J. Floros

发表

Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution.

S. Kimball, Guirong Wang, Xiaoxuan Guo, 2009, American journal of physiology. Lung cellular and molecular physiology.

High-throughput DNA methylation profiling using universal bead arrays.

Wei Jiang, Jian-Bing Fan, M. Chee, 2006, Genome research.

An alternatively spliced surfactant protein B mRNA in normal human lung: disease implication.

J. Floros, Z. Lin, G. Wang, 1999, The Biochemical journal.

Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants.

Zhenwu Lin, P. Silveyra, J. Floros, 2015, American journal of physiology. Lung cellular and molecular physiology.

Human SPA genetic variants and bleomycin-induced cytokine production by THP-1 cells : effect of ozone-induced SPA oxidation

Guirong Wang, J. Floros, Weixiong Huang, 2004 .

Human SP-A genetic variants and bleomycin-induced cytokine production by THP-1 cells: effect of ozone-induced SP-A oxidation.

Guirong Wang, J. Floros, Weixiong Huang, 2004, American journal of physiology. Lung cellular and molecular physiology.

Combined SP-A-bleomycin effect on cytokines by THP-1 cells: impact of surfactant lipids on this effect.

Guirong Wang, J. Floros, Weixiong Huang, 2002, American journal of physiology. Lung cellular and molecular physiology.

Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis

Zhenwu Lin, A. Estrada, M. Selman, 2003, Human Genetics.

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

Rongling Wu, Zhenwu Lin, R. Wu, 2017, World journal of gastroenterology.

Glucose decreases steady state mRNA content of hydrophobic surfactant proteins B and C in fetal rat lung explants.

J. Floros, I. Gewolb, H. H. Rayani, 1999, Experimental lung research.

DNA methylation markers of surfactant proteins in lung cancer.

Jian-Bing Fan, T. Goldmann, E. Vollmer, 2007, International journal of oncology.

Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury.

P. Silveyra, J. Floros, 2012, Frontiers in bioscience.

An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture.

S. Diangelo, P. Silveyra, J. Floros, 2014, American journal of physiology. Lung cellular and molecular physiology.

SP-A1 and SP-A2 variants differentially enhance association of Pseudomonas aeruginosa with rat alveolar macrophages.

J. Floros, Weixiong Huang, D. Phelps, 2005, American journal of physiology. Lung cellular and molecular physiology.

SP-A 1 and SPA 2 variants differentially enhance association of Pseudomonas aeruginosa with rat alveolar macrophages

J. Floros, Weixiong Huang, D. Phelps, 2004 .

Glucocorticoid inhibition of human SP-A1 promoter activity in NCI-H441 cells.

J. Floros, R. Hoover, K. H. Thomas, 1999, The Biochemical journal.

The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome

W. Freeman, J. Floros, R. Haque, 2009, Proteome Science.

Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants.

Guirong Wang, Xiaoxuan Guo, J. Floros, 2008, American journal of physiology. Lung cellular and molecular physiology.

Surfactant protein (SP) B associations and interactions with SP‐A in white and black subjects with respiratory distress syndrome

S. Diangelo, R. Fan, Xiaoxuan Guo, 2001, Pediatrics international : official journal of the Japan Pediatric Society.

Donor Surfactant Protein D (SP‐D) Polymorphisms Are Associated With Lung Transplant Outcome

S. Diangelo, F. D'Ovidio, J. Floros, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives.

J. Brody, A. Rishi, J. Floros, 1995, Developmental biology.

Characterization of ts13 cells a temperature-sensitive mutant of the G1 phase of the cell cycle.

R. Baserga, T. Ashihara, J. Floros, 1978, Cell biology international reports.

37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)

G. Auzinger, D. Pavelescu, M. Dickinson, 2017, Critical Care.

Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants

J. Floros, N. Tsotakos, 2021, Frontiers in Immunology.

Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population.

M. Selman, A. Pardo, S. Diangelo, 2000, The Journal of infectious diseases.

Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome.

J. Floros, D. Phelps, T. Umstead, 2014, Journal of proteomics.

In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement

C. Yengo, J. Floros, D. Phelps, 2011, Proteome Science.

Cyclic Changes in the Level of the Innate Immune Molecule, Surfactant Protein‐A, and Cytokines in Vaginal Fluid

G. E. Sousa, K. Ahn, J. Weisz, 2012, American journal of reproductive immunology.

Major Effect of Oxidative Stress on the Male, but Not Female, SP-A1 Type II Cell miRNome

J. Floros, N. Thorenoor, D. Phelps, 2019, Frontiers in Immunology.

Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis

M. Selman, A. Pardo, J. Floros, 2022, Frontiers in Immunology.

Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response.

J. López-Barneo, A. Pascual, J. Pérez-Gil, 2014, Journal of proteomics.

Impact of sex and ozone exposure on the course of pneumonia in wild type and SP-A (-/-) mice.

Guirong Wang, J. Floros, D. Phelps, 2012, Microbial pathogenesis.

Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae - infected mice under different exposure conditions.

T. Cooper, Guirong Wang, J. Floros, 2011, International Journal of Physiology, Pathophysiology and Pharmacology.

Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children

J. Floros, N. Thomas, A. S. Pimentel, 2022, Frontiers in Immunology.

Differentiation of xenografted human fetal lung parenchyma.

J. Weisz, R. Myers, P. Welsh, 2008, Early human development.

Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure

Guirong Wang, J. Floros, D. Phelps, 2019, Front. Immunol..

Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein.

R. Kriz, J. Floros, H. Taeusch, 1986, The Journal of biological chemistry.

Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure.

P. Silveyra, J. Floros, F. Bhatti, 2013, American journal of physiology. Lung cellular and molecular physiology.

Proline hydroxylation alters the electrophoretic mobility of pulmonary surfactant‐associated protein A

J. Floros, D. Phelps, 1988, Electrophoresis.

Humanized SFTPA1 and SFTPA2 Transgenic Mice Reveal Functional Divergence of SP-A1 and SP-A2

S. Diangelo, Guirong Wang, Xiaoxuan Guo, 2010, The Journal of Biological Chemistry.

Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function.

Guirong Wang, J. Floros, A. Mikerov, 2009, Critical reviews in eukaryotic gene expression.

Surfactant Protein A2 (SP-A2) Variants Expressed in CHO Cells Stimulate Phagocytosis of Pseudomonas aeruginosa More than Do SP-A1 Variants

Guirong Wang, J. Floros, N. Thomas, 2007, Infection and Immunity.

Differential effects of human SP-A1 and SP-A2 variants on phospholipid monolayers containing surfactant protein B.

Guirong Wang, J. Floros, K. Keough, 2007, Biochimica et biophysica acta.

Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health.

Guirong Wang, J. Floros, M. Kavuru, 2007, American journal of physiology. Lung cellular and molecular physiology.

The 35 kd pulmonary surfactant-associated protein is encoded on chromosome 10

S. Latt, G. Veldman, J. Floros, 1987, Human Genetics.

Structural analysis and lipid-binding properties of recombinant human surfactant protein a derived from one or both genes.

C. Casals, J. Floros, G. Wang, 2002, Biochemistry.

Both human SP-A1 and Sp-A2 genes are expressed in small and large intestine.

M. J. Page, Zhenwu Lin, W. Koltun, 2001, Pediatric pathology & molecular medicine.

Both Human SP-A1 and SP-A2 Genes are Expressed in Small and Large Intestine

Zhenwu Lin, W. Koltun, J. Floros, 2001 .

Human surfactant protein A (SP-A) variants: why so many, why such a complexity?

J. Floros, 2001, Swiss medical weekly.

Human SPA protein variants derived from one or both genes stimulate TNF-a production in the THP-1 cell line

Guirong Wang, J. Floros, D. Phelps, 2000 .

Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line.

Guirong Wang, J. Floros, G. Wang, 2000, American journal of physiology. Lung cellular and molecular physiology.

Human SP-A: genotype and single-strand conformation polymorphism analysis.

P. Rogan, J. Floros, L. Križková, 1994, The American journal of physiology.

Conservation analysis of rat and human SP-A gene identifies 5' flanking sequences of rat SP-A that bind rat lung nuclear proteins.

A. Rishi, D. Kouretas, J. Floros, 1993, Experimental lung research.

The utility of postmortem lung for RNA studies; variability and correlation of the expression of surfactant proteins in human lung.

H. Harding, J. Floros, J. Longmate, 1991, Experimental lung research.

Initiation of Fetal Rat Lung Phospholipid and Surfactant-Associated Protein A mRNA Synthesis

J. Floros, I. Gross, Christine M. Wilson, 1989, Pediatric Research.

Postnatal stimulation of rat surfactant protein A synthesis by dexamethasone.

H. Harding, J. Floros, J. Ware, 1989, The American journal of physiology.

Expression of the 35kDa and low molecular weight surfactant-associated proteins in the lungs of infants dying with respiratory distress syndrome.

J. Floros, D. Demello, D. Lagunoff, 1989, The American journal of pathology.

Increases in the 35kDa surfactant‐associated protein and its mRNA following in vivo dexamethasone treatment of fetal and neonatal rats

J. Floros, S. Kourembanas, H. Taeusch, 1987 .

Effect of low doses of lipopolysaccharide prior to ozone exposure on bronchoalveolar lavage: Differences between wild type and surfactant protein A-deficient mice.

K. Ahn, J. Floros, R. Haque, 2009, Pneumon.

Oral Administration of Surfactant Protein-A Reduces Pathology in an Experimental Model of Necrotizing Enterocolitis

J. M. Rhoads, J. Floros, F. McCormack, 2015, Journal of pediatric gastroenterology and nutrition.

Regularity of distribution of immunoreactive pulmonary surfactant protein A in rat tissues.

J. Floros, H. Zhou, G. Wang, 2004, International journal of molecular medicine.

Surfactant Protein B Intron 4 Variation in German Patients with COPD and Acute Respiratory Failure

P. von Wichert, J. Floros, C. Seifart, 2002, Disease markers.

Effect of ozone exposure and infection on bronchoalveolar lavage: sex differences in response patterns.

Guirong Wang, J. Floros, R. Haque, 2014, Toxicology letters.

Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population.

M. Rämet, M. Hallman, J. Floros, 2000, American journal of human genetics.

SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation

N. Christensen, S. Diangelo, P. Silveyra, 2015, PloS one.

Surfactant Protein B in Human Fetal Lung: Developmental and Glucocorticoid Regulation

Ning Yue, H. Shuman, J. Floros, 1995, Pediatric Research.

Localization of pulmonary surfactant proteins using immunohistochemistry and tissue in situ hybridization.

J. Floros, D. Phelps, 1991, Experimental lung research.

Aberrant SP‐B mRNA in lung tissue of patients with congenital alveolar proteinosis (CAP)

Zhenwu Lin, S. Diangelo, J. Batanian, 2000, Clinical genetics.

Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs

S. Diangelo, F. D'Ovidio, J. Floros, 2019, The Journal of thoracic and cardiovascular surgery.

Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival

J. Floros, N. Thorenoor, D. Phelps, 2018, Front. Immunol..

Pilot Study Exploring Lung Allograft Surfactant Protein A (SP‐A) Expression in Association With Lung Transplant Outcome

S. Keshavjee, M. Mura, F. D'Ovidio, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells

K. Hartshorn, M. White, Guirong Wang, 2007, Medical Microbiology and Immunology.

Modulatory effects of ozone on THP-1 cells in response to SP-A stimulation.

B. Janic, J. Floros, D. Phelps, 2005, American journal of physiology. Lung cellular and molecular physiology.

Differences in N-linked glycosylation between human surfactant protein-B variants of the C or T allele at the single-nucleotide polymorphism at position 1580: implications for disease.

N. Christensen, S. Guttentag, B. Wigdahl, 2003, The Biochemical journal.

The effect of ozone exposure on the ability of human surfactant protein a variants to stimulate cytokine production.

Guirong Wang, J. Floros, D. Phelps, 2001, Environmental health perspectives.

Novel, Non-Radioactive, Simple and Multiplex PCR-cRFLP Methods for Genotyping Human SP-A and SP-D Marker Alleles

Zhenwu Lin, S. Diangelo, Guirong Wang, 2002, Disease markers.

SP-A 3'-UTR is involved in the glucocorticoid inhibition of human SP-A gene expression.

J. Floros, R. Hoover, 1999, American journal of physiology. Lung cellular and molecular physiology.

An SP-B gene mutation responsible for SP-B deficiency in fatal congenital alveolar proteinosis: evidence for a mutation hotspot in exon 4.

J. Floros, Z. Lin, D. Demello, 1998, Molecular genetics and metabolism.

Characterization of markers flanking the human SP-B locus.

M. Koptides, D. Kouretas, S. Diangelo, 1997, Disease markers.

Effect of genotype on the levels of surfactant protein A mRNA and on the SP-A2 splice variants in adult humans.

J. Floros, A. Karinch, D. Demello, 1997, The Biochemical journal.

Dinucleotide repeats in the human surfactant protein-B gene and respiratory-distress syndrome.

S. Buchter, J. Floros, A. Karinch, 1995, The Biochemical journal.

Mapping the human pulmonary surfactant-associated protein B gene (SFTP3) to chromosome 2p12-->p11.2.

W. Modi, J. Floros, N. Vamvakopoulos, 1995, Cytogenetics and cell genetics.

Surfactant Protein A (SP-A)1 And SP-A2 Differentially Affect F-Actin Levels in The Alveolar Macrophage

J. Floros, 2021, American Journal of Biomedical Science & Research.

The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0)

J. Floros, N. Thorenoor, 2022, Frontiers in Immunology.

Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1

V. Chinchilli, J. Weisz, J. Floros, 2020, Biomarker research.

Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1

V. Chinchilli, J. Weisz, J. Floros, 2019, Biomarker Research.

Protocol for genomic DNA preparation from fresh or frozen serum for PCR amplification.

J. Floros, Z. Lin, 2000, BioTechniques.

Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A

J. Floros, D. Phelps, A. Abbasi, 2021, Antioxidants.

Surfactant protein A is defective in abrogating inflammation in asthma.

D. Voelker, M. Kraft, J. Wright, 2011, American journal of physiology. Lung cellular and molecular physiology.

Polymorphisms of surfactant protein gene A, B, D, and of SP-B-linked microsatellite markers in COPD of a Mexican population.

M. Selman, A. Pardo, S. Diangelo, 2000, Chest.

Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species.

J. Floros, D. Demello, D. Hatzis, 1994, Experimental lung research.

Differences in biochemical properties and in biological function between human SP-A1 and SP-A2 variants, and the impact of ozone-induced oxidation.

Guirong Wang, J. Floros, D. Phelps, 2004, Biochemistry.

Family-Based Association Tests Suggest Linkage Between Surfactant Protein B (SP-B) (and Flanking Region) and Respiratory Distress Syndrome (RDS): SP-B Haplotypes and Alleles From SP-B–Linked Loci Are Risk Factors for RDS

S. Diangelo, R. Fan, Xiaoxuan Guo, 2006, Pediatric Research.

An in vitro cell model system for the study of the effects of ozone and other gaseous agents on phagocytic cells.

B. Janic, J. Floros, D. Phelps, 2003, Journal of immunological methods.

Localization of surfactant protein synthesis in human lung by in situ hybridization.

J. Floros, D. Phelps, 1988, The American review of respiratory disease.

Surfactant-associated proteins in tracheal aspirates of infants with respiratory distress syndrome after surfactant therapy.

J. Floros, R. Soll, H. Taeusch, 1988, The American review of respiratory disease.

Donor surfactant protein A2 polymorphism and lung transplant survival

S. Diangelo, F. D'Ovidio, J. Floros, 2019, European Respiratory Journal.

Two‐Dimensional gel electrophoresis of dexamethasoneinduced organ‐specific developmental proteins (fsa,fsb) in rat lung fibroblasts

Barry T. Smith, J. Floros, D. Phelps, 1985 .

Differences in the Alveolar Macrophage Proteome in Transgenic Mice Expressing Human SP-A1 and SP-A2

Guirong Wang, J. Floros, D. Phelps, 2013 .

Differences in the alveolar macrophage proteome in transgenic mice expressing human SP-A1 and SP-A2.

Guirong Wang, P. Silveyra, J. Floros, 2013, Journal of proteomics and genomics research.

From birds to humans: new concepts on airways relative to alveolar surfactant.

W. Bernhard, J. Floros, P. Haslam, 2004, American journal of respiratory cell and molecular biology.

Imaging NAD(H) Redox Alterations in Cryopreserved Alveolar Macrophages from Ozone-Exposed Mice and the Impact of Nutrient Starvation during Long Lag Times

He N. Xu, J. Floros, Lin Z. Li, 2021, Antioxidants.

Sex and SP-A2 Dependent NAD(H) Redox Alterations in Mouse Alveolar Macrophages in Response to Ozone Exposure: Potential Implications for COVID-19

He N. Xu, Zhenwu Lin, J. Floros, 2020, Antioxidants.

Dihydrotestosterone blocks fetal lung fibroblast-pneumonocyte factor at a pretranslational level.

J. Torday, J. Floros, H. Nielsen, 1987, The Journal of biological chemistry.

Inhibition of lung maturation by monoclonal antibodies against fibroblast–pneumonocyte factor

Barry T. Smith, M. Post, J. Floros, 1984, Nature.

Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice

W. Freeman, J. Floros, Mehboob Ali, 2010, Proteome Science.

Researchin the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice

W. Freeman, J. Floros, Mehboob Ali, 2010 .

Single-cell analysis reveals differential regulation of the alveolar macrophage actin cytoskeleton by surfactant proteins A1 and A2: implications of sex and aging

C. Yengo, V. Chinchilli, J. Floros, 2016, Biology of Sex Differences.

Effect of Cys 85 on biochemical properties and biological function of human SP-A variants

Guirong Wang, J. Floros, A. Mikerov, 2008 .

Induction of cell DNA replication in G1-specific ts mutants by microinjection of SV40 DNA.

N. Galanti, R. Baserga, J. Floros, 1981, Experimental cell research.

Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein.

J. Dougherty, R. Kriz, J. Floros, 1987, The Journal of biological chemistry.

Association of the haem oxygenase-1 gene with inflammatory bowel disease.

He N. Xu, R. Wu, Han Hao, 2017, Swiss medical weekly.

Steel factor affects SCL expression during normal erythroid differentiation.

J. Cheung, C. Begley, D. Wojchowski, 1994, Blood.

Rare SP‐A alleles and the SP‐A1‐6A4 allele associate with risk for lung carcinoma

P von Wichert, S. Diangelo, U. Seifart, 2005, Clinical genetics.

SP-A 3'-UTR is involved in the glucocorticoid inhibition of human SP-A gene expression.

J. Floros, R. Hoover, 1999, The American journal of physiology.

Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line.

M. Koptides, J. Floros, D. Phelps, 1997, The American journal of physiology.

5' splicing and allelic variants of the human pulmonary surfactant protein A genes.

J. Floros, A. Karinch, 1995, American journal of respiratory cell and molecular biology.

Genetic Variants of Surfactant Proteins A, B, C, and D in Bronchopulmonary Dysplasia

S. Diangelo, R. Fan, J. Floros, 2007, Disease markers.

Immunogold localization of SP-A in lungs of infants dying from respiratory distress syndrome.

J. Floros, D. Demello, D. Phelps, 1993, The American journal of pathology.

Sixty years of surfactant research.

J. Floros, 1990, The American journal of physiology.

Preparation of transcriptionally active nuclear extracts from mammalian tissues.

M. Koptides, K. Stuempfle, J. Floros, 1996, BioTechniques.

Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions

J. Floros, N. Thorenoor, N. Tsotakos, 2021, Frontiers in Immunology.

Penn State Hershey--center for pediatric cardiovascular research.

Kyung Sun, Kerem Pekkan, Ronald Wilson, 2009, Artificial Organs.

Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films.

J. Pérez-Gil, J. Floros, E. Lopez-Rodriguez, 2016, Biophysical journal.

Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid

Zhenwu Lin, J. Weisz, J. Floros, 2004, Immunology.

Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group.

Arthur S Slutsky, M. Leppert, E. Hoffman, 2003, American journal of respiratory and critical care medicine.

Biosynthesis and in vitro translation of the major surfactant-associated protein from human lung.

J. Floros, H. Taeusch, D. Phelps, 1985, The Journal of biological chemistry.

Hormonal effects on the surfactant protein B (SP-B) mRNA in cultured fetal rat lung.

C. Wilson, J. Floros, I. Gross, 1991, American journal of respiratory cell and molecular biology.

Dexamethasone in vivo raises surfactant protein B mRNA in alveolar and bronchiolar epithelium.

J. Floros, D. Phelps, 1991, The American journal of physiology.

Identification of an SV40 DNA sequence related to the reactivation of silent rRNA genes in human > mouse hybrid cells

N. Galanti, R. Baserga, J. Floros, 1981 .

Characterization and biological activity of cloned simian virus 40 DNA fragments.

L. Kaczmarek, S. Weissman, N. Galanti, 1981, The Journal of biological chemistry.

Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.

Todd M Umstead, Lino Tessarollo, Kunio Nagashima, 2013, Cell reports.

Differences in the translation efficiency and mRNA stability mediated by 5'-UTR splice variants of human SP-A1 and SP-A2 genes.

Guirong Wang, Xiaoxuan Guo, J. Floros, 2005, American journal of physiology. Lung cellular and molecular physiology.

Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues.

Zhenwu Lin, J. Floros, 2002, Physiological genomics.

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

J. Floros, N. Thorenoor, D. Phelps, 2017, Biology of Sex Differences.

IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants

Zhenwu Lin, D. Gordon, G. Worthen, 2012, Pediatric Research.

Surfactant protein C: hormonal control of SP-C mRNA levels in vitro.

J. Floros, I. Gross, S. Veletza, 1992, The American journal of physiology.

Characterizing a Focused Landscape of Familial Acute Respiratory Distress Syndrome

Inimary T. Toby, S. Diangelo, N. Thomas, 2019, Biomarkers and Applications.

Dexamethasone Enhances Surfactant Protein Gene Expression in Streptozotocin-Induced Immature Rat Lungs

J. Floros, J. Warshaw, H. H. Rayani, 1995, Pediatric Research.

Delayed hydrophobic surfactant protein (SP-B, SP-C) expression in fetuses of streptozotocin-treated rats.

S. Guttentag, J. Floros, J. Warshaw, 1992, American journal of respiratory cell and molecular biology.

Regulation of surfactant protein A mRNA by hormones and butyrate in cultured fetal rat lung.

C. Wilson, J. Floros, I. Gross, 1990, The American journal of physiology.

DNA methylation profile and expression of surfactant protein A2 gene in lung cancer

S. Diangelo, P. Silveyra, J. Floros, 2015, Experimental lung research.

A Pilot Proteomic Study of Vestibular Fluid From Patients With Vulvodynia

J. Weisz, J. Floros, Debra A. Shearer, 2022, Journal of lower genital tract disease.

Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A

J. Floros, D. Phelps, T. Umstead, 2012, Proteome Science.

Congenital alveolar proteinosis caused by a novel mutation of the surfactant protein B gene and misalignment of lung vessels in consanguineous kindred infants

K. Müller, C. Roll, J. Floros, 1999, European Journal of Pediatrics.

Polymorphisms of human SP‐A, SP‐B, and SP‐D genes: association of SP‐B Thr131Ile with ARDS

V. Chinchilli, S. Pietschmann, J. Floros, 2000, Clinical genetics.

Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing.

Anamika Singh, M. Raval, S. Diangelo, 2013, Journal of molecular biochemistry.

Molecular basis for a pulmonary mesenchymal-epithelial interaction.

M. Post, J. Floros, B. Smith, 1986, Progress in clinical and biological research.

Air pollution and epigenetics: effects on SP-A and innate host defence in the lung.

P. Silveyra, J. Floros, 2012, Swiss medical weekly.

Genetic Variants and Monoallelic Expression of Surfactant Protein‐D in Inflammatory Bowel Disease

Zhenwu Lin, J. Hegarty, W. Koltun, 2011, Annals of human genetics.

Deletions within a CA-repeat-rich region of intron 4 of the human SP-B gene affect mRNA splicing.

Zhenwu Lin, Xiaoxuan Guo, J. Floros, 2005, The Biochemical journal.

Expression and cDNA sequence of helix destabilizing protein (HDP) in rat lung.

J. Floros, H. H. Rayani, J. Wert, 1998, Experimental lung research.

Factors affecting SP-A-mediated phagocytosis in human monocytic cell lines.

J. Floros, Jianqiang Ding, D. Phelps, 2004, Respiratory medicine.

Genomic DNA extraction from small amounts of sera to be used for genotype analysis.

J. Floros, Z. Lin, 1998, BioTechniques.

Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review).

J. Floros, M. Vaid, 2009, Oncology reports.

Characterization of bovine surfactant for infants with respiratory distress syndrome.

R. Slavin, J. Floros, M. Avery, 1986, Pediatrics.

Study of human SP-A, SP-B and SP-D loci: allele frequencies, linkage disequilibrium and heterozygosity in different races and ethnic groups

J. Floros, Wenlei Liu, C. Bentley, 2003, BMC Genetics.

Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure.

P. Silveyra, J. Floros, F. Bhatti, 2013, American journal of physiology. Lung cellular and molecular physiology.

Childhood asthma: causes, risks, and protective factors; a role of innate immunity.

J. Floros, Georgios T. Noutsios, 2014, Swiss medical weekly.

Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene.

Guirong Wang, P. Silveyra, J. Floros, 2010, American journal of physiology. Lung cellular and molecular physiology.

Surfactant protein genetics in community-acquired pneumonia: balancing the host inflammatory state

J. Floros, N. Thomas, 2011, Critical care.

Stimulated DNA synthesis in frog nuclei by cytoplasmic extracts of temperature-sensitive mammalian cells.

R. Baserga, J. Floros, H. Chang, 1978, Science.

The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 Infection

D. Kouretas, J. Floros, N. Goutzourelas, 2020, Antioxidants.

SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children

Shouhao Zhou, N. Yehya, Chenqi Fu, 2022, Frontiers in Genetics.

SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population

Shouhao Zhou, M. Selman, A. Pardo, 2021, Frontiers in Medicine.

Association of SNP–SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure

R. Wu, N. Yehya, S. Diangelo, 2020, Journal of clinical medicine.

Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis

R. Wu, Meixia Ye, Zhenwu Lin, 2018, Front. Immunol..

Surfactant Protein A and B Genetic Variants and Respiratory Distress Syndrome: Allele Interactions

R. Fan, J. Floros, 2001, Neonatology.

Family‐based transmission disequilibrium test (TDT) and case–control association studies reveal surfactant protein A (SP‐A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences

M. Rämet, S. Diangelo, R. Fan, 2001, Clinical genetics.

Association of Pulmonary Surfactant Protein A (SP-A) Gene and Respiratory Distress Syndrome: Interaction with SP-B

T. T. Have, J. Floros, M. Dunn, 1998, Pediatric Research.

Surfactant proteins: molecular genetics of neonatal pulmonary diseases.

J. Floros, P. Kala, 1998, Annual review of physiology.

Racial differences in allelic distribution at the human pulmonary surfactant protein B gene locus (SP-B).

T. Tenhave, P. Rogan, J. Floros, 1996, Experimental lung research.

Genetics of the hydrophilic surfactant proteins A and D.

J. Floros, R. Hoover, 1998, Biochimica et biophysica acta.

Human SP-A: then and now.

J. Floros, A. Karinch, 1995, The American journal of physiology.

Surfactant protein gene A, B, and D marker alleles in chronic obstructive pulmonary disease of a Mexican population.

M. Selman, A. Pardo, S. Diangelo, 2001, The European respiratory journal.

Human SP-A locus: allele frequencies and linkage disequilibrium between the two surfactant protein A genes.

K. Watterberg, P. Rogan, M. Koptides, 1996, American journal of respiratory cell and molecular biology.

An allelic variant of the 6A gene for human surfactant protein A.

A. Rishi, J. Floros, D. Hatzis, 1992, The American journal of physiology.

Single Nucleotide Polymorphisms Interactions of the Surfactant Protein Genes Associated With Respiratory Distress Syndrome Susceptibility in Preterm Infants

Meixia Ye, B. Nagourney, J. Floros, 2021, Frontiers in Pediatrics.

Transmission of Surfactant Protein Variants and Haplotypes in Children Hospitalized With Respiratory Syncytial Virus

S. Diangelo, R. Fan, J. Floros, 2009, Pediatric Research.

Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome

S. Diangelo, R. Fan, J. Floros, 2007, Acta paediatrica.

Organization of the human SP-A and SP-D loci at 10q22-q23. Physical and radiation hybrid mapping reveal gene order and orientation.

J. Floros, R. Hoover, 1998, American journal of respiratory cell and molecular biology.

A point of view: quantitative and qualitative imbalance in disease pathogenesis; pulmonary surfactant protein A genetic variants as a model.

Guirong Wang, J. Floros, G. Wang, 2001, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone.

Guirong Wang, Xiaoxuan Guo, J. Floros, 2003, American journal of physiology. Lung cellular and molecular physiology.

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

J. Floros, N. Thorenoor, D. Phelps, 2018, Respiratory Research.

Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.

Xiaoxuan Guo, J. Floros, S. Hawgood, 2007, Toxicology and applied pharmacology.

Caution is advised when cDNA expression libraries are screened by southwestern methodologies.

K. Stuempfle, J. Floros, 1997, BioTechniques.

Regulation of expression of human SP-A1 and SP-A2 genes in fetal lung explant culture.

J. Floros, P. Ballard, A. Karinch, 1998, Biochimica et biophysica acta.

Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A.

J. Floros, A. Karinch, 1995, Biochemical Journal.

The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation.

M. Raval, S. Diangelo, Guirong Wang, 2011, American journal of physiology. Lung cellular and molecular physiology.

Differential Sex-Dependent Regulation of the Alveolar Macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and Sex Differences Attenuation after 18 h of Ozone Exposure

J. Floros, N. Thorenoor, D. Phelps, 2020, Antioxidants.

Impact of Surfactant Protein-A Variants on Survival in Aged Mice in Response to Klebsiella pneumoniae Infection and Ozone: Serendipity in Action

J. Floros, N. Thorenoor, Xuesheng Zhang, 2020, Microorganisms.

Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences

Y. Kawasawa, J. Floros, N. Thorenoor, 2019, Front. Immunol..

Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: A pilot study

S. Diangelo, P. Silveyra, J. Floros, 2014, Experimental lung research.

Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.

P. Silveyra, J. Floros, 2013, Gene.

translationis an enhancer for transcription and The untranslated exon B of human surfactant protein

M. Raval, S. Diangelo, P. Silveyra, 2011 .

Pulmonary Surfactant-Update on Function, Molecular Biology and Clinical Implications

R. Spragg, J. Floros, U. Pison, 2005 .

Induction of AP-1 binding to intron 1 of SP-A1 and SP-A2 is implicated in the phorbol ester inhibition of human SP-A promoter activity.

J. Floros, J. Pavlovic, R. Hoover, 2000, Experimental lung research.

14-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA.

J. Floros, P. Ghattas, Georgios T. Noutsios, 2015, American journal of physiology. Lung cellular and molecular physiology.

Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae

Y. Kawasawa, J. Floros, N. Thorenoor, 2020, Frontiers in Immunology.

Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella Pneumoniae infection

J. Weisz, P. Silveyra, J. Floros, 2012, Experimental lung research.

Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice

J. Floros, D. Phelps, Lynnlee C. Depicolzuane, 2022, Frontiers in Pediatrics.

in rat large intestine and other tissues gene SP-D Heterogeneous allele expression of pulmonary

Zhenwu Lin, J. Floros, 2016 .

Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection

V. Chinchilli, J. Weisz, J. Floros, 2022, Frontiers in Immunology.

Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

P. Silveyra, J. Floros, N. Thomas, 2019, Front. Immunol..

Impact of Ozone, Sex, and Gonadal Hormones on Bronchoalveolar Lavage Characteristics and Survival in SP-A KO Mice Infected with Klebsiella pneumoniae

Guirong Wang, J. Floros, D. Phelps, 2020, Microorganisms.

Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences

Xiaoxuan Guo, J. Floros, R. Haque, 2008, Respiratory research.

Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection

V. Chinchilli, J. Floros, D. Phelps, 2008, Respiratory research.

The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue

V. Chinchilli, J. Weisz, J. Floros, 2022, Scientific Reports.

Differential allele expression of host defense genes, pulmonary surfactant protein-A and osteopontin, in rat.

Zhenwu Lin, J. Floros, Yunhua Wang, 2004, Molecular immunology.

Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.

V. Chinchilli, J. Weisz, J. Floros, 2020, JCI insight.

37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3)

Hester F. Lingsma, J. M. Vieira, M. Majdan, 2017, Critical Care.

Human Surfactant Proteins (SP-) A1 and SP-A2: to Include or Not in Surfactant Replacement Therapy, and If Yes, Both or Which One?

J. Floros, D. Phelps, 2014 .

Interfacial Behavior of Murine Pulmonary Surfactant Expressing Different Human Surfactant Protein SP-A Variants

J. Pérez-Gil, J. Floros, E. Lopez-Rodriguez, 2013 .

Inhibition of ozone-induced SP-A oxidation by plant polyphenols

D. Kouretas, S. Haroutounian, D. Stagos, 2007, Free radical research.

Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes.

J. Curtis, J. Floros, Bin Hu, 2004, American journal of respiratory cell and molecular biology.

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

J. Floros, N. Thorenoor, D. Phelps, 2017, Biology of Sex Differences.

Differential Expression of PGC1α in Intratumor Redox Subpopulations of Breast Cancer.

He N. Xu, Zhenwu Lin, J. Floros, 2018, Advances in experimental medicine and biology.

Sex ‐ dependent NAD(H) Redox Alteration in Alveolar Macrophages from Mice Expressing SP ‐ A2 (but not from SP ‐ A KO) in Response to Ozone Exposure: Potential Implications for COVID ‐ 19

He N. Xu, Zhenwu Lin, J. Floros, 2020 .

Post-translational modification of the major human surfactant-associated proteins.

J. Floros, H. Taeusch, D. Phelps, 1986, The Biochemical journal.

The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome

W. Freeman, J. Floros, R. Haque, 2009, Proteome Science.

Structure, function, and expression of pulmonary surfactant proteins; considerations for use in artificial surfactants. Part I. Introduction.

J. Floros, 2001, Pediatric pathology & molecular medicine.

CALL PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis 14-3-3 isoforms bind directly exon B of the 5 = -UTR of human surfactant protein A2 mRNA

J. Floros, P. Ghattas, Georgios T. Noutsios, 2015 .

Improved Method for the Construction of Cosmid Sublibraries from Yeast Artificial Chromosomes

K. Stuempfle, J. Floros, 1999 .

Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1

V. Chinchilli, J. Weisz, J. Floros, 2020, Biomarker Research.

The toll of ozone

J. Floros, D. Phelps, T. Umstead, 2011 .

37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3)

Hester F. Lingsma, J. M. Vieira, M. Majdan, 2017, Critical Care.

Surfactant protein A expression is delayed in fetuses of streptozotocin-treated rats.

S. Guttentag, J. Floros, J. Warshaw, 1992, The American journal of physiology.

Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: A pilot study

S. Diangelo, P. Silveyra, J. Floros, 2014, Experimental lung research.

Highlights of early pulmonary surfactant: Research from bench to clinic

J. Floros, Georgios T. Noutsios, 2013 .

Impact of sex and ozone exposure on the course of pneumonia in wild type and SP-A (-/-) mice.

Guirong Wang, J. Floros, D. Phelps, 2012, Microbial pathogenesis.

In Vitro Exposure of Proteins to Ozone

Guirong Wang, J. Floros, D. Phelps, 2002, Toxicology mechanisms and methods.