J. Whitcomb

发表

Crystal structure of HIV‐1 reverse transcriptase in complex with a polypurine tract RNA:DNA

A. D. Clark, Jianping Ding, S. Sarafianos, 2001, The EMBO journal.

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

Sebastian Bonhoeffer, Colombe Chappey, Trevor Hinkley, 2011, Nature Genetics.

Antiretroviral-drug resistance among patients recently infected with HIV.

Elizabeth Connick, Richard A Koup, Lei Wang, 2002, The New England journal of medicine.

Emergence of CXCR4-Using Human Immunodeficiency Virus Type 1 (HIV-1) Variants in a Minority of HIV-1-Infected Patients following Treatment with the CCR5 Antagonist Maraviroc Is from a Pretreatment CXCR4-Using Virus Reservoir

Mike Youle, M. Youle, J. Whitcomb, 2006, Journal of Virology.

Dual-tropic HIV type 1 isolates vary dramatically in their utilization of CCR5 and CXCR4 coreceptors

C. Petropoulos, Wei Huang, J. Whitcomb, 2010, AIDS.

Detailed Transmission Network Analysis of a Large Opiate-Driven Outbreak of HIV Infection in the United States

Debra Hanson, Michael W. Spiller, Philip J Peters, 2017, The Journal of infectious diseases.

Characterization of emergent HIV resistance in treatment-naive subjects enrolled in a vicriviroc phase 2 trial.

C. Tremblay, J. Whitcomb, W. Greaves, 2010, The Journal of infectious diseases.

Suppression of Dualtropic Human Immunodeficiency Virus Type 1 by the CXCR4 Antagonist AMD3100 Is Associated with Efficiency of CXCR4 Use and Baseline Virus Composition

C. Petropoulos, N. Parkin, E. Stawiski, 2008, Antimicrobial Agents and Chemotherapy.

Natural Variation of Drug Susceptibility in Wild-Type Human Immunodeficiency Virus Type 1

C. Petropoulos, C. Chappey, N. Parkin, 2004, Antimicrobial Agents and Chemotherapy.

Virologic Characterization of HIV Type 1 With a Codon 70 Deletion in Reverse Transcriptase

D. Kuritzkes, H. Hatano, Zixin Hu, 2007, Journal of acquired immune deficiency syndromes.

Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection.

B. Gazzard, J. Whitcomb, G. Moyle, 2005, The Journal of infectious diseases.

Coreceptor Tropism Can Be Influenced by Amino Acid Substitutions in the gp41 Transmembrane Subunit of Human Immunodeficiency Virus Type 1 Envelope Protein

C. Petropoulos, N. Parkin, E. Stawiski, 2008, Journal of Virology.

The EV-O-derived cell line DF-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors.

S. Hughes, M. VanBrocklin, D. Foster, 1998, Virology.

The sequence of human immunodeficiency virus type 2 circle junction suggests that integration protein cleaves the ends of linear DNA asymmetrically

S. Hughes, J. Whitcomb, 1991, Journal of virology.

Sequence of the circle junction of human immunodeficiency virus type 1: implications for reverse transcription and integration

R. Kumar, J. Whitcomb, S. H. Hughes, 1990 .

TheSequence ofHumanImmunodeficiency VirusType2Circle Junction Suggests ThatIntegration Protein Cleaves theEndsof

S. Hughes, J. Whitcomb, 1991 .

Loss of Asparagine-Linked Glycosylation Sites in Variable Region 5 of Human Immunodeficiency Virus Type 1 Envelope Is Associated with Resistance to CD4 Antibody Ibalizumab

C. Petropoulos, E. Stawiski, Wei Huang, 2011, Journal of Virology.

Geographic Disparities in Access to Syringe Services Programs Among Young Persons With Hepatitis C Virus Infection in the United States

J. Whitcomb, S. Hariri, H. Kaufman, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Replication of avian leukosis viruses with mutations at the primer binding site: use of alternative tRNAs as primers

S. Hughes, J. Whitcomb, B. Ortiz‐Conde, 1995, Journal of virology.

Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals.

T. Wrin, C. Petropoulos, F. Hecht, 2009, AIDS research and human retroviruses.

Coreceptor Tropism Can Be Inﬂuenced by Amino Acid Substitutions in the gp41 Transmembrane Subunit of Human Immunodeﬁciency Virus Type 1 Envelope Protein (cid:1)

C. Petropoulos, N. Parkin, E. Stawiski, 2008 .

Prediction of Virological Response and Assessment of Resistance Emergence to the HIV-1 Attachment Inhibitor BMS-626529 During 8-Day Monotherapy With Its Prodrug BMS-663068

M. Krystal, J. Whitcomb, N. Ray, 2013, Journal of acquired immune deficiency syndromes.

Sequence of the Circle Junction of Human Immunodeficiency Virus Type 1: Implications for Reverse Transcription and Integration

R. Kumar, S. Hughes, J. Whitcomb, 1990, Journal of virology.

Development and Characterization of a Novel Single-Cycle Recombinant-Virus Assay To Determine Human Immunodeﬁciency Virus Type 1 Coreceptor Tropism (cid:1)

T. Wrin, C. Petropoulos, E. Paxinos, 2007 .

Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates

T. Wrin, C. Petropoulos, E. Paxinos, 2002, AIDS.

Inhibition of purified recombinant reverse transcriptase from wild-type and zidovudine-resistant clinical isolates of human immunodeficiency virus type 1 by zidovudine, stavudine, and lamivudine triphosphates.

D. Kuritzkes, C. Petropoulos, J. Whitcomb, 2001, The Journal of infectious diseases.

A Decade of HIV-1 Drug Resistance in the United States: Trends and Characteristics in a Large Protease/Reverse Transcriptase and Co-Receptor Tropism Database from 2003 to 2012

Joseph M. Volpe, C. Petropoulos, J. Whitcomb, 2014, Antiviral therapy.

A new PCR based method for the generation of nested deletions.

S. Hughes, J. Whitcomb, A. Rashtchian, 1993, Nucleic acids research.

Inhibition of Tumor Development by Dehydroepiandrosterone and Related Steroids

J. Whitcomb, A. Schwartz, L. Pashko, 1986, Toxicologic pathology.

A Novel Phenotypic Drug Susceptibility Assay for Human Immunodeficiency Virus Type 1

Christos J. Petropoulos, Terri Wrin, Jeannette M. Whitcomb, 2000, Antimicrobial Agents and Chemotherapy.

Retroviral reverse transcription and integration: progress and problems.

S. Hughes, J. Whitcomb, S H Hughes, 1992, Annual review of cell biology.

Prevalence of Darunavir Resistance in the United States from 2010 to 2017

J. Whitcomb, R. Nettles, Dongmei Yang, 2018, AIDS research and human retroviruses.

Subtle decreases in stavudine phenotypic susceptibility predict poor virologic response to stavudine monotherapy in zidovudine-experienced patients.

D. Katzenstein, M. Hughes, R. Shafer, 2002, Journal of acquired immune deficiency syndromes.

Exploring the Complexity of the HIV-1 Fitness Landscape

Sebastian Bonhoeffer, Christos J. Petropoulos, Gabriel E. Leventhal, 2012, PLoS genetics.

A Novel Proximity Assay for the Detection of Proteins and Protein Complexes: Quantitation of HER1 and HER2 Total Protein Expression and Homodimerization in Formalin-fixed, Paraffin-Embedded Cell Lines and Breast Cancer Tissue

Yining Shi, John Winslow, Weidong Huang, 2009, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

Coreceptor Tropism in Human Immunodeficiency Virus Type 1 Subtype D: High Prevalence of CXCR4 Tropism and Heterogeneous Composition of Viral Populations

Wei Huang, Christos J. Petropoulos, Susan H. Eshleman, 2007, Journal of Virology.

Co-receptor Tropism in Subtype D HIV-1 : High Prevalence of CXCR 4 Tropism and Heterogeneous Composition of Viral Populations

C. Petropoulos, E. Paxinos, N. Parkin, 2007 .

Estimating the Fitness Cost of Escape from HLA Presentation in HIV-1 Protease and Reverse Transcriptase

Sebastian Bonhoeffer, Christos J. Petropoulos, Mojgan Haddad, 2012, PLoS Comput. Biol..

HIV-1 chemokine coreceptor utilization in paired cerebrospinal fluid and plasma samples: a survey of subjects with viremia.

C. Petropoulos, R. Price, T. Liegler, 2005, The Journal of infectious diseases.

Effect of the Q207D Mutation in HIV Type 1 Reverse Transcriptase on Zidovudine Susceptibility and Replicative Fitness

Daniel R Kuritzkes, D. Kuritzkes, J. Whitcomb, 2005, Journal of acquired immune deficiency syndromes.

Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens.

M. Hirsch, D. Richman, C. Petropoulos, 2000, JAMA.

Assessing Predicted HIV-1 Replicative Capacity in a Clinical Setting

Huldrych F. Günthard, Sebastian Bonhoeffer, Christos J. Petropoulos, 2011, PLoS pathogens.

Genotypic and Phenotypic Resistance in Clinical Samples Submitted for HCV NS5B Drug Resistance Testing in the Us

Joseph M. Volpe, C. Petropoulos, J. Reeves, 2016 .

Development and Characterization of a Novel Single-Cycle Recombinant-Virus Assay To Determine Human Immunodeficiency Virus Type 1 Coreceptor Tropism

Christos J. Petropoulos, Terri Wrin, Wei Huang, 2006, Antimicrobial Agents and Chemotherapy.

Reduced Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) from Patients with Primary HIV Infection to Nonnucleoside Reverse Transcriptase Inhibitors Is Associated with Variation at Novel Amino Acid Sites

D. Richman, S. Little, C. Petropoulos, 2000, Journal of Virology.

Broad nucleoside reverse-transcriptase inhibitor cross-resistance in human immunodeficiency virus type 1 clinical isolates.

Colombe Chappey, C. Petropoulos, C. Chappey, 2003, The Journal of infectious diseases.

Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication

C. Petropoulos, A. Gamarnik, Wei Huang, 2003, Journal of Virology.

Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark®) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor Specimens

C. Petropoulos, Weidong Huang, J. Whitcomb, 2010, Pathology research international.

Principal component analysis of general patterns of HIV-1 replicative fitness in different drug environments.

C. Petropoulos, S. Bonhoeffer, C. Chappey, 2010, Epidemics.

Reduced antiretroviral drug susceptibility among patients with primary HIV infection.

E. Rosenberg, B. Walker, D. Richman, 1999, JAMA.

Virus Replication Susceptibility to Delavirdine and Impair Reverse Transcriptase Increase Human Immunodeficiency Virus Type 1 Amino Acid Substitutions at Position 190 of

C. Petropoulos, A. Gamarnik, Wei Huang, 2002 .

The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis

R. Haubrich, D. Richman, C. Kemper, 2002, AIDS.

Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1.

C. Petropoulos, E. Stawiski, Wei Huang, 2011, Virology.

A Case-Based Reasoning System for Genotypic Prediction of HIV-1 Co-receptor tropism

Wei Huang, Eoin Coakley, Mark C. Evans, 2013, J. Bioinform. Comput. Biol..

Assessing chemokine co-receptor usage in HIV

Eoin Coakley, C. Petropoulos, J. Whitcomb, 2005, Current opinion in infectious diseases.

Comparison of central HER2 testing with quantitative total HER2 expression and HER2 homodimer measurements using a novel proximity-based assay.

E. Perez, W. Lingle, R. Jenkins, 2010, American journal of clinical pathology.

Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy

D. Katzenstein, R. Shafer, C. Petropoulos, 2001, AIDS.

Production of avian leukosis virus particles in mammalian cells can be mediated by the interaction of the human immunodeficiency virus protein Rev and the Rev-responsive element.

S. Hughes, B. Felber, J. Whitcomb, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Clonal analysis of HIV-1 genotype and function associated with virologic failure in treatment-experienced persons receiving maraviroc: Results from the MOTIVATE phase 3 randomized, placebo-controlled trials

D. Robertson, Wei Huang, J. Whitcomb, 2018, PloS one.

Rapid detection of influenza virus H1 by the polymerase chain reaction.

P. Cerutti, C. Pourzand, O. Haller, 1990, Biochemical and biophysical research communications.