V. Subramaniam

D. Hewett, G. Anderson, L. Powell, 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

The relationship between systemic iron homeostasis and erythropoiesis

V. Subramaniam, Gautam Rishi, 2017, Bioscience reports.

Monoclonal antibody HFD9 identifies a novel 28 kDa integral membrane protein on the cis-Golgi.

B. Tang, M. Ericsson, G. Griffiths, 1995, Journal of cell science.

Co-factors in liver disease: the role of HFE-related hereditary hemochromatosis and iron.

V. Subramaniam, D. Wallace, 2009, Biochimica et biophysica acta.

Screening for hemochromatosis in asymptomatic subjects with or without a family history.

D. Hewett, D. Purdie, G. Anderson, 2006, Archives of internal medicine.

Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis.

G. Anderson, V. Subramaniam, A. Clouston, 2011, American journal of physiology. Gastrointestinal and liver physiology.

Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice

L. Vitetta, D. Briskey, D. Crawford, 2017, World journal of gastrointestinal pathophysiology.

In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact

V. Subramaniam, Gautam Rishi, D. Wallace, 2013, PloS one.

Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury

D. Crane, G. Anderson, V. Subramaniam, 2013, Laboratory Investigation.

Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet

J. Reiling, S. Andrikopoulos, D. Crawford, 2018, Cellular and molecular gastroenterology and hepatology.

Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high‐calorie diet

J. Reiling, D. Crawford, V. Subramaniam, 2016, Physiological reports.

Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease

L. Vitetta, J. Peake, D. Briskey, 2016, Therapeutic advances in gastroenterology.

A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis.

D. Crane, G. Anderson, V. Subramaniam, 2013, Alcoholism, clinical and experimental research.

GS28, a 28-Kilodalton Golgi SNARE That Participates in ER-Golgi Transport

S. Wong, R. Philp, V. Subramaniam, 1996, Science.

Lymphotoxin‐β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury

J. Olynyk, V. Subramaniam, Janina E E Tirnitz-Parker, 2009, Hepatology.

GS15, a 15-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE) Homologous to rbet1*

S. Wong, T. Zhang, Yue Xu, 1997, The Journal of Biological Chemistry.

Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression

V. Subramaniam, J. Berger, Gautam Rishi, 2020, Bioscience reports.

A SNARE involved in protein transport through the Golgi apparatus

V. Subramaniam, F. Peter, S. Lowe, 1997, Nature.

Preferential association of syntaxin 8 with the early endosome.

H. Horstmann, G. Griffiths, V. Subramaniam, 2000, Journal of cell science.

Alpha-SNAP but not gamma-SNAP is required for ER-Golgi transport after vesicle budding and the Rab1-requiring step but before the EGTA-sensitive step.

S. Wong, B. Tang, V. Subramaniam, 1998, Journal of cell science.

N-Ethylmaleimide-sensitive Factor (NSF) and α-Soluble NSF Attachment Proteins (SNAP) Mediate Dissociation of GS28-Syntaxin 5 Golgi SNAP Receptors (SNARE) Complex*

W. Hong, V. Subramaniam, W. Hong, 1997, The Journal of Biological Chemistry.

In vitro identification and characterisation of iron chelating catechol-containing natural products and derivatives

V. Subramaniam, Rohan A. Davis, Gautam Rishi, 2021, BioMetals.

Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease

J. Reiling, M. House, J. Olynyk, 2018, Hepatology communications.

Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment

N. Hamilton, I. Poser, K. Khanna, 2013, Cell Cycle.

Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron‐deficient anemia

V. Subramaniam, Gautam Rishi, D. Wallace, 2016, American journal of hematology.

Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels.

C. McLaren, J. Barton, Wen‐Pin Chen, 2019, Blood cells, molecules & diseases.

Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease.

M. Chatfield, L. Powell, V. Subramaniam, 2018, Blood.

Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report

V. Subramaniam, N. Heerasing, P. Hamblin, 2018, Journal of Medical Case Reports.

Iron storage disease in Asia‐Pacific populations: The importance of non‐HFE mutations

V. Subramaniam, D. Crawford, D. Wallace, 2013, Journal of gastroenterology and hepatology.

A novel mutation in ferroportin implicated in iron overload.

G. Anderson, L. Powell, V. Subramaniam, 2007, Journal of Hepatology.

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload

V. Subramaniam, D. Wallace, L. Summerville, 2007 .

Clinical expression of C282Y homozygous HFE haemochromatosis at 14 years of age

T. S. St. Pierre, V. Subramaniam, E. Rossi, 2006, Annals of clinical biochemistry.

Biology of the iron efflux transporter, ferroportin.

V. Subramaniam, Gautam Rishi, 2021, Advances in protein chemistry and structural biology.

Pocket-sized iron regulators: one size fits all?

V. Subramaniam, 2016, Blood.

Linking hypoxia and iron homeostasis: a ‘plate’ full of factors

V. Subramaniam, D. Wallace, 2014, Gut.

Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis.

V. Subramaniam, H. Harley, D. Wallace, 2004, Journal of hepatology.

A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient

G. Anderson, L. Powell, V. Subramaniam, 2003, Gut.

Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis.

L. Powell, V. Subramaniam, J. Searle, 2002, Blood.

Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y.

J. Dooley, A. Walker, L. Powell, 2002, Journal of hepatology.

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

D. Purdie, G. Anderson, D. Crawford, 2003, The Lancet.

Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes.

M. Emond, C. McLaren, L. Gurrin, 2018, Annals of hepatology.

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

C. López-Otín, G. Velasco, V. Subramaniam, 2015, British journal of haematology.

Hepatic iron deposition does not predict extrahepatic iron loading in mouse models of hereditary hemochromatosis.

V. Subramaniam, G. Ramm, L. Wockner, 2012, The American journal of pathology.

Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders.

V. Subramaniam, D. Crawford, D. Wallace, 2015, Journal of hepatology.

Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice.

V. Subramaniam, D. Wallace, L. Ostini, 2014, American journal of physiology. Gastrointestinal and liver physiology.

Evidence for dimerization of ferroportin in a human hepatic cell line using proximity ligation assays

V. Subramaniam, Gautam Rishi, D. Wallace, 2020, Bioscience reports.

G80S-linked ferroportin disease: classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective.

S. Bell, V. Subramaniam, B. Demediuk, 2011, Journal of hepatology.

Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis

G. Anderson, L. Powell, V. Subramaniam, 2009, Hepatology.

Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia.

G. Velasco, V. Subramaniam, N. Bennett, 2015, American journal of physiology. Cell physiology.

Protein and Vesicle Trafficking , Cytoskeleton Defective trafficking and localization of mutated transferrin receptor 2 : implications for type 3 hereditary hemochromatosis

V. Subramaniam, D. Wallace, L. Summerville, 2008 .

Ferroportin disease due to the A77D mutation in Australia

V. Subramaniam, L. Fletcher, D. Crawford, 2005, Gut.

HbO-Arab mutation originated in the Pomak population of Greek Thrace

G. Anderson, L. Powell, V. Subramaniam, 2005 .

How much iron is too much?

G. Anderson, L. Powell, V. Subramaniam, 2008, Expert review of gastroenterology & hepatology.

Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: LoxP system

G. Kay, V. Subramaniam, I. Tonks, 2004, Genesis.

Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo.

V. Subramaniam, D. Wallace, 2015, International immunology.

GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes.

M. Emond, C. McLaren, L. Gurrin, 2016, Blood cells, molecules & diseases.

Cancer: The role of iron and ferroptosis.

V. Subramaniam, Gautam Rishi, Gary Huang, 2021, The international journal of biochemistry & cell biology.

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

Jonathan M. Harris, V. Subramaniam, D. Wallace, 2010, American journal of physiology. Cell physiology.

The dynamics of hepcidin‐ferroportin internalization and consequences of a novel ferroportin disease mutation

V. Subramaniam, A. Tuckfield, D. Wallace, 2017, American journal of hematology.

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

V. Subramaniam, D. Wallace, L. Summerville, 2007, Gastroenterology.

Inhibition by brefeldin A of protein secretion from the apical cell surface of Madin-Darby canine kidney cells.

S. Wong, B. Tang, V. Subramaniam, 1991, The Journal of biological chemistry.

Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis.

L. Powell, V. Subramaniam, G. Ramm, 2013, World journal of gastroenterology.

Juvenile iron overload--advances, but no answers.

V. Subramaniam, D. Crawford, D. Wallace, 2008, The Journal of pediatrics.

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin

V. Subramaniam, D. Wallace, L. Summerville, 2005, Gut.

The effect of the flavonol rutin on serum and liver iron content in a genetic mouse model of iron overload

V. Subramaniam, Gautam Rishi, D. Wallace, 2021, Bioscience reports.

Iron loading and oxidative stress in the Atm-/- mouse liver.

D. Watters, V. Subramaniam, D. Wallace, 2011, American journal of physiology. Gastrointestinal and liver physiology.

Carrier-mediated thyroid hormone transport into placenta by placental transthyretin.

B. McKinnon, R. Mortimer, V. Subramaniam, 2009, The Journal of clinical endocrinology and metabolism.

Basic Science Liver

V. Subramaniam, I. Oancea, J. Begun, 2017 .

The altered expression of iron metabolism genes in models of liver injury suggests iron deficiency in cholestasis and inappropriate regulation of hepcidin in hepatocellular cirrhosis

K. Stuart, D. Crawford, V. Subramaniam, 2011 .

Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex

K. Rosengren, V. Subramaniam, R. Clark, 2022, Molecules.

A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane.

D. James, S. Wong, S. Rea, 1998, Molecular biology of the cell.

Cytosolic factors block antibody binding to the C-terminal cytoplasmic tail of the KDEL receptor.

S. Wong, B. Tang, V. Subramaniam, 1994, European journal of cell biology.

cDNA Cloning and Characterization of Rat Salivary Glycoproteins

D. M. Carlson, V. Subramaniam, Y. Miao, 1995 .

GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6.

S. Wong, W. Hong, T. Zhang, 1999, Molecular biology of the cell.

The functional roles of T-cadherin in mammalian biology

V. Subramaniam, J. Sternberg, L. Hebbard, 2017 .

Genetic Diagnosis in Hereditary Hemochromatosis: Discovering and Understanding the Biological Relevance of Variants.

D. Swinkels, V. Subramaniam, Gautam Rishi, 2021, Clinical chemistry.

Non-HFE haemochromatosis.

V. Subramaniam, D. Wallace, 2007, World journal of gastroenterology.

Signaling pathways regulating hepcidin.

V. Subramaniam, Gautam Rishi, V. N. Subramaniam, 2019, Vitamins and hormones.

Hepcidin: regulation of the master iron regulator

V. Subramaniam, Gautam Rishi, D. Wallace, 2015, Bioscience reports.

Increased Iron Stores Correlate with Worse Disease Outcomes in a Mouse Model of Schistosomiasis Infection

B. Kelly, Malcolm K. Jones, V. Subramaniam, 2010, PloS one.

Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis

V. Subramaniam, Gautam Rishi, D. Wallace, 2019, Pharmaceuticals.

Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2.

V. Subramaniam, Gautam Rishi, D. Wallace, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2.

V. Subramaniam, D. Wallace, L. Ostini, 2011, Blood.

Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading

Paul John Clark, V. Subramaniam, Gautam Rishi, 2018, Human Genomics.

Hfe-associated steatohepatitis: Expression profiling and identifying the molecular basis of liver injury

D. Crawford, V. Subramaniam, K. Bridle, 2013 .

Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes.

V. Subramaniam, D. Wallace, L. Summerville, 2005, Journal of hepatology.

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload

D. Nickerson, M. Emond, C. McLaren, 2015, Hepatology.

Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes

J. Reiling, J. Whitehead, D. Crawford, 2018, Cellular and molecular gastroenterology and hepatology.

Centrobin regulates the assembly of functional mitotic spindles

K. Khanna, J. Jeffery, R. Parton, 2010, Oncogene.

Biochemical fractionation and characterization of proteins from Golgi-enriched membranes.

S. Wong, V. Subramaniam, W. Hong, 1992, The Journal of biological chemistry.

The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data

V. Subramaniam, D. Wallace, V. N. Subramaniam, 2015, Genetics in Medicine.

Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum.

A. Pelletier, J. Bergeron, C. Lavoie, 2000, Molecular biology of the cell.

Apical cell surface expression of rat dipeptidyl peptidase IV in transfected Madin-Darby canine kidney cells.

S. Wong, B. Tang, V. Subramaniam, 1991, The Journal of biological chemistry.

Transthyretin-thyroid hormone internalization by trophoblasts.

R. Mortimer, V. Subramaniam, H. Li, 2013, Placenta.

A 29-Kilodalton Golgi SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Vti1-rp2) Implicated in Protein Trafficking in the Secretory Pathway*

B. Tang, Yue Xu, V. Subramaniam, 1998, The Journal of Biological Chemistry.

The Mammalian Protein (rbet1) Homologous to Yeast Bet1p Is Primarily Associated with the Pre-Golgi Intermediate Compartment and Is Involved in Vesicular Transport from the Endoplasmic Reticulum to the Golgi Apparatus

B. Tang, W. Hong, Yue Xu, 1997, The Journal of cell biology.

Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease

D. D. Di Monte, P. Mastroberardino, V. Subramaniam, 2020, Cell Death & Differentiation.

IgG antibodies to foods in IBS.

P. Browett, V. Subramaniam, H. Kua, 2005, Gut.

Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox

D. Crawford, V. Subramaniam, K. Bridle, 2015, Journal of gastroenterology and hepatology.

Molecular and cellular characterization of transferrin receptor 2

V. Subramaniam, D. Wallace, L. Summerville, 2007, Cell Biochemistry and Biophysics.

Purification and partial characterisation of recombinant human hepcidin.

V. Subramaniam, L. Sly, D. Wallace, 2006, Biochimie.

M. Emond, C. McLaren, L. Gurrin, 2015 .

Reply:

M. Emond, C. McLaren, L. Gurrin, 2017, Hepatology.

Reply to HEP 16‐0784.R1 and HEP 16‐0898

M. Emond, C. McLaren, L. Gurrin, 2016 .

Reply to: GNPAT variant is associated with iron phenotype in healthy Taiwanese women: A population without the HFE C282Y mutation

M. Emond, C. McLaren, L. Gurrin, 2016 .

Study Site Differences in GNPAT p.D519G (rs11558492) Allele Frequencies in Men with HFE Homozygosity

M. Emond, C. McLaren, L. Gurrin, 2015 .

Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin

W. Hong, V. Subramaniam, D. Wallace, 2015, Scientific Reports.

Abstracts of the Australian Gastroenterology Week 2013. October 7-9, 2013. Melbourne, Victoria, Australia.

V. Subramaniam, K. Bridle, L. Fletcher, 2013, Journal of gastroenterology and hepatology.

HFE gene and hemochromatosis

V. Subramaniam, L. Powell, G. Ramm, 2004, Journal of gastroenterology and hepatology.

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

G. Anderson, V. Subramaniam, D. Frazer, 2009, Hepatology.

Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron‐deficient anemia

V. Subramaniam, Gautam Rishi, D. Wallace, 2016, American journal of hematology/oncology.

Apical cell surface expression of rat dipeptidyl peptidase IV in transfected Madin-Darby canine kidney cells.

V. Subramaniam, S. H. Low, S. Wong, 1991, The Journal of biological chemistry.