J. Ju

发表

Minimum Information about a Biosynthetic Gene cluster.

Carla S. Jones, M. Smanski, Jan Claesen, 2015, Nature chemical biology.

Halogenated anthraquinones from the marine-derived fungus Aspergillus sp. SCSIO F063.

J. Ju, Hongbo Huang, Fazuo Wang, 2012, Journal of natural products.

Exploration and genome mining of natural products from marine Streptomyces

J. Ju, Zhijie Yang, Jianqiao He, 2019, Applied Microbiology and Biotechnology.

Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Yunchang Xie, J. Ju, Tianyu Zhang, 2017, Nature Communications.

Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont

Xiaoyi Wei, Wenli Li, J. Ju, 2020, Communications biology.

Isolation and characterization of a novel pyrene-degrading Bacillus vallismortis strain JY3A.

J. Ju, J. Ling, Guoying Zhang, 2011, The Science of the total environment.

Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.

B. Shen, F. Hoffmann, H. Osada, 2009, Organic letters.

Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3β

B. Shen, Herb Chen, J. Adler, 2009, Molecular Cancer Therapeutics.

Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase.

Siwen Niu, Changsheng Zhang, J. Ju, 2011, Journal of the American Chemical Society.

Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127

Haibo Zhang, Siwen Niu, Changsheng Zhang, 2011, The Journal of Antibiotics.

Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 ΔilaR.

J. Ju, Xiangcheng Zhu, Tianyu Zhang, 2020, Journal of natural products.

Chemoenzymatic synthesis of β-carboline derivatives using McbA, a new ATP-dependent amide synthetase

J. Ju, Hongbo Huang, Yongxiang Song, 2014 .

Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66

Wenli Li, Yanhong Qiu, J. Ju, 2016, Microbial Cell Factories.

The roles of genes associated with regulation, transportation, and macrocyclization in desotamide biosynthesis in Streptomyces scopuliridis SCSIO ZJ46

J. Ju, Qinglian Li, Wenjuan Ding, 2020, Applied Microbiology and Biotechnology.

Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation

Siwen Niu, Yiguang Zhu, Changsheng Zhang, 2012, Applied and Environmental Microbiology.

Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis*

B. Shen, H. Osada, J. Ju, 2008, Journal of Biological Chemistry.

Chemical Synthesis and Structure-Activity Relationship Study Yield Desotamide a Analogues with Improved Antibacterial Activity

J. Ju, Yongxiang Song, Qinglian Li, 2021, Marine drugs.

Neoabyssomicins A–C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802

Xiaoyi Wei, J. Ju, Yongxiang Song, 2017 .

Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.

Caiguo Huang, Yuemao Shen, Qingbo Zhang, 2012, Organic letters.

Cyclic heptapeptides, cordyheptapeptides C-E, from the marine-derived fungus Acremonium persicinum SCSIO 115 and their cytotoxic activities.

J. Ju, Hongbo Huang, Yuchan Chen, 2012, Journal of natural products.

Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea.

Yongjun Lu, J. Ju, Z. She, 2011, Journal of natural products.

Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802

Jiang Chen, J. Ju, Yongxiang Song, 2018, Microbial Cell Factories.

Staurosporine produced by marine-derived actinomycete Streptomyces roseoflavus MB-97 isolated from coastal sediment

B. Shen, J. Ju, Jiang-chun Hu, 2008 .

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

B. Shen, G. Wilding, D. Church, 2015, Proceedings of the National Academy of Sciences.

Involvement of SgvP in Carbon–Sulfur Bond Formation during Griseoviridin Biosynthesis

Yunchang Xie, J. Ju, Yongxiang Song, 2014, Chembiochem : a European journal of chemical biology.

Characterization of the Noncanonical Regulatory and Transporter Genes in Atratumycin Biosynthesis and Production in a Heterologous Host

J. Ju, Zhijie Yang, Jianqiao He, 2019, Marine drugs.

Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived Streptomyces sp. SCSIO ZS0520

J. Ju, Yongxiang Song, Junying Ma, 2022, Marine drugs.

Discovery, Structure Correction, and Biosynthesis of Actinopyrones, Cytotoxic Polyketides from the Deep-Sea Hydrothermal-Vent-Derived Streptomyces sp. SCSIO ZS0520.

Jie Yuan, Xiaoyi Wei, J. Ju, 2021, Journal of natural products.

Julichrome Monomers from Marine Gastropod Mollusk‐Associated Streptomyces and Stereochemical Revision of Julichromes Q3 ⋅ 5 and Q3 ⋅ 3

J. Ju, Changli Sun, Xuehong Chen, 2020, Chemistry & biodiversity.

marine E ﬃ cacy of Compounds Isolated from Streptomyces olivaceus against the Morphogenesis and Virulence of Candida albicans

Shihao Song, Xiuyun Sun, Yinyue Deng, 2019 .

Biosynthetic Baeyer-Villiger Chemistry Enables Access to Two Anthracene Scaffolds from a Single Gene Cluster in Deep-Sea-Derived Streptomyces olivaceus SCSIO T05.

Liyan Wang, J. Ju, Hongbo Huang, 2018, Journal of natural products.

The Chemistry of Purine Nucleoside-Based Antibiotics

J. Ju, Hongbo Huang, Junying Ma, 2019 .

Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity.

B. Shen, M. Ma, J. Ju, 2013, Journal of the American Chemical Society.

Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.

B. Shen, Hui Jiang, J. Ju, 2005, Journal of the American Chemical Society.

iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase*

B. Shen, Hui Jiang, C. Farnet, 2009, The Journal of Biological Chemistry.

Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

B. Shen, F. Hoffmann, J. Ju, 2009, Journal of the American Chemical Society.

Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues.

B. Shen, Hui Jiang, J. Ju, 2006, Organic letters.

Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32.

Caiguo Huang, Changsheng Zhang, J. Ju, 2012, Journal of natural products.

Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299

Wenjun Li, Siwen Niu, Changsheng Zhang, 2011, Marine drugs.

Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.

Changsheng Zhang, J. Ju, Hongbo Huang, 2011, Biochemical and biophysical research communications.

Characterization of FdmV as an Amide Synthetase for Fredericamycin A Biosynthesis in Streptomyces griseus ATCC 43944*

B. Shen, Shuangjun Lin, J. Ju, 2010, The Journal of Biological Chemistry.

Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity

J. Ju, Qinglian Li, Xuhua Mo, 2014 .

Activation and Characterization of Bohemamine Biosynthetic Gene Cluster from Streptomyces sp. CB02009.

Changsheng Zhang, J. Ju, Y. Duan, 2020, Organic letters.

Coordinated Action of NRPS, Baeyer-Villiger Monooxygenase, and Methyltransferase Ensures the Economical Biosynthesis of Bohemamines in Streptomyces sp. CB02009

Changsheng Zhang, J. Ju, Y. Duan, 2020 .

On-PKS Baeyer-Villiger-Type O-Atom Insertion Catalyzed by Luciferase-Like Monooxygenase OvmO during Olimycin Biosynthesis.

J. Ju, Chunyan Zhang, Hua Zhang, 2020, Organic letters.

Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453.

B. Shen, Z. Deng, J. Ju, 2008, Acta biochimica et biophysica Sinica.

New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141

Shenmin Zhang, J. Ju, Hongbo Huang, 2014 .

Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria.

J. Ju, Yuchan Chen, Yongxiang Song, 2014, Journal of natural products.

Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652.

J. Ju, Hongbo Huang, Yuchan Chen, 2012, Journal of natural products.

Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host.

J. Ju, Yongxiang Song, Qinglian Li, 2015, Journal of natural products.

Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations

Xiaoyi Wei, Q. Liu, J. Ju, 2018 .

Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain.

Xiaoyi Wei, J. Ju, Tianyu Zhang, 2019, Organic letters.

Deciphering the Biosynthetic Origin of L-allo-Isoleucine.

J. Ju, Jing Liu, Qinglian Li, 2016, Journal of the American Chemical Society.

Conversion of (2S)‐Arginine to (2S,3R)‐Capreomycidine by VioC and VioD from the Viomycin Biosynthetic Pathway of Streptomyces sp. Strain ATCC11861

B. Shen, J. Ju, Michael G. Thomas, 2004, Chembiochem : a European journal of chemical biology.

Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406.

J. Ju, Hongbo Huang, Yuchan Chen, 2013, Journal of natural products.

03219A, a new Δ8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment

Yun Zhang, J. Ju, Hongbo Huang, 2013, The Journal of Antibiotics.

Discovery and Engineered Overproduction of Antimicrobial Nucleoside Antibiotic A201A from the Deep-Sea Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652

Wenjun Li, Changsheng Zhang, J. Ju, 2011, Antimicrobial Agents and Chemotherapy.

Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.

B. Shen, Herb Chen, J. Adler, 2009, American journal of surgery.

Identification of the Biosynthetic Gene Cluster and Regulatory Cascade for the Synergistic Antibacterial Antibiotics Griseoviridin and Viridogrisein in Streptomyces griseoviridis

Yunchang Xie, J. Ju, Hongbo Huang, 2012, Chembiochem : a European journal of chemical biology.

Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis.

J. Ju, Hua Wang, Houjin Zhang, 2014, Acta crystallographica. Section F, Structural biology communications.

MGCEP 1.0: A Genetic-Engineered Marine-Derived Chassis Cell for a Scaled Heterologous Expression Platform of Microbial Bioactive Metabolites.

J. Ju, Zhijie Yang, Junying Ma, 2022, ACS synthetic biology.

Development of the CRISPR-Cas9 System for the Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7

J. Ju, Yongxiang Song, Junying Ma, 2022, Journal of fungi.

Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin

Tilman Schneider-Poetsch, Ben Shen, Rachel Green, 2010, Nature chemical biology.

Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin.

B. Shen, Hui Jiang, J. Ju, 2005, Journal of the American Chemical Society.

Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR

Xiujuan Xin, J. Ju, Faliang An, 2022, Bioresources and Bioprocessing.

Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes [4 + 2] Cycloaddition during Neoabyssomicin Biosynthesis

M. Ma, J. Ju, Hongbo Huang, 2020, ACS omega.

Genome Sequencing of Streptomyces atratus SCSIOZH16 and Activation Production of Nocardamine via Metabolic Engineering

J. Ju, Junying Ma, Chunyan Zhang, 2018, Front. Microbiol..

Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001

J. Ju, Y. Duan, Yong Huang, 2019, Natural product research.

Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07.

Changsheng Zhang, J. Ju, Zhihui Zheng, 2012, Bioorganic & medicinal chemistry letters.

Medium optimization and subsequent fermentative regulation enabled the scaled‐up production of anti‐tuberculosis drug leads ilamycin‐E1/E2

J. Ju, Xiangcheng Zhu, Junying Ma, 2022, Biotechnology journal.

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks.

B. Shen, L. Gawron, T. Beerman, 2007, Cancer research.

Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-l-galactose mutase

J. Ju, Hongbo Huang, Yongxiang Song, 2017, Proceedings of the National Academy of Sciences.

Grincamycins I – K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32

Jie Yuan, J. Ju, Hongbo Huang, 2017, Planta Medica.

A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66

Wenli Li, Yanhong Qiu, J. Ju, 2016, Marine drugs.

Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis

Yunjun Yan, Yunchang Xie, J. Ju, 2013, FEBS letters.

Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme.

Changsheng Zhang, J. Ju, Hongbo Huang, 2012, Journal of the American Chemical Society.

New Cytochalasins from the Marine-Derived Fungus Xylaria sp. SCSIO 156

Changsheng Zhang, J. Ju, Hongbo Huang, 2011 .

Antimicrobial Polyketides from the Marine-Derived Fungus Spiromastix sp. SCSIO F190.

J. Ju, Junying Ma, Hua Zhang, 2022, Journal of natural products.

Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.

Wenjun Li, Caiguo Huang, Changsheng Zhang, 2011, Journal of natural products.

N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete

A. Mándi, T. Kurtán, Qingbo Zhang, 2012 .

Genome-Directed Discovery of Tetrahydroisoquinolines from Deep-Sea Derived Streptomyces niveus SCSIO 3406.

J. Ju, Yongxiang Song, N. Wong, 2021, The Journal of organic chemistry.

Natural Hydroxamate-Containing Siderophore Acremonpeptides A-D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115.

J. Ju, Hongbo Huang, M. Luo, 2019, Journal of natural products.

Metabolic Blockade-Based Genome Mining Reveals Lipochain-Linked Dihydro-β-alanine Synthetases Involved in Autucedine Biosynthesis.

J. Ju, Junying Ma, Chunyan Zhang, 2022, Organic letters.

New Borrelidins from Onchidium sp. Associated Streptomyces olivaceus SCSIO LO13

J. Ju, Hua Zhang, Qing Xie, 2019, Chemistry & biodiversity.

Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073

Yunchang Xie, J. Ju, Junying Ma, 2019, Marine drugs.

Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender Units*

B. Shen, Z. Deng, J. Ju, 2010, The Journal of Biological Chemistry.

Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase.

Weiming Zhu, Yiguang Zhu, Changsheng Zhang, 2012, Organic letters.

Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology

H. Tan, Wenli Li, J. Ju, 2015, Microbial Cell Factories.

Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101.

Yongjun Dang, J. Ju, Hongbo Huang, 2017, Journal of natural products.

Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32

Yun Zhang, Zengxia Li, J. Ju, 2017, The Journal of Antibiotics.

Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

Jie Yuan, J. Ju, Yongxiang Song, 2020, The Journal of Antibiotics.

Identification and Biological Evaluation of Secondary Metabolites from Marine Derived Fungi-Aspergillus sp. SCSIOW3, Cultivated in the Presence of Epigenetic Modifying Agents

Liyan Wang, J. Ju, Mengjie Li, 2017, Molecules.

Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster.

J. Ju, Tianyu Zhang, Zhijie Yang, 2019, Organic letters.

Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived Fungus Myrothecium sp. Bzo-l062

K. Umezawa, Liyan Wang, J. Ju, 2020, Marine drugs.

Elucidation of the Tailoring Steps in Julichrome Biosynthesis by Marine Gastropod Mollusk-Associated Streptomyces sampsonii SCSIO 054.

J. Ju, Qinglian Li, Yuliang Dong, 2020, Organic letters.

Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues

B. Shen, Hui Jiang, J. Cleveland, 2014, Biochemistry.

Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation.

J. Ju, Hongbo Huang, M. Luo, 2013, Organic letters.

New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus.

B. Shen, J. Ju, Jeong-Woo Seo, 2007, Organic letters.

Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis.

B. Shen, T. Liu, J. Ju, 2011, Organic letters.

The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster.

B. Shen, J. Ju, Xiangcheng Zhu, 2020, Journal of natural products.

Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis.

J. Ju, Junying Ma, Xiangjing Qin, 2015, Organic letters.

Antitumor antibiotics: bleomycin, enediynes, and mitomycin.

B. Shen, M. Hager, J. Thorson, 2005, Chemical reviews.

Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.

Yucheng Gu, J. Ju, Xiangcheng Zhu, 2017, Journal of natural products.

Cytotoxic Kendomycins Containing the Carbacylic Ansa Scaffold from the Marine-Derived Verrucosispora sp. SCSIO 07399.

J. Ju, Hua Zhang, Qing Xie, 2019, Journal of natural products.

Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077

J. Ju, Hongbo Huang, Pachaiyappan Saravana Kumar, 2018, Natural product research.

Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802.

Xiaoyi Wei, J. Ju, Hongbo Huang, 2018, Journal of natural products.

Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.

J. Ju, Yongxiang Song, Hua Zhang, 2018, Bioorganic & medicinal chemistry.

Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594

J. Li, J. Ju, Hongbo Huang, 2015, Marine drugs.

Genome Sequencing of Streptomyces olivaceus SCSIO T05 and Activated Production of Lobophorin CR4 via Metabolic Engineering and Genome Mining

J. Ju, Chunyan Zhang, Xiangjing Qin, 2019, Marine drugs.

Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps.

Changsheng Zhang, Yi-Qiang Cheng, J. Ju, 2011, Angewandte Chemie.

Halo- and Thiocarbazomycins from Coral- and Coral Reef Sands-Derived Actinomycetes

J. Ju, Changli Sun, Songbiao Shi, 2022, Marine drugs.

Biosynthesis of the β-Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring β-Amino Acyl-S-carrier Protein Intermediates

B. Shen, P. Dorrestein, N. Kelleher, 2005 .

Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus

B. Shen, H. Osada, J. Ju, 2006, Journal of bacteriology.

A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496

J. Ju, Hongbo Huang, M. Luo, 2016, Natural product research.

Genome Mining and Metabolic Profiling Uncover Polycyclic Tetramate Macrolactams from Streptomyces koyangensis SCSIO 5802

Xiaoyi Wei, J. Ju, Hua Zhang, 2021, Marine drugs.

A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer–Villiger Oxidation in Neoabyssomicin Biosynthesis

Liyan Wang, J. Ju, Yongxiang Song, 2020 .

Octyl substituted butenolides from marine-derived Streptomyces koyangensis

J. Ju, Hongbo Huang, Yongxiang Song, 2019, Natural product research.

Identification and Heterologous Expression of the Kendomycin B Biosynthetic Gene Cluster from Verrucosispora sp. SCSIO 07399

Jiang Chen, Yingying Chen, J. Ju, 2021, Marine drugs.

Cytotoxic Anthracycline Metabolites from a Recombinant Streptomyces.

Jie Yuan, Yucheng Gu, J. Ju, 2018, Journal of natural products.

Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway

J. Ju, Zhijie Yang, Junying Ma, 2019, Journal of Hematology & Oncology.

Angucycline Glycosides from Mangrove-Derived Streptomyces diastaticus subsp. SCSIO GJ056

Yucheng Gu, J. Ju, Hongbo Huang, 2018, Marine drugs.

Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries.

J. Ju, Hongbo Huang, Zhijie Yang, 2018, Organic letters.

Polyether antibiotics K-41A and K-41Am inhibit HIV-1 replication via suppressing the activities of HIV-1 reverse transcriptase and integrase

Jiang Chen, J. Ju, L. Ye, 2020 .

Characterization of Tailoring Methyltransferases Involved in K-41A Biosynthesis: Modulating Methylation to Improve K-41A Anti-infective Activity.

Jiang Chen, Yucheng Gu, J. Ju, 2020, Organic letters.

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

B. Shen, P. Dorrestein, N. Kelleher, 2008, Proceedings of the National Academy of Sciences.

Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway.

Changsheng Zhang, J. Ju, Hongbo Huang, 2011, Organic letters.

Grincamycin B functions as a potent inhibitor for glioblastoma stem cell via targeting RHOA and PI3K/AKT.

X. Bian, J. Ju, Hongbo Huang, 2020, ACS chemical neuroscience.

Efficacy of Compounds Isolated from Streptomyces olivaceus against the Morphogenesis and Virulence of Candida albicans

Shihao Song, Xiuyun Sun, Yinyue Deng, 2019, Marine drugs.

Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.

Yiguang Zhu, Qingbo Zhang, Changsheng Zhang, 2012, Journal of the American Chemical Society.

Morelsins A–F, six sesquiterpenoids from the liquid culture of Morchella importuna

J. Ju, Cailing Yang, Shiji Xiao, 2020 .

Symbiotic bacteria associated with puffer fish Gastrophysus spadiceus and evaluation of their antimicrobial activities

Wenjun Li, Nimaichand Salam, J. Ju, 2017, 3 Biotech.

Complete genome sequence of the deep South China Sea-derived Streptomyces niveus SCSIO 3406, the producer of cytotoxic and antibacterial marfuraquinocins

J. Ju, Yongxiang Song, Qinglian Li, 2021, PloS one.

Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses

B. Shen, T. Beerman, J. Ju, 2007, Proceedings of the National Academy of Sciences.

Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis.

B. Shen, H. Osada, J. Ju, 2009, Journal of natural products.

Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01

J. Ju, Jiang-chun Hu, Yun Zhang, 2021, The Journal of Antibiotics.

Signal Mimics Derived from a Metagenomic Analysis of the Gypsy Moth Gut Microbiota

B. Shen, J. Handelsman, C. Guan, 2007, Applied and Environmental Microbiology.

Chemical constituents from marine derived fungus Talaromyces cellulolyticus SHJ-3 and its chemotaxonomic significance

J. Ju, Junying Ma, Han Xu, 2022, Biochemical Systematics and Ecology.

Development of Marker Recycling Systems for Sequential Genetic Manipulation in Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7

J. Ju, Yongxiang Song, Junying Ma, 2023, Journal of fungi.

Metabolic blockade-based genome mining of Streptomyces cacaoi SCSIO 68063: Isolation and identification of BE-18257 and pentaminomycin analogues

J. Ju, Chenghai Gao, Qinglian Li, 2022, Tetrahedron.

Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs.

J. Ju, Hongbo Huang, Yongxiang Song, 2019, Organic & biomolecular chemistry.

Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling.

H. Xiang, Pengwei Li, Yihua Chen, 2018, Journal of the American Chemical Society.

Exploration and genome mining of natural products from marine Streptomyces

J. Ju, Zhijie Yang, Jianqiao He, 2019, Applied Microbiology and Biotechnology.

Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity

Shuyao Wang, Wenli Li, J. Ju, 2018, Microbial Cell Factories.

Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2

Ji Xiao, Zhongmei Zhou, Fubing Li, 2019, International journal of biological sciences.

Discovery of McbB, an enzyme catalyzing the β-carboline skeleton construction in the marinacarboline biosynthetic pathway.

J. Ju, Hongbo Huang, Yongxiang Song, 2013, Angewandte Chemie.

AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis.

Liyan Wang, J. Ju, Hongbo Huang, 2018, Organic letters.

Characterization of a Single Gene Cluster Responsible for Methylpendolmycin and Pendolmycin Biosynthesis in the Deep Sea Bacterium Marinactinospora thermotolerans

Wenjun Li, Changsheng Zhang, J. Ju, 2012, Chembiochem : a European journal of chemical biology.

Mathermycin, a Lantibiotic from the Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652

J. Ju, Huan Wang, Erquan Chen, 2017, Applied and Environmental Microbiology.

Identification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis

Yunchang Xie, J. Ju, Junying Ma, 2017, Microbial Cell Factories.

Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation.

B. Shen, J. Ju, S. Rajski, 2008, Journal of natural products.

Characterization of the Glycosyltransferase and Methyltransferase Encoded Remotely from the Actinopyrone Biosynthetic Gene Cluster Enables Access to Diverse Analogues

Xiaoyi Wei, J. Ju, Wenli Li, 2022, Organic Letters.

Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning the Oxazolomycin Biosynthetic Gene Cluster from Streptomyces albus JA3453

B. Shen, Z. Deng, J. Ju, 2006, Journal of bacteriology.

Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

B. Shen, F. Hoffmann, H. Osada, 2010, Journal of the American Chemical Society.

Discovery of Antimycin-Type Depsipeptides from a wbl Gene Mutant Strain of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66 and Their Effects on Pro-inflammatory Cytokine Production

Wenli Li, J. Ju, Huayue Li, 2017, Front. Microbiol..

Genome mining and metabolic profiling illuminate the chemistry driving diverse biological activities of Bacillus siamensis SCSIO 05746

Yunchang Xie, J. Ju, Jiang-chun Hu, 2019, Applied Microbiology and Biotechnology.

Characterization of Regulatory and Transporter Genes in the Biosynthesis of Anti-Tuberculosis Ilamycins and Production in a Heterologous Host

J. Ju, Zhijie Yang, Jianqiao He, 2020, Marine drugs.

Elucidating the Sugar Tailoring Steps in the Cytorhodin Biosynthetic Pathway.

Yucheng Gu, J. Ju, Xuhua Mo, 2017, Organic letters.

CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces

Yucheng Gu, J. Ju, Junying Ma, 2019, Communications Biology.

Anti-Pathogenic Depsidones and its Derivatives from a Coral-Derived Fungus Aspergillus Unguis Scsio Sx7s7

J. Ju, Yongxiang Song, Zhenbin Zhou, 2022, SSRN Electronic Journal.

Genome mining and metabolic profiling illuminate the chemistry driving diverse biological activities of Bacillus siamensis SCSIO 05746

Yunchang Xie, J. Ju, Jiang-chun Hu, 2019, Applied Microbiology and Biotechnology.

Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety.

J. Ju, Hongbo Huang, M. Luo, 2013, Organic letters.

CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces

Yucheng Gu, J. Ju, Junying Ma, 2019, Communications Biology.

Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin

K. Umezawa, Liyan Wang, Yinzhi Lin, 2020, The Journal of Antibiotics.

Cytotoxic Naphtho‐γ‐pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis (GX1‐5E)

Mengfeng Li, Cai-huan Huang, J. Ju, 2011 .

Mutasynthesis of Antibacterial Halogenated Actinomycin Analogues.

Liwu Fu, J. Ju, Junying Ma, 2021, Journal of natural products.

Analysis of the Gypsy Moth Gut Microbiota . Appl . 2007 . Signal Mimics Derived from a Metagenomic

B. Shen, J. Handelsman, C. Guan, 2007 .

Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Yunchang Xie, J. Ju, Tianyu Zhang, 2017, Nature Communications.

Enzymatic Synthesis of a Diastereomer of Neoabyssomicin Derivative Using the Diels‐Alderase AbyU

Xiaoyi Wei, M. Ma, J. Ju, 2021 .

Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands

J. Ju, N. Wong, C. Ling, 2020, Microbiology.

Biosynthesis of the anti-infective marformycins featuring pre-NRPS assembly line N-formylation and O-methylation and post-assembly line C-hydroxylation chemistries.

Yunchang Xie, J. Ju, Jing Liu, 2015, Organic Letters.

Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus

Yunchang Xie, J. Ju, Junying Ma, 2019, Metabolic engineering communications.

Lynamicin B is a Potential Pesticide by Acting as a Lepidoptera-Exclusive Chitinase Inhibitor.

Tian Liu, J. Ju, Yongxiang Song, 2021, Journal of agricultural and food chemistry.

Characterization of a Sugar‐O‐methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity

Siwen Niu, Changsheng Zhang, J. Ju, 2011, Chembiochem : a European journal of chemical biology.

Minimum Information about a Biosynthetic Gene cluster.

M. Smanski, Jan Claesen, B. Shen, 2015, Nature chemical biology.

Mathermycin, a Lantibiotic from the Marine Actinomycete Marinactinospora thermotolerans SCSIO 00652

J. Ju, Huan Wang, Erquan Chen, 2017, Applied and Environmental Microbiology.

Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

B. Shen, F. Hoffmann, J. Ju, 2008, Bioorganic & medicinal chemistry letters.

Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities

J. Ju, Tianyu Zhang, Junying Ma, 2021, Frontiers in Chemistry.

Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units.

J. Ju, Tianyu Zhang, Zhijie Yang, 2020, Journal of natural products.

Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster

J. Ju, Yanjiao Zhang, Xuhua Mo, 2017, Microbial Cell Factories.

Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme.

Changsheng Zhang, J. Ju, Hongbo Huang, 2012, Journal of the American Chemical Society.

Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66.

Wenli Li, J. Ju, Huayue Li, 2020, Bioorganic chemistry.

Genome Sequencing of Streptomyces griseus SCSIO PteL053, the Producer of 2,2′-Bipyridine and Actinomycin Analogs, and Associated Biosynthetic Gene Cluster Analysis

G. Govindarajan, J. Ju, Junying Ma, 2023, Journal of Marine Science and Engineering.

Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps.

Changsheng Zhang, Yi-Qiang Cheng, J. Ju, 2011, Angewandte Chemie.