K. Chien

发表

Control of the negative IRES trans-acting factor KHSRP by ubiquitination

Chuan-Tien Hung, Yu-An Kung, S. Shih, 2016, Nucleic acids research.

FunctionAnnotator, a versatile and efficient web tool for non-model organism annotation

Timothy H. Wu, Ruei-chi R. Gan, C. Chiu, 2017, Scientific Reports.

Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins.

K. Chien, Wen‐guey Wu, Ting-Shou Chen, 2005, Biochemistry.

Fusion of sphingomyelin vesicles induced by proteins from Taiwan cobra (Naja naja atra) venom. Interactions of zwitterionic phospholipids with cardiotoxin analogues.

K. Chien, W. Wu, W. N. Huang, 1991, The Journal of biological chemistry.

Low-molecular-mass secretome profiling identifies HMGA2 and MIF as prognostic biomarkers for oral cavity squamous cell carcinoma

Ying Liang, Kai-Ping Chang, Yu-Tsun Lin, 2015, Scientific Reports.

Enhanced Interferon Signaling Pathway in Oral Cancer Revealed by Quantitative Proteome Analysis of Microdissected Specimens Using 16O/18O Labeling and Integrated Two-dimensional LC-ESI-MALDI Tandem MS*

Ying Liang, Yuan-Ming Yeh, Kai-Ping Chang, 2009, Molecular & Cellular Proteomics.

The Hsp90-Dependent Proteome Is Conserved and Enriched for Hub Proteins with High Levels of Protein–Protein Connectivity

Krishna B S Swamy, Jau-Song Yu, S. C. Schuyler, 2014, Genome biology and evolution.

Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology.

Ying Liang, Kai-Ping Chang, Chun-Ta Liao, 2011, Journal of proteome research.

Site-specific separation and detection of phosphopeptide isomers with pH-mediated stacking capillary electrophoresis-electrospray ionization-tandem mass spectrometry.

Jau-Song Yu, K. Chien, Jeng-Ting Chen, 2013, Journal of separation science.

LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration

K. Chien, Yu-Hung Lin, Y. Zhen, 2017, Molecular biology of the cell.

Responding to a Zoonotic Emergency with Multi-omics Research: Pentatrichomonas hominis Hydrogenosomal Protein Characterization with Use of RNA Sequencing and Proteomics.

C. Chiu, Po-Jung Huang, Kuo-Yang Huang, 2016, Omics : a journal of integrative biology.

Dephosphorylation of Nucleophosmin by PP1β Facilitates pRB Binding and Consequent E2F1-dependent DNA Repair

Hsuan Liu, B. Tan, K. Chien, 2010, Molecular biology of the cell.

Influence of peptide conformation on oligosaccharide binding characteristics—a study using apamin-based chimeric peptide

P. Lyu, G. Jayaraman, Cheng-Wei Wu, 2003, Peptides.

Super-SILAC mix coupled with SIM/AIMS assays for targeted verification of phosphopeptides discovered in a large-scale phosphoproteome analysis of hepatocellular carcinoma.

Chia-Chun Wu, Yu-Tsun Lin, Jau-Song Yu, 2017, Journal of proteomics.

Identification of secretory gelsolin as a plasma biomarker associated with distant organ metastasis of colorectal cancer

Ying Liang, M. Tsai, Yung-Chin Hsiao, 2011, Journal of Molecular Medicine.

Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Can Accurately Differentiate between Mycobacterium masilliense (M. abscessus subspecies bolletti) and M. abscessus (Sensu Stricto)

Meng-Rui Lee, P. Hsueh, L. Teng, 2013, Journal of Clinical Microbiology.

Cobra venom proteome and glycome determined from individual snakes of Naja atra reveal medically important dynamic range and systematic geographic variation.

W. Sung, Sheng‐yu Huang, K. Chien, 2015, Journal of proteomics.

“Pseudo-pseudogenes” in bacterial genomes: Proteogenomics reveals a wide but low protein expression of pseudogenes in Salmonella enterica

C. Chiu, Hsiu-Ling Chen, K. Chien, 2022, Nucleic acids research.

Low Serum Fetuin-A as a Biomarker to Predict Pneumococcal Necrotizing Pneumonia and Hemolytic Uremic Syndrome in Children

C. Chiu, K. Chien, Hao-Yuan Lee, 2016, Medicine.

Golgi-SNARE GS 28 potentiates cisplatin-induced apoptosis by forming GS 28 – MDM 2 – p 53 complexes and by preventing the ubiquitination and degradation of p 53

C. Chao, N. Sun, K. Chien, 2012 .

Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53.

C. Chao, N. Sun, K. Chien, 2012, The Biochemical journal.

Oral cancer plasma tumor marker identified with bead-based affinity-fractionated proteomic technology.

Chun-Ta Liao, Hung-Ming Wang, C. Liao, 2005, Clinical chemistry.

Binding of a de novo designed peptide to specific glycosaminoglycans

P. Lyu, C. Wu, G. Jayaraman, 2000, FEBS letters.

Photofrin binds to procaspase-3 and mediates photodynamic treatment-triggered methionine oxidation and inactivation of procaspase-3

P. Lyu, K. Chien, L. Chi, 2012, Cell Death and Disease.

Assessment of candidate biomarkers in paired saliva and plasma samples from oral cancer patients by targeted mass spectrometry.

Kai-Ping Chang, Chia-Yu Yang, Yung-Chin Hsiao, 2020, Journal of proteomics.

Quantitative Proteomics Reveals Regulation of Karyopherin Subunit Alpha-2 (KPNA2) and Its Potential Novel Cargo Proteins in Nonsmall Cell Lung Cancer *□S

Yu-Sun Chang, Jau-Song Yu, K. Chien, 2012 .

Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein

C. Chiu, Chung-Yung Chen, Tzong-Yuan Wu, 2015, Journal of Virology.

Metabolic Reprogramming of Host Cells in Response to Enteroviral Infection

Ch Lai, H. Ho, M. Cheng, 2020, Cells.

Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation.

Zchong‐Zcho Wu, C. Chao, N. Sun, 2011, Biochemical pharmacology.

Hyperinvasiveness of Salmonella enterica serovar Choleraesuis linked to hyperexpression of type III secretion systems in vitro

C. Chiu, K. Chien, Yi-Hsin Wang, 2016, Scientific Reports.

Heparin Binding Stabilizes the Membrane-bound Form of Cobra Cardiotoxin*

Kuan-Ming Chen, K. Chien, S. Sue, 2002, The Journal of Biological Chemistry.

Two distinct types of cardiotoxin as revealed by the structure and activity relationship of their interaction with zwitterionic phospholipid dispersions.

Y. Hseu, K. Chien, W. Wu, 1994, The Journal of biological chemistry.

Comparison of Protein Variation in Protobothrops mucrosquamatus Venom between Northern and Southeast Taiwan and Association with Human Envenoming Effects

K. Chien, Liao-Chun Chiang, Y. Mao, 2022, Toxins.

The kinases Mst 1 and Mst 2 positively regulate phagocyte ROS induction and bactericidal activity

Jiahuai Han, Hongtan Wu, Shihao Zhang, 2016 .

Quantitative Proteomics Reveals Regulation of Karyopherin Subunit Alpha-2 (KPNA2) and Its Potential Novel Cargo Proteins in Nonsmall Cell Lung Cancer *

Yu-Sun Chang, Jau-Song Yu, K. Chien, 2012, Molecular & Cellular Proteomics.

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Qiao Wu, S. Zhang, K. Chien, 2017, Nature Communications.

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Qinxi Li, Jiawei Wu, Qinxi Li, 2012, Science.

Comparative and targeted proteomic analyses of urinary microparticles from bladder cancer and hernia patients.

P. Chang, Yu-Sun Chang, Jau-Song Yu, 2012, Journal of proteome research.

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation.

Qiao Wu, K. Chien, Xiang Chen, 2018, Molecular cell.

Identification of a new in vivo phosphorylation site in the cytoplasmic carboxyl terminus of EBV-LMP1 by tandem mass spectrometry.

Jau-Song Yu, Yu-Sun Chang, K. Chien, 2006, Biochemical and biophysical research communications.

Enteroviral 2B Interacts with VDAC3 to Regulate Reactive Oxygen Species Generation That Is Essential to Viral Replication

Ch Lai, H. Ho, M. Cheng, 2022, Viruses.

Cancer cell‐secreted proteomes as a basis for searching potential tumor markers: Nasopharyngeal carcinoma as a model

Kai-Ping Chang, S. Hao, N. Tsang, 2005, Proteomics.

Integrative Omics Analysis Reveals Soluble Cadherin-3 as a Survival Predictor and an Early Monitoring Marker of EGFR Tyrosine Kinase Inhibitor Therapy in Lung Cancer

G. Chang, Jau-Song Yu, K. Chien, 2020, Clinical Cancer Research.

Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression.

A. Cowin, K. Chien, Hang-zi Chen, 2018, Cancer research.

FunctionAnnotator, a versatile and efficient web tool for non-model organism annotation

Timothy H. Wu, Ruei-chi R. Gan, C. Chiu, 2017, Scientific Reports.

The kinases Mst1 and Mst2 positively regulate phagocyte ROS induction and bactericidal activity

Jiahuai Han, Hongtan Wu, Shihao Zhang, 2015, Nature Immunology.

Targeted proteomics pipeline reveals potential biomarkers for the diagnosis of metastatic lung cancer in pleural effusion.

Yu-Sun Chang, Jau-Song Yu, K. Chien, 2014, Journal of proteome research.

Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma.

Ying Liang, M. Tsai, Kai-Ping Chang, 2013, Journal of proteomics.

Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics.

Yu-Sun Chang, Jau-Song Yu, K. Chien, 2013, Journal of proteomics.

Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance

Ying Liang, Kwang-Huei Lin, K. Chien, 2007, Proteomics.

Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase.

C. Tung, M. Cheng, Yu-Tsun Lin, 2018, Cell reports.

Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma

Ying Liang, Kai-Ping Chang, Yu-Sun Chang, 2013, Cancer.

Separation and Determination of Low Abundant Flavonoids in Scutellaria Baicalensis Georgi by Micellar Electrokinetic Capillary Electrophoresis

Jau-Song Yu, K. Chien, Y. Leu, 2009 .

Oxidation of protein-bound methionine in Photofrin-photodynamic therapy-treated human tumor cells explored by methionine-containing peptide enrichment and quantitative proteomics approach

Jau-Song Yu, Chia-Chun Wu, Jau-Song Yu, 2017, Scientific Reports.

Structural Basis of Membrane-induced Cardiotoxin A3 Oligomerization*

C. Hsiao, F. Forouhar, K. Chien, 2003, Journal of Biological Chemistry.

Size-exclusion chromatography using reverse-phase columns for protein separation.

K. Chien, L. Chi, Tung-Yung Huang, 2018, Journal of chromatography. A.

SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network

Bi-Chang Chen, Jau-Song Yu, Yu-Tsun Lin, 2020, Journal of Cell Science.

The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness

A. Cheng, Yun-Shien Lee, Guo-Rung You, 2018, Scientific Reports.

Marine prebiotics mediate decolonization of Pseudomonas aeruginosa from gut by inhibiting secreted virulence factor interactions with mucins and enriching Bacteroides population

Yuan-Ming Yeh, Yuan-chuan Lee, K. Chien, 2023, Journal of Biomedical Science.

Pseudogene recoding revealed from proteomic analysis of salmonella serovars.

C. Chiu, Hsiu-Ling Chen, K. Chien, 2012, Journal of proteome research.

GSK‐3 mediates the okadaic acid‐induced modification of collapsin response mediator protein‐2 in human SK‐N‐SH neuroblastoma cells

Jau-Song Yu, W. Chan, K. Chien, 2008, Journal of cellular biochemistry.

Conformational change and inactivation of membrane phospholipid-related activity of cardiotoxin V from Taiwan cobra venom at acidic pH.

P. Ho, K. Chien, W. Wu, 1996, Biochemistry.

Solution structure of cardiotoxin V from Naja naja atra.

A. Singhal, K. Chien, W. Wu, 1993, Biochemistry.

An immuno-MALDI mass spectrometry assay for the oral cancer biomarker, matrix metalloproteinase-1, in dried saliva spot samples.

Kai-Ping Chang, Yung-Chin Hsiao, Chia-Chun Wu, 2020, Analytica chimica acta.

Development of a Multiplexed Assay for Oral Cancer Candidate Biomarkers Using Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry*

Kai-Ping Chang, Yung-Chin Hsiao, Chia-Chun Wu, 2017, Molecular & Cellular Proteomics.

Oxidation of protein-bound methionine in Photofrin-photodynamic therapy-treated human tumor cells explored by methionine-containing peptide enrichment and quantitative proteomics approach

Jau-Song Yu, Chia-Chun Wu, K. Chien, 2017, Scientific Reports.

Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication.

J. Horng, Mei-Ling Li, Peng-Nien Huang, 2008, The Journal of general virology.

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

Jiahuai Han, Jiawei Wu, Sheng-Cai Lin, 2012, Autophagy.

Identification of the lamin A/C phosphoepitope recognized by the antibody P-STM in mitotic HeLa S3 cells

Jau-Song Yu, K. Chien, Jeng-Ting Chen, 2013, BMC Biochemistry.

Identification of secretory gelsolin as a plasma biomarker associated with distant organ metastasis of colorectal cancer

Ying Liang, M. Tsai, Yung-Chin Hsiao, 2012, Journal of Molecular Medicine.

Variability Assessment of 90 Salivary Proteins in Intraday and Interday Samples from Healthy Donors by Multiple Reaction Monitoring‐Mass Spectrometry

Yung-Chin Hsiao, Yu-Sun Chang, Jau-Song Yu, 2018, Proteomics. Clinical applications.

Dopamine transporter is downregulated and its association with chaperone protein Hsc70 is enhanced by activation of dopamine D3 receptor

K. Chien, Jin-Chung Chen, Pi-Kai Chang, 2020, Brain Research Bulletin.

Rapid enrichment of phosphopeptides and phosphoproteins from complex samples using magnetic particles coated with alumina as the concentrating probes for MALDI MS analysis.

Jau-Song Yu, Yu-Chie Chen, K. Chien, 2007, Journal of proteome research.

Development of a Multiplexed Assay for Oral Cancer Candidate Biomarkers Using Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry*

Kai-Ping Chang, Yung-Chin Hsiao, Chia-Chun Wu, 2017, Molecular & Cellular Proteomics.