A. Pope

发表

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

Jean Zhang, T. Graybill, D. Israel, 2015, ACS combinatorial science.

Properties of the reversible K(+)-competitive inhibitor of the gastric (H+/K+)-ATPase, SK&F 97574. I. In vitro activity.

M. Boehm, A. Pope, M. Parsons, 1995, Biochemical pharmacology.

High-throughput screening: new technology for the 21st century.

R. Hertzberg, A. Pope, A J Pope, 2000, Current opinion in chemical biology.

The Role of Chemical Biology in Drug Discovery

A. Pope, 2012 .

Characterization of Isoleucyl-tRNA Synthetase from Staphylococcus aureus

A. Pope, Murray J. B. Brown, K. Moore, 1998, The Journal of Biological Chemistry.

Characterisation of chloride transport at the tonoplast of higher plants using a chloride-sensitive fluorescent probe

R. Leigh, A. Pope, 1990, Planta.

Simple Absorbance-Based Assays for Ultra-High Throughput Screening

A. Pope, P. Lavery, M. J. Brown, 2001, Journal of biomolecular screening.

Time-Resolved Fluorescence Energy Transfer DNA Helicase Assays for High Throughput Screening

D. Earnshaw, Hakim Djaballah, A. Pope, 1999, Journal of biomolecular screening.

Kinetics of the Vacuolar H-Pyrophosphatase : The Roles of Magnesium, Pyrophosphate, and their Complexes as Substrates, Activators, and Inhibitors.

R. Leigh, D. Sanders, A. Pope, 1992, Plant physiology.

Demonstration of a 9 kV reverse breakdown and 59 mΩ-cm2 specific on-resistance AlGaN/GaN Schottky barrier diode

A. Baca, A. Tauke-Pedretti, A. Pope, 2019, Solid-State Electronics.

Macroscopic versus microscopic fluorescence techniques in (ultra)-high-throughput screening

U. Haupts, A. Pope, M. Rudiger, 2000 .

Ligand Binding to Transmembrane Receptors on Intact Cells or Membrane Vesicles Measured in a Homogeneous 1-Microliter Assay Format

A. Pope, K. Murray, M. Klumpp, 2001, Journal of biomolecular screening.

Factors influencing the viscous properties of chicken tracheal mucins.

P. W. Kent, A. Pope, N. Mian, 1982, Biochimica et biophysica acta.

Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens

S. Thrall, G. Hofmann, L. Lafrance, 2012, Journal of biomolecular screening.

Effect of Potent Urease Inhibitor, Fluorofamide, on Helicobacter sp. in Vivo and in Vitro

A. Pope, S. Richardson, Judith I. Hills, 2004, Digestive Diseases and Sciences.

The use of a chloride-sensitive fluorescent probe to measure chloride transport in isolated tonoplast vesicles

R. Leigh, A. Pope, 1988, Planta.

Some characteristics of anion transport at the tonoplast of oat roots, determined from the effects of anions on pyrophosphatedependent proton transport

R. Leigh, A. Pope, 1987, Planta.

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

A. Pope, D. Hamprecht, P. Brown, 2001, Bioorganic & medicinal chemistry letters.

Reversible inhibitors of the gastric H+/K(+)-transporting ATPase: a new class of anti-secretory agent.

A. Pope, M. Parsons, 1993, Trends in pharmacological sciences.

The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

A. Fosberry, A. Pope, P. Milner, 2002, Bioorganic & medicinal chemistry letters.

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3=benzodiazepines

A. Pope, M. Parsons, 1993 .

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.

A. Pope, D. Eggleston, R. Haltiwanger, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase.

A. Pope, S. Rittenhouse, L. Mensah, 2000, The Journal of antibiotics.

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.

A. Pope, D. Eggleston, R. Copley, 2000, Bioorganic & medicinal chemistry letters.

SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties.

S. Ready, N. Coates, A. Pope, 2000, The Journal of antibiotics.

Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases.

N. F. Osborne, A. Pope, C. Richardson, 1999, Bioorganic & medicinal chemistry.

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

A. Pope, L. Mensah, R. L. Jarvest, 2001, Bioorganic & medicinal chemistry letters.

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

A. K. Forrest, H. Boyd, R. Sheppard, 2002, Journal of medicinal chemistry.

Characterisation of the effects of anthranilic and (indanyloxy) acetic acid derivatives on chloride transport in membrane vesicles.

A. Pope, R. Ife, D. Keeling, 1991, Biochimica et biophysica acta.

Template Effects in the Formation of a Tetramethylene-Bridged Hemicarceplex

A. Pope, J. Sherman, D. Makeiff, 2000 .

Reversible inhibitors of the gastric (H+/K+)-ATPase as both potential therapeutic agents and probes of pump function.

G. Sachs, A. Pope, 1992, Biochemical Society transactions.

Kinetic evidence for two types of active site in the N‐acetyl‐β‐D‐hexosaminidase of bovine kidney

D. G. Herries, A. Pope, N. Mian, 1978, FEBS letters.

Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy Transfer

S. Rees, Shelagh Wilson, G. Milligan, 2001, The Journal of Biological Chemistry.

4-(2-PYRTOYL)-5-phenylthiazoles as novel non-bicyclic reversible inhibitors of the gastric H+/K+-atpase

A. Pope, C. Leach, C. Theobald, 1995 .

Development of Phenotypic Screening Assays for γ-Globin Induction Using Primary Human Bone Marrow Day 7 Erythroid Progenitor Cells

Xin Zeng, Francesca Zappacosta, R. Ames, 2013, Journal of biomolecular screening.

Single-Molecule Detection Technologies in Miniaturized High-Throughput Screening: Fluorescence Intensity Distribution Analysis

Stephen Ashman, U. Haupts, A. Pope, 2003, Journal of biomolecular screening.

Real Experiences of uHTS: A Prototypic 1536-Well Fluorescence Anisotropy-Based uHTS Screen and Application of Well-Level Quality Control Procedures

D. Earnshaw, U. Haupts, A. Pope, 2001, Journal of biomolecular screening.

Single-Molecule Detection Technologies in Miniaturized High Throughput Screening: Binding Assays for G Protein-Coupled Receptors Using Fluorescence Intensity Distribution Analysis and Fluorescence Anisotropy

U. Haupts, A. Pope, K. Moore, 2001, Journal of biomolecular screening.

Directional Ca2+ effect on stimulation of mucin secretion from chicken trachea in vitro.

P. W. Kent, A. Pope, A. Smith, 1982, The Biochemical journal.

Perspectives on the Discovery of Small-Molecule Modulators for Epigenetic Processes

Deepak Bandyopadhyay, Alan P. Graves, Simon F. Semus, 2012, Journal of biomolecular screening.

Single Molecule Detection Technologies in Miniaturized High Throughput Screening: Fluorescence Correlation Spectroscopy

Stephen Ashman, U. Haupts, A. Pope, 1999, Journal of biomolecular screening.

Characterization of Cl− transport in vacuolar membrane vesicles using a Cl−-sensitive fluorescent probe: Reaction kinetic models for voltageand concentration-dependence of Cl− flux

R. Leigh, D. Sanders, A. Pope, 1990, The Journal of Membrane Biology.

Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.

R. Leduc, J. Cottom, N. Campobasso, 2019, Cell chemical biology.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Gang Yao, Bing Xia, Jing Chai, 2017, Nature Communications.

Dissipation of pH Gradients in Tonoplast Vesicles and Liposomes by Mixtures of Acridine Orange and Anions: Implications for the Use of Acridine Orange as a pH Probe.

R. Leigh, A. Pope, 1988, Plant physiology.

Parallel Hit Progression Strategy Identifies Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation.

Deepak Bandyopadhyay, M. Akabas, T. Graybill, 2019, ACS infectious diseases.

A Standard Operating Procedure for Assessing Liquid Handler Performance in High-Throughput Screening

Paul B Taylor, Stephen Ashman, Stuart M Baddeley, 2002, Journal of biomolecular screening.

FlashPlate Scintillation Proximity Assays for Characterization and Screening of DNA Polymerase, Primase, and Helicase Activities

D. Earnshaw, A. Pope, A J Pope, 2001, Journal of biomolecular screening.

Developments in fluorescence lifetime-based analysis for ultra-HTS

U. Haupts, A. Pope, Sandra Turconi, 2001 .

Fluorescence correlation spectroscopy: Lead discovery by miniaturized HTS

Manfred Auer, Franz-Josef Meyer-Almes, Kurt A. Stoeckli, 1998 .

A Homogenous 384-Well High Throughput Screen for Novel Tumor Necrosis Factor Receptor: Ligand Interactions Using Time Resolved Energy Transfer

A. Pope, P. Hurskainen, K. Murray, 1999, Journal of biomolecular screening.

Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors.

A. West, A. Pope, J. Humphries, 2003, European journal of medicinal chemistry.

A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation.

Pankaj Agarwal, Dwight M. Morrow, Q. Xie, 2014, Molecular bioSystems.

High-Throughput Screens Development and Validation of Reagents and Assays for EZH 2 Peptide and Nucleosome

Sharon, S. Thrall, G. Hofmann, 2012 .

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

A. Pope, S. Rittenhouse, P. Brown, 2003, Bioorganic & medicinal chemistry letters.

Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership.

T. Selwood, R. Kohli, A. Pope, 2018, ACS infectious diseases.

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.

A. K. Forrest, M. Doyle, A. Pope, 2000, Biochemistry.

Introduction LANCE™ vs. HTRF® Technologies (or Vice Versa)

A. Pope, 1999 .

A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology.

A. Pope, L. Mensah, N. Benson, 2000, Analytical biochemistry.

Epigenetic-Targeted Drug Discovery

T. Heightman, A. Pope, 2011, Journal of biomolecular screening.

A High-Content Imaging Screen for Cellular Regulators of β-Catenin Protein Abundance

Pankaj Agarwal, Dwight M. Morrow, Zining Wu, 2016, Journal of biomolecular screening.

Effects of Substrate and Inhibitor Binding on Proteolysis of Isoleucyl-tRNA Synthetase from Staphylococcus aureus*

A. Pope, K. Moore, K. Fantom, 1998, The Journal of Biological Chemistry.

Homogeneous fluorescence readouts for miniaturized high-throughput screening: theory and practice.

U. Haupts, A. Pope, K. Moore, 1999, Drug discovery today.

Understanding Tonoplast Function: Some Emerging Problems

R. Leigh, A. Pope, 1987 .

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Robert H Bates, G. Besra, J. Lelièvre, 2017, Nature Communications.

Properties of the reversible, K(+)-competitive inhibitor of the gastric (H+/K+)-ATPase, SK&F 97574. II. Pharmacological properties.

A. Pope, M. Parsons, C. Leach, 1995, Biochemical pharmacology.

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

C. Janson, A. Pope, A. Saldanha, 1999, Bioorganic & medicinal chemistry letters.