R. Schwaab

发表

J. Oldenburg, R. Schwaab, 2001, Seminars in thrombosis and hemostasis.

Impact of polymorphisms of the major histocompatibility complex class II, interleukin‐10, tumor necrosis factor‐α and cytotoxic T‐lymphocyte antigen‐4 genes on inhibitor development in severe hemophilia A

R. Fimmers, J. Astermark, S. Lacroix-Desmazes, 2009, Journal of thrombosis and haemostasis : JTH.

Haemophilia A: Mutation Type Determines Risk of Inhibitor Formation

J. Oldenburg, R. Schwaab, E. Tuddenham, 1995, Thrombosis and Haemostasis.

Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain.

J. Oldenburg, R. Schwaab, H. Brackmann, 1991, Thrombosis research.

Characterization of the factor VIII defect in 147 patients with sporadic hemophilia A: family studies indicate a mutation type-dependent sex ratio of mutation frequencies.

J. Oldenburg, R. Schwaab, H. Brackmann, 1996, American journal of human genetics.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY A novel cause of mild/moderate hemophilia A: mutations scattered in the factor

J. Vermylen, M. Hoylaerts, T. VandenDriessche, 2022 .

Lithuanian haemophilia A and B registry comprising phenotypic and genotypic data

C. Müller, J. Oldenburg, S. Rost, 2001, British journal of haematology.

Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males

Rainer Schwaab, Tim Becker, T. Wienker, 2007, Human Genetics.

Quality management and quality assurance in haemophilia care: a model at the Bonn haemophilia centre

P Hanfland, J. Oldenburg, R. Schwaab, 2002, Haemophilia : the official journal of the World Federation of Hemophilia.

Expression and characterization of von Willebrand factor dimerization defects in different types of von Willebrand disease.

J. Oldenburg, R. Schwaab, Z. Ruggeri, 2001, Blood.

Results of a Screening for von Willebrand Disease Type 2N in Patients with Suspected Haemophilia A or von Willebrand Disease Type 1

J. Oldenburg, R. Schwaab, R. Schneppenheim, 1996, Thrombosis and Haemostasis.

Environmental and genetic factors influencing inhibitor development.

J. Oldenburg, R. Schwaab, E. Tuddenham, 2004, Seminars in hematology.

Moderation of hemophilia A phenotype by the factor V R506Q mutation.

R. Kaufman, D. Ginsburg, K. Michaelides, 1996, Blood.

Analysis of the essential sequences of the factor VIII gene in twelve haemophilia A patients by single‐stranded conformation polymorphism

J. Lavinha, R. Schwaab, E. Tuddenham, 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Assay discrepancy in mild haemophilia A due to a factor VIII missense mutation (Asn694Ile) in a large Danish family

J. Oldenburg, R. Schwaab, P. Hanfland, 2000, British journal of haematology.

Regulation of human factor IX expression using doxycycline-inducible gene expression system

Xiaomin Wang, H. Fechner, J. Oldenburg, 2003, Thrombosis and Haemostasis.

Missense mutations at ALA‐10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy

J. Oldenburg, W. Kress, A. Fregin, 1997, British journal of haematology.

Identification and DNA sequence analysis of 15 new alpha 1-antitrypsin variants, including two PI*Q0 alleles and one deficient PI*M allele.

W. Poller, R. Schwaab, M. Kirchgesser, 1994, American journal of human genetics.

Expression of CYP19 (aromatase) mRNA in the human temporal lobe.

J. Schramm, B. Stoffel‐Wagner, R. Schwaab, 1998, Biochemical and biophysical research communications.

Inhibitor development in correlation to factor VIII genotypes

J. Oldenburg, O. el-Maarri, R. Schwaab, 2002, Haemophilia : the official journal of the World Federation of Hemophilia.

Induction of Immune Tolerance in Haemophilia A Inhibitor Patients by the ‘Bonn Protocol’: Predictive Parameter for Therapy Duration and Outcome

J. Oldenburg, R. Schwaab, H. Brackmann, 1999, Vox Sanguinis.

Utilization of Previously Treated Patients (PTPs), Noninfected Patients (NIPs), and Previously Untreated Patients (PUPs) in the Evaluation of New Factor VIII and Factor IX Concentrates

C. Prowse, C. Négrier, R. Schwaab, 1999, Thrombosis and Haemostasis.

Immune Tolerance for the Treatment of Factor VIII Inhibitors ‐ Twenty Years' ‘Bonn Protocol’

J. Oldenburg, R. Schwaab, H. Brackmann, 1996, Vox sanguinis.

Characterization of mutations within the factor VIII gene of 73 unrelated mild and moderate haemophiliacs

J. Oldenburg, R. Schwaab, K. Olek, 1995, British journal of haematology.

NovoSeven® in immune tolerance therapy

J. Oldenburg, R. Schwaab, H. Brackmann, 2000, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Factor VIII gene mutations found by a comparative study of SSCP, DGGE and CMC and their analysis on a molecular model of factor VIII protein

J. Oldenburg, K. Michaelides, R. Schwaab, 1997, Human Genetics.

Haemophilia A: from mutation analysis to new therapies

J. Oldenburg, M. Spannagl, R. Schwaab, 2005, Nature Reviews Genetics.

Allelic Discrimination of Factor V Leiden Using a 5’ Nuclease Assay

R. Schwaab, P. Hanfland, D. Happich, 1999, Thrombosis and Haemostasis.

Analysis of mRNA in hemophilia A patients with undetectable mutations reveals normal splicing in the factor VIII gene

J. Oldenburg, O. el-Maarri, A. Terzić, 2005, Journal of thrombosis and haemostasis : JTH.

Immune tolerance induction: a role for recombinant activated factor VII (rFVIIa)?

J. Oldenburg, R. Schwaab, H. Brackmann, 1998, European journal of haematology. Supplementum.

Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994.

P. Reitsma, R. Schwaab, G. Brownlee, 1994, Nucleic acids research.

The B-cell epitope of the monoclonal anti-factor VIII antibody ESH8 characterized by peptide array analysis

J. Oldenburg, R. Schwaab, T. Albert, 2008, Thrombosis and Haemostasis.

Long Term Optimisation of F8 Gene Mutation Screening by DHPLC

E. Seifried, H. Singer, J. Oldenburg, 2005 .

Evaluation of Denaturing High Performance Liquid Chromatography (DHPLC) in the Analysis of Hemophilia A

J. Oldenburg, O. el-Maarri, S. Rost, 2002 .

Genotype-Phenotype Correlation in Hemophilia A

J. Oldenburg, R. Schwaab, W. Schramm, 2001 .

Identification of a single nucleotide C-to-T transition and five different deletions in patients with severe hemophilia B.

R. Schwaab, H. Brackmann, K. Olek, 1989, American journal of human genetics.

A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor.

J. Vermylen, L. Vander Elst, K. Thielemans, 2000, Blood.

Point mutations scattered in the FVIII C1 and C2 domains reduce FVIII binding to vWF and are associated to mild/moderate hemophilia A

R. Schwaab, J. Vermylen, K. Peerlinck, 1999 .

Factor VIII intron‐1 inversion: frequency and inhibitor prevalence

J. Oldenburg, O. el-Maarri, R. Schwaab, 2006, Journal of thrombosis and haemostasis : JTH.

HLA Genotype of Patients with Severe Haemophilia A due to Intron 22 Inversion with and without Inhibitors of Factor VIII

J. Oldenburg, R. Schwaab, E. Tuddenham, 1997, Thrombosis and Haemostasis.

Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene

K. Michaelides, R. Schwaab, E. Tuddenham, 1994, British journal of haematology.

Inhibitor development and mortality in non‐severe hemophilia A

J. Bom, R. Schwaab, A. Tagliaferri, 2015, Journal of thrombosis and haemostasis : JTH.

Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition.

E G Tuddenham, S. Bidichandani, J. Gitschier, 1994, Nucleic acids research.

Haemophilia B: database of point mutations and short additions and deletions, 7th edition

M. Goossens, P. M. Green, S. S. Sommer, 1990, Nucleic Acids Res..

Haemophilia B: database of point mutations and short additions and deletions--eighth edition

M. Goossens, F. Giannelli, P. M. Green, 1998, Nucleic Acids Res..

[Significance of mutation analysis in patients with haemophilia A].

E. Seifried, J. Oldenburg, R. Schwaab, 2003, Hamostaseologie.

Recombinant expression of mutations causing von Willebrand disease type Normandy: characterization of a combined defect of factor VIII binding and multimerization

J. Oldenburg, R. Schwaab, H. Lenk, 2004, Thrombosis and Haemostasis.

Experiences with recombinant factor VIII products: development of inhibitors and immune tolerance therapy.

H. Ehrlich, J. Oldenburg, R. Schwaab, 1998, Annals of hematology.

Significance of F8 missense mutations with respect to inhibitor formation

J. Oldenburg, A. Pavlova, R. Schwaab, 2013, Thrombosis and Haemostasis.

Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition.

E G Tuddenham, S. Antonarakis, D. Cooper, 1994, Nucleic acids research.

Small deletion/insertion mutations within poly-A runs of the factor VIII gene mitigate the severe haemophilia A phenotype.

J. Oldenburg, R. Schwaab, H. Brackmann, 1998, Thrombosis and haemostasis.

Risk factors for inhibitor development in hemophilia A.

J. Oldenburg, R. Schwaab, H. Brackmann, 2000, Haematologica.

Analysis of expression kinetics and activity of a new B-domain truncated and full-length FVIII protein in three different cell lines

J. Oldenburg, W. Poller, R. Schwaab, 1999, Annals of Hematology.

Haemophilia B (sixth edition): a database of point mutations and short additions and deletions

M. Goossens, F. Giannelli, P. M. Green, 1996, Nucleic Acids Res..

Molecular defects in hemophilia A: identification and characterization of mutations in the factor VIII gene and family analysis.

R. Schwaab, H. Brackmann, K. Olek, 1989, Blood.

Haemophilia A: Carrier detection by DNA analysis

J. Oldenburg, R. Schwaab, H. Brackmann, 1988, Blut.

De novo factor VIII gene intron 22 inversion in a female carrier presents as a somatic mosaicism.

J. Oldenburg, O. el-Maarri, S. Rost, 2000, Blood.

Direct and indirect estimation of the sex ratio of mutation frequencies in hemophilia A.

K. Zerres, J. Oldenburg, R. Schwaab, 1993, American journal of human genetics.

Direct andIndirect Estimation oftheSexRatioofMutation Frequencies inHemophilia A

K. Zerres, J. Oldenburg, R. Schwaab, 1993 .

Gene therapy for hemophilia

K. Ponder, R. Schwaab, T. Albert, 2002, Current opinion in hematology.

Inhibitor development in mild and moderate hemophilia A seems to be associated with an increased mortality risk

J. Astermark, P. Kamphuisen, J. Bom, 2011 .

[Characterization of factor VIII antibody epitopes from haemophilia A patients using cellulose bound FVIII peptide libraries].

J. Oldenburg, R. Schwaab, W. Schramm, 2003, Hamostaseologie.

Lack of F8 mRNA: a novel mechanism leading to hemophilia A.

T. Haaf, H. Singer, J. Oldenburg, 2006, Blood.

Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci

R. Fimmers, T. Wienker, T. Becker, 2011, Human molecular genetics.

A G+3-to-T donor splice site mutation leads to skipping of exon 50 in von Willebrand factor mRNA.

R. Schwaab, H. Brackmann, K. Olek, 1994, Genomics.

Methylation at Global LINE-1 Repeats in Human Blood Are Affected by Gender but Not by Age or Natural Hormone Cycles

T. Wienker, N. Nüsgen, H. Singer, 2011, PloS one.

Correction: Methylation at Global LINE-1 Repeats in Human Blood Are Affected by Gender but Not by Age or Natural Hormone Cycles

N. Nüsgen, H. Singer, J. Oldenburg, 2015, PloS one.

Measurements of DNA Methylation at Seven Loci in Various Tissues of CD1 Mice

N. Nüsgen, J. Oldenburg, O. el-Maarri, 2012, PloS one.

A novel tetracycline-controlled transactivator–transrepressor system enables external control of oncolytic adenovirus replication

H. Fechner, W. Hillen, H. Scherübl, 2003, Gene Therapy.

Mutations in haemophilia A

J. Oldenburg, R. Schwaab, H. Brackmann, 1993, British journal of haematology.

11 novel Mutations in the Factor VIII encoding Gene lead to severe or moderate Hemophilia A

N. Klopp, J. Oldenburg, R. Schwaab, 2003 .

Congenital Deficiency of Vitamin K Dependent Coagulation Factors in Two Families Presents as a Genetic Defect of the Vitamin K-Epoxide-Reductase-Complex

L. Schurgers, J. Oldenburg, A. Fregin, 2000, Thrombosis and Haemostasis.

Adenovirus-mediated regulatable Expression of human Factor IX in vitro and in vivo

Xiaomin Wang, H. Fechner, J. Oldenburg, 2003 .

Response to DDAVP in mild/moderate haemophilia A patients according to the underlying Factor VIII genotype

J. Oldenburg, T. Lambert, B. Guillet, 2003 .

ΔC in Exon 18 of the von Willebrand Gene Is Uncommon in German vWD Type III Patients

R. Schwaab, H. Brackmann, K. Olek, 1993, Thrombosis and Haemostasis.

Missense Mutations at ALA-10 in the Factor IX Propeptide: A Novel Mechanism for Severe Bleeding During Oral Anticoagulant Therapy

J. Oldenburg, W. Kress, A. Fregin, 1998 .

[The national GTH haemophilia registry as database within the scope of the German human genome project].

J. Oldenburg, R. Schwaab, W. Schramm, 2003, Hamostaseologie.

Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition.

S. Bidichandani, J. Gitschier, R. Schwaab, 1994, Nucleic acids research.

Application of the TaqMan-PCR for Genotyping of the Prothrombi G20210A Mutation and of the Thermolabile Methylenetetrahydrofolate Reductase Mutation

R. Schwaab, P. Hanfland, B. Pötzsch, 2000, Thrombosis and Haemostasis.

Kinetic parameters of monoclonal antibodies ESH2, ESH4, ESH5, and ESH8 on coagulation factor VIII and their influence on factor VIII activity

J. Oldenburg, R. Schwaab, T. Albert, 2009, Journal of molecular recognition : JMR.

Abstract

J. Oldenburg, B. Guillet, A. Rafowicz, 2003 .

Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host.

U. Liebert, W. Poller, R. Schwaab, 1996, Gene therapy.

Small Deletion/Insertion Mutations within Poly-A Runs of the Factor VIII Gene Mitigate the Severe Haemophilia A Phenotype

J. Oldenburg, R. Schwaab, H. Brackmann, 1998, Thrombosis and Haemostasis.

cofactor activity and binding to von Willebrand factor A human antibody directed to the factor VIII C1 domain inhibits factor VIII

J. Vermylen, K. Thielemans, R. Schwaab, 2013 .

Localization and Characterization of Mutations Within the Factor VIII Gene in a Cohort of 212 Patients with Hemophilia A

J. Oldenburg, S. Rost, R. Schwaab, 2001 .

Mutation and Inhibitor Incidence in a Defined Cohort of Severely Affected Haemophilia A Patients Born After 1977

J. Oldenburg, F. Schakowski, S. Rost, 2000 .

Corrigendum: The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRS (Nucleic Acids Research (1996) 24 (100-102))

S. Antonarakis, H. Kazazian, A. Wacey, 1996 .

The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRS

Stylianos E. Antonarakis, Rainer Schwaab, Adam I. Wacey, 1996, Nucleic Acids Res..

Haemophilia B: database of point mutations and short additions and deletions.

P. Reitsma, K. High, R. Schwaab, 1990, Nucleic acids research.

Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene.

D. Cooper, J. Gitschier, R. Schwaab, 1991, Nucleic acids research.

Haemophilia A: database of ncleotide substituttions, deletions, insertions and rearrangements of the factor VIII gene

S. Antonarakis, D. Cooper, H. Kazazian, 1991 .

as a somatic mosaicism De novo factor VIII gene intron 22 inversion in a female carrier presents

J. Oldenburg, O. el-Maarri, S. Rost, 2013 .

Efficient factor VIII affinity purification using a small synthetic ligand

J. Oldenburg, H. Kessler, R. Schwaab, 2008, Journal of thrombosis and haemostasis : JTH.

Modified expression of coagulation factor VIII by addition of a glycosylation site at the N terminus of the protein

J. Oldenburg, R. Schwaab, T. Albert, 2008, Annals of Hematology.

Haemophilia B: database of point mutations and short additions and deletions--fourth edition, 1993

M. Goossens, F. Giannelli, P. M. Green, 1993, Nucleic Acids Res..

Identical point mutations in the factor VIII gene that have different clinical manifestations of hemophilia A.

J. Oldenburg, R. Schwaab, H. Brackmann, 1990, American journal of human genetics.