Zining Wu

发表

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

Jean Zhang, T. Graybill, D. Israel, 2015, ACS combinatorial science.

A Luciferase Reporter Gene System for High-Throughput Screening of γ-Globin Gene Activators.

Zining Wu, M. Ouellette, Hu Li, 2016, Methods in molecular biology.

2-Aminomethyl piperidines as novel urotensin-II receptor antagonists.

L. Mcmillan, D. Behm, S. Douglas, 2008, Bioorganic & medicinal chemistry letters.

N-alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists.

S. Douglas, Yonghui Wang, R. Rivero, 2008, Bioorganic & medicinal chemistry letters.

Aminomethylpiperazines as selective urotensin antagonists.

D. Behm, S. Douglas, Zining Wu, 2008, Bioorganic & medicinal chemistry letters.

Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

J. Bertin, V. Kasparcova, Jong W. Yu, 2013, PloS one.

Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

J. Bertin, V. Kasparcova, Zining Wu, 2014, PloS one.

Development of a High-Throughput Cul3-Keap1 Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Identifying Nrf2 Activators

G. Hofmann, Zining Wu, Hu Li, 2018, SLAS discovery : advancing life sciences R & D.

High-level expression of immunoreactive recombinant cat allergen (Fel d 1): Targeting to antigen-presenting cells.

M. Chapman, L. Vailes, Zining Wu, 2002, The Journal of allergy and clinical immunology.

Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells.

Zining Wu, S. Hoffman, M. Nuttall, 2006, Bone.

A hit deconstruction approach for the discovery of fetal hemoglobin inducers.

H. Eberl, A. Gilmartin, Zining Wu, 2018, Bioorganic & medicinal chemistry letters.

High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.

P. A. Harris, J. Bertin, C. Duraiswami, 2015, Bioorganic & medicinal chemistry letters.

Solution assembly of cytokine receptor ectodomain complexes

Kirk W. Johnson, B. Goldstein, T. Laue, 1995 .

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

J. Luengo, Mark Cockerill, D. Mcnulty, 2020, Haematologica.

2' biaryl amides as novel and subtype selective M1 agonists. Part II: Further optimization and profiling.

C. Langmead, I. Forbes, R. Rivero, 2010, Bioorganic & medicinal chemistry letters.

2' biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR.

C. Langmead, J. Foley, I. Forbes, 2010, Bioorganic & medicinal chemistry letters.

MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo‐allergic and anaphylactoid reactions

A. Bridges, Andrew J. Brown, Zining Wu, 2019, Pharmacology research & perspectives.

Ligand Binding Analysis of Soluble Interleukin-2 Receptor Complexes by Surface Plasmon Resonance (*)

Kirk W. Johnson, Zining Wu, T. Ciardelli, 1995, The Journal of Biological Chemistry.

Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens

S. Thrall, G. Hofmann, L. Lafrance, 2012, Journal of biomolecular screening.

New quinoline NK3 receptor antagonists with CNS activity.

Paul W Smith, P. Wyman, Zining Wu, 2009, Bioorganic & medicinal chemistry letters.

Marek's Disease Virus (MDV) Encodes an Interleukin-8 Homolog (vIL-8): Characterization of the vIL-8 Protein and a vIL-8 Deletion Mutant MDV

G. Dubyak, H. Kung, D. Robinson, 2001, Journal of Virology.

Development of Phenotypic Screening Assays for γ-Globin Induction Using Primary Human Bone Marrow Day 7 Erythroid Progenitor Cells

Xin Zeng, Francesca Zappacosta, R. Ames, 2013, Journal of biomolecular screening.

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group.

R. A. Reid, M. Head, E. Baloglu, 2013, Nature chemical biology.

BacMam recombinant baculoviruses in G protein-coupled receptor drug discovery.

Thomas Kost, John Trill, Michael Romanos, 2004, Receptors & channels.

Biochemical and Biophysical Properties of the Core-binding Factor α2 (AML1) DNA-binding Domain*

J. Bushweller, N. Speck, B. Crute, 1996, The Journal of Biological Chemistry.

Expression of human O6‐methylguanine‐DNA methyltransferase in chinese hamster ovary cells and restoration of cellular resistance to certain N‐nitroso compounds

A. Eastman, E. Bresnick, Zining Wu, 1991, Molecular carcinogenesis.

A Point Mutation in Interleukin-2 That Alters Ligand Internalization*

Zining Wu, T. Ciardelli, D. Chang, 1996, The Journal of Biological Chemistry.

Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.

I. Wilson, R. Sun, J. Luz, 2005, Journal of molecular biology.

Solution assembly of the pseudo‐high affinity and intermediate affinity interleukin‐2 receptor complexes

B. Goldstein, T. Laue, Zining Wu, 2008, Protein science : a publication of the Protein Society.

Kinetic analysis of ligand binding to interleukin‐2 receptor complexes created on an optical biosensor surface

D. Myszka, Zining Wu, T. Ciardelli, 1996, Protein science : a publication of the Protein Society.

Solution Assembly of a Soluble, Heteromeric, High Affinity Interleukin-2 Receptor Complex (*)

B. Goldstein, T. Laue, Zining Wu, 1995, The Journal of Biological Chemistry.

Methyltransferase in Mammalian Cells-Methylguanine-DNA 6 O Irradiation-induced Expression of Updated Version

A. Eastman, E. Bresnick, Zining Wu, 2006 .

A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation.

Pankaj Agarwal, Dwight M. Morrow, Q. Xie, 2014, Molecular bioSystems.

High-Throughput Screens Development and Validation of Reagents and Assays for EZH 2 Peptide and Nucleosome

Sharon, S. Thrall, G. Hofmann, 2012 .

Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays

Joseph G Boyer, G. Hofmann, D. Grillot, 2018, PloS one.

In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics.

Paul W Smith, C. Langmead, C. Davies, 2010, European journal of pharmacology.

Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.

Paul N. Mortenson, W. Rumsey, H. Willems, 2019, Journal of medicinal chemistry.

Analysis of the role of the interleukin-2 receptor gamma chain in ligand binding.

Byron Goldstein, David G Myszka, B. Goldstein, 2002, Biochemistry.

Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists.

Todd L Graybill, H. Sarau, J. Foley, 2009, Bioorganic & medicinal chemistry letters.

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.

M. Verdonk, W. Rumsey, H. Willems, 2021, Journal of medicinal chemistry.

Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.

C. Langmead, I. Forbes, R. Rivero, 2010, ACS medicinal chemistry letters.

A High-Content Imaging Screen for Cellular Regulators of β-Catenin Protein Abundance

Pankaj Agarwal, Dwight M. Morrow, Zining Wu, 2016, Journal of biomolecular screening.

Identification of Potent and Selective RNA Antagonists of the IFN-γ-Inducible CXCL10 Chemokine†

Trevor D. Chapman, Janet L. Smith, D. Daniels, 2005 .

Irradiation-induced expression of O6-methylguanine-DNA methyltransferase in mammalian cells.

C. Chan, A. Eastman, E. Bresnick, 1992, Cancer research.

Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells

Kendall A. Smith, J. Ritz, K. Smith, 1994, The Journal of experimental medicine.

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1

M. Whittington, C. Langmead, C. Davies, 2008, British journal of pharmacology.

Biochemical and Biophysical Properties of the Core-binding Factor a2 (AML1) DNA-binding Domain*

J. Bushweller, N. Speck, B. Crute, 1996 .

Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells

Kendall A. Smith, J. Ritz, M. Streuli, 1994, The Journal of experimental medicine.