C. Huxley

发表

Expression of the human CFTR gene from episomal oriP-EBNA1-YACs in mouse cells.

D. Huertas, S. Howe, A. McGuigan, 2000, Human molecular genetics.

Analysis of a YAC with human telomeres and oriP from epstein-barr virus in yeast and 293 cells.

T. Tolmachova, C. Huxley, K. Simpson, 1999, Nucleic acids research.

Retrofitting BACs with G418 resistance, luciferase, and oriP and EBNA-1 – new vectors for in vitro and in vivo delivery

E. Wagner, C. Magin-Lachmann, C. Huxley, 2003, BMC biotechnology.

Transfer of the human HPRT and GART genes from yeast to mammalian cells by microinjection of YAC DNA

A. Gnirke, C. Huxley, 1991, Somatic cell and molecular genetics.

Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.

G. Stamatoyannopoulos, H. Haugen, C. Clegg, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Analysis of DNase-I-hypersensitive sites at the 3' end of the cystic fibrosis transmembrane conductance regulator gene (CFTR).

A. Harris, C. Huxley, H. Nuthall, 1999 .

Transgenic mice containing a 248-kilobase human beta locus yeast artificial chromosome display proper developmental control of human globin genes.

G. Stamatoyannopoulos, H. Haugen, C. Clegg, 1993, Transactions of the Association of American Physicians.

Microinjection of intact 200- to 500-kb fragments of YAC DNA into mammalian cells.

A. Gnirke, M. Olson, C. Huxley, 1993, Genomics.

Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice.

D. Figarella-Branger, C. Huxley, M. Fontès, 1998, Human molecular genetics.

Nerve‐dependent changes in skeletal muscle myosin heavy chain after experimental denervation and cross‐reinnervation and in a demyelinating mouse model of Charcot–Marie–Tooth disease type 1A

S. Hughes, C. Huxley, A. Maggs, 2008, Muscle & nerve.

Bmc Musculoskeletal Disorders Analyses of the Differentiation Potential of Satellite Cells from Myod -/-, Mdx, and Pmp22 C22 Mice

C. Mann, Heidi Bildsoe, S. Hughes, 2022 .

The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2.

H. Lehrach, D. Duboule, B. Hogan, 1990, Genomics.

Skipping of exon 9 of human CFTR in YAC-transgenic mice.

C. Huxley, A. Manson, 2001, Genomics.

Development of early postnatal peripheral nerve abnormalities in Trembler‐J and PMP22 transgenic mice

R. King, C. Huxley, A. Robertson, 1999, Journal of anatomy.

Insertion of expanded CAG trinucleotide repeat motifs into a yeast artificial chromosome containing the human Machado-Joseph disease gene.

C. Huxley, S. Chamberlain, C. Cemal, 1999, Gene.

Mouse genetic corneal disease resulting from transgenic insertional mutagenesis

J. Ramalho, C. Huxley, M. Seabra, 2004, British Journal of Ophthalmology.

TheMouseSurfeit LocusContains a Cluster ofSixGenes Associated withFourCpG-Rich Islands in32Kilobases ofGenomicDNA

M. Fried, C. Huxley, 1990 .

One of the tightly clustered genes of the mouse surfeit locus is a highly expressed member of a multigene family whose other members are predominantly processed pseudogenes

M. Fried, C. Huxley, T. Williams, 1988, Molecular and cellular biology.

Myelin disorders

C. Huxley, 1998, Neuropathology and applied neurobiology.

Ordering Up Big MACs

T. Haaf, C. Huxley, M. Gennaro, 1994, Bio/Technology.

Comparison of YACs containing mouse centromeric satellite sequences cloned in rad52 and RAD52 host strains

A. McGuigan, C. Huxley, A. Manson, 1998, Mammalian Genome.

Investigation of Schizosaccharomyces pombe as a cloning host for human telomere and alphoid DNA.

C. Huxley, K. Mann, 2000, Gene.

Bacterial delivery of large intact genomic-DNA-containing BACs into mammalian cells

V. Gorgoulis, A. Kotsinas, T. Kaname, 2012, Bioengineered bugs.

V. Gorgoulis, A. Kotsinas, T. Kaname, 2012 .

Simple and efficient vectors for retrofitting BACs and PACs with mammalian neoR and EGFP marker genes.

T. Kaname, C. Huxley, 2001, Gene.

Increased missegregation and chromosome loss with decreasing chromosome size in vertebrate cells

C. Huxley, C. Farr, W. Mills, 2006, Chromosoma.

A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection.

M. Newport, B. Oostra, R. Williamson, 1996, The New England journal of medicine.

Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models

M. Seeliger, J. Ramalho, C. Huxley, 2002, BMC Cell Biology.

Mammalian artificial chromosomes: a new tool for gene therapy.

C. Huxley, 1994, Gene therapy.

Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred.

R. Williamson, M. Levin, M. Shaw, 1995, Journal of Medical Genetics.

The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA

M. Fried, C. Huxley, M Fried, 1990, Molecular and cellular biology.

Recombining overlapping BACs into a single larger BAC

C. Huxley, G. Kotzamanis, 2004, BMC biotechnology.

Factor VIII mRNA expression from a BAC carrying the intact locus made by homologous recombination.

C. Huxley, C. Grillot‐Courvalin, H. Abdulrazzak, 2007, Genomics.

Construction of human artificial chromosome vectors by recombineering.

H. Cooke, S. Howe, C. Huxley, 2005, Gene.

The primary and final effector mechanisms required for kinin-induced epithelial chloride secretion.

C. Huxley, A. Cuthbert, 1998, American journal of physiology. Gastrointestinal and liver physiology.

The primary and final effector mechanisms required for kinin-induced epithelial chloride secretion.

C. Huxley, A. Cuthbert, 1998, The American journal of physiology.

Transfer of yeast artificial chromosomes from yeast to mammalian cells.

A. Gnirke, C. Huxley, 1991, BioEssays : news and reviews in molecular, cellular and developmental biology.

The human HPRT gene on a yeast artificial chromosome is functional when transferred to mouse cells by cell fusion.

D. Schlessinger, M. Olson, Y. Hagino, 1991, Genomics.

A General Role for Rab 27 a in Secretory Cells

T. Tolmachova, C. Huxley, M. Seabra, 2003 .

Chapter 65 – Transgenic Models of Inherited Neuropathy

C. Huxley, A. Robertson, 2005 .

Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA.

D. Figarella-Branger, C. Huxley, M. Fontès, 1996, Human molecular genetics.

A general role for Rab27a in secretory cells.

Clare Huxley, T. Tolmachova, C. Huxley, 2003, Molecular biology of the cell.

Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A.

J. Perea, R. King, J. Muddle, 2001, Human molecular genetics.

Cloning, mapping and characterization of the human RAB27A gene.

J. Ramalho, T. Tolmachova, R. Schultz, 1999, Gene.

Comparison of a new pmp22 transgenic mouse line with other mouse models and human patients with CMT1A *

J. Perea, R. King, J. Muddle, 2002, Journal of anatomy.

Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene

J. Ramalho, T. Tolmachova, A. McGuigan, 2001, BMC Genetics.

Exploring gene function: use of yeast artificial chromosome transgenesis.

C. Huxley, 1998, Methods.

Contiguous Arrays of Satellites 1, 3, and β Form a 1.5-Mb Domain on Chromosome 22p

C. Coutelle, C. Huxley, C. Shiels, 1997 .

YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.

M. Pook, C. Huxley, L. Lawrence, 2002, Human molecular genetics.

Analysis of a DNase I hypersensitive site located -20.9 kb upstream of the CFTR gene.

A. Harris, G. Vassaux, C. Huxley, 1999, European journal of biochemistry.

In Vivo Analysis of DNase I Hypersensitive Sites in the Human CFTR Gene

A. Harris, C. Huxley, H. Nuthall, 1999, Molecular medicine.

Rapid assessment of S. cerevisiae mating type by PCR.

I. Dunham, C. Huxley, E. Green, 1990, Trends in genetics : TIG.

Use of yeast artificial chromosomes (YASs) for studying control of gene expression: Correct regulation of the genes of a human β-globin locus YAC following transfer to mouse erythroleukemia cell lines

A. Gnirke, G. Stamatoyannopoulos, K. Leppig, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Targeting mutations to YACs by homologous recombination.

K. Duff, C. Huxley, K. Duff, 1996, Methods in molecular biology.

The mouse surfeit locus contains a very tight cluster of four "housekeeping" genes that is conserved through evolution.

J. Yon, M. Fried, C. Huxley, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Analysis of ribosomal and alphoid repetitive DNA by fiber-FISH.

C. Coutelle, C. Huxley, C. Shiels, 1997, Cytogenetics and cell genetics.

Insertion of a pathogenic mutation into a yeast artificial chromosome containing the human amyloid precursor protein gene.

J. Hardy, F. Schulz, A. McGuigan, 1994, Gene therapy.

The mouse rpL7a gene is typical of other ribosomal protein genes in it's 5' region but differs in being located in a tight cluster of CpG-rich islands.

M. Fried, C. Huxley, 1990, Nucleic acids research.

Stable episomal maintenance of yeast artificial chromosomes in human cells

A. McGuigan, C. Huxley, K. Simpson, 1996, Molecular and cellular biology.

Mammalian artificial chromosomes and chromosome transgenic

C. Huxley, 1997 .

In vitro and in vivo delivery of intact BAC DNA – comparison of different methods

C. Magin-Lachmann, E. Wagner, C. Huxley, 2004, The journal of gene medicine.

Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.

N. Tanimoto, M. Seeliger, M. Dallman, 2006, The Journal of clinical investigation.

Replication of yeast DNA and novel chromosome formation in mouse cells.

A. McGuigan, C. Huxley, 1996, Nucleic acids research.

Modular bacterial artificial chromosome vectors for transfer of large inserts into mammalian cells.

P. D. de Jong, K. Osoegawa, H. Prydz, 2000, Genomics.

Gene therapy for cystic fibrosis.

C. Coutelle, C. Huxley, S. Hart, 1993, Archives of disease in childhood.

Removal and restoration of epithelial chloride secretory activity of kinins by gene manipulation.

J. Hess, C. Huxley, A. Cuthbert, 1996, Immunopharmacology.

Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic mice.

Clare Huxley, J. Perea, T. Tolmachova, 2002, Gene.

Complementation of null CF mice with a human CFTR YAC transgene

M. Evans, W. Colledge, K. Kasschau, 1997, The EMBO journal.

Copy number-dependent expression of a YAC-cloned human CFTR gene in a human epithelial cell line

G. Vassaux, C. Huxley, A. Manson, 1997, Gene Therapy.

Isolation of DNA from the centromere of human chromosome 7 by microdissection

E. Green, R. Williamson, B. Horsthemke, 1997, Chromosome Research.

CFTR expression from a BAC carrying the complete human gene and associated regulatory elements

V. Gorgoulis, C. Kittas, A. Harris, 2008, Journal of cellular and molecular medicine.

Alphoid DNA from different chromosomes forms de novo minichromosomes with high efficiency

K. Osoegawa, P. Jong, T. Kaname, 2005, Chromosome Research.

An element in intron 1 of the CFTR gene augments intestinal expression in vivo.

R. Rowntree, A. Harris, G. Vassaux, 2001, Human molecular genetics.

Analysis of DNase-I-hypersensitive sites at the 3' end of the cystic fibrosis transmembrane conductance regulator gene (CFTR).

A. Harris, C. Huxley, H. Nuthall, 1999, The Biochemical journal.

Extrachromosomal maintenance and amplification of yeast artificial chromosome DNA in mouse cells.

C. Huxley, T. Featherstone, 1993, Genomics.

A shuttle system for transfer of YACs between yeast and mammalian cells.

C. Huxley, Kaetrin Simpson, 1996, Nucleic acids research.