J. Lich

发表

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Michelle C. Schaeffer, Carol A. Capriotti, P. A. Harris, 2017, Journal of medicinal chemistry.

The Effect of Al and Fe Doping on Solar Cells Made from Compensated Silicon

J. Bauer, M. Kaes, J. Lich, 2012 .

Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis

M. Braunstein, J. Ting, I. C. Allen, 2013, PloS one.

Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity

J. Bertin, F. Sutterwala, B. Koller, 2010, The Journal of Immunology.

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Non-canonical NF-κB Signaling and MAP Kinase Activation

Monika Schneider, C. Jobin, I. C. Allen, 2013 .

NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling.

H. Herfarth, Monika Schneider, J. Ting, 2012, Immunity.

Heat Shock Protein 90 Associates with Monarch-1 and Regulates Its Ability to Promote Degradation of NF- B-Inducing Kinase

J. Ting, M. Kotb, R. Aziz, 2007 .

Heat Shock Protein 90 Associates with Monarch-1 and Regulates Its Ability to Promote Degradation of NF-κB-Inducing Kinase1

J. Ting, M. Kotb, R. Aziz, 2007, The Journal of Immunology.

Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-κB Activation and p52-Dependent Chemokine Expression in Monocytes1

J. Ting, J. Arthur, J. Lich, 2007, The Journal of Immunology.

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

P. A. Harris, Wei Wang, J. Bertin, 2018, Cancer cell.

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers

P. A. Harris, J. Bertin, A. Verticelli, 2017, Pharmacology research & perspectives.

Functional analysis of antigen processing and major histocompatibility complex class II-restricted presentation.

J. Blum, J. Lich, 2001, Methods in molecular biology.

Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.

J. Ting, J. Arthur, J. Lich, 2007, Journal of immunology.

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Michelle C. Schaeffer, Carol A. Capriotti, Paul E. Lamoureux, 2019, Journal of medicinal chemistry.

Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues

P. A. Harris, J. Bertin, N. Campobasso, 2017, Pharmacology research & perspectives.

Editing of an Immunodominant Epitope of Glutamate Decarboxylase by HLA-DM1

J. Elliott, Delu Zhou, J. Blum, 2003, The Journal of Immunology.

Glutamate Decarboxylase by HLA-DM Editing of an Immunodominant Epitope of

J. Elliott, Delu Zhou, J. Blum, 2003 .

Complexes by HLA-DM Cutting Edge: Editing of Recycling Class II:Peptide

J. Blum, J. Lich, S. Pathak, 2001 .

Cutting Edge: Editing of Recycling Class II:Peptide Complexes by HLA-DM1

J. Blum, J. Lich, S. Pathak, 2001, The Journal of Immunology.

Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions.

J. Ting, J. Lich, 2007, Microbes and infection.

Characterization of NLRP12 during the Development of Allergic Airway Disease in Mice

J. Ting, I. C. Allen, J. Arthur, 2012, PloS one.

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.

Michelle C. Schaeffer, Carol A. Capriotti, P. A. Harris, 2013, ACS medicinal chemistry letters.

RIP3 induces apoptosis independent of pronecrotic kinase activity.

Kenta Moriwaki, Viera Kasparcova, John Bertin, 2014, Molecular cell.

Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses

Z. Ye, H. Iocca, J. Ting, 2008, Proceedings of the National Academy of Sciences.

NLRX1 is a regulator of mitochondrial antiviral immunity

M. Heise, Zhijian J. Chen, M. Accavitti-Loper, 2008, Nature.

Criteria for effective design, construction, and gene knockdown by shRNA vectors

L. R. Livingstone, H. Iocca, J. Ting, 2006, BMC biotechnology.

The CATERPILLER Protein Monarch-1 Is an Antagonist of Toll-like Receptor-, Tumor Necrosis Factor α-, and Mycobacterium tuberculosis-induced Pro-inflammatory Signals*

M. Braunstein, M. Accavitti-Loper, J. Ting, 2005, Journal of Biological Chemistry.

Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.

Y. Hod, J. Ting, J. MacKeigan, 2003, Cancer research.

CATERPILLER (NLR) family members as positive and negative regulators of inflammatory responses.

J. Ting, J. Lich, 2007, Proceedings of the American Thoracic Society.

Cryopyrin: in from the cold.

J. Ting, J. Arthur, J. Lich, 2006, Immunity.

Cell Lung Carcinoma : Identification of RS / DJ-1 and RhoGDI Proteomic Profiling Drug-Induced Apoptosis in Non-Small Updated Version

Y. Hod, J. Ting, J. MacKeigan, 2003 .

Monocytesp52-Dependent Chemokine Expression in B Activation and k Non-Canonical NF-Cutting Edge: Monarch-1 Suppresses

Arthur, J. Lich, C. Moore, 2007 .

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

P. A. Harris, J. Bertin, Kwok-Kin Wong, 2020, Cancer cell.

Cytoplasmic Processing Is a Prerequisite for Presentation of an Endogenous Antigen by Major Histocompatibility Complex Class II Proteins

J. Elliott, J. Blum, J. Lich, 2000, The Journal of experimental medicine.

ATP Binding by Monarch-1/NLRP12 Is Critical for Its Inhibitory Function

Z. Ye, J. Ting, J. Lich, 2007, Molecular and Cellular Biology.

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

P. A. Harris, J. Bertin, M. Mahajan, 2019, ACS medicinal chemistry letters.

Cutting Edge: ASC Mediates the Induction of Multiple Cytokines by Porphyromonas gingivalis via Caspase-1-Dependent and -Independent Pathways1

H. Iocca, J. Ting, D. Bergstralh, 2006, The Journal of Immunology.

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity*

J. Bertin, K. Brown, C. Duraiswami, 2012, The Journal of Biological Chemistry.

G-CSF drives autoinflammation in APLAID

Ashley P Ng, P. Baker, A. Garnham, 2023, Nature Immunology.

Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.

J. Ting, M. Kotb, R. Aziz, 2007, Journal of immunology.

Criteria for effective design, construction, and gene knockdown by shRNA vectors

L. R. Livingstone, H. Iocca, J. Ting, 2006 .

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity*

J. Bertin, K. Brown, C. Duraiswami, 2012, The Journal of Biological Chemistry.