivo triglyceride composition of abdominal adipose tissue measured by 1H MRS at 3T

Alexandra N. Schlein, A. Gamst, C. Sirlin, 2017, Journal of magnetic resonance imaging : JMRI.

Temperature‐corrected proton density fat fraction estimation using chemical shift‐encoded MRI in phantoms

Jean A. Tkach, S. Reeder, T. Chenevert, 2021, Magnetic resonance in medicine.

Longitudinal comparison between MRI , MRS and histology-determined steatosis in NAFLD patients at two-time points in a randomized trial

D. Brenner, C. Sirlin, M. Peterson, 2013 .

A phase 2 clinical trial of metformin as a treatment for non‐diabetic paediatric non‐alcoholic steatohepatitis

R. Deutsch, J. Schwimmer, J. Lavine, 2005, Alimentary pharmacology & therapeutics.

CLINICAL ADVANCES IN LIVER, PANCREAS, AND BILIARY TRACT Heritability of Nonalcoholic Fatty Liver Disease

N. Schork, C. Sirlin, M. Shiehmorteza, 2009 .

Proof of concept study of an apoptosis-signal regulating kinase (ASK1) inhibitor (selonsertib) in combination with an acetyl-CoA carboxylase inhibitor (GS-0976) or a farnesoid X receptor agonist (GS-9674) in NASH

P. Kwo, M. Hellerstein, E. Gane, 2018 .

Estimation of Hepatic Proton-Density Fat Fraction by Using MR Imaging at 3.0 T 1

S. Horgan, A. Gamst, C. Sirlin, 2011 .

Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis

Kathryn J Fowler, R. Ehman, A. Gamst, 2021, European Radiology.

Nephrogenic systemic fibrosis in liver disease: A systematic review

C. Sirlin, M. Shiehmorteza, S. Mazhar, 2009, Journal of magnetic resonance imaging : JMRI.

Assessment of a high‐SNR chemical‐shift‐encoded MRI with complex reconstruction for proton density fat fraction (PDFF) estimation overall and in the low‐fat range

Alexandra N. Schlein, A. Gamst, S. Reeder, 2019, Journal of magnetic resonance imaging : JMRI.

Accuracy of multiecho magnitude‐based MRI (M‐MRI) for estimation of hepatic proton density fat fraction (PDFF) in children

A. Gamst, C. Sirlin, T. Wolfson, 2015, Journal of magnetic resonance imaging : JMRI.

Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging

Sabrina Fox‐Bosetti, C. Sirlin, N. Shire, 2013, Journal of magnetic resonance imaging : JMRI.

Liver histology and diffusion‐weighted MRI in children with nonalcoholic fatty liver disease: A MAGNET study

C. Sirlin, T. Wolfson, J. Schwimmer, 2017, Journal of magnetic resonance imaging : JMRI.

Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium.

C. Sirlin, S. Venkatesh, M. Middleton, 2023, Radiology.

Inter‐examination precision of magnitude‐based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects

A. Gamst, C. Sirlin, T. Wolfson, 2014, Journal of magnetic resonance imaging : JMRI.