I. Okazaki

发表

Lung Adenocarcinoma in Never Smokers: Problems of Primary Prevention from Aspects of Susceptible Genes and Carcinogens.

Y. Sohara, I. Okazaki, S. Ishikawa, 2016, Anticancer research.

Difference in gene expression for matrix metalloproteinase‐1 between early and advanced hepatocellular carcinomas

Y. Otani, N. Wada, K. Kameyama, 1997, Hepatology.

Emerging insights into Transforming growth factor β Smad signal in hepatic fibrogenesis

Y. Inagaki, I. Okazaki, 2007, Gut.

Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis.

Y. Inagaki, H. Inoue, Y. Sugioka, 2008, Life sciences.

Collagenase activity in experimental hepatic fibrosis

I. Okazaki, K. Maruyama, 1974, Nature.

Mammalian collagenase increases in early alcoholic liver disease and decreases with cirrhosis.

C. Lieber, I. Okazaki, L. Feinman, 1982, Life sciences.

Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.

Y. Inagaki, J. Itoh, I. Okazaki, 2008, Gastroenterology.

Statistical follow-up studies on146 cases of liver cirrhosis

I. Okazaki, M. Tsuchiya, K. Maruyama, 1974, Gastroenterologia Japonica.

Ten year survival rate of 131 patients with liver cirrhosis excluded the association of liver carcinoma at the establishment of diagnosis

I. Okazaki, M. Tsuchiya, K. Funatsu, 2007, Gastroenterologia Japonica.

Serum concentrations of basement membrane proteins in NIDDM as a prognostic marker for nephropathy.

I. Okazaki, Y. Atsumi, K. Matsuoka, 1995, Diabetes research and clinical practice.

Serum type III procollagen peptide: indicator for pulmonary fibrosis: II. Application in 80 asbestos insulation workers.

R. Lilis, I. Okazaki, Y. Suzuki, 1987, American journal of industrial medicine.

Serum type III procollagen peptide: indicator for pulmonary fibrosis. I. A tool for early detection of pulmonary fibrosis as a complication in cancer therapy.

I. Okazaki, K. Maruyama, K. Miura, 1986, The Keio journal of medicine.

Detection of individual over-smoking using conventional laboratory tests.

Y. Inagaki, T. Kinoue, Tetsu Watanabe, 2006, The Tokai journal of experimental and clinical medicine.

Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis

Y. Inagaki, I. Okazaki, Wataru Ando, 2017, Clinical and molecular hepatology.

Assays of serum laminin and type III procollagen peptide for monitoring the clinical course of diabetic microangiopathy.

I. Okazaki, K. Matsuoka, K. Maruyama, 1988, Diabetes research and clinical practice.

Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.

Y. Inagaki, K. Ikeda, George Bou-Gharios, 2009, Gastroenterology.

ALDH1 and SALL4 Expression in Cell Block Samples from Patients with Lung Adenocarcinoma and Malignant Pleural Effusion

H. Tomita, Y. Hatano, A. Hara, 2021, Diagnostics.

MNM_A_252991 1..13

Y. Inagaki, S. Shibata, I. Okazaki, 2020 .

Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers

Y. Otani, M. Kitajima, K. Kameyama, 1994, Journal of Gastroenterology.

Expression of Interstitial Collagenase (Matrix Metalloproteinase‐1) in Gastric Cancers

T. Kubota, Y. Otani, K. Kumai, 1997, Japanese journal of cancer research : Gann.

Interferon alfa down‐regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice

H. Yamauchi, B. de Crombrugghe, Y. Inagaki, 2003, Hepatology.

Bone marrow–derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice

H. Okano, Y. Matsuzaki, Y. Inagaki, 2007, Hepatology.

Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat.

I. Okazaki, M. Arai, A. Okada, 2001, Journal of hepatology.

Hepatic progenitor cell expansion in early-stage nonalcoholic steatohepatitis: evidence from immunohistochemistry and immunoelectron microscopy of matrix metalloproteinase-1

Y. Inagaki, I. Okazaki, Wataru Ando, 2017, Medical Molecular Morphology.

Spatiotemporal expression of matrix metalloproteinase-1 in progression of nonalcoholic steatohepatitis

Y. Inagaki, I. Okazaki, Wataru Ando, 2016 .

Wound healing of acetic acid-induced gastric ulcer in rats and the effects of cimetidine and calcitonin, with special reference to prolylhydroxylase and collagenase enzyme activity

I. Okazaki, M. Arai, I. Kurose, 1995, Journal of Gastroenterology.

All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPβ-LIP

T. Matsuura, Tetsu Watanabe, Tetsuro Suzuki, 2006 .

Stem Cells Expressing Matrix Metalloproteinase-13 mRNA Appear during Regression Reversal of Hepatic Cirrhosis

H. Okano, Y. Sugioka, Tetsu Watanabe, 2003 .

Iron increases collagenase production by rabbit synovial fibroblasts.

C. Brinckerhoff, P. Sinclair, I. Okazaki, 1981, The Journal of laboratory and clinical medicine.

Direct measurement of neutral collagenase activity in homogenates from baboon and human liver.

C. Lieber, I. Okazaki, L. Feinman, 1981, Biochimica et biophysica acta.

Aortitis Syndrome associated with Ulcerative Colitis

H. Asakura, I. Okazaki, Kyoichi Hiramatsu, 1976, Vascular surgery.

Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs)

Y. Inagaki, I. Okazaki, Hajime Kuroda, 2014, Cancers.

The role of lymphatic system in intestinal absorption (III) clinical and basic studies of reevaluation ofl31I-Triolein test

H. Asakura, I. Okazaki, M. Tsuchiya, 1968, Gastroenterologia Japonica.

Pathology of Alcoholic Liver Disease with Special Emphasis on Alcoholic Hepatitis

H. Ishii, I. Okazaki, M. Tsuchiya, 1985 .

Acute hepatitis in an adult with acquired rubella infection

I. Okazaki, M. Arai, T. Nomiyama, 1995, Journal of Gastroenterology.

Genes associated with succeptibility to lung adenocarcinoma among never smokers suggest the mechanism of disease.

Y. Sohara, I. Okazaki, S. Ishikawa, 2014, Anticancer research.

Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.

Y. Sugioka, Tetsu Watanabe, I. Okazaki, 2003, Metabolism: clinical and experimental.

c‐jun NH2‐terminal kinase pathway is involved in constitutive matrix metalloproteinase‐1 expression in a hepatocellular carcinoma‐derived cell line

Y. Inagaki, Y. Sugioka, Tetsu Watanabe, 2004, International journal of cancer.

Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats

R. Ala-aho, V. Kähäri, J. Itoh, 2011, Pathobiology.

Novel breast cancer screening: combined expression of miR-21 and MMP-1 in urinary exosomes detects 95% of breast cancer without metastasis

Y. Kohgo, I. Okazaki, S. Ishikawa, 2019, Scientific Reports.

Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice.

H. Kiyama, K. Namikawa, Y. Inagaki, 2005, Gastroenterology.

Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.

H. Yamauchi, Y. Inagaki, A. Nakao, 2003 .

Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.

K. Kameyama, I. Okazaki, M. Arai, 2000, Journal of hepatology.

New Insights into the Extracellular Matrix

T. Yonezawa, Y. Ninomiya, Tetsu Watanabe, 2003 .

Chylous Ascites Formation and a Review of 84 Cases

H. Asakura, I. Okazaki, M. Tsuchiya, 1973, Angiology.

Reversibility of Liver Fibrosis

Y. Inagaki, Y. Sugioka, Tetsu Watanabe, 2005 .

Comparative socio-cultural analysis of smoking behavior and difficulty of quitting smoking in Japan and Thailand.

Tetsu Watanabe, I. Okazaki, H. Furuya, 2004, [Nihon koshu eisei zasshi] Japanese journal of public health.

Treatment strategy for liver fibrosis through recruitment and differentiation of bone marrow stem/progenitor cells

Y. Inagaki, I. Okazaki, R. Higashiyama, 2007, Hepatology research : the official journal of the Japan Society of Hepatology.

Sequential Matrix Metalloproteinase-1 Expression Triggered by Infiltrating Monocytic Lineage Cells Modulates Pathophysiological Aspects of Human Nonalcoholic Steatohepatitis

H. Okano, Y. Inagaki, S. Shibata, 2020 .

Molecular mechanism of the reversibility of hepatic fibrosis: With special reference to the role of matrix metalloproteinases

Tetsu Watanabe, I. Okazaki, M. Arai, 2000, Journal of gastroenterology and hepatology.

Additional candidates to conventional genes susceptible for lung cancer and changing trend in Japan.

Tetsu Watanabe, I. Okazaki, S. B. Billah, 2010, Oncology reports.

Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cancer cell lines.

Y. Inagaki, Y. Sugioka, Tetsu Watanabe, 2009, International journal of oncology.

General lectures (II)

K. Kondo, Y. Sato, K. Akagi, 1973, Gastroenterologia Japonica.

Radiographic and endoscopic features of colonic ulcers in systemic lupus erythematosus.

H. Asakura, I. Okazaki, M. Tsuchiya, 1975, The American journal of gastroenterology.

Introduction: MMPs, ADAMs/ADAMTSs research products to achieve big dream.

K. Nabeshima, I. Okazaki, 2012, Anti-cancer agents in medicinal chemistry.

Endogenous urinary 3-hydroxyproline has 96% specificity and 44% sensitivity for cancer screening.

I. Okazaki, M. Tsuchiya, K. Kubochi, 1992, Journal of Laboratory and Clinical Medicine.

[Gene expression of MMPs and TIMPs in the process of hepatic fibrosis].

I. Okazaki, M. Arai, K. Maruyama, 1993, Nihon rinsho. Japanese journal of clinical medicine.

Morphogenesis of acidophilic bodies in experimental D-Galactosamine induced hepatitis

I. Okazaki, M. Tsuchiya, M. Oda, 1973, Gastroenterologia Japonica.

All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPbeta-LIP.

T. Matsuura, Tetsu Watanabe, Tetsuro Suzuki, 2006, The Biochemical journal.

Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol.

T. Muramatsu, M. Taniyama, I. Okazaki, 2000, Alcoholism, clinical and experimental research.

ELISA measurement for urinary 3-hydroxyproline-containing peptides and its preliminary application to healthy persons and cancer patients.

Y. Inagaki, Toshihiko Hayashi, Y. Imamura, 2010, Anticancer research.

Extranodal NK/T-cell lymphoma of nasal type primarily presenting with pericardial effusion

I. Okazaki, Toshihide Ito, S. Nakamura, 2006 .

Molecular Mechanisms of Matrix Metalloproteinase-1 Gene Expression in Hepatic Stellate Cells

H. Ishii, Tetsu Watanabe, I. Okazaki, 2001 .

Reversibility of hepatic fibrosis: from the first report of collagenase in the liver to the possibility of gene therapy for recovery.

I. Okazaki, M. Arai, T. Watanabe, 2001, The Keio journal of medicine.

Hepatic Fibrolysis and Hepatic Sinusoidal Cells

Tetsu Watanabe, I. Okazaki, M. Arai, 1999 .

Collagen biosynthesis in gastric cancer: Immunohistochemical analysis of prolyl 4‐hydroxylase

I. Okazaki, K. Ishibiki, K. Yoshino, 1999, Journal of surgical oncology.

Treatment Strategies for Organ Fibrosis Based on Regulation of Collagen Metabolism

Y. Inagaki, I. Okazaki, T. Nemoto, 2003 .

Reply:

Y. Inagaki, Tetsu Watanabe, I. Okazaki, 2007 .

Changes in serum levels of metalloproteinases and their inhibitors by treatment of chronic hepatitis C with interferon

I. Okazaki, N. Fujimoto, M. Arai, 2005, Digestive Diseases and Sciences.

Elevation of laminin and beta-subunit of prolyl 4-hydroxylase in the sera of human subjects with Schistosomiasis mansoni.

S. Tateno, T. Takeuchi, S. Kobayashi, 1989, The Japanese journal of experimental medicine.

Novel strategies for hepatocellular carcinoma based on MMPs science.

Y. Inagaki, I. Okazaki, 2012, Anti-cancer agents in medicinal chemistry.

A case of subacute hepatitis with reversible liver fibrosis

H. Ishii, I. Okazaki, M. Tsuchiya, 1981, Gastroenterologia Japonica.

The Splanchnic Circulation

C. Zarins, P. Vaupel, H. Hutten, 1976 .

Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.

Y. Inagaki, K. Ikeda, George Bou-Gharios, 2009, Gastroenterology.

HEPATOLOGY: MICROCIRCULATION AND PATHOGENESIS OF ALCOHOLIC LIVER INJURY Molecular mechanism of the reversibility of hepatic fibrosis: With special reference to the role of matrix metalloproteinases

Tetsu Watanabe, I. Okazaki, M. Arai, 2000 .

Collagenase production by rabbit liver cells in monolayer culture.

I. Okazaki, M. Tsuchiya, K. Maruyama, 1983, The Journal of laboratory and clinical medicine.

Formation and degradation of basement membrane collagen.

I. Okazaki, T. Takagi, K. Maruyama, 1991, Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

Different appearance of hepatic collagenase and lysosomal enzymes in recovery of experimental hepatic fibrosis.

I. Okazaki, M. Tsuchiya, K. Maruyama, 1978, Biochemistry and experimental biology.