H. Bernstein

发表

P. Sarnow, H. Bernstein, 2022 .

The double life of a bacterial lipoprotein

H. Bernstein, 2011, Molecular microbiology.

Sequential Translocation of Polypeptides across the Bacterial Outer Membrane through the Trimeric Autotransporter Pathway

H. Bernstein, R. Sikdar, 2019, mBio.

Selective pressure for rapid membrane integration constrains the sequence of bacterial outer membrane proteins

K. G. Fleming, H. Bernstein, Janine H. Peterson, 2016, Molecular microbiology.

The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding

H. Bernstein, Janine H. Peterson, C. Woolhead, 2010, Molecular microbiology.

The E. coli Signal Recognition Particle Is Required for the Insertion of a Subset of Inner Membrane Proteins

J. A. Newitt, H. Bernstein, N. Ulbrandt, 1997, Cell.

Signal Recognition Particle

H. Bernstein, 2002 .

Basic Amino Acids in a Distinct Subset of Signal Peptides Promote Interaction with the Signal Recognition Particle*

H. Bernstein, Janine H. Peterson, C. Woolhead, 2003, Journal of Biological Chemistry.

Charge-dependent secretion of an intrinsically disordered protein via the autotransporter pathway

H. Bernstein, Wanyoike Kang'ethe, 2013, Proceedings of the National Academy of Sciences.

DnaK Promotes the Selective Export of Outer Membrane Protein Precursors in SecA-deficient Escherichia coli*

H. Bernstein, H. Qi, J. Hyndman, 2002, The Journal of Biological Chemistry.

Physiological Basis for Conservation of the Signal Recognition Particle Targeting Pathway in Escherichia coli

H. Bernstein, J. Hyndman, 2001, Journal of bacteriology.

The Structure of Multiple Polypeptide Domains Determines the Signal Recognition Particle Targeting Requirement ofEscherichia coli Inner Membrane Proteins

J. A. Newitt, H. Bernstein, N. Ulbrandt, 1999, Journal of bacteriology.

The N-domain of the signal recognition particle 54-kDa subunit promotes efficient signal sequence binding.

J. A. Newitt, H. Bernstein, J. Newitt, 1997, European journal of biochemistry.

Membrane protein biogenesis: the exception explains the rules.

H. Bernstein, H D Bernstein, 1998, Proceedings of the National Academy of Sciences of the United States of America.

SecA Is Required for the Insertion of Inner Membrane Proteins Targeted by the Escherichia coli Signal Recognition Particle*

H. Bernstein, H. Qi, 1999, The Journal of Biological Chemistry.

Cell biology: All clear for ribosome landing

H. Bernstein, 2012, Nature.

Identification of a novel post‐insertion step in the assembly of a bacterial outer membrane protein

H. Bernstein, Sunyia Hussain, J. Peterson, 2018, Molecular microbiology.

An In Vitro Assay for Outer Membrane Protein Assembly by the BAM Complex.

H. Bernstein, G. Román-Hernández, 2015, Methods in molecular biology.

Reconstitution of bacterial autotransporter assembly using purified components

H. Bernstein, J. Peterson, G. Román-Hernández, 2014, eLife.

Sequential and spatially restricted interactions of assembly factors with an autotransporter β domain

P. Tian, H. Bernstein, J. Peterson, 2011, Proceedings of the National Academy of Sciences.

Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane

H. Bernstein, R. Ieva, 2009, Proceedings of the National Academy of Sciences.

Incorporation of a polypeptide segment into the β‐domain pore during the assembly of a bacterial autotransporter

H. Bernstein, Kristen M. Skillman, R. Ieva, 2007, Molecular microbiology.

Are bacterial 'autotransporters' really transporters?

H. Bernstein, 2007, Trends in microbiology.

Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter

R. Ghirlando, T. Barnard, H. Bernstein, 2005, Molecular microbiology.

Enterohemorrhagic Escherichia coli Reduces Mucus and Intermicrovillar Bridges in Human Stem Cell-Derived Colonoids

M. Halushka, M. Estes, M. Donowitz, 2015, Cellular and molecular gastroenterology and hepatology.

Evidence for a novel GTPase priming step in the SRP protein targeting pathway

A. Teplyakov, H. Bernstein, A. Teplyakov, 2001, The EMBO journal.

The Shape of the Ribosome Exit Tunnel Affects Cotranslational Protein Folding

G. Heijne, M. Carroni, H. Bernstein, 2018 .

An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter.

H. Bernstein, R. Szabady, Kristen M. Skillman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Trigger Factor Retards Protein Export in Escherichia coli*

H. Bernstein, Hin C. Lee, 2002, The Journal of Biological Chemistry.

Cotranslational Translocation of Proteins into Canine Rough Microsomes

H. Bernstein, 1998, Current protocols in cell biology.

Cytosolic protein translocation factors is SRP still unique?

T. Rapoport, P. Walter, H. Bernstein, 1989, Cell.

A Mutation in the Escherichia coli secY Gene That Produces Distinct Effects on Inner Membrane Protein Insertion and Protein Export*

H. Bernstein, J. Newitt, 1998, The Journal of Biological Chemistry.

Signal Recognition Particle

H. Bernstein, 2002 .

The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal

H. Bernstein, H C Lee, H D Bernstein, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter.

E. Tajkhorshid, S. Buchanan, J. Gumbart, 2012, Journal of molecular biology.

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

Peter Walter, S. Brenner, P. Walter, 1989, Nature.

The surprising complexity of signal sequences.

R. Hegde, H. Bernstein, Harris D Bernstein, 2006, Trends in biochemical sciences.

The Coupling of SecA Expression to Secretion Efficiency by SecM-Mediated Translation Arrest

H. Bernstein, 2014 .

A clostripain‐like protease plays a major role in generating the secretome of enterotoxigenic Bacteroides fragilis

D. E. Anderson, H. Bernstein, J. Pierce, 2020, Molecular microbiology.

Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria.

H. Bernstein, M. Wilson, 2016, Trends in microbiology.

Analysis of the Outer Membrane Proteome and Secretome of Bacteroides fragilis Reveals a Multiplicity of Secretion Mechanisms

D. E. Anderson, H. Bernstein, M. Wilson, 2015, PloS one.

Chaperone OsmY facilitates the biogenesis of a major family of autotransporters

J. Bardwell, H. Bernstein, Sunyia Hussain, 2019, Molecular microbiology.

Signal Recognition Particle (SRP)-mediated Targeting and Sec-dependent Translocation of an Extracellular Escherichia coli Protein*

M. Urbanus, B. Oudega, H. Bernstein, 2003, The Journal of Biological Chemistry.

Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells

R. Vale, G. Mccaffrey, H. Bernstein, 1992, The Journal of cell biology.

The translational regulatory function of SecM requires the precise timing of membrane targeting

H. Bernstein, Mee-Ngan F. Yap, 2011, Molecular microbiology.

Protein secretion in gram-negative bacteria via the autotransporter pathway.

H. Bernstein, Nathalie Dautin, Harris D Bernstein, 2007, Annual review of microbiology.

An Unusual Signal Peptide Extension Inhibits the Binding of Bacterial Presecretory Proteins to the Signal Recognition Particle, Trigger Factor, and the SecYEG Complex*

H. Bernstein, R. Szabady, J. Peterson, 2006, Journal of Biological Chemistry.

The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

Fátima Pardo Avila, G. von Heijne, R. Best, 2018, bioRxiv.

Looks can be deceiving: recent insights into the mechanism of protein secretion by the autotransporter pathway

H. Bernstein, 2015, Molecular microbiology.

Mechanistic link between β barrel assembly and the initiation of autotransporter secretion

H. Bernstein, O. Pavlova, J. Peterson, 2013, Proceedings of the National Academy of Sciences.

Genomic Diversity of Enterotoxigenic Strains of Bacteroides fragilis

H. Bernstein, J. Pierce, 2016, PloS one.

Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment

P. Tian, H. Bernstein, N. Dautin, 2010, Proceedings of the National Academy of Sciences.

Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism

D. E. Anderson, T. Barnard, H. Bernstein, 2007, The EMBO journal.

Folding of a bacterial integral outer membrane protein is initiated in the periplasm

D. E. Anderson, H. Bernstein, R. Sikdar, 2017, Nature Communications.

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.

H. Bernstein, Arthur E Johnson, Harris D Bernstein, 2006, Molecular cell.

Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog.

P. Walter, D. Zopf, D. Freymann, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding

J. Hinshaw, H. Bernstein, M. Larion, 2021, bioRxiv.

Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion

Julie L. Chaney, T. Lithgow, J. Nataro, 2015, Molecular microbiology.

The Escherichia coli outer membrane protein OmpA acquires secondary structure prior to its integration into the membrane

H. Bernstein, Xu Wang, 2022, The Journal of biological chemistry.

Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor

P. Walter, H. Bernstein, Joshua D. Miller, 1994, Nature.

Bacterial Outer Membrane Proteins Are Targeted to the Bam Complex by Two Parallel Mechanisms

H. Bernstein, Xu Wang, J. Peterson, 2021, mBio.

Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly

H. Bernstein, M. T. Doyle, J. Peterson, 2022, mBio.

BamA forms a translocation channel for polypeptide export across the bacterial outer membrane.

H. Bernstein, M. T. Doyle, 2021, Molecular cell.

Type V Secretion in Gram-Negative Bacteria.

H. Bernstein, 2019, EcoSal Plus.

Residues in a Conserved α-Helical Segment Are Required for Cleavage but Not Secretion of an Escherichia coli Serine Protease Autotransporter Passenger Domain

H. Bernstein, N. Dautin, 2011, Journal of bacteriology.

Autotransporter structure reveals intra-barrel cleavage followed by conformational changes

S. Buchanan, P. Lukacik, T. Barnard, 2007, Nature Structural &Molecular Biology.

Reconstitution of Bam Complex-Mediated Assembly of a Trimeric Porin into Proteoliposomes

H. Bernstein, Sunyia Hussain, J. Peterson, 2021, mBio.

Bam complex-mediated assembly of bacterial outer membrane proteins synthesized in an in vitro translation system

H. Bernstein, Sunyia Hussain, J. Peterson, 2020, Scientific Reports.

Bacterial outer membrane proteins assemble via asymmetric interactions with the BamA β-barrel

H. Bernstein, M. T. Doyle, 2019, Nature Communications.

The Bam complex catalyzes efficient insertion of bacterial outer membrane proteins into membrane vesicles of variable lipid composition

H. Bernstein, Sunyia Hussain, 2018, The Journal of Biological Chemistry.

Mutations in the Escherichia coli Ribosomal Protein L22 Selectively Suppress the Expression of a Secreted Bacterial Virulence Factor

Yap Mee-Ngan, H. Bernstein, 2013, Journal of bacteriology.

Characterization of a Novel Two-Partner Secretion System in Escherichia coli O157:H7

H. Bernstein, P. Choi, Ashley J Dawson, 2007, Journal of bacteriology.

Carboxyl-terminal Targeting and Novel Post-translational Processing of JAW1, a Lymphoid Protein of the Endoplasmic Reticulum*

L. Staudt, J. Yewdell, T. Behrens, 1996, The Journal of Biological Chemistry.

Identification of a Post-targeting Step Required for Efficient Cotranslational Translocation of Proteins across the Escherichia coli Inner Membrane*

P. Tian, H. Bernstein, 2009, Journal of Biological Chemistry.

The patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

H. Bernstein, M. T. Doyle, Sarah E. Hanson, 2023, bioRxiv.

An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle.

P. Walter, D. Zopf, K. Strub, 1990, Science.

Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain.

Oliver Weichenrieder, S. Cusack, O. Weichenrieder, 2004, Nucleic acids research.

A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14.

Kelvin Hsu, R. Maraia, H. Bernstein, 1997, Nucleic acids research.

The methionine‐rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.

P. Walter, D. Zopf, H. Bernstein, 1990, The EMBO journal.

GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding

P. Walter, D. Zopf, H. Bernstein, 1993, The Journal of cell biology.

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.

H. Bernstein, Mee-Ngan F. Yap, 2009, Molecular cell.

Protein targeting: Getting into the groove

H. Bernstein, 1998, Current Biology.

FtsY Binds to the Escherichia coli Inner Membrane via Interactions with Phosphatidylethanolamine and Membrane Proteins*

D. Andrews, H. Bernstein, H. Qi, 2001, The Journal of Biological Chemistry.

Folding of a bacterial integral outer membrane protein is initiated in the periplasm

D. E. Anderson, H. Bernstein, R. Sikdar, 2017, Nature Communications.

The biogenesis and assembly of bacterial membrane proteins.

H. Bernstein, Harris D. Bernstein, 2000, Current opinion in microbiology.

Type V Secretion: the Autotransporter and Two-Partner Secretion Pathways.

H. Bernstein, 2010, EcoSal Plus.

Molecular basis for the structural stability of an enclosed β-barrel loop.

P. Tian, H. Bernstein, 2010, Journal of molecular biology.

Author response: Reconstitution of bacterial autotransporter assembly using purified components

H. Bernstein, J. Peterson, G. Román-Hernández, 2014 .

Monitoring the assembly of a secreted bacterial virulence factor using site-specific crosslinking.

H. Bernstein, O. Pavlova, R. Ieva, 2013, Journal of visualized experiments : JoVE.

Function of the Omp85 Superfamily of Outer Membrane Protein Assembly Factors and Polypeptide Transporters.

H. Bernstein, M. T. Doyle, 2022, Annual review of microbiology.

Epidermal growth factor-induced topoisomerase(s). Intracellular translocation and relation to DNA synthesis.

H. Bernstein, R. Miskimins, W. Miskimins, 1983, Experimental cell research.

Stepwise Folding of an Autotransporter Passenger Domain Is Not Essential for Its Secretion*

H. Bernstein, Wanyoike Kang'ethe, 2013, The Journal of Biological Chemistry.

Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion

Julie L. Chaney, T. Lithgow, J. Nataro, 2015, Molecular microbiology.

Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding

H. Bernstein, M. T. Doyle, J. Jimah, 2022, Cell.