G. Otten

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Engineered alphavirus replicon vaccines based on known attenuated viral mutants show limited effects on immunogenicity.

P. Mason, C. Beard, Giulietta Maruggi, 2013, Virology.

Distribution of DNA Vaccines Determines Their Immunogenicity After Intramuscular Injection in Mice1

D. McDonald, J. Ulmer, J. Donnelly, 2000, The Journal of Immunology.

Priming of CTL responses by DNA vaccines: direct transfection of antigen presenting cells versus cross-priming.

J. Ulmer, G. Otten, 2000, Developments in biologicals.

Enhancement of DNA vaccine potency in rhesus macaques by electroporation.

Mark G. Lewis, J. Ulmer, J. Donnelly, 2004, Vaccine.

Implications for Vaccine Design Vaccine : Response by a Self-Amplifying RNA Induction of an IFN-Mediated Antiviral

J. Ulmer, A. Pulichino, Giulietta Maruggi, 2017 .

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

Jason C Debasitis, J. Ulmer, A. Pulichino, 2017, The Journal of Immunology.

A phase 1, randomized, observer blind, antigen and adjuvant dosage finding clinical trial to evaluate the safety and immunogenicity of an adjuvanted, trivalent subunit influenza vaccine in adults ≥ 65 years of age.

G. Otten, M. Ciarlet, B. Leav, 2020, Vaccine.

Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion.

H. Liao, B. Haynes, D. Montefiori, 2015, The Journal of infectious diseases.

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

K. A. Wall, P. Marrack, J. Kappler, 1983, Immunological reviews.

Antigen processing and presentation.

G. Otten, 1989, Current opinion in immunology.

Defective assembly of class I major histocompatibility complex molecules in an embryonic cell line

G. Otten, E. Bikoff, E. Robertson, 1991, European journal of immunology.

Immunogenicity by Electroporation In Vivo Increased DNA Vaccine Delivery and

J. Ulmer, M. Selby, D. Rabussay, 2000 .

Flow cytometry analysis using the Becton Dickinson FACS Calibur.

G. Otten, W. Yokoyama, K. Holmes, 2002, Current protocols in immunology.

Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization.

J. Ulmer, G. Otten, X. Paliard, 2000, Vaccine.

Nonviral delivery of self-amplifying RNA vaccines

Thomas Krucker, Rino Rappuoli, Yen Cu, 2012, Proceedings of the National Academy of Sciences.

The development of self-emulsifying oil-in-water emulsion adjuvant and an evaluation of the impact of droplet size on performance.

M. Amiji, Manmohan J. Singh, Luis A. Brito, 2015, Journal of pharmaceutical sciences.

Stable Nanoemulsions for the Delivery of Small Molecule Immune Potentiators.

Manmohan J. Singh, Luis A. Brito, G. Otten, 2018, Journal of pharmaceutical sciences.

Interleukin 2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways.

K. Herold, D. Lancki, T. Gajewski, 1987, Journal of immunology.

The Preparation and Physicochemical Characterization of Aluminum Hydroxide/TLR7a, a Novel Vaccine Adjuvant Comprising a Small Molecule Adsorbed to Aluminum Hydroxide.

Manmohan J. Singh, G. Otten, P. Malyala, 2018, Journal of pharmaceutical sciences.

Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein

D. Driver, M. L. Mackichan, B. Belli, 2000, Journal of Virology.

Relative Potency of Cellular and Humoral Immune Responses Induced by DNA Vaccination

J. Ulmer, M. Selby, G. Otten, 2001, Intervirology.

Injection in Mice Their Immunogenicity After Intramuscular Distribution of DNA Vaccines Determines

D. McDonald, J. Ulmer, J. Donnelly, 2000 .

Cloned helper T lymphocytes exposed to interleukin 2 become unresponsive to antigen and concanavalin A but not to calcium ionophore and phorbol ester

G. Otten, M. Prystowsky, F. Fitch, 1986, European journal of immunology.

Ligand Binding TLR7 Abolishes Signaling without Affecting A Point Mutation in the Amino Terminus of

I. Leykin, B. Beutler, M. Mbow, 2011 .

Self-amplifying mRNA bicistronic influenza vaccines raise cross-reactive immune responses in mice and prevent infection in ferrets

E. Settembre, G. Palladino, G. Otten, 2022, Molecular therapy. Methods & clinical development.

Increased DNA Vaccine Delivery and Immunogenicity by Electroporation In Vivo

J. Ulmer, M. Selby, D. Rabussay, 2000, The Journal of Immunology.

Regulation of Activation of Cloned Murine T Cells

K. Herold, D. Lancki, G. Otten, 1986 .

Interleukin 2 inhibits antigen-stimulated lymphokine synthesis in helper T cells by inhibiting calcium-dependent signalling.

K. Herold, G. Otten, F. Fitch, 1987, Journal of immunology.

Induction of Potent Immune Responses by Cationic Microparticles with Adsorbed Human Immunodeficiency Virus DNA Vaccines

J. Ulmer, Manmohan J. Singh, M. Schaefer, 2001, Journal of Virology.

Generation of a parvovirus B19 vaccine candidate.

C. Mandl, E. Settembre, P. Dormitzer, 2013, Vaccine.

Beta-adrenergic receptors on splenic lymphocytes from axotomized mice.

G. Otten, S. Atweh, B. Arnason, 1984, International journal of immunopharmacology.

An Alphavirus Replicon Particle Chimera Derived from Venezuelan Equine Encephalitis and Sindbis Viruses Is a Potent Gene-Based Vaccine Delivery Vector

T. Dubensky, C. Greer, J. Polo, 2003, Journal of Virology.

Toxicity of methyldopa (Aldomet) to mouse neuroblastoma cells in vivo.

G. Otten, B. Arnason, M. Sportiello, 1983, Cancer research.

Rational design of small molecules as vaccine adjuvants

M. Cooke, A. Herman, E. De Gregorio, 2014, Science Translational Medicine.

Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models

E. Settembre, G. Palladino, G. Otten, 2022, Molecular Therapy - Methods & Clinical Development.

The role of non-viral antigens in the cotton rat model of respiratory syncytial virus vaccine-enhanced disease.

P. Dormitzer, J. Markovits, G. Palmer, 2013, Vaccine.

Multiple hemopoietic lineages are found after stimulation of mouse bone marrow precursor cells with interleukin 3.

J. Ihle, J. Vardiman, M. F. Naujokas, 1984, The American journal of pathology.

A cationic nanoemulsion for the delivery of next-generation RNA vaccines.

C. Mandl, P. Dormitzer, P. Mason, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Regulation of gene expression in vivo following transduction by two separate rAAV vectors

S. Leff, R. Mandel, D. Bohl, 1998, Nature Biotechnology.

Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene

Mary Schaefer, Mark Selby, C. Greer, 2000, Journal of Virology.

Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 Subtype B pol and gagpol DNA Vaccines

J. Ulmer, J. Donnelly, Hong Liu, 2003, Journal of Virology.

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice.

K. Ley, T. Tedder, M. Arbonés, 1994, Immunity.

MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon

R. Germain, G. Otten, E. Bikoff, 1991, Nature.

Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation.

J. Ulmer, J. Donnelly, D. Rabussay, 2006, Vaccine.

Self-amplifying mRNA vaccines.

C. Mandl, P. Dormitzer, P. Mason, 2015, Advances in genetics.

Evaluation of Envelope Vaccines Derived from the South African Subtype C Human Immunodeficiency Virus Type 1 TV1 Strain

D. Montefiori, P. Luciw, J. Ulmer, 2005, Journal of Virology.

A therapeutic SIV DNA vaccine elicits T-cell immune responses, but no sustained control of viremia in SIVmac239-infected rhesus macaques.

Brigitte E. Sanders-Beer, J. Ulmer, J. Donnelly, 2008, AIDS research and human retroviruses.

PMA alone induces proliferation of some murine T cell clones but not others.

G. Nau, D. K. Kim, G. Otten, 1986, Journal of immunology.

Antibody-Mediated Protection against Mucosal Simian-Human Immunodeficiency Virus Challenge of Macaques Immunized with Alphavirus Replicon Particles and Boosted with Trimeric Envelope Glycoprotein in MF59 Adjuvant

J. Ulmer, J. Donnelly, I. Srivastava, 2010, Journal of Virology.

Induction of Broad and Potent Anti-Human Immunodeficiency Virus Immune Responses in Rhesus Macaques by Priming with a DNA Vaccine and Boosting with Protein-Adsorbed Polylactide Coglycolide Microparticles

J. Ulmer, J. Donnelly, Manmohan J. Singh, 2003, Journal of Virology.

Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production.

R. Germain, G. Otten, 1991, Science.

Quantitative assessment of antigen-specific CD8+ T cells in the mouse: application to vaccine research.

J. Ulmer, G. Otten, S. Barnett, 2003, Immunology letters.

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

D. G. Gibson, J. Gill, Z. Qi, 2013, Emerging Microbes & Infections.

Sympathetic ablation alters lymphocyte membrane properties.

G. Otten, S. Atweh, B. Arnason, 1985, Journal of immunology.

Lack of Interference with Immunogenicity of a Chimeric Alphavirus Replicon Particle-Based Influenza Vaccine by Preexisting Antivector Immunity

R. Rappuoli, Y. Uematsu, C. Greer, 2012, Clinical and Vaccine Immunology.

alphavirus replicon particle-based influenza vaccine by pre-

R. Rappuoli, Y. Uematsu, C. Greer, 2012 .

Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ

N. Sardesai, J. Ulmer, G. Otten, 2013, Vaccines.

A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding

I. Leykin, B. Beutler, M. Mbow, 2011, The Journal of Immunology.

Evaluation of human immunodeficiency virus type 1 subtype C gag, pol, and gagpol DNA and alphavirus replicon vaccines.

J. Ulmer, J. Donnelly, C. Greer, 2006, Vaccine.

Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant

Jerome H. Kim, H. Liao, B. Haynes, 2018, PloS one.

Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression.

R. Germain, D. Margulies, G. Otten, 1992, Journal of immunology.

Enhanced Potency of Plasmid DNA Microparticle Human Immunodeficiency Virus Vaccines in Rhesus Macaques by Using a Priming-Boosting Regimen with Recombinant Proteins

D. Montefiori, T. Dubensky, D. Driver, 2005, Journal of Virology.

Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production.

G. Otten, R. McGuinness, J. F. Hales, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Two color light scattering identifies physical differences between lymphocyte subpopulations.

M. Loken, G. Otten, Gillis R. Otten, 1982, Cytometry.

Nonviral delivery of self-amplifying RNA vaccines

C. Mandl, R. Rappuoli, P. Dormitzer, 2012, Proceedings of the National Academy of Sciences.

A cationic nanoemulsion for the delivery of next-generation RNA vaccines.

C. Mandl, P. Dormitzer, P. Mason, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine

M. Pizza, M. Giuliani, Manmohan J. Singh, 2012, Human vaccines & immunotherapeutics.