Paolo A. Centrella

发表

Design, synthesis and selection of DNA-encoded small-molecule libraries.

Baoguang Zhao, Cecil E. Rise, M. Gefter, 2009, Nature chemical biology.

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

Jean Zhang, T. Graybill, D. Israel, 2015, ACS combinatorial science.

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Christoph E. Dumelin, A. Keefe, J. Cuozzo, 2015, Scientific Reports.

Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target

Christoph E. Dumelin, A. Keefe, R. Cooke, 2018, SLAS discovery : advancing life sciences R & D.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

Hongfeng Deng, G Joseph Franklin, Kenneth E Lind, 2012, Journal of medicinal chemistry.

Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries

Baoguang Zhao, Cecil E. Rise, M. Gefter, 2009 .

Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

A. Keefe, M. Clark, Paolo A. Centrella, 2019, Molecules.

Antiparasitic activities of novel, orally available fumagillin analogs.

Anjan Debnath, Joseph L DeRisi, Jiri Gut, 2009, Bioorganic & medicinal chemistry letters.

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.

A. Keefe, M. Augustin, J. Cuozzo, 2021, Bioorganic & medicinal chemistry.

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.

C. Chung, A. Satz, M. Clark, 2015, ACS medicinal chemistry letters.

Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.

C. D. Thompson, Amy A Sarjeant, C. Arico-Muendel, 2013, ACS medicinal chemistry letters.

Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity

C. D. Thompson, C. Arico-Muendel, D. Benjamin, 2013, Drug Metabolism and Disposition.

DMD048355 814..826

C. D. Thompson, C. Arico-Muendel, D. Benjamin, 2013 .

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

J. Cuozzo, M. Clark, Paolo A. Centrella, 2015, ACS medicinal chemistry letters.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Gang Yao, Bing Xia, Jing Chai, 2017, Nature Communications.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Anthony D. Keefe, Christoph E. Dumelin, S. Kazmirski, 2017, ACS medicinal chemistry letters.

Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.

Hongfang Yang, William McDowell, Paolo A Centrella, 2014, Journal of medicinal chemistry.

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.

C. Eyermann, A. Keefe, A. Ferguson, 2021, Journal of medicinal chemistry.

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library

Diana Gikunju, Anthony D. Keefe, Ying Zhang, 2017, Chembiochem : a European journal of chemical biology.

Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.

Anthony D. Keefe, Christoph E. Dumelin, A. Keefe, 2021, Journal of medicinal chemistry.

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

Christoph E. Dumelin, A. Keefe, O. Fedorov, 2017, ACS chemical biology.

Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.

C. D. Thompson, G. Hannig, C. Arico-Muendel, 2009, Journal of medicinal chemistry.

Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT).

D. Israel, J. Marino, M. Clark, 2021, Bioorganic & medicinal chemistry.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Christoph E. Dumelin, A. Keefe, J. Breed, 2016, Proceedings of the National Academy of Sciences.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

J. Cuozzo, M. Clark, Raksha A. Acharya, 2012, Journal of medicinal chemistry.

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Nicholas D. Adams, J. Cuozzo, M. Clark, 2015, ACS medicinal chemistry letters.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Robert H Bates, G. Besra, J. Lelièvre, 2017, Nature Communications.

A resource to enable chemical biology and drug discovery of WDR Proteins

Anthony D. Keefe, Christopher J. Mulhern, S. Kearnes, 2024, bioRxiv.

Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

Anthony D. Keefe, Nancy Su, N. Selmi, 2024, ACS Medicinal Chemistry Letters.

Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.

Anthony D. Keefe, J. Cuozzo, Paolo A. Centrella, 2024, Journal of medicinal chemistry.

Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening

Anthony D. Keefe, D. Schnappinger, J. Cuozzo, 2024, ACS infectious diseases.

Discovery of a first-in-class small molecule ligand for WDR91 using DNA-encoded chemical library selection followed by machine learning

Anthony D. Keefe, Jianwen A. Feng, J. Cuozzo, 2023, bioRxiv.

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.

Anthony D. Keefe, Christopher J. Mulhern, S. Kearnes, 2024, Journal of medicinal chemistry.