M. Clark

发表

Design, synthesis and selection of DNA-encoded small-molecule libraries.

Baoguang Zhao, Cecil E. Rise, M. Gefter, 2009, Nature chemical biology.

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Christoph E. Dumelin, A. Keefe, J. Cuozzo, 2015, Scientific Reports.

Selecting chemicals: the emerging utility of DNA-encoded libraries.

M. Clark, Matthew A Clark, 2010, Current opinion in chemical biology.

Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target

Christoph E. Dumelin, A. Keefe, R. Cooke, 2018, SLAS discovery : advancing life sciences R & D.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

Hongfeng Deng, G Joseph Franklin, Kenneth E Lind, 2012, Journal of medicinal chemistry.

Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries

Baoguang Zhao, Cecil E. Rise, M. Gefter, 2009 .

A Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.

Anthony D. Keefe, A. Keefe, F. Ruebsam, 2020, Journal of medicinal chemistry.

Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

A. Keefe, M. Clark, Paolo A. Centrella, 2019, Molecules.

Chemical ligation methods for the tagging of DNA-encoded chemical libraries.

A. Keefe, M. Clark, A. Litovchick, 2015, Current opinion in chemical biology.

Flexibility and Solvation of Amyloid-β Hydrophobic Core*

D. Ostrovsky, D. Gantz, G. Hoatson, 2016, The Journal of Biological Chemistry.

Development and design of the tertiary amino effect reaction for DNA-encoded library synthesis

G. Basarab, N. Selmi, R. Goodnow, 2016 .

The unusual internal motion of the villin headpiece subdomain

A. Wand, Kyle W. Harpole, C. McKnight, 2016, Protein science : a publication of the Protein Society.

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.

A. Keefe, M. Augustin, J. Cuozzo, 2021, Bioorganic & medicinal chemistry.

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.

C. Chung, A. Satz, M. Clark, 2015, ACS medicinal chemistry letters.

Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.

Anthony D. Keefe, A. Keefe, Y. A. Arnautova, 2021, Journal of medicinal chemistry.

Novel Catalyst System for Suzuki-Miyaura Coupling of Challenging DNA-Linked Aryl Chlorides.

M. Clark, Yun Ding, Jennifer L Delorey, 2016, Bioconjugate chemistry.

Evaluating the effect of grain size and salts on liquid water content in frozen soils of Antarctica by combining NMR, chemical equilibrium modeling, and scattered diffraction analysis

R. Sletten, B. Hagedorn, M. Clark, 2017 .

Running title : Flexibility and Solvation of A β Hydrophobic Core

D. Ostrovsky, D. Gantz, G. Hoatson, 2016 .

Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms.

M. Clark, R. Cianciolo, Sangwoon Chung, 2020, Biochemical pharmacology.

Synthesis and metal-binding properties of chelating fluorescein derivatives.

S. Lippard, M. Clark, Jyoti Tibrewala, 2003, Organic letters.

An extensible interface for QM/MM molecular dynamics simulations with AMBER

Andreas W. Götz, Matthew A. Clark, Ross C. Walker, 2014, J. Comput. Chem..

Oxidation of bicyclic oxazolines: applications to glycomimetics and novel saccharide derivatives

B. Ganem, Qunzhao Wang, M. Clark, 2002 .

Robust Suzuki-Miyaura cross-coupling on DNA-linked substrates.

M. Clark, Yun Ding, 2015, ACS combinatorial science.

Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.

Anthony D. Keefe, E. Hennessy, A. Keefe, 2021, Journal of medicinal chemistry.

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

J. Cuozzo, M. Clark, Paolo A. Centrella, 2015, ACS medicinal chemistry letters.

Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags

A. Keefe, M. Clark, A. Litovchick, 2014, Artificial DNA, PNA & XNA.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Anthony D. Keefe, Christoph E. Dumelin, S. Kazmirski, 2017, ACS medicinal chemistry letters.

Effects of phenobarbital and interleukin-6 on cytochrome P4502B1 and 2B2 in cultured rat hepatocytes.

M. Clark, J. Williams, P. Gottschall, 1996, Biochemical pharmacology.

Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes.

M. Clark, M. Clark, J. Williams, 1995, Biochemical pharmacology.

Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.

Hongfang Yang, William McDowell, Paolo A Centrella, 2014, Journal of medicinal chemistry.

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.

C. Eyermann, A. Keefe, A. Ferguson, 2021, Journal of medicinal chemistry.

Machine learning on DNA-encoded libraries: A new paradigm for hit-finding

Xia Tian, Matthew A. Clark, Ying Zhang, 2020, Journal of medicinal chemistry.

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library

Diana Gikunju, Anthony D. Keefe, Ying Zhang, 2017, Chembiochem : a European journal of chemical biology.

Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.

Anthony D. Keefe, Christoph E. Dumelin, A. Keefe, 2021, Journal of medicinal chemistry.

Electronic Absorption Spectra from MM and ab initio QM/MM Molecular Dynamics: Environmental Effects on the Absorption Spectrum of Photoactive Yellow Protein.

Christine M Isborn, Todd J Martínez, Ross C Walker, 2012, Journal of chemical theory and computation.

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

Christoph E. Dumelin, A. Keefe, O. Fedorov, 2017, ACS chemical biology.

Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).

Yun Ding, J. Cuozzo, D. Israel, 2015, ACS medicinal chemistry letters.

Design concepts for DNA-encoded library synthesis.

M. Clark, Y. Zhang, 2021, Bioorganic & medicinal chemistry.

Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT).

D. Israel, J. Marino, M. Clark, 2021, Bioorganic & medicinal chemistry.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Christoph E. Dumelin, A. Keefe, J. Breed, 2016, Proceedings of the National Academy of Sciences.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

J. Cuozzo, M. Clark, Raksha A. Acharya, 2012, Journal of medicinal chemistry.

Fast Motions of Key Methyl Groups in Amyloid-β Fibrils.

D. Ostrovsky, G. Hoatson, M. Clark, 2016, Biophysical journal.

Fast Motions of Key Methyl Groups in Amyloid-beta Fibrils

D. Ostrovsky, G. Hoatson, M. Clark, 2018 .

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Nicholas D. Adams, J. Cuozzo, M. Clark, 2015, ACS medicinal chemistry letters.

An extensible interface for QM/MM molecular dynamics simulations with AMBER

R. Walker, M. Clark, A. Götz, 2014, J. Comput. Chem..

Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

Anthony D. Keefe, Jianwen A. Feng, J. Cuozzo, 2023, bioRxiv.