Ying Zhang

发表

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Christoph E. Dumelin, A. Keefe, J. Cuozzo, 2015, Scientific Reports.

Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells.

Ying Sun, S. Ekins, P. Swaan, 2008, Journal of medicinal chemistry.

Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target

Christoph E. Dumelin, A. Keefe, R. Cooke, 2018, SLAS discovery : advancing life sciences R & D.

A Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.

A. Keefe, F. Ruebsam, J. Cuozzo, 2020, Journal of medicinal chemistry.

Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

A. Keefe, M. Clark, Paolo A. Centrella, 2019, Molecules.

Chemical ligation methods for the tagging of DNA-encoded chemical libraries.

A. Keefe, M. Clark, A. Litovchick, 2015, Current opinion in chemical biology.

Development and design of the tertiary amino effect reaction for DNA-encoded library synthesis

G. Basarab, N. Selmi, R. Goodnow, 2016 .

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry.

A. Keefe, M. Augustin, J. Cuozzo, 2021, Bioorganic & medicinal chemistry.

Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.

A. Keefe, Y. A. Arnautova, Shilpi Arora, 2021, Journal of medicinal chemistry.

Novel TYK2 Inhibitors with an N-(Methyl-d 3)pyridazine-3-carboxamide Skeleton for the Treatment of Autoimmune Diseases.

Fei Liu, Bin Wang, Hongjian Xu, 2022, ACS medicinal chemistry letters.

Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.

Anthony D. Keefe, E. Hennessy, A. Keefe, 2021, Journal of medicinal chemistry.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Christoph E. Dumelin, S. Kazmirski, A. Keefe, 2017, ACS medicinal chemistry letters.

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.

C. Eyermann, A. Keefe, A. Ferguson, 2021, Journal of medicinal chemistry.

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Anthony D. Keefe, Christopher J. Mulhern, A. Keefe, 2023, Journal of medicinal chemistry.

Machine learning on DNA-encoded libraries: A new paradigm for hit-finding

Xia Tian, Matthew A. Clark, Ying Zhang, 2020, Journal of medicinal chemistry.

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library

Diana Gikunju, Anthony D. Keefe, Ying Zhang, 2017, Chembiochem : a European journal of chemical biology.

Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors.

A. Keefe, G. Müller, L. Babiss, 2021, ACS medicinal chemistry letters.

Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa.

Anthony D. Keefe, Christoph E. Dumelin, A. Keefe, 2021, Journal of medicinal chemistry.

Discovery of a New-Generation S-Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2.

Jiahong Zheng, Ying Zhang, Huaxuan Li, 2023, Journal of medicinal chemistry.

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

Christoph E. Dumelin, A. Keefe, O. Fedorov, 2017, ACS chemical biology.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Christoph E. Dumelin, A. Keefe, J. Breed, 2016, Proceedings of the National Academy of Sciences.

A resource to enable chemical biology and drug discovery of WDR Proteins

Anthony D. Keefe, Christopher J. Mulhern, S. Kearnes, 2024, bioRxiv.

Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

Anthony D. Keefe, Nancy Su, N. Selmi, 2024, ACS Medicinal Chemistry Letters.