Kak‐Shan Shia

发表

Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting molecules

Shu-Jen Chen, S. Shih, G. Hakimelahi, 2004, Medicinal research reviews.

Development of a Cross‐Conjugated Vinylogous [4+2] Anionic Annulation and Application to the Total Synthesis of Natural Antibiotic (±)‐ABX

Kak‐Shan Shia, Jing‐Kai Huang, 2020, Angewandte Chemie.

Development of a Cross‐Conjugated Vinylogous [4+2] Anionic Annulation and Application to the Total Synthesis of Natural Antibiotic (±)‐ABX

Kak‐Shan Shia, Jing‐Kai Huang, 2020, Angewandte Chemie.

Targeting Tumor Associated Phosphatidylserine with New Zinc Dipicolylamine-Based Drug Conjugates.

C. Chen, Yu-Wei Liu, B. Gray, 2017, Bioconjugate chemistry.

Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents.

Lie-Chwen Lin, Jen‐Shin Song, J. Liao, 2015, European journal of medicinal chemistry.

Protective Effect of CXCR4 Antagonist CX807 in a Rat Model of Hemorrhagic Stroke

Jen‐Shin Song, Seong-Jin Yu, Kak‐Shan Shia, 2020, International journal of molecular sciences.

Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: a novel class of potent enterovirus inhibitors.

S. Shih, T. Hsu, Kak‐Shan Shia, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions.

Jen‐Shin Song, Wei-Jen Lin, Kak‐Shan Shia, 2016, Organic & biomolecular chemistry.

Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR‐Cas9 Activation

Mingzi M. Zhang, Shawn Hoon, Huimin Zhao, 2018, Chembiochem : a European journal of chemical biology.

A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis

Kak‐Shan Shia, M. Hung, Wenchi Hsiao, 2015, Diabetes, obesity & metabolism.

Total Synthesis of Tetarimycin A, (±)-Naphthacemycin A9, and (±)-Fasamycin A: Structure-Activity Relationship Studies against Drug-Resistant Bacteria.

Chun‐Cheng Lin, Kak‐Shan Shia, Tsai-Ling Yang Lauderdale, 2018, The Journal of organic chemistry.

Studies on Antibiotics Active against Resistant Bacteria. Total Synthesis of MRSA-Active Tetarimycin A and Its Analogues.

Kak‐Shan Shia, Tsai-Ling Yang Lauderdale, Jing‐Kai Huang, 2015, Organic letters.

General Approach to 2,3-Dibenzyl-γ-butyrolactone Lignans: Application to the Total Synthesis of (±)-5'-Methoxyyatein, (±)-5'-Methoxyclusin, and (±)-4'-Hydroxycubebinone

Hsing-Jang Liu, Kak‐Shan Shia, P. Amancha, 2010 .

Stem cell mobilizers targeting chemokine receptor CXCR4: renoprotective application in acute kidney injury.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2015, Journal of medicinal chemistry.

Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-dioxygenase inhibitors.

Yi-Hui Peng, Su-Ying Wu, Jen‐Shin Song, 2020, Journal of medicinal chemistry.

A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain

C. Chen, Jen‐Shin Song, Seong-Jin Yu, 2017, Cell transplantation.

Design, synthesis, and biological evaluation of a series of beta-lactam-based prodrugs.

A. Saboury, A. Moosavi-Movahedi, S. Hakimelahi, 2002, Bioorganic & medicinal chemistry.

Carbapenem-based prodrugs. Design, synthesis, and biological evaluation of carbapenems.

A. Saboury, A. Moosavi-Movahedi, G. Hakimelahi, 2005, European journal of medicinal chemistry.

A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment

Jen‐Shin Song, Yunching Chen, Yi-Yu Ke, 2021, Proceedings of the National Academy of Sciences.

Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.

Reed E S Harrison, Jen‐Shin Song, D. Morikis, 2019, Cell chemical biology.

Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.

H. Hsieh, Jen‐Shin Song, Yu-Wei Liu, 2015, Journal of medicinal chemistry.

Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA Agents.

Jen‐Shin Song, Jinq-chyi Lee, Yu-Wei Liu, 2016, ACS medicinal chemistry letters.

Anionic Diels–Alder Chemistry of Cyclic Sodium Dien-1-olates Delivering Highly Stereoselective and Functionalized Polycyclic Adducts

Kak‐Shan Shia, Jing‐Kai Huang, 2021, Organic letters.

Protective Effect of CXCR4 Antagonist DBPR807 against Ischemia-Reperfusion Injury in a Rat and Porcine Model of Myocardial Infarction: Potential Adjunctive Therapy for Percutaneous Coronary Intervention

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2022, International journal of molecular sciences.

Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity.

M. Pasdar, A. Moosavi-Movahedi, J. Chamani, 2003, Bioorganic & medicinal chemistry.

Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist.

Jen‐Shin Song, Chung-Shan Yu, Kak‐Shan Shia, 2019, Bioorganic & medicinal chemistry.

Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties

Jen‐Shin Song, Kak‐Shan Shia, K. K. Mong, 2021, RSC advances.

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Mingzi M. Zhang, Huimin Zhao, E. Ang, 2020, Microbial cell factories.

Manganese(III)-Catalyzed Oxidative Cyclization of Aryl 1-Cyanoalk-5-ynyl Ketone Systems: A Convenient and General Approach to Cyclopenta[b]naphthalene Derivatives

Kak‐Shan Shia, Jing‐Kai Huang, Y. Jhang, 2014 .

Palladium(0)/Copper(I)‐Catalyzed Tandem Cyclization of Aryl 1‐Cyanoalk‐5‐ynyl Ketone System: Rapid Assembly of Cyclopenta[b]naphthalene and Benzo[b]fluorene Derivatives

Kak‐Shan Shia, Y. Yeh, Tzu-Ting Kao, 2013 .

Tandem cyclization of α-cyano α-alkynyl aryl ketones induced by tert-butyl hydroperoxide and tetrabutylammonium iodide.

C. Tseng, Kak‐Shan Shia, Y. Yeh, 2012, Organic letters.

A convenient new procedure for converting primary amides into nitriles.

Kak‐Shan Shia, C. Kuo, C. Yao, 2007, Chemical communications.

A modified Robinson annulation process to α,α-disubstituted-β,γ-unsaturated cyclohexanone system. Application to the total synthesis of nanaimoal

Kak‐Shan Shia, T. Ly, Nai-Wen Tseng, 2003 .

The Total Synthesis of Retrojusticidin B, Justicidin E, and Helioxanthin.

Chun‐Cheng Lin, Kak‐Shan Shia, Tzu-Ting Kao, 2015, The Journal of organic chemistry.

Organocerium compounds in synthesis

Kak‐Shan Shia, B. Zhu, X. Shang, 1999 .

Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.

Y. Chao, Jen‐Shin Song, Kak‐Shan Shia, 2008, Journal of medicinal chemistry.

Diels-Alder chemistry of 2-diethoxyphosphinylcyclohex-2-enones. A new approach to complex phosphonates and synthetic applications of the beta-keto phosphonate system.

Kak‐Shan Shia, T. Ly, Jen-Dar Wu, 2002, Chemical communications.

An Efficient New Procedure for the One-Pot Conversion of Aldehydes into the Corresponding Nitriles

Kak‐Shan Shia, C. Kuo, Jia-Liang Zhu, 2007 .

Reductive cleavage of benzyl ethers with lithium naphthalenide. A convenient method for debenzylation

Kak‐Shan Shia, J. Yip, Hsing‐Jang Liu, 1997 .

Polyene Cyclization Promoted by the Cross Conjugated α‐Carbalkoxy Enone System. An Efficient Approach to Highly Functionalized Decalins

Kak‐Shan Shia, Daqing Sun, Hsing‐Jang Liu, 1999 .

Polyene cyclization promoted by the cross conjugated a-carbalkoxy enone system

Kak‐Shan Shia, Daqing Sun, Hsing‐Jang Liu, 1996 .

Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced o

Y. Chao, Jen‐Shin Song, T. Yeh, 2013, Journal of medicinal chemistry.

Temperature-Controlled Thiation of α-Cyano-β-Alkynyl Carbonyl Derivatives for De Novo Synthesis of 2-Aminothiophenes and Thieno[2,3- c]isothiazoles.

Kak‐Shan Shia, I. Chen, Yen‐Ku Wu, 2018, The Journal of organic chemistry.

Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors.

Chia-Liang Tai, Yen-Chun Lee, Shin-Ru Shih, 2002, Journal of medicinal chemistry.

Palladium(II) acetate mediated oxidative cyclization of ω-unsaturated α-cyano ketones for facile construction of methylenecyclohexane ring system.

S. Kuo, Kak‐Shan Shia, Min-Tsang Hsieh, 2012, Organic & biomolecular chemistry.

Conia-ene annulation of the α-cyano β-TMS-capped alkynyl cycloalkanone system and its synthetic application.

Kak‐Shan Shia, P. Amancha, Ying-Chieh Wong, 2011, Organic & biomolecular chemistry.

The first total synthesis of xenitorins B and C: assignment of absolute configuration.

Kak‐Shan Shia, Wenju Chang, Hsing‐Jang Liu, 2006, Organic & biomolecular chemistry.

An improved general synthetic approach to cis-clerodane diterpenoids. A more efficient total synthesis of (±)-6β-acetoxy-2-oxokolavenool

Kak‐Shan Shia, Jen-Dar Wu, Hsing‐Jang Liu, 2001 .

Diels–Alder chemistry of 2-cyanoalk-2-enones. A convenient general approach to angularly substituted polycyclic systems

Kak‐Shan Shia, Jia-Liang Zhu, Hsing‐Jang Liu, 2000 .

Reductive alkylation of α-cyano ketones induced by samarium iodide

Kak‐Shan Shia, Jia-Liang Zhu, Hsing‐Jang Liu, 1999 .

Lithium naphthalenide induced reductive alkylation of α-cyano ketones. A general method for regiocontrol of α, α-dialkylation of ketones

Kak‐Shan Shia, Jia-Liang Zhu, Hsing‐Jang Liu, 1998 .

A convenient new procedure for the construction of highly substituted acetates. Reductive alkylation of α-cyano esters

Kak‐Shan Shia, J. Yip, Hsing‐Jang Liu, 1997 .

Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-oxacephem: a novel agent against resistant pathogenic microorganisms.

Max K. Leong, A. Moosavi-Movahedi, J. Chamani, 2003, Organic & biomolecular chemistry.

A facile two-carbon ring expansion process based on the 2-cyano-1-vinylcycloalkanol system

Kak‐Shan Shia, T. Ly, Jia-Liang Zhu, 1999 .

Cobalt(II)-Catalyzed Aerobic Oxidation of Terminal-Capped Alkynyl α-Cyano Alkanone Systems. An Oxygen-Mediated Radical Chain Reaction.

C. Tseng, Kak‐Shan Shia, Jing‐Kai Huang, 2016, The Journal of organic chemistry.

Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones.

Chia-Liang Tai, Yen-Chun Lee, Ying-Ting Lin, 2004, Bioorganic & medicinal chemistry letters.

Synthetic studies on clerodane diterpenoids. 4. The total synthesis of (±)-6β-acetoxy-2-oxokolavenool

Kak‐Shan Shia, Hsing‐Jang Liu, 1998 .

Synthetic studies on clerodane diterpenoids. The total synthesis of (±)-2-oxo-5α,8α-13,14,15,16-tetranorclerod-3-en-12-oic acid

Kak‐Shan Shia, Daqing Sun, Yu Wang, 1997 .

Organocerium compounds in synthesis

Kak‐Shan Shia, B. Zhu, X. Shang, 1999 .

Palladium(II) acetate mediated oxidative cyclization of ω-unsaturated α-cyano ketones. A facile methylenecyclopentane annulation process

Kak‐Shan Shia, Hsing‐Jang Liu, Liang-Rern Kung, 2003 .

Beckmann Rearrangement of Ketoximes Induced by Phenyl Dichlorophosphate at Ambient Temperature

Kak‐Shan Shia, C. Kuo, C. Yao, 2012, Molecules.

A concise total synthesis of (+/-)-acutifolone A.

Kak‐Shan Shia, T. Ly, Hsing‐Jang Liu, 2009, Organic & biomolecular chemistry.

Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection

Yi-lin Li, Y. Mizushina, J. Tzen, 2018, Journal of food and drug analysis.

Synthesis and anticancer evaluation of vitamin K3 analogues

Kak‐Shan Shia, Kak-Shan Shia, Huan-Yi Tseng, 2002 .

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.

Su-Ying Wu, Jian-Sung Wu, Yi-Hui Peng, 2016, Journal of medicinal chemistry.

Diels-Alder reactions of 2-bromo-2-cycloalkenones. A convenient approach to the doubly cisoid fully conjugated dienone system

Kak‐Shan Shia, Hsing‐Jang Liu, 1995 .

Design, Synthesis, and Structure—Activity Relationships of Pyrazolo[3,4‐d]pyrimidines: A Novel Class of Potent Enterovirus Inhibitors.

S. Shih, T. Hsu, Kak‐Shan Shia, 2004 .

Mutation in Enterovirus 71 Capsid Protein VP1 Confers Resistance to the Inhibitory Effects of Pyridyl Imidazolidinone

Y. Chao, Guang-Wu Chen, S. Shih, 2004, Antimicrobial Agents and Chemotherapy.

Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology

Jen‐Shin Song, Yi-Yu Ke, Kak‐Shan Shia, 2018, Medicinal research reviews.

Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors

Kak‐Shan Shia, M. Hung, R S Vijayakumar, 2012, International Journal of Obesity.

Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy

C. Chen, Jen‐Shin Song, Jinq-chyi Lee, 2022, Journal of medicinal chemistry.

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Mingzi M. Zhang, Huimin Zhao, E. Ang, 2019, bioRxiv.

Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists.

Jen‐Shin Song, Kun-Yi Hsin, Kak‐Shan Shia, 2022, Bioorganic chemistry.

Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists.

Y. Chao, Jen‐Shin Song, Kak‐Shan Shia, 2008, Organic & biomolecular chemistry.

Discovery of 1‐(2,4‐Dichlorophenyl)‐4‐ethyl‐5‐(5‐(2‐(4‐(trifluoromethyl)phenyl)ethynyl)thiophen‐2‐yl)‐N‐(piperidin‐1‐yl)‐1H‐pyrazole‐3‐carboxamide as a Potential Peripheral Cannabinoid‐1 Receptor Inverse Agonist

Y. Chao, Jen‐Shin Song, T. Yeh, 2010, ChemMedChem.

Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives.

Ying-Ting Lin, Chung-Ming Chang, Kak‐Shan Shia, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of a cephalosporin–monohydroguaiaretic acid prodrug activated by a monoclonal antibody–β-lactamase conjugate

M. Pasdar, A. Saboury, A. Moosavi-Movahedi, 2002 .

Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug Conjugates.

C. Chen, Yu-Wei Liu, B. Gray, 2019, Journal of medicinal chemistry.

Total Synthesis of (–)‐Isopisiferin: Confirmation of Absolute Configuration

Kak‐Shan Shia, Hsing‐Jang Liu, Ning-Wei Jan, 2010 .

Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

C. Chen, Y. Chao, Su-Ying Wu, 2012, ChemMedChem.

Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.

Y. Chao, Jen‐Shin Song, T. Yeh, 2009, Journal of Medicinal Chemistry.

An Efficacious Synthetic Strategy for cis-Clerodane Diterpenoids. Application to the Total Synthesis of (±)-6β-Acetoxy-2-oxokolavenool

Kak‐Shan Shia, Y. Ho, Liu, 2001 .

Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities.

Y. Chao, T. Yeh, Kak‐Shan Shia, 2010, Pharmacological research.

Total Synthesis of Tetarimycin A, (±)-Naphthacemycin A9, and (±)-Fasamycin A: Structure-Activity Relationship Studies against Drug-Resistant Bacteria.

Chun‐Cheng Lin, Kak‐Shan Shia, Tsai-Ling Yang Lauderdale, 2018, The Journal of organic chemistry.

Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists.

Y. Chao, Jen‐Shin Song, Kak‐Shan Shia, 2008, Organic & biomolecular chemistry.