M. Pelc

发表

A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation

J. Gierse, J. Masferrer, A. Wittwer, 2010, Journal of Pharmacology and Experimental Therapeutics.

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds.

M. C. Walker, A. Thorarensen, M. Pelc, 2011, Bioorganic & medicinal chemistry letters.

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain.

M. C. Walker, S. Kamtekar, A. Thorarensen, 2011, Bioorganic & medicinal chemistry letters.

Structure based design of novel irreversible FAAH inhibitors.

A. Thorarensen, M. Pelc, J. McDonald, 2009, Bioorganic & medicinal chemistry letters.

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).

D. Rohrer, C. Carron, C. Wegner, 2010, ACS medicinal chemistry letters.

Development of a Large-Scale Route to Glecaprevir: Synthesis of the Side Chain and Final Assembly

Russell D. Cink, S. Chemburkar, R. Henry, 2020 .

Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification

Dennie S. Welch, Russell D. Cink, N. Nere, 2020 .

Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis

David R. Hill, Jeffrey M. Kallemeyn, Shuang Chen, 2020 .

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

David C. Wood, K. Fennell, R. Kurumbail, 2018, Journal of medicinal chemistry.

Synthesis of the A,G-spiroimine of pinnatoxins by a microwave-assisted tandem Claisen-Mislow-Evans rearrangement

M. Pelc, A. Zakarian, 2006 .

An approach to the imine ring system of pinnatoxins.

M. Pelc, A. Zakarian, 2005, Organic Letters.

Sterols and fatty acids in the seeds of evening primrose (Oenothera sp.) and willow herb (Epilobium sp.)

M. Pelc, O. Kosakowska, J. Przybył, 2005 .

ACCUMULATION OF PHENOLIC COMPOUNDS IN LEAVES AND UNDERGROUND ORGANS OF DROPWORT (FILIPENDULA VULGARIS MOENCH)

M. Pelc, J. Przybył, Z. Węglarz, 2011 .

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.

David R. Anderson, G. Poda, Betsy S. Pierce, 2010, Bioorganic & medicinal chemistry letters.

An Efficient and RegioselectiveDifluoromethylation of 3-Iodoindazole with Chlorodifluoromethane

A. Thorarensen, M. Pelc, S. R. Turner, 2010 .

Structure based design of novel irreversible FAAH inhibitors.

A. Thorarensen, M. Pelc, J. McDonald, 2009, Bioorganic & medicinal chemistry letters.

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.

David R. Anderson, G. Poda, Betsy S. Pierce, 2010, Bioorganic & medicinal chemistry letters.