N. Maihle

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Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer.

D. Fishman, A. Rademaker, K. Podratz, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Lin28 regulates HER2 and promotes malignancy through multiple mechanisms

J. Bordeaux, D. Rimm, V. Neumeister, 2012, Cell cycle.

Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm.

J. Boerner, N. Maihle, A. Danielsen, 2003, Experimental cell research.

The Role of Body Mass Index in the Relative Risk of Developing Premenopausal versus Postmenopausal Breast Cancer

N. Maihle, M. Cleary, 1997, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Presence and indirect immunofluorescent localization of calmodulin in Paramecium tetraurelia

A. Means, J. Chafouleas, N. Maihle, 1981, The Journal of cell biology.

The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities.

N. Maihle, J. Bonner, B. R. Folven, 1994, International journal of radiation oncology, biology, physics.

Monoclonal antibodies specific for peptide epitopes of the epidermal growth factor receptor's extracellular domain.

P. Roche, A. Baron, J. Lafky, 1997, Hybridoma.

Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases

S. Bell, N. Maihle, J. Degen, 1993 .

Native avian c-erbB gene expresses a secreted protein product corresponding to the ligand-binding domain of the receptor.

H. Kung, N. Maihle, M. Raines, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Ligand-independent oncogenic signaling by the epidermal growth factor receptor

J. Boerner, N. Maihle, A. Danielsen, 2003 .

A randomized phase II study of sequential docetaxel and doxorubicin/cyclophosphamide in patients with metastatic breast cancer.

E. Perez, J. Ingle, J. Kugler, 2002, Annals of oncology : official journal of the European Society for Medical Oncology.

Soluble epidermal growth factor receptor (sEGFR) [corrected] and cancer antigen 125 (CA125) as screening and diagnostic tests for epithelial ovarian cancer.

D. Fishman, A. Rademaker, K. Podratz, 2005, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms.

C. James, G. Eley, T. Magnuson, 2001, Genomics.

Genetically Obese MMTV-TGF-α/LepobLepob Female Mice do not Develop Mammary Tumors

J. Grande, N. Maihle, S. Juneja, 2003, Breast Cancer Research and Treatment.

Diet-Induced Obesity and Mammary Tumor Development in MMTV-neu Female Mice

J. Grande, N. Maihle, S. Juneja, 2004, Nutrition and cancer.

Prevention of Mammary Tumorigenesis by Intermittent Caloric Restriction: Does Caloric Intake During Refeeding Modulate the Response?

J. Grande, N. Maihle, S. Juneja, 2007, Experimental biology and medicine.

Activation of Rho Is Required for Ligand-independent Oncogenic Signaling by a Mutant Epidermal Growth Factor Receptor*

J. Boerner, N. Maihle, A. Danielsen, 2001, The Journal of Biological Chemistry.

Metformin alters DNA methylation genome-wide via the H19/SAHH axis

H. Taylor, G. Carmichael, A. Mitsuhashi, 2016, Oncogene.

Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors.

J. Grande, N. Maihle, S. Juneja, 2003, Breast cancer research and treatment.

Sequence, expression and function of an mRNA encoding a soluble form of the human interleukin-6 receptor (sIL-6R).

J. Lust, D. Jelinek, N. Maihle, 1995, Current topics in microbiology and immunology.

An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation

H. Kung, N. Maihle, T. Flickinger, 1992, Molecular and cellular biology.

Can Block Ligand-Dependent Transformation

H. Kung, N. Maihle, T. Flickinger, 2022 .

Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female mice.

J. Grande, N. Maihle, M. Cleary, 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Activation of c-fos gene expression by a kinase-deficient epidermal growth factor receptor

G. .. Korf, N. Maihle, D. Connolly, 1994, Molecular and cellular biology.

Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation.

N. Maihle, C. A. Lovejoy, D. Connolly, 2004, Experimental cell research.

Disease tropism of c-erbB: effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation.

H. Kung, H. Shu, N. Maihle, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbB

H. Kung, N. Maihle, M. Moscovici, 1988, Journal of virology.

Expression of EGFR isoform D is regulated by HER receptor activators in breast cancer cells

E. Cora, N. Maihle, J. Ryu, 2022, Biochemistry and biophysics reports.

A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human sera.

D. O'Kane, V. Suman, K. Podratz, 1998, Journal of immunological methods.

Cloning of murine tissue factor and regulation of gene expression by transforming growth factor type beta 1.

M. Subramaniam, S. Blatti, N. Maihle, 1991, The Journal of biological chemistry.

Anti-HER-2 therapy following severe trastuzumab-induced cardiac toxicity

N. Maihle, Shou-Ching Tang, I. Sadek, 2017, Genes & diseases.

Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors.

J. Grande, N. Maihle, S. Juneja, 2004, Experimental biology and medicine.

Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases

N. Maihle, J. Degen, D. Connolly, 1993, Molecular and cellular biology.

Generation of skeletal, smooth and low molecular weight non-muscle tropomyosin isoforms from the chicken tropomyosin 1 gene.

S. Hughes, N. Maihle, S. Forry-Schaudies, 1990, Journal of molecular biology.

Generation and characterization of polyclonal antibodies specific for human p110 sEGFR.

A. Baron, N. Maihle, J. Reiter, 2002, Hybridoma and hybridomics.

Tissue- and transformation-specific phosphotyrosyl proteins in v-erbB-transformed cells

N. Maihle, D. Connolly, M. Mcmanus, 1995, Journal of virology.

Effect of Moderate Caloric Restriction and/or Weight Cycling on Mammary Tumor Incidence and Latency in MMTV-Neu Female Mice

N. Maihle, M. Cleary, T. Christensen, 2002, Nutrition and cancer.

Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues

N. Maihle, Hakjoo Lee, 1998, Oncogene.

Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: A study of 93 cases

D. Bostwick, N. Maihle, J. Qian, 2004, The Prostate.

Soluble epidermal growth factor receptor acridinium-linked immunosorbent assay.

A. Baron, J. Lafky, N. Maihle, 2006, Methods in molecular biology.

Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis

J. Boerner, N. Maihle, Ze Wang, 2003, Oncogene.

Serum sErbB 1 and Epidermal Growth Factor Levels As Tumor Biomarkers in Women with Stage III or IV Epithelial Ovarian Cancer 1

V. Suman, K. Podratz, A. Baron, 1999 .

Suramin Induces Phosphorylation of the High‐Affinity Nerve Growth Factor Receptor in PC12 Cells and Dorsal Root Ganglion Neurons

A. Windebank, N. Maihle, D. Connolly, 1996, Journal of neurochemistry.

Ras-independent oncogenic transformation by an EGF-receptor mutant.

G. Martin, J. Boerner, N. Maihle, 2000, Journal of cell science.

Tyrosine Phosphorylation of Caldesmon Is Required for Binding to the Shc·Grb2 Complex*

N. Maihle, A. Danielsen, Z. Wang, 1999, The Journal of Biological Chemistry.

Clinical implementation of soluble EGFR (sEGFR) as a theragnostic serum biomarker of breast, lung and ovarian cancer.

A. Baron, N. Maihle, J. Wilken, 2009, IDrugs : the investigational drugs journal.

The epidermal growth factor receptor conundrum

A. Baron, N. Maihle, J. Wilken, 2011, Cancer.

Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells.

M. Pittelkow, N. Maihle, I. Sehgal, 1994, Molecular biology of the cell.

Molecular Basis of Oncogenesis by Non-Acute Avian Retroviruses

H. Kung, N. Maihle, 1986 .

Mechanism of c-erbB transduction: newly released transducing viruses retain poly(A) tracts of erbB transcripts and encode C-terminally intact erbB proteins

H. Kung, N. Maihle, L. Crittenden, 1988, Journal of virology.

Retroviral insertional mutagenesis: the making of a receptor-oncogene.

H. Kung, H. Shu, N. Maihle, 1990, Developments in biological standardization.

Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity

N. Maihle, D. Connolly, S. Toutenhoofd, 1994, Journal of virology.

C-erbB and the epidermal growth-factor receptor: a molecule with dual identity.

H. Kung, N. Maihle, 1989, Biochimica et biophysica acta.

Proviral insertional activation of c-erbB: differential processing of the protein products arising from two alternate transcripts

H. Kung, N. Maihle, M. Raines, 1988, Molecular and cellular biology.

Soluble Epidermal Growth Factor Receptor (SEG-FR) and Cancer Antigen 125 (CA125) as Screening and Diagnostic Tests for Epithelial Ovarian Cancer

D. Fishman, A. Rademaker, K. Podratz, 2005, Cancer Epidemiology Biomarkers & Prevention.

Calmodulin localization during capping and receptor-mediated endocytosis

J. Condeelis, P. Satir, J. Salisbury, 1981, Nature.

A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly.

W. Lingle, J. Salisbury, N. Maihle, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Trastuzumab-induced HER reprogramming in "resistant" breast carcinoma cells.

Andre T Baron, Murli Narayan, Lyndsay N Harris, 2009, Cancer research.

Leptin Receptor-Deficient MMTV-TGF-α/Leprdb Leprdb Female Mice Do Not Develop Oncogene-Induced Mammary Tumors

J. Grande, N. Maihle, S. Juneja, 2004 .

A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma.

C. James, G. Eley, Soyeon Park, 2002, Neuro-oncology.

Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development.

Xin Hu, N. Maihle, S. Juneja, 2003, Journal of the National Cancer Institute.

Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity.

J. Ingle, W. Lingle, J. Salisbury, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-α mice

J. Grande, N. Maihle, M. Cleary, 2007, Breast Cancer Research.

Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions

N. Maihle, B. Huntley, M. A. Adelsman, 1996, Journal of virology.

Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis.

Shuang Huang, Guangyu Wu, N. Maihle, 2014, Cellular signalling.

Searching for a system: the quest for ovarian cancer biomarkers.

K. Rodland, N. Maihle, 2010, Cancer biomarkers : section A of Disease markers.

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4.

M. Sliwkowski, H. Lee, R. Akita, 2001, Cancer research.

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

Yingqun Huang, N. Maihle, Y. Huang, 2010, Oncogene.

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor.

R. Kyle, P. Greipp, J. Lust, 1992, Cytokine.

EGFR/HER-targeted therapeutics in ovarian cancer.

A. Branscum, P. Schwartz, A. Santin, 2012, Future medicinal chemistry.

Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer.

A. Baron, J. Lafky, N. Maihle, 2008, Biochimica et biophysica acta.

The EGF/ErbB Receptor Family and Apoptosis

N. Maihle, A. Danielsen, Andrew J. Danielsen, 2002, Growth factors.

A phase II evaluation of gefitinib in the treatment of persistent or recurrent endometrial cancer: a Gynecologic Oncology Group study.

Meenakshi Singh, A. Godwin, K. Leslie, 2013, Gynecologic oncology.

Trastuzumab Sensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics

N. Maihle, J. Wilken, K. Webster, 2010, Journal of ovarian research.

Soluble Human Epidermal Growth Factor Receptor 2 (sHER2) as a Potential Risk Assessment, Screening, and Diagnostic Biomarker of Lung Adenocarcinoma

Ping Yang, A. Branscum, A. Baron, 2013, Diagnostics.

GT198 Expression Defines Mutant Tumor Stroma in Human Breast Cancer.

Liang Cheng, N. Mivechi, N. Maihle, 2016, The American journal of pathology.

TUMORIGENESIS AND NEOPLASTIC PROGRESSION GT198 Expression De ﬁ nes Mutant Tumor Stroma in Human Breast Cancer

Liang Cheng, N. Mivechi, N. Maihle, 2016 .

Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment

A. Branscum, P. Schwartz, Jie Xu, 2013, Cell cycle.

Malignant pericytes expressing GT198 give rise to tumor cells through angiogenesis

A. Arbab, Liyong Zhang, N. Mivechi, 2017, Oncotarget.

Serum sErbB1 and epidermal growth factor levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer.

V. Suman, K. Podratz, A. Baron, 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Protein secretion in Tetrahymena thermophila: characterization of the secretory mutant strain SB281.

N. Maihle, B. Satir, 1985, Journal of cell science.

The Granulin-Epithelin Precursor Is a Steroid-Regulated Growth Factor in Endometrical Cancer

A. Berchuck, W. Lingle, K. Podratz, 2006, The Journal of the Society for Gynecologic Investigation: JSGI.

Studies on epidermal growth factor receptor signaling in vertebrate limb patterning

N. Maihle, M. Omi, C. Dealy, 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

Ultrastructure of the flagellar apparatus of the green alga Tetraselmis subcordiformis - With special consideration given to the function of the rhizoplast and rhizanchora

J. Swanson, G. L. Floyd, J. Salisbury, 1981 .

Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo

Jae-Wook Jeong, Jae-Wook Jeong, N. Maihle, 2013, Arthritis Research & Therapy.

Cross‐talk between EGFR and BMP signals regulates chondrocyte maturation during endochondral ossification

D. Threadgill, S. Yadav, N. Maihle, 2021, Developmental dynamics : an official publication of the American Association of Anatomists.

Reduced expression of the epidermal growth factor signaling system in preeclampsia.

D. Armant, B. Kilburn, N. Maihle, 2015, Placenta.

Characterization and Expression of Novel 60‐kDa and 110‐kDa EGFR Isoforms in Human Placenta

N. Maihle, Jill L Reiter, Nita J Maihle, 2003, Annals of the New York Academy of Sciences.

EGF/ErbB receptor family in ovarian cancer.

H. Lee, K. Podratz, B. Barrette, 2002, Cancer treatment and research.

ResearchSensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics

N. Maihle, J. Wilken, K. Webster, 2010 .

Soluble epidermal growth factor receptor: a biomarker of epithelial ovarian cancer.

D. Fishman, A. Rademaker, K. Podratz, 2009, Cancer treatment and research.

A preliminary study of serum concentrations of soluble epidermal growth factor receptor (sErbB1), gonadotropins, and steroid hormones in healthy men and women.

E. Perez, V. Suman, K. Podratz, 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

A chromosomal region 7 p 11 . 2 transcript map : Its development and application to the study of EGFR amplicons in glioblastoma 1

C. James, G. Eley, Soyeon Park, 2001 .

Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2+ Breast Cancer

Hong Yan Liu, N. Maihle, Shu-hua Zhao, 2017, Molecular therapy. Nucleic acids.

Morphological and ultrastructural features of Nikitinsporites canadensis chaloner, a devonian megaspore from the frasnian of canada

T. Taylor, N. Maihle, L. Hills, 1980 .

EGFR isoforms and gene regulation in human endometrial cancer cells

K. Leslie, N. Maihle, G. Pickett, 2010, Molecular Cancer.

Receptor-mediated endocytosis by clathrin-coated vesicles: evidence for a dynamic pathway.

J. Condeelis, P. Satir, J. Salisbury, 1982, Cold Spring Harbor symposia on quantitative biology.

Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer.

G. Powis, M. Pittelkow, N. Maihle, 1994, Proceedings of the National Academy of Sciences of the United States of America.

CALMODULIN IN THE CILIATES PARAMECIUM TETRALJRELIA AND TETRAHYMENA THERMOPHILA *

N. Maihle, B. Satir, 1980, Annals of the New York Academy of Sciences.

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.

N. Maihle, A. Danielsen, Andrew J. Danielsen, 2002, Experimental cell research.

Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth

Hong Yan Liu, N. Maihle, Shou-Ching Tang, 2018, Molecular pharmaceutics.

Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-α mice

J. Grande, N. Maihle, M. Cleary, 2004, International Journal of Obesity.

Aspirin Treatment Effect and Association with PIK3CA Mutation in Breast Cancer: A Biomarker Analysis.

Yunyun Zhou, N. Maihle, Shou-Ching Tang, 2019, Clinical breast cancer.

An Oncogenic Epidermal Growth Factor Receptor Signals via a p21-activated Kinase-Caldesmon-Myosin Phosphotyrosine Complex*

F. Matsumura, J. Boerner, N. Maihle, 2000, The Journal of Biological Chemistry.

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Huidong Shi, J. Roig, J. Cowell, 2019, The Journal of Biological Chemistry.

Identification of immunoreactive regions of homology between soluble epidermal growth factor receptor and α5-integrin.

A. Baron, N. Maihle, J. Wilken, 2011, Biochemistry.

Serum soluble epidermal growth factor receptor concentrations decrease in postmenopausal metastatic breast cancer patients treated with letrozole.

E. Perez, J. Ingle, V. Suman, 2005, Cancer research.

Shedding of soluble epidermal growth factor receptor (sEGFR) is mediated by a metalloprotease/fibronectin/integrin axis and inhibited by cetuximab.

Andre T Baron, R. Nieves-Alicea, A. Baron, 2013, Biochemistry.

POSSIBLE FUNCTIONS OF CALMODULIN IN PROTOZOA *

R. Garofalo, N. Maihle, D. Gilligan, 1980, Annals of the New York Academy of Sciences.

Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells.

R. Nieves-Alicea, E. Cora, N. Maihle, 2008, Experimental cell research.

Primary trastuzumab resistance: new tricks for an old drug

N. Maihle, J. Wilken, 2010, Annals of the New York Academy of Sciences.

Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins.

B. O’Malley, O. Conneely, D. Toft, 1991, The Journal of biological chemistry.

Protein secretion in Tetrahymena thermophila. Characterization of the major proteinaceous secretory proteins.

N. Maihle, B. Satir, 1986, The Journal of biological chemistry.

Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish

Z. Gong, P. Meikle, S. Lirette, 2022, Cancer & metabolism.

Nadir CA125 concentration as a prognostic indicator in ovarian cancer

A. Baron, N. Maihle, 2005, Nature Clinical Practice Oncology.

A Pilot Randomized Controlled Trial Evaluating Essential Oils for Chemotherapy-Induced Peripheral Neuropathy.

N. Maihle, V. Barnes, J. Zadinsky, 2023, Pain management nursing : official journal of the American Society of Pain Management Nurses.

A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor.

N. Maihle, J. Reiter, 1996, Nucleic acids research.

Requirement for ErbB2/ErbB signaling in developing cartilage and bone

N. Maihle, G. Clinton, C. Dealy, 2007, Development, growth & differentiation.

Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice.

J. Grande, N. Maihle, M. Cleary, 2004, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Leptin—A Growth Factor in Normal and Malignant Breast Cells and for Normal Mammary Gland Development

N. Maihle, M. Cleary, Xin Hu, 2003 .

Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development.

Xin Hu, N. Maihle, S. Juneja, 2002, Journal of the National Cancer Institute.

Re: Leptin - A growth factor in normal and malignant breast cells and for normal mammary gland development (multiple letters) [2]

W. Berdel, H. Serve, E. Oelmann, 2003 .

Identification of a biochemical marker for the secretory pathway in Tetrahymena thermophila

N. Maihle, B. Satir, 1986, Journal of Cellular Biochemistry.

Correspondence re: S. Shintani et al., Intragenic mutation analysis of the human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes. Cancer Res., 59: 4142-4147, 1999.

G. Eley, N. Maihle, J. Reiter, 2000, Cancer research.