M. Hernandez-Fuentes

发表

Reduced TCR Signaling Contributes to Impaired Th17 Responses in Tolerant Kidney Transplant Recipients

R. Lechler, S. John, D. Boardman, 2018, Transplantation.

Reduced TCR-signalling contributes to impaired Th17 responses in tolerant kidney transplant recipients

E. Nova-Lamperti, M. Hernandez-Fuentes, 2017 .

Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients

Graham M Lord, R. Lechler, G. Lombardi, 2017, Transplantation.

CD40 and reduced BCR signalling leads to higher IL-10 production in B-cells from tolerant kidney transplant patients.

Graham M Lord, R. Lechler, G. Lombardi, 2016 .

Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

Graham M Lord, R. Lechler, P. Mark, 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft

R. Houlgatte, G. Ramstein, K. Newell, 2015, Kidney international.

Biomarkers of tolerance

M. Hernandez-Fuentes, R. Gökmen, 2013, Current opinion in organ transplantation.

Non-invasive biomarkers to guide management following renal transplantation: the need for a multiplatform approach

M. Hernandez-Fuentes, P. Chowdhury, 2013, Current opinion in organ transplantation.

Biomarkers of Tolerance in Transplantation: Hope or hype?

M. Hernandez-Fuentes, R. Hilton, 2010 .

Multiparameter Immune Profiling of Operational Tolerance in Liver Transplantation

M. Ramoni, I. Bilbao, C. Margarit, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Integration of Lyoplate Based Flow Cytometry and Computational Analysis for Standardized Immunological Biomarker Discovery

Graham M Lord, N. Aghaeepour, V. Maino, 2013, PloS one.

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

E. Ballestar, J. Wojcik, Javier Martín, 2020, Arthritis & rheumatology.

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

E. Ballestar, J. Wojcik, R. Mejías, 2020, Arthritis & rheumatology.

Everolimus and Basiliximab Permit Suppression by Human CD4+CD25+ Cells in vitro

R. Lechler, M. Hernandez-Fuentes, D. Game, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population

Graham M Lord, W. Guan, A. Israni, 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Circulating Vascular Progenitor Cells in Patients With Type 1 Diabetes and Microalbuminuria

N. Dattani, L. Gnudi, G. Viberti, 2010, Diabetes Care.

Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy1

R. Lechler, M. Hernandez-Fuentes, A. Chaudhry, 2001, The Journal of Immunology.

An Analysis of Lymphocyte Phenotype After Steroid Avoidance With Either Alemtuzumab or Basiliximab Induction in Renal Transplantation

A. Cherukuri, A. Salama, M. Hernandez-Fuentes, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection.

R. Lechler, M. Hernandez-Fuentes, I. Rebollo-Mesa, 2015, Kidney international.

The genetic determinants of renal allograft rejection

Graham M Lord, M. Weale, G. Cavalleri, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The alloresponse.

R. Lechler, M. Hernandez-Fuentes, R. Baker, 1999, Reviews in immunogenetics.

Accurate apoptosis measurement requires quantification of loss of expression of surface antigens and cell fragmentation

A. Órfão, M. Hernandez-Fuentes, A. De La Hera, 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Loss of lineage antigens is a common feature of apoptotic lymphocytes

A. Órfão, M. Hernandez-Fuentes, M. Álvarez-Mon, 2004, Journal of leukocyte biology.

Chronic graft loss. Immunological and non-immunological factors.

R. Lechler, M. Hernandez-Fuentes, Maria P Hernandez-Fuentes, 2005, Contributions to nephrology.

Relative Resistance of Human CD4+ Memory T Cells to Suppression by CD4+CD25+ Regulatory T Cells

Graham M Lord, R. Lechler, S. John, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses

A. ten Brinke, M. Hernandez-Fuentes, E. Martínez-Cáceres, 2017, Front. Immunol..

Immunologic monitoring

R. Lechler, M. Hernandez-Fuentes, A. Warrens, 2003, Immunological reviews.

Dependency of the Trans Vivo Delayed Type Hypersensitivity Response on the Action of Regulatory T Cells: Implications for Monitoring Transplant Tolerance

K. Wood, S. Chapman, M. Hernandez-Fuentes, 2006, Transplantation.

Implications for the Pathogenesis of Chronic Alloresponses in Renal Allograft Recipients: Loss of Direct and Maintenance of Indirect

M. Hernandez-Fuentes, R. Baker, A. Chaudhry, 2013 .

In vitro assays for immune monitoring in transplantation.

A. Salama, M. Hernandez-Fuentes, 2006, Methods in molecular biology.

THE ROLE OF THE ALLOGRAFT IN THE INDUCTION OF DONOR-SPECIFIC T CELL HYPORESPONSIVENESS

M. Hernandez-Fuentes, R. Baker, A. Chaudhry, 2001, Transplantation.

The role of T-cell anergy in the maintenance of donor-specific hyporesponsiveness in renal transplant recipients.

R. Lechler, M. Hernandez-Fuentes, R. Baker, 2001, Transplantation proceedings.

A low blood lymphocyte count is associated with an expansion of activated cytotoxic lymphocytes in patients with B‐cell chronic lymphocytic leukaemia

M. Hernandez-Fuentes, J. García‐Suárez, Alfredo Prieto Martín, 1997, European journal of haematology.

Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases

M. Alarcón‐Riquelme, M. González-Gay, N. Barbarroja, 2022, Arthritis & Rheumatology.

IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses

Graham M Lord, G. Lombardi, E. Nova-Lamperti, 2016, Scientific Reports.

Immunologic human renal allograft injury associates with an altered IL-10/TNF-α expression ratio in regulatory B cells.

A. Cherukuri, A. Salama, D. Rothstein, 2014, Journal of the American Society of Nephrology : JASN.

Clinical operational tolerance after kidney transplantation: a short literature review.

G. Orlando, M. Hernandez-Fuentes, F. Pisani, 2008, Transplantation proceedings.

A new method for the simultaneous analysis of growth and death of immunophenotypically defined cells in culture.

A. Órfão, M. Hernandez-Fuentes, A. De La Hera, 2000, Cytometry.

Allorecognition and the alloresponse: clinical implications.

R. Lechler, M. Hernandez-Fuentes, B. Afzali, 2007, Tissue antigens.

Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients

E. Coto, A. Aransay, J. Lozano, 2021, Frontiers in Immunology.

Standardization procedure for flow cytometry data harmonization in prospective multicenter studies

M. González-Gay, N. Barbarroja, J. Pers, 2020, Scientific Reports.

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

James A. Hutchinson, A. Scheffold, J. Bluestone, 2020, The Lancet.

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

Graham M Lord, D. Ståhl, T. Strom, 2019, EBioMedicine.

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

Graham M Lord, J. Sanderson, S. Yagel, 2015, Gut.

Cross‐Validation of IFN‐γ Elispot Assay for Measuring Alloreactive Memory/Effector T Cell Responses in Renal Transplant Recipients

D. Roelen, F. Claas, H. Volk, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Long‐ and short‐term outcomes in renal allografts with deceased donors: A large recipient and donor genome‐wide association study

Sarah A. Gagliano, Graham M Lord, M. Weale, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Long-and short-term outcomes in renal allografts with deceased donors : A

Sarah A. Gagliano, Graham M Lord, M. Weale, 2018 .

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.

Graham M Lord, G. Lombardi, C. Scottà, 2012, Blood.

Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejection.

M. Yacoub, R. Lechler, G. Lombardi, 2000, Circulation.

A 'biomarker signature' for tolerance in transplantation

R. Lechler, M. Hernandez-Fuentes, 2010, Nature Reviews Nephrology.

Identification of a B cell signature associated with renal transplant tolerance in humans.

M. Suthanthiran, A. Kirk, R. Lechler, 2010, The Journal of clinical investigation.

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.

Graham M Lord, R. Lechler, B. Gerstmayer, 2010, The Journal of clinical investigation.

Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

M. Roncarolo, A. Ambrosi, F. Ciceri, 2013, Front. Immunol..

Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation

S. Christakoudi, Manohursingh Runglall, P. Mobillo, 2018, Molecular and Cellular Endocrinology.

Graft dysfunction in chronic antibody-mediated rejection correlates with B-cell–dependent indirect antidonor alloresponses and autocrine regulation of interferon-γ production by Th1 cells

R. Lechler, H. Wilkinson, M. Hernandez-Fuentes, 2017, Kidney international.

Establishing the optimal method to estimate the frequencies of alloreactive CD4+ T cells.

R. Lechler, M. Hernandez-Fuentes, O. Barroso-Herrera, 2002, Transplantation proceedings.

Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy

Graham M Lord, D. Ståhl, R. Lechler, 2020, EBioMedicine.

CD4+CD25+ regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients.

R. Lechler, M. Hernandez-Fuentes, D. Game, 2003, Journal of the American Society of Nephrology : JASN.

Genetic loci influencing kidney function and chronic kidney disease

Mark N. Wass, Graham M Lord, P. Elliott, 2010, Nature Genetics.

Genome-Wide Sequencing of Cellular microRNAs Identifies a Combinatorial Expression Signature Diagnostic of Sepsis

Graham M Lord, R. Beale, D. Persing, 2013, PloS one.

Analysis of the peripheral T‐cell repertoire in kidney transplant patients

R. Lechler, H. Volk, M. Goldman, 2010, European journal of immunology.

Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature

E. Ballestar, N. Barbarroja, M. Martínez-Bueno, 2021, Scientific Reports.

Genome-Wide Regulatory Analysis Reveals That T-bet Controls Th17 Lineage Differentiation through Direct Suppression of IRF4

Graham M Lord, Richard G. Jenner, Aditi Kanhere, 2013, The Journal of Immunology.

IRF4Differentiation through Direct Suppression of That T-bet Controls Th17 Lineage Genome-Wide Regulatory Analysis Reveals

Graham M Lord, Richard G. Jenner, Aditi Kanhere, 2013 .

Tolerant T cells display impaired trafficking ability

R. Lechler, P. Tan, D. Scott, 2005, European journal of immunology.

Reversibility with interleukin-2 suggests that T cell anergy contributes to donor-specific hyporesponsiveness in renal transplant patients.

R. Lechler, W. Ng, M. Hernandez-Fuentes, 2002, Journal of the American Society of Nephrology : JASN.

Differential Role of Naïve and Memory CD4+ T‐Cell Subsets in Primary Alloresponses

R. Lechler, M. Hernandez-Fuentes, M. Buckland, 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Retrospective tissue typing of the kidney donor from recipient urine.

R. Lechler, M. Hernandez-Fuentes, A. Warrens, 2008, Kidney international.

Strategy to achieve biomarker-driven immunosuppression after solid organ transplantation by an academic-industry partnership within the European BIO-DrIM consortium

F. Bemelman, H. Volk, P. Reinke, 2016, Advances in Precision Medicine.

Incidence, Risk Factors, and Effect on Allograft Survival of Glomerulonephritis Post-transplantation in a United Kingdom Population: Cohort Study

Graham M Lord, M. Clatworthy, C. Bunce, 2022, Frontiers in Nephrology.

Lack of adjustment for confounding could lead to misleading conclusions

S. Christakoudi, M. Hernandez-Fuentes, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Assessment of the immunological contribution to Chronic Allograft Nephropathy

R. Lechler, M. Hernandez-Fuentes, R. Baker, 2000 .

Biomarkers of tolerance: searching for the hidden phenotype

P. Sagoo, M. Hernandez-Fuentes, I. Rebollo-Mesa, 2011, Kidney international supplements.

Biomarkers of tolerance: searching for the hidden

P. Sagoo, M. Hernandez-Fuentes, I. Rebollo-Mesa, 2011 .

Promoting transplantation tolerance; adoptive regulatory T cell therapy

R. Lechler, G. Lombardi, M. Hernandez-Fuentes, 2013, Clinical and experimental immunology.

Donor‐Specific Indirect Pathway Analysis Reveals a B‐Cell‐Independent Signature which Reflects Outcomes in Kidney Transplant Recipients

V. Seyfert-Margolis, K. Newell, M. Hernandez-Fuentes, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.