S. Berger

发表

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Michelle C. Schaeffer, Carol A. Capriotti, P. A. Harris, 2017, Journal of medicinal chemistry.

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages

M. Boes, L. Rameh, Guoxing Wang, 2010, Nature Immunology.

Endovascular Coil Embolisation of Metachronous Mycotic Aneurysms

I. Awad, D. Wecht, S. Berger, 1998, Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

D. Green, J. Bertin, C. Dillon, 2017, The Journal of experimental medicine.

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

J. Bertin, S. Berger, P. Gough, 2014, Proceedings of the National Academy of Sciences.

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

Michelle C. Schaeffer, Carol A. Capriotti, P. A. Harris, 2014, Journal of immunology.

CD43‐independent augmentation of mouse T‐cell function by glycoprotein cleaving enzymes

Richard A. Miller, S. Berger, G. Garcia, 2006, Immunology.

T cells in aging mice: genetic, developmental, and biochemical analyses

A. Galecki, D. Burke, Richard A. Miller, 2005, Immunological reviews.

A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice.

Richard A. Miller, S. Berger, A. A. Sadighi Akha, 2005, International immunology.

Age‐associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells

Richard A. Miller, S. Berger, G. Garcia, 2005, European journal of immunology.

Enhancement of CD8 T‐cell function through modifying surface glycoproteins in young and old mice

Richard A. Miller, S. Berger, A. A. Sadighi Akha, 2006, Immunology.

Signaling lymphocyte activation molecule regulates development of colitis in mice.

F. Luscinskas, R. de Waal Malefyt, Guoxing Wang, 2012, Gastroenterology.

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

D. Maucort-Boulch, Aidan MacNamara, T. Rimmele, 2020, Critical Care.

The SLAM and SAP gene families control innate and adaptive immune responses.

P. Engel, S. Berger, Á. Lányi, 2008, Advances in immunology.

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[ d]thiazol-5-ylamino)-6-( tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

J. Bertin, K. Erhard, M. Convery, 2019, Journal of medicinal chemistry.

Receptor-interacting protein 1 kinase inhibition therapeutically ameliorates experimental T cell-dependent colitis in mice

J. Bertin, A. Rowles, S. Berger, 2020, Cell Death & Disease.

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Michelle C. Schaeffer, Carol A. Capriotti, Paul E. Lamoureux, 2019, Journal of medicinal chemistry.

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

J. Bertin, M. Ringenberg, K. Foley, 2015, PloS one.

A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis

P. Tak, S. Hawkins, D. Tompson, 2021, BMJ open gastroenterology.

A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score

D. Maucort-Boulch, Aidan MacNamara, T. Rimmele, 2022, Annals of Intensive Care.

Intestinal permeability in participants with thermal injury: A case series from a prospective, longitudinal study (HESTIA)

W. Dunn, J. Lord, C. Winder, 2020 .

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.

Michelle C. Schaeffer, Carol A. Capriotti, P. A. Harris, 2013, ACS medicinal chemistry letters.

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.

Deepak Bandyopadhyay, Lauren Dare, Michelle C. Schaeffer, 2016, Journal of medicinal chemistry.

RIP3 induces apoptosis independent of pronecrotic kinase activity.

Kenta Moriwaki, Viera Kasparcova, John Bertin, 2014, Molecular cell.

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

J. Bertin, Hao Wu, M. Kelliher, 2018, Science.

A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis

P. Tak, C. Peterfy, E. Quattrocchi, 2021, Arthritis Research & Therapy.

Response to Inhibition of Receptor‐Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo‐Controlled Study

J. Bertin, K. Papp, D. Tompson, 2020, Clinical pharmacology and therapeutics.

Hypervascular tumor of the buccal space in an adult as a late recurrence of juvenile angiofibroma.

M. Citardi, C. Putman, S. Berger, 1996, AJNR. American journal of neuroradiology.

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

J. Bertin, K. Erhard, D. Lipshutz, 2019 .

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

M. Bertrand, J. Bertin, P. Vandenabeele, 2014, Nature.

Oral-maxillary sinus fistula (oroantral fistula): clinical features and findings on multiplanar CT.

S. Berger, J. Abrahams, 1995, AJR. American journal of roentgenology.

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

Richard G. Lee, M. Laakso, J. Bertin, 2020, Nature Metabolism.

Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes

Wesley H. Stepp, B. Cairns, D. van Duin, 2017, PloS one.

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.

J. Bertin, M. Convery, D. Lipshutz, 2016, Journal of medicinal chemistry.

T Cell– and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer

James R. Brown, R. Hotchkiss, R. Fields, 2019, The Journal of Immunology.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

J. Bertin, M. Convery, D. Lipshutz, 2018, ACS medicinal chemistry letters.

Caspase‐8 Collaborates with Caspase‐11 to Drive Tissue Damage and Execution of Endotoxic Shock

Michelle C. Schaeffer, Carol A. Capriotti, J. Bertin, 2018, Immunity.

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.

T. Chatila, R. de Waal Malefyt, R. Herzog, 2010, International immunology.

Inflammatory disease of the jaw: appearance on reformatted CT scans.

S. Berger, J. Abrahams, J. J. Abrahams, 1998, AJR. American journal of roentgenology.

Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice.

R. de Waal Malefyt, R. Herzog, P. Engel, 2012, Gastroenterology.

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

P. A. Harris, J. Bertin, M. Mahajan, 2019, ACS medicinal chemistry letters.

Key Regulator of Inflammation in a Dispensable for Normal Development but Is Cutting Edge: RIP1 Kinase Activity Is

William J. Kaiser, Peter J. Gough, Ambria Harris, 2014 .

A novel isoform of the Ly108 gene ameliorates murine lupus

L. Morel, H. Morse, P. Engel, 2011, The Journal of experimental medicine.

Drilling into RIP1 biology: what compounds are in your toolkit?

J. Bertin, S. Berger, P. Gough, 2015, Cell Death and Disease.

Cutting Edge: Slamf8 Is a Negative Regulator of Nox2 Activity in Macrophages

M. Fresno, Guoxing Wang, S. Berger, 2012, The Journal of Immunology.

Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

Michelle C. Schaeffer, Carol A. Capriotti, J. Bertin, 2015, Cell Death Discovery.

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages

M. Boes, L. Rameh, Guoxing Wang, 2010, Nature Immunology.

Identification of small-molecule protein–protein interaction inhibitors for NKG2D

Jennifer D. Venable, J. Edwards, A. Thompson, 2023, Proceedings of the National Academy of Sciences of the United States of America.