D. Wisnoski

发表

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

Jean Zhang, T. Graybill, D. Israel, 2015, ACS combinatorial science.

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Michelle C. Schaeffer, Carol A. Capriotti, P. A. Harris, 2017, Journal of medicinal chemistry.

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

P Jeffrey Conn, Craig W Lindsley, J. Huff, 2004, Journal of medicinal chemistry.

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C. Lindsley, P. Conn, M. Jacobson, 2004 .

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2004, Journal of Pharmacology and Experimental Therapeutics.

Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.

Philip Hardwicke, John Bertin, Bryan W King, 2015, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists.

K. Evans, R. Rivero, Hongshi Yu, 2010, Bioorganic & medicinal chemistry letters.

Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.

K. Evans, R. Rivero, R. Griffin, 2009, Journal of medicinal chemistry.

Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.

M. Lambert, K. Evans, L. Leesnitzer, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and Structure—Activity Relationships of a Series of 3-Aryl-4-isoxazolecarboxamides as a New Class of TGR5 Agonists.

K. Evans, R. Rivero, Hongshi Yu, 2010 .

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Michelle C. Schaeffer, Carol A. Capriotti, Paul E. Lamoureux, 2019, Journal of medicinal chemistry.

Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

Michelle C. Schaeffer, Carol A. Capriotti, J. Bertin, 2015, Cell Death Discovery.

Nω-NITRO-Nω'-SUBSTITUTED GUANIDINES: A SIMPLE CLASS OF NITRIC OXIDE SYNTHASE INHIBITORS.

D. J. Wolff, D. Heck, J. Laskin, 2014, Modern research in inflammation.

Acetonitrile/water gas-phase reaction products observed by use of atmospheric pressure chemical ionization: adducts formed with sulfonamides.

D. Wisnoski, C. W. Ross, H. Ramjit, 2005, Rapid Communications in Mass Spectrometry.

Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.

B. Ma, C. Lindsley, M. Jacobson, 2009, Bioorganic & medicinal chemistry letters.

General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines

C. Lindsley, D. Wisnoski, Yi Wang, 2004 .

p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.

D. Zaller, D. Schmatz, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

Broadening the scope of 1,2,4-triazine synthesis by the application of microwave technology

C. Lindsley, D. Wisnoski, W. Leister, 2003 .

Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using microwave irradiation.

C. Lindsley, D. Wisnoski, Yi Wang, 2004, Organic letters.

General Microwave-Assisted Protocols for the Expedient Synthesis of Quinoxalines and Heterocyclic Pyrazines.

C. Lindsley, D. Wisnoski, Yi Wang, 2004 .

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.

W. Shipe, J. Barrow, M. Seager, 2010, Bioorganic & medicinal chemistry letters.

A ‘one pot’ microwave-mediated synthesis of the basic canthine skeleton: expedient access to unnatural β-carboline alkaloids

C. Lindsley, D. Wisnoski, Yi Wang, 2003 .

Cyclization of unsaturated amides with triflic anhydride and samarium diiodide

Jennifer E. Kowalchick, D. Wisnoski, Christopher M. Micklitsch, 2001 .

The Heck reaction with unprotected allylic amidines and guanidines

D. Wisnoski, B. Maryanoff, W. Kinney, 2002 .

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

C. Lindsley, P. Conn, M. Jacobson, 2007, Bioorganic & medicinal chemistry letters.

Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries.

C. Lindsley, D. Wisnoski, W. Leister, 2003, Journal of combinatorial chemistry.

RIP3 induces apoptosis independent of pronecrotic kinase activity.

Kenta Moriwaki, Viera Kasparcova, John Bertin, 2014, Molecular cell.

Microwave-initiated living free radical polymerization: rapid formation of custom Rasta resins

C. Lindsley, D. Wisnoski, W. Leister, 2003 .

The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis.

Baoguang Zhao, Neysa Nevins, S. Thrall, 2012, Biochemistry.

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

C. Lindsley, P. Conn, M. Jacobson, 2005, Journal of Pharmacology and Experimental Therapeutics.

The synthesis and preclinical evaluation in rhesus monkey of [18F]MK‐6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Sandra M. Sanabria-Bohórquez, Christine Ryan, Kerry Riffel, 2011, Synapse.

Running Title: Mglur5 Potentiation in Rat Behavioral Models List of Non-standard Abbreviations: Ampa, Α-amino-3-hydroxy-5-methyl-4

C. Lindsley, M. Jacobson, D. Wisnoski, 2004 .