J. Spencer

发表

P. Isaacson, J. Spencer, P. G. Isaacson, 1995, Journal of clinical pathology.

Immunoproliferative small-intestinal disease. An immunohistochemical study.

P. Isaacson, J. Spencer, S. Price, 1989, The American journal of surgical pathology.

Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective

M. Singer, M. Shankar-Hari, W. Sewell, 2012, Critical Care.

Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjögren’s Syndrome1

M. McGurk, G. Valesini, S. Challacombe, 2007, The Journal of Immunology.

CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjögren’s Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid Organization1

G. Valesini, S. Challacombe, C. Pitzalis, 2008, The Journal of Immunology.

Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells

P. Isaacson, J. Spencer, D. Dunn-Walters, 1995, The Journal of experimental medicine.

Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation.

P. Isaacson, L. Boursier, J. Spencer, 1998, Human pathology.

Somatic hypermutation and B-cell lymphoma.

J. Spencer, C. Thiede, D. Dunn-Walters, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Role of innate immunity in cancer.

J. Spencer, S. Golby, 2001, Current opinion in gastroenterology.

Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells

P. Isaacson, J. Spencer, P. Beverley, 1990, Clinical and experimental immunology.

Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype.

J. Spencer, T. Macdonald, M. Salmela, 2000, The American journal of pathology.

HLA-DR expression in human fetal intestinal epithelium.

J. Spencer, T. Macdonald, A. Weinel, 1988, Gut.

Proliferation of T‐cell subsets that contact tumour cells in colorectal cancer

J. Spencer, C. Chinyama, S. Golby, 2002, Clinical and experimental immunology.

Location and sequence of rearranged immunoglobulin genes in human thymus

P. Isaacson, J. Spencer, C. J. Howe, 1995, European journal of immunology.

Extrathymic T cell differentiation in the human intestine early in life.

A. Akbar, C. Pitzalis, J. Spencer, 1998, Journal of immunology.

Hypermutation at A-T Base Pairs: The A Nucleotide Replacement Spectrum Is Affected by Adjacent Nucleotides and There Is No Reverse Complementarity of Sequences Flanking Mutated A and T Nucleotides12

J. Spencer, D. Dunn-Walters, Jo Spencer, 2005, The Journal of Immunology.

Antisense transcripts of V(D)J rearrangements; artifacts caused by false priming?

J. Spencer, F. Barone, D. Dunn-Walters, 2009, Molecular immunology.

Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

F. Ciccarelli, Lorena Benedetti, Matteo Cereda, 2016, Nature Communications.

Antibiotic treatment for low-grade gastric MALT lymphoma

P. Isaacson, C. Doglioni, J. Spencer, 1994, The Lancet.

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

H. L. Wright, R. Moots, T. Spector, 2012 .

Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

C. Elia, H. Souza, J. Spencer, 1999, Gut.

Immunohistochemical analysis of human CD5 positive B cells: mantle cells and mantle cell lymphoma are not equivalent in terms of CD5 expression

J. Spencer, W. Su, K. F. Yeong, 2000, Journal of clinical pathology.

Human marginal-zone B cells.

J. Spencer, D. Dunn-Walters, M. Perry, 1998, Immunology today.

HELICOBACTER PYLORI‐SPECIFIC TUMOUR‐INFILTRATING T CELLS PROVIDE CONTACT DEPENDENT HELP FOR THE GROWTH OF MALIGNANT B CELLS IN LOW‐GRADE GASTRIC LYMPHOMA OF MUCOSA‐ASSOCIATED LYMPHOID TISSUE

P. Isaacson, J. Spencer, J. Crabtree, 1996, The Journal of pathology.

Will the advances in our understanding of mucosal immunology contribute to improvements in clinical control of IBD?

D. Gibbons, J. Spencer, 2011, Mucosal Immunology.

The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

P. Isaacson, J. Spencer, J. Crabtree, 1993, The Lancet.

Gastric lymphoma and Helicobacter pylori.

P. Isaacson, J. Spencer, P. G. Isaacson, 1994, Important advances in oncology.

Effect of somatic hypermutation on potential N-glycosylation sites in human immunoglobulin heavy chain variable regions.

L. Boursier, J. Spencer, D. Dunn-Walters, 2000, Molecular immunology.

Reduced CD27−IgD− B Cells in Blood and Raised CD27−IgD− B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease

J. Sanderson, William Guesdon, N. Zhang, 2019, Front. Immunol..

Circulating T follicular helper cell and regulatory T cell frequencies are influenced by B cell depletion in patients with granulomatosis with polyangiitis.

D. D'cruz, S. Sangle, T. Tree, 2014, Rheumatology.

Immunoepidemiology of intestinal helminthic infections. 3. Mucosal macrophages and cytokine production in the colon of children with Trichuris trichiura dysentery.

D. Bundy, J. Spencer, T. Macdonald, 1994, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Proliferation and differentiation of tumour cells from B‐cell lymphoma of mucosa‐associated lymphoid tissue in vitro

P. Isaacson, J. Spencer, T. Hussell, 1993, The Journal of pathology.

Malignant lymphoma and autoimmune disease

P. Isaacson, J. Spencer, 1993, Histopathology.

Expression of HLA-DR antigens on epithelium associated with lymphoid tissue in the human gastrointestinal tract.

P. Isaacson, J. Spencer, T. Finn, 1986, Gut.

HLA-D REGION ANTIGEN EXPRESSION ON STOMACH EPITHELIUM IN ABSENCE OF AUTOANTIBODIES

P. Isaacson, J. Spencer, S. Pugh, 1986, The Lancet.

Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine).

P. Isaacson, P. Ciclitira, T. Diss, 1989, Gut.

Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine

J. Spencer, T. Macdonald, T. T. MacDonald, 1988, The Journal of experimental medicine.

Gamma/delta T cells and the diagnosis of coeliac disease

P. Isaacson, J. Spencer, T. Macdonald, 1991, Clinical and experimental immunology.

Activation of mucosal Vβ3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B

P. Lionetti, J. Spencer, S. Murch, 1993, European journal of immunology.

T cell subclasses in fetal human ileum.

P. Isaacson, J. Spencer, T. Macdonald, 1986, Clinical and experimental immunology.

The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine.

P. Isaacson, J. Spencer, T. Macdonald, 1986, Clinical and experimental immunology.

Human Peyer's patches: an immunohistochemical study.

P. Isaacson, J. Spencer, T. Finn, 1986, Gut.

Changes in the rate of crypt epithelial cell proliferation and mucosal morphology induced by a T-cell-mediated response in human small intestine.

P. Richman, R. Ferreira, J. Spencer, 1990, Gastroenterology.

Density of gamma/delta T cells in small bowel mucosa related to HLA-DQ status without coeliac disease.

J. Spencer, J. Walker-Smith, A. Phillips, 1993, Lancet.

Density of γ/δ T cells in small bowel mucosa related to HLA-DQ status without coeliac disease

J. Spencer, J. Walker-Smith, A. Phillips, 1993, The Lancet.

IgA Plasma Cell Development

L. Boursier, J. Spencer, J. Edgeworth, 2007 .

Where do IgA plasma cells in the gut come from?

J. Spencer, S. Golby, 2002, Gut.

Stimulation of mucosal T cells in situ with anti-CD3 antibody: location of the activated T cells and their distribution within the mucosal micro-environment.

N. Cerf-Bensussan, J. Spencer, T. Macdonald, 1988, Clinical and experimental immunology.

Gamma/delta T cells in the gut epithelium.

J. Spencer, T. Macdonald, J. Viney, 1990, Gut.

8 Immunology of gastrointestinal lymphoma

P. Isaacson, J. Spencer, 1987 .

Areas of Lymphoid Organization Association with Reactive and Malignant Syndrome and MALT Lymphoma : in Salivary Glands of Patients with Sjögren ' s CXCL 13 , CCL 21 , and CXCL 12 Expression and Costantino Pitzalis

S. Challacombe, J. Spencer, R. Carsetti, 2008 .

Areas of Lymphoid Organization Association with Reactive and Malignant Syndrome and MALT Lymphoma: in Salivary Glands of Patients with Sjögren's CXCL13, CCL21, and CXCL12 Expression

G. Valesini, S. Challacombe, J. Spencer, 2008 .

Gut-associated lymphoid tissue contains the molecular machinery to support T-cell-dependent and T-cell-independent class switch recombination

J. Spencer, F. Barone, P. Patel, 2009, Mucosal Immunology.

Defective CD8+CD28− regulatory T cell suppressor function in rheumatoid arthritis is restored by tumour necrosis factor inhibitor therapy

E. Choy, J. Spencer, V. Corrigall, 2013, Clinical and experimental immunology.

Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections

J. Spencer, A. Dogan, D. Dunn-Walters, 1996, European journal of immunology.

Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis.

A. Axon, J. Spencer, M. Dixon, 1990, Gut.

Is gastric lymphoma an infectious disease?

P. Isaacson, J. Spencer, 1993, Human pathology.

Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori.

P. Isaacson, J. Spencer, T. Macdonald, 1997, Journal of clinical pathology.

Subsets of gamma/delta T cells in human intestinal epithelium

P. Isaacson, T. Diss, J. Spencer, 1990 .

Post‐mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the β cell

M. Peakman, J. Spencer, 2009, Clinical and experimental immunology.

35 – Gut-Associated Lymphoid Tissue

J. Spencer, T. Macdonald, 1994 .

IgVH gene analysis suggests that peritoneal B cells do not contribute to the gut immune system in man

L. Boursier, J. Spencer, P. Brandtzaeg, 2002, European journal of immunology.

Ontogeny of the gut‐associated lymphoid system in man

J. Spencer, T. Macdonald, T. T. MacDonald, 1994, Acta paediatrica (Oslo, Norway : 1992). Supplement.

Translational Mini‐Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögren's syndrome: clinical implications and effects of B cell‐targeted therapies

J. Spencer, A. Vossenkämper, P. Lutalo, 2012, Clinical and experimental immunology.

Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma

A. Ahmed, J. Spencer, S. Diebold, 2017, PloS one.

The human intestinal B-cell response

L. Sollid, J. Spencer, 2016, Mucosal Immunology.

Transitional B Cells: How Well Are the Checkpoints for Specificity Understood?

J. Spencer, A. Vossenkämper, 2011, Archivum Immunologiae et Therapiae Experimentalis.

J. Sanderson, L. Boursier, J. Spencer, 2002, Gut.

Biased JH usage in plasma cell immunoglobulin gene sequences from colonic mucosa in ulcerative colitis but not in Crohn’s disease

L. Boursier, J. Spencer, D. Dunn-Walters, 1999, Gut.

A new humanIghV4.21-related pseudogene capable ofVDJ rearrangement

P. Isaacson, J. Spencer, D. Dunn-Walters, 1996, Immunogenetics.

A new human IghV4.21-related pseudogene capable of V D J rearrangement

P. Isaacson, J. Spencer, D. Dunn-Walters, 1996, Immunogenetics.

Characteristics of Human IgA and IgM Genes Used by Plasma Cells in the Salivary Gland Resemble Those Used in Duodenum But Not Those Used in the Spleen1

S. Challacombe, P. Ciclitira, L. Boursier, 2000, The Journal of Immunology.

But Not Those Used in the Spleen Gland Resemble Those Used in Duodenum Genes Used by Plasma Cells in the Salivary Characteristics of Human IgA and IgM

P. Ciclitira, J. Spencer, P. Morgan, 2000 .

Histopathology and immunohistochemistry of the caecum in children with the Trichuris dysentery syndrome.

P. Richman, D. Bundy, T. Diss, 1991, Journal of clinical pathology.

Gut immunology.

J. Spencer, T. Macdonald, 1990, Bailliere's clinical gastroenterology.

Lambda Light Chain Revision in the Human Intestinal IgA Response1

L. Boursier, J. Spencer, F. Barone, 2008, The Journal of Immunology.

Subepithelial dendritic B cells in orofacial granulomatosis

J. Sanderson, S. Challacombe, L. Boursier, 2010, Inflammatory bowel diseases.

Human intestinal IgA response is generated in the organized gut-associated lymphoid tissue but not in the lamina propria.

L. Boursier, J. Spencer, J. Edgeworth, 2005, Gastroenterology.

Primary B-cell gastric lymphoma.

P. Isaacson, J. Spencer, T. Finn, 1986, Human pathology.

Immunohistochemical analysis of T cell proliferation in normal tonsil and B cell lymphoma.

P. Isaacson, J. Spencer, J. Wang, 1995, Journal of clinical pathology.

Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes.

N. Brousse, P. Isaacson, A. Jarry, 1988, The American journal of pathology.

Sequence analysis of rearranged IgVH genes from microdissected human Peyer's patch marginal zone B cells.

P. Isaacson, J. Spencer, D. Dunn-Walters, 1996, Immunology.

CLASSIFYING PRIMARY GUT LYMPHOMAS

P. Isaacson, D. Wright, J. Spencer, 1988, The Lancet.

IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans.

S. John, L. Boursier, J. Spencer, 2011, Gastroenterology.

Characterization of cells of the B lineage in the human adult greater omentum

L. Boursier, J. Spencer, S. Montalto, 2006, Immunology.

Effects of Interferon-y and Tumour Necrosis Factor-cu on Epithelial HLA Class-II Expression on Jejunal Mucosal Biopsy Specimens Cultured in Vitro

P. Ciclitira, J. Spencer, C. Hung, 1992 .

A comparative study of the gut-associated lymphoid tissue of primates and rodents

P. Isaacson, J. Spencer, T. Finn, 1986, Virchows Archiv. B, Cell pathology including molecular pathology.

Gut associated lymphoid tissue: a morphological and immunocytochemical study of the human appendix.

P. Isaacson, J. Spencer, T. Finn, 1985, Gut.

T cell receptor V beta expression by mucosal T cells.

J. Spencer, T. Macdonald, M. Choy, 1991, Journal of clinical pathology.

CD95 and CD95-ligand expression in endocrine pancreas of NOD, NOR and BALB/c mice

R. Testi, A. Signore, J. Spencer, 1997, Diabetologia.

Ontogeny of the mucosal immune response

J. Spencer, T. Macdonald, 2004, Springer Seminars in Immunopathology.

T-Cell Subpopulations in Intestinal Mucosa

J. Spencer, T. Macdonald, 1991 .

Do vascular addressins mediate tissue specific lymphocyte extravasation?

P. Isaacson, J. Spencer, 1988, The Journal of pathology.

Cyclosporin A enhances T cell‐mediated induction of E‐selectin

J. Spencer, T. Macdonald, T. T. MacDonald, 1993, European journal of immunology.

Cytotoxicity and interleukin‐1β processing following Shigella flexneri infection of human monocyte‐derived dendritic cells

P. Sansonetti, J. Spencer, G. Griffin, 2002, European journal of immunology.

The phenotype of HLA-binding B-cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-γ production against purified HLA proteins.

J. Spencer, N. Mamode, A. Dorling, 2022, Kidney international.

Immunologic aspects of Helicobacter pylori infection and malignant transformation of B cells.

J. Spencer, J. Crabtree, 1996, Seminars in gastrointestinal disease.

Tests of association of immunoglobulin allotype genes and viral oncogenesis in chickens

A. A. Benedict, J. Spencer, A. Fadly, 2004, Immunogenetics.

Low grade B cell lymphoma of gut-associated lymphoid tissue (GALT): a model of the structure and migration pathways of the B cell component of normal human GALT.

P. Isaacson, J. Spencer, 1990, Digestion.

The human gut contains a novel population of B lymphocytes which resemble marginal zone cells.

P. Isaacson, K. Pulford, J. Spencer, 1985, Clinical and experimental immunology.

Primary B cell gastric lymphoma. A genotypic analysis.

P. Isaacson, T. Diss, J. Spencer, 1989, The American journal of pathology.

Relative distribution of tumour cells and reactive cells in follicular lymphoma

A. Wotherspoon, J. Spencer, A. Wotherspoon, 2001, The Journal of pathology.

MALIGNANT HISTIOCYTOSIS OF THE INTESTINE: A T-CELL LYMPHOMA

H. Stein, D. Mason, P. Isaacson, 1985, The Lancet.

Properties of human thymic B cells.

P. Isaacson, J. Spencer, T. Hussell, 1992, Immunology.

Malignant lymphoma of mucosa‐associated lymphoid tissue

P. Isaacson, J. Spencer, P. G. Isaacson, 1987, Histopathology.

Asplenia and spleen hypofunction

G. Corazza, A. Di Sabatino, J. Spencer, 2022, Nature Reviews Disease Primers.

Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes.

L. Boursier, J. Spencer, D. Dunn-Walters, 1998, Journal of immunology.

Immunohistochemical analysis of ageing human B and T cell populations reveals an age-related decline of CD8 T cells in spleen but not gut-associated lymphoid tissue (GALT)

J. Sanderson, J. Spencer, D. Dunn-Walters, 2000, Mechanisms of Ageing and Development.

Heterogeneity in Intraepithelial Lymphocyte Subpopulations in Fetal and Postnatal Human Small Intestine

P. Isaacson, J. Spencer, T. Macdonald, 1989, Journal of pediatric gastroenterology and nutrition.

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function

W. Agace, J. Spencer, Nicole von Burg, 2021, Mucosal Immunology.

Human intestinal lymphoid tissue in time and space

J. Spencer, L. Montorsi, Jacqueline H Y Siu, 2018, Mucosal Immunology.

Disrupted Peyer’s Patch Microanatomy in COVID-19 Including Germinal Centre Atrophy Independent of Local Virus

M. Shankar-Hari, S. Neil, J. Spencer, 2021, bioRxiv.

The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD)

J. Fell, J. Spencer, T. Macdonald, 1996, Clinical and experimental immunology.

Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis

M. Singer, M. Shankar-Hari, R. Beale, 2017, Critical care medicine.

Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts

Mohamed Reda Keddar, C. Swanton, G. Wilson, 2021, Gastroenterology.

Flanking Mutated A and T Nucleotides Reverse Complementarity of Sequences by Adjacent Nucleotides and There Is No Affected Nucleotide Replacement Spectrum Is Hypermutation at A-T Base Pairs: The A

J. Spencer, 2005 .

Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments.

L. Boursier, J. Spencer, W. Su, 2003, Molecular immunology.

Characteristics of sequences around individual nucleotide substitutions in IgVH genes suggest different GC and AT mutators.

J. Spencer, D. Dunn-Walters, M. Dunn, 1999, Journal of immunology.

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

Stephen Kelly, Michele Bombardieri, Costantino Pitzalis, 2009, PLoS medicine.

Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue

J. Sanderson, F. Ciccarelli, S. Heck, 2018, Nature Communications.

The Human Intestinal IgA Response; Burning Questions

J. Spencer, L. Klavinskis, Louise D. Fraser, 2012, Front. Immun..

Selective biopsy of human Peyer's patches during ileal endoscopy.

J. Spencer, T. Macdonald, J. Walker-Smith, 1987, Gastroenterology.

A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution

Mohamed Reda Keddar, F. Ciccarelli, Michele Bortolomeazzi, 2021, Nature Communications.

CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival

P. Isaacson, G. Valesini, S. Challacombe, 2007, Arthritis Research & Therapy.

Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood

P. Dhami, D. D'cruz, William Guesdon, 2021, bioRxiv.

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

F. Fraternali, G. Besra, G. Anderson, 2019, eLife.

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

D. Gibbons, J. Spencer, Deena Gibbons, 2011, Mucosal Immunology.

Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus

A. Cope, D. D'cruz, J. Spencer, 2015, European journal of immunology.

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

Mohamed Reda Keddar, C. Swanton, G. Wilson, 2020, bioRxiv.

Ontogenetic aspects of the intestinal immune system in man

J. Spencer, T. Macdonald, C. Braegger, 1995 .

Biases in Ig λ Light Chain Rearrangements in Human Intestinal Plasma Cells 1

J. Sanderson, L. Boursier, J. Spencer, 2004, The Journal of Immunology.

Sequence analysis of light chain genes from human intestinal plasma cells demonstrates that lambda genes are almost all in‐frame and highly mutated and most kappa genes are highly mutatedwhen in‐frame and minimally mutated when out‐of‐frame

L. Boursier, J. Spencer, D. Dunn-Walters, 2000, European journal of immunology.

Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study

M. Singer, M. Shankar-Hari, J. Spencer, 2018, Critical Care.

Studies on the adjuvant action of beryllium. II. Systemic effects with particular reference to secretory immunity.

J. Spencer, J. Hall, 1984, Immunology.

Sneddon syndrome associated with two novel ADA2 gene mutations.

J. McGrath, D. D'cruz, S. Sangle, 2020, Rheumatology.

ChAdOx1 nCoV-19 (AZD1222) vaccine elicits monoclonal antibodies with potent cross-neutralizing activity against SARS-CoV-2 viral variants

M. Malim, C. Graham, K. Doores, 2021, bioRxiv.

Somatic hypermutation and B‐cell malignancies

J. Spencer, D. Dunn-Walters, 1999, The Journal of pathology.

Genes HOut-of-Frame Human IgV Hypermutation Deduced by Analysis of Base-Specific Sequences That Bias Somatic

L. Boursier, J. Spencer, D. Dunn-Walters, 1998 .

Response to autoimmune enteropathy to cyclosporin A therapy.

J. Spencer, J. Walker-Smith, A. Phillips, 1991, Gut.

Expression of disulfide‐linked and non‐disulfide‐linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes

P. Isaacson, T. Diss, J. Spencer, 1989 .

intestinal epithelium . HLA-DR expression in human fetal

J. Spencer, T. Macdonald, A. Weinel, 2022 .

Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell–like Differentiation in Patients with Granulomatosis with Polyangiitis

D. D'cruz, S. Sangle, S. John, 2022, The Journal of Immunology.

Inactivation of unused alleles of human immunoglobulin light chain genes as a mechanism of self-preservation.

J. Spencer, S. Nayar, W. Su, 2010, Molecular immunology.

Cell-mediated immune injury in the intestine.

J. Spencer, T. Macdonald, 1992, Gastroenterology clinics of North America.

Expression of disulfide-linked and non-disulfide-linked forms of the T cell receptor gamma/delta heterodimer in human intestinal intraepithelial lymphocytes.

P. Isaacson, T. Diss, J. Spencer, 1989, European journal of immunology.

Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue

C. Chapman, P. Isaacson, J. Spencer, 1996, Clinical molecular pathology.

Human intestinal B cells in inflammatory diseases

M. Bemark, J. Spencer, 2023, Nature Reviews Gastroenterology & Hepatology.

Sequence analysis of human IgVH genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches

P. Isaacson, J. Spencer, D. Dunn-Walters, 1997, European journal of immunology.

Age‐ and tissue‐specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees

Ramit Mehr, J. Spencer, R. Mehr, 2002, European journal of immunology.

Gastric MALT lymphoma and Helicobacter pylori.

J. Spencer, A. Wotherspoon, 1997, Cancer surveys.

Chapter 77 – Gastrointestinal Lymphoma

A. Wotherspoon, J. Spencer, W. Su, 2005 .

Phenotypic characterization of CD3–7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells

David I. Wilson, N. Hanley, Andrea Knight, 2005, The Journal of Immunology.

Phenotypic Characterization of CD3−7+ Cells in Developing Human Intestine and an Analysis of Their Ability to Differentiate into T Cells 1

David I. Wilson, N. Hanley, Andrea Knight, 2005, The Journal of Immunology.

Analysis of Their Ability to Differentiate into in Developing Human Intestine and an Cells + 7 − Phenotypic Characterization of CD 3 and

David I. Wilson, N. Hanley, Andrea Knight, 2005 .

MONOCLONAL ANTIBODY (HML-1) LABELLING OF T-CELL LYMPHOMAS

H. Stein, S. Hamilton-Dutoit, P. Isaacson, 1989, The Lancet.

Immunoglobulin specificity of low grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type.

P. Isaacson, J. Spencer, J. Crabtree, 1993, The American journal of pathology.

A study of the properties of a low‐grade mucosal B‐cell lymphoma using a monoclonal antibody specific for the tumour immunoglobulin

P. Isaacson, T. Diss, J. Spencer, 1990, The Journal of pathology.

Human marginal zone B cell development from early T2 progenitors

J. Sanderson, P. Dhami, S. Heck, 2020, bioRxiv.

A role for gut-associated lymphoid tissue in shaping the human B cell repertoire

J. Sanderson, D. D'cruz, K. Taylor, 2013, The Journal of experimental medicine.

Tumour infiltrating T-cells in gastric lymphoma

P. Isaacson, J. Spencer, T. Hussell, 2004, Virchows Archiv.

E-cadherin expression in intestinal epithelium.

J. Spencer, Z. D. Wang, A. Doğan, 1995, Journal of clinical pathology.

Chemotactic response of Helicobacter pylori to human plasma and bile.

J. Spencer, M. Worku, R. Sidebotham, 2004, Journal of medical microbiology.

Pivotal Advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation

M. Bemark, J. Spencer, S. Koethe, 2011, Journal of leukocyte biology.

Clinical evidence for allergy in orofacial granulomatosis and inflammatory bowel disease

J. Sanderson, M. Lomer, K. Taylor, 2013, Clinical and Translational Allergy.

Human tonsillar germinal center T cells are a diverse and widely disseminated population

J. Spencer, D. Dunn-Walters, S. Golby, 1999, European journal of immunology.

Cellular and molecular mechanisms of IMMunE dysfunction and Recovery from SEpsis-related critical illness in adults: An observational cohort study (IMMERSE) protocol paper

M. Singer, M. Shankar-Hari, M. Saqi, 2020, Journal of the Intensive Care Society.

Ontogeny and induction of adhesion molecule expression in human fetal intestine

J. Spencer, T. Macdonald, A. Doan, 1993, Clinical and experimental immunology.

Generation of Immunoglobulin diversity in human gut-associated lymphoid tissue.

J. Spencer, F. Barone, D. Dunn-Walters, 2009, Seminars in immunology.

B cells in human lymphoid structures

J. Spencer, L. Montorsi, Jacqueline H Y Siu, 2022, Clinical and experimental immunology.

Expression of cell adhesion molecules in the fetal gut.

J. Spencer, T. Macdonald, A. Doğan, 1995, Advances in experimental medicine and biology.

B cell development and proliferation of mature B cells in human fetal intestine

L. Boursier, J. Spencer, D. Dunn-Walters, 2002, Journal of leukocyte biology.

Antibiotic treatment for low-grade gastric MALT lymphoma.

C. Doglioni, P. Isaacson, A. Wotherspoon, 1994, Lancet.

Changes inintraepithelial lymphocyte subpopulations incoeliac disease andenteropathy associated Tcell lymphoma (malignant histiocytosis oftheintestine)

P. Isaacson, T. Diss, J. Spencer, 1989 .

Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus.

A. Cope, D. D'cruz, D. Kipling, 2015, Molecular immunology.

A role for antigen in the evolution of gastrointestinal MALT-type B cell lymphoma.

P. Isaacson, J. Spencer, T. Hussell, 1995, Advances in experimental medicine and biology.

Granulomatosis with polyangiitis involves sustained mucosal inflammation that is rich in B-cell survival factors and autoantigen.

J. Sanderson, D. D'cruz, S. Sangle, 2012, Rheumatology.

Quantitative assessment of NFκB transcription factor activity.

M. Peakman, J. Spencer, P. Lavender, 2020, Journal of immunological methods.

Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity

L. Boursier, J. Spencer, D. D’cruz, 2010, Lupus.

Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis

M. Singer, M. Shankar-Hari, R. Beale, 2015, Intensive Care Medicine.

Ontogenetic aspects of the intestinal immune system in man

J. Spencer, T. Macdonald, C. Braegger, 1995 .

Ontogenetic aspects of the intestinal immune system in man

J. Spencer, T. Macdonald, C. Braegger, 1992, International journal of clinical & laboratory research (Print).

Effects of interferon-gamma and tumour necrosis factor-alpha on epithelial HLA class-II expression on jejunal mucosal biopsy specimens cultured in vitro.

P. Ciclitira, R. Sturgess, J. Spencer, 1992, Scandinavian Journal of Gastroenterology.

Studies on the lymphocytes of sheep. IV. Migration patterns of lung-associated lymphocytes efferent from the caudal mediastinal lymph node.

J. Spencer, J. Hall, 1984, Immunology.

IgA antibodies in the bile of rats. III. The role of intrathoracic lymph nodes and the migration pattern of their blast cells.

J. Spencer, J. Hall, L. Gyure, 1983, Immunology.

Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?*

M. Singer, M. Shankar-Hari, J. Spencer, 2017, Critical care medicine.

The role of activated T cells in transformed intestinal mucosa.

J. Spencer, T. Macdonald, 1990, Digestion.

A common migratory highway between human spleen and mucosa-associated lymphoid tissues; data from nature's own experiments

J. Spencer, A. Doğan, Jo Spencer, 2009, Mucosal Immunology.

Monocytoid B-cell lymphomas.

J. Spencer, P. Isaacson, 1990, The American journal of surgical pathology.

Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells

L. Boursier, J. Spencer, D. Dunn-Walters, 1997, European journal of immunology.

Immunohistochemical and ultrastructural analysis of an extracellular matrix bound antigen preferentially associated with mucosal postcapillary venules.

J. Spencer, T. Hussell, M. Perry, 1996, Journal of Anatomy.

Leaders The biology of low grade MALT lymphoma

P. Isaacson, J. Spencer, 2022 .

Immunoproliferative small-intestinal disease. An immunohistochemical study.

J. Spencer, A. Doğan, P. G. Isaacson, 1989, The American journal of surgical pathology.

A basement membrane molecule preferentially associated with mucosal post-capillary venules.

P. Isaacson, J. Spencer, T. Hussell, 1995, Advances in experimental medicine and biology.

Analysis of strand biased 'G'.C hypermutation in human immunoglobulin V(lambda) gene segments suggests that both DNA strands are targets for deamination by activation-induced cytidine deaminase.

L. Boursier, J. Spencer, W. Su, 2004, Molecular immunology.

Dual role for Bcl-2 in antibody affinity maturation

J. Spencer, D. Dunn-Walters, 2005, Nature Cell Biology.

Weller et al, T-independent responses to polysaccharides in humans mobilize marginal zone B cells pre-diversified against gut bacterial antigens .

M. Bemark, J. Spencer, T. Tull, 2023, Immunology letters.

Ontogenetic aspects of the intestinal immune system in man

J. Spencer, T. Macdonald, C. Braegger, 1992 .

Characteristics of IgVH genes used by human intestinal plasma cells from childhood

L. Boursier, J. Spencer, D. Dunn-Walters, 1999, Immunology.

Reply to “Gut-associated lymphoid tissue contains the molecular machinery to support T-cell-dependent and T-cell-independent class switch recombination”

J. Spencer, F. Barone, 2010, Mucosal Immunology.

Generation of Immunoglobulin diversity in human gut-associated lymphoid tissue.

J. Spencer, F. Barone, D. Dunn-Walters, 2009, Seminars in immunology.

HLA-DRexpression inhumanfetal intestinal epithelium

J. Spencer, T. Macdonald, A. Weinel, 1988 .

Heterogeneity of non-lymphoid cells expressing HLA-D region antigens in human fetal gut.

P. Isaacson, J. Spencer, T. Macdonald, 1987, Clinical and Experimental Immunology.

Aggressive mucosa associated lymphoid tissue lymphomas are associated with mutations inBcl10

J. Spencer, 1999, Gut.

Circulating T follicular helper cell and regulatory T cell frequencies are influenced by B cell depletion in patients with granulomatosis with polyangiitis.

D. D'cruz, S. Sangle, T. Tree, 2014, Rheumatology.

Gastrointestinal and hepatic immunology: Lymphoid cells and tissues of the gastrointestinal tract

J. Spencer, T. T. MacDonald, 1994 .