A. Spiegel

J. Miller, Jeffery L. Miller, A. Spiegel, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A Missense Mutation in the Seven-transmembrane Domain of the Human Ca2+ Receptor Converts a Negative Allosteric Modulator into a Positive Allosteric Modulator*

K. Jacobson, S. Costanzi, J. Feyen, 2006, Journal of Biological Chemistry.

Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function

A. Spiegel, Jianxin Hu, 2003, Trends in Endocrinology & Metabolism.

The Carboxyl Terminus of the Human Calcium Receptor

A. Spiegel, P. Goldsmith, K. Ray, 1997, The Journal of Biological Chemistry.

Executive summary of the Strategic Plan for National Institutes of Health Obesity Research.

A. Spiegel, B. Alving, 2005, The American journal of clinical nutrition.

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.

G. Milligan, M. Pines, P. Gierschik, 1986, Proceedings of the National Academy of Sciences of the United States of America.

In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein.

S. Hermouet, A. Spiegel, S. Aznavoorian, 1996, Cellular signalling.

Subcellular localization of Gi alpha in human neutrophils.

D. Rotrosen, H. Malech, A. Spiegel, 1988, The Journal of biological chemistry.

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.

A. Shenker, A. Spiegel, P. Goldsmith, 1991, Transactions of the Association of American Physicians.

Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line.

G. Milligan, P. Backlund, A. Spiegel, 1988, Biochemistry.

Common ancestral mutations in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland

F. Collins, S. Chandrasekharappa, S. Guru, 1998, Human mutation.

The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.

F. Collins, K. Bilimoria, S. Chandrasekharappa, 2001, Oncogene.

Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.

J. Feramisco, J. Meinkoth, V. Lamorte, 1992, The Journal of biological chemistry.

Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein.

R. Lasker, A. Spiegel, S. Marx, 1983, The American journal of medicine.

Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system.

A. Spiegel, M. Forte, F. Quan, 1989, The Journal of biological chemistry.

The Hypocalciuric or Benign Variant of Familial Hypercalcemia: Clinical and Biochemical Features in Fifteen Kindreds

R. Lasker, A. Spiegel, S. Marx, 1981, Medicine.

Contents

G. Milligan, G. Wilkin, P. Francis, 2020, Primary Care Diabetes.

Immunolocalization of G protein alpha-subunits in the Drosophila CNS

A. Spiegel, P. Goldsmith, M. Forte, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism.

A. Spiegel, S. Marx, M. Levine, 1980, Biochemical and biophysical research communications.

A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D.

H. DeLuca, E. Brown, D. Gardner, 1978, The Journal of clinical endocrinology and metabolism.

Inherited diseases involving g proteins and g protein-coupled receptors.

L. Weinstein, A. Spiegel, 2004, Annual review of medicine.

Localization of parathyroid adenomas in patients who have undergone surgery. Part I. Noninvasive imaging methods.

J. Norton, T. Shawker, J. Doppman, 1987, Radiology.

NIH research on obesity and type 2 diabetes: providing the scientific evidence base for actions to improve health

E. Nabel, A. Spiegel, 2006, Nature Medicine.

Hyperfunctioning cystic parathyroid glands: CT and sonographic findings.

J. Norton, T. Shawker, J. Doppman, 1984, AJR. American journal of roentgenology.

Parathyroid adenomas in the aortopulmonary window.

J. Norton, J. Doppman, D. Fraker, 1996, Radiology.

MEN1 gene mutation analysis of high‐grade neuroendocrine lung carcinoma

F. Collins, M. Emmert-Buck, W. Travis, 2000, Genes, chromosomes & cancer.

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Cancer research.

Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism.

F. Collins, M. Emmert-Buck, S. Libutti, 2003, Cancer research.

Defects in G protein-coupled signal transduction in human disease.

A. Spiegel, A M Spiegel, 1996, Annual review of physiology.

11q13 allelotype analysis in 27 northern American MEN1 kindreds identifies two distinct founder chromosomes.

F. Collins, L. Liotta, M. Emmert-Buck, 1998, Molecular genetics and metabolism.

Targeted therapies: Good news for advanced-stage pancreatic neuroendocrine tumors

S. Libutti, A. Spiegel, 2011, Nature Reviews Clinical Oncology.

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

G. Milligan, P. Gierschik, H. Malech, 1987, The Journal of biological chemistry.

Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.

G. Milligan, M. Pines, P. Gierschik, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Human cDNA clones for an alpha subunit of Gi signal-transduction protein.

M. Nirenberg, J. Kamholz, A. Spiegel, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Stable overexpression of MEN1 suppresses tumorigenicity of RAS

F. Collins, Y. Kim, S. Chandrasekharappa, 1999, Oncogene.

Mutations of the GNAS1 Gene, Stromal Cell Dysfunction, and Osteomalacic Changes in Non–McCune–Albright Fibrous Dysplasia of Bone

S. Wientroub, M. Collins, P. Bianco, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Familial hypocalciuric hypercalcemia. The relation to primary parathyroid hyperplasia

R. Lasker, A. Spiegel, S. Marx, 1982 .

Divalent cation metabolism. Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.

E. Brown, M. Brennan, D. Gardner, 1978, The American journal of medicine.

G proteins in clinical medicine.

A. Spiegel, 1988, Hospital practice.

Decreased insulin content and secretion in RIN 1046-38 cells overexpressing α2-Adrenergic receptorsreceptors

A. Spiegel, C. Woodard, M. Rodríguez-Pena, 1997, Endocrine.

Direct Identification and Characterization of β-Adrenergic Receptors and Functional Relationship of Adenylyl Cyclase

E. Brown, J. Gardner, A. Spiegel, 1978 .

Stable changes in expression or activation of G protein αi or αq subunits affect the expression of both β1 and β2 subunits

S. Hermouet, A. Spiegel, T. Murakami, 1993 .

Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers.

P. Gierschik, A. Spiegel, M. Levine, 1985, The New England journal of medicine.

12 Parathyroid hormone and vitamin D receptors

A. Spiegel, S. Marx, 1983 .

Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.

M. Y. Degtyarev, T. L. Jones, A. Spiegel, 1994, The Journal of biological chemistry.

Albright's hereditary osteodystrophy and defective G proteins.

A. Spiegel, A. M. Spiegel, 1990, The New England journal of medicine.

Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein

R. Weinstock, A. Spiegel, A. Moses, 1986, Nature.

Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds.

T. Jap, A. Spiegel, M. Levine, 1986, The Journal of clinical endocrinology and metabolism.

The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism.

A. Spiegel, M. Levine, R. Downs, 1985, The Journal of clinical endocrinology and metabolism.

Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism.

A. Spiegel, M. Levine, R. Downs, 1983, The Journal of clinical investigation.

Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I. a cause of impaired synthesis of 3',5'-cyclic AMP by intact and broken cells.

A. Spiegel, M. Levine, R. Downs, 1983, The Journal of clinical investigation.

Pseudohypoparathyroidism: the molecular basis for hormone resistance--a retrospective.

A. Spiegel, S. Marx, M. Levine, 1982, The New England journal of medicine.

The role of guanine nucleotides in regulation of adenylate cyclase activity.

A. Spiegel, S. Marx, M. Levine, 1981, Recent progress in hormone research.

Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.

K. Jacobson, A. Spiegel, Jianxin Hu, 2000, Endocrinology.

G proteins--the disease spectrum expands.

A. Spiegel, 2013, The New England journal of medicine.

Heterogeneous gland size in sporadic multiple gland parathyroid hyperplasia.

S. Libutti, J. Doppman, H. Alexander, 1999, Journal of the American College of Surgeons.

An association between neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia in three kindreds.

R. Lasker, A. Spiegel, S. Marx, 1982, The New England journal of medicine.

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

D. Absher, K. Chien, J. Feramisco, 1994, The Journal of biological chemistry.

The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification.

M. Y. Degtyarev, T. L. Jones, A. Spiegel, 1993, Biochemistry.

The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.

M. Caron, G. Milligan, J. Benovic, 1987, The Journal of biological chemistry.

Human cDNA clones for four species of G alpha s signal transduction protein.

M. Nirenberg, J. Kamholz, A. Spiegel, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1.

J. Norton, J. Doppman, R. Quarto, 1986, The New England journal of medicine.

Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni.

L. Birnbaumer, P. Gierschik, A. Spiegel, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Protein kinase C-mediated phosphorylation of retinal rod outer segment membrane proteins.

Y. Zick, L. Traub, A. Spiegel, 1989, Cellular signalling.

Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone.

H. Jüppner, A. Abou-Samra, L. Y. Xie, 1994, Endocrinology.

Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.

M. Caron, R. Lefkowitz, E. Lapetina, 1991, Cellular signalling.

Gsα, Pseudohypoparathyroidism, Fibrous Dysplasia, and McCune–Albright Syndrome

L. Weinstein, M. Collins, A. Spiegel, 2013 .

Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Treatment of Hypercalcemia Secondary to Parathyroid Carcinoma with a Novel Calcimimetic Agent

S. Silverberg, J. Bilezikian, M. Skarulis, 1997 .

Pheromone action regulates G-protein a-subunit myristoylation in the yeast Saccharomyces cerevisiae ( posttranslational modiflcation / mutants / adaptation )

J. Thorner, H. Dohlman, A. Spiegel, 2005 .

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

F. Collins, M. Emmert-Buck, S. Libutti, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mitogenic effects of pertussis toxin-sensitive G-protein α subunits: The mitogenic action of αi2 in NIH 3T3 cells is mimicked by αi1, but not αi3

S. Hermouet, A. Spiegel, P. Mazancourt, 1993 .

Hyperparathyroidism in hereditary syndromes: special expressions and special managements.

F. Collins, S. Libutti, W. Simonds, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1

J. Norton, J. Menczel, A. Spiegel, 1991, Clinical endocrinology.

Familial hypocalciuric hypercalcemia: recognition among patients referred after unsuccessful parathyroid exploration.

J. Doppman, E. Brown, M. Brennan, 1980, Annals of internal medicine.

Evidence for direct interaction of Gs alpha with the Ca2+ channel of skeletal muscle.

E. Stefani, S. Hamilton, L. Toro, 1991, The Journal of biological chemistry.

Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.

S. Libutti, S. Offermanns, N. Wettschureck, 2007, Molecular endocrinology.

Sporadic hypoparathyroidism caused by de Novo gain-of-function mutations of the Ca(2+)-sensing receptor.

K. Ray, J. Baron, A. Spiegel, 1997, The Journal of clinical endocrinology and metabolism.

The G protein connection: molecular basis of membrane association.

W. Simonds, P. Backlund, A. Spiegel, 1991, Trends in biochemical sciences.

Family studies in patients with primary parathyroid hyperplasia.

E. Brown, A. Spiegel, S. Marx, 1977, The American journal of medicine.

Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families

L. Liotta, M. Emmert-Buck, I. Lubensky, 1998, Human mutation.

Abnormalities in G protein-coupled signal transduction pathways in human disease.

L. Weinstein, A. Shenker, A. Spiegel, 1993, The Journal of clinical investigation.

Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS.

M. Merino, L. Weinstein, A. Shenker, 1993, The Journal of pediatrics.

Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells.

J. Doppman, E. Brown, M. Brennan, 1979, The American journal of medicine.

Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia.

E. Brown, M. Brennan, D. Gardner, 1978, The Journal of clinical endocrinology and metabolism.

Cholera-toxin-dependent ADP-ribosylation of the adenylate cyclase regulatory protein in turkey erythrocyte membranes.

A. Spiegel, M. Levine, R. Downs, 1981, Archives of biochemistry and biophysics.

Receptor and effector interactions of Gs Functional studies with antibodies to the αs carboxyl‐terminal decapeptide

W. Simonds, A. Spiegel, P. Goldsmith, 1989, FEBS letters.

Antibodies against a retinal guanine nucleotide‐binding protein cross‐react with a single plasma membrane protein in non‐retinal tissues

P. Gierschik, A. Spiegel, C. Woodard, 1984, FEBS letters.

Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism.

W. Travis, J. Doppman, D. Fraker, 1991, Annals of surgery.

A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor

A. Spiegel, P. Goldsmith, O. Hauache, 1999, FEBS letters.

Expression of GTP-binding proteins and prostaglandin E2 receptors during human T cell activation.

M. Brann, B. Howard, W. Holter, 1991, Cellular immunology.

Localization and operative management of undescended parathyroid adenomas in patients with persistent primary hyperparathyroidism.

J. Norton, T. Shawker, J. Doppman, 1994, Surgery.

Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism.

E. Brown, M. Brennan, A. Broadus, 1979, The Journal of clinical endocrinology and metabolism.

Molecular Cloning of Human Gαq cDNA and Chromosomal Localization of the Gαq Gene (GNAQ) and a Processed Pseudogene

J. Battey, O. Mcbride, B. Haddad, 1995 .

Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene.

J. Battey, O. Mcbride, B. Haddad, 1995, Genomics.

Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.

E. Brown, D. Gardner, A. Spiegel, 1980, The Journal of clinical endocrinology and metabolism.

Neonatal primary hyperparathyroidism with autosomal dominant inheritance.

E. Brown, A. Spiegel, S. Marx, 1977, The Journal of pediatrics.

Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase

D. Cooper, A. Spiegel, P. Goldsmith, 1990, Brain Research.

A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma.

J. Norton, T. Shawker, J. Doppman, 1996, Annals of surgery.

Receptor-effector coupling by G proteins

A. Spiegel, 1990 .

Inherited endocrine diseases involving G proteins and G protein-coupled receptors.

A. Spiegel, 2007, Endocrine development.

Receptor-effector coupling by G-proteins implications for endocrinology

A. Spiegel, 1989, Trends in Endocrinology & Metabolism.

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.

G. Milligan, P. Backlund, A. Spiegel, 1988, Biochemistry.

Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development.

G. Milligan, P. Gierschik, A. Spiegel, 1987, Biochemistry.

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

W. Simonds, A. Spiegel, P. Goldsmith, 1988, The Journal of biological chemistry.

Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.

J. Battey, F. Brucker-Davis, B. Weintraub, 1996, The Journal of clinical endocrinology and metabolism.

Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma.

J. Doppman, E. Brown, M. Brennan, 1978, The New England journal of medicine.

Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.

M. Pines, Y. Zick, P. Gierschik, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Obesity on the brain

N. Volkow, Story C. Landis, Ting-kai Li, 2005, Nature Neuroscience.

alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates.

D. Klein, H. Korf, P. Gierschik, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Identification and characterization of JunD missense mutants that lack menin binding

F. Collins, S. Chandrasekharappa, A. Hickman, 2000, Oncogene.

Autosomal Dominant Hypocalcemia in Monozygotic Twins Caused by a De Novo Germline Mutation Near the Amino‐Terminus of the Human Calcium Receptor

S. Mora, A. Spiegel, Jianxin Hu, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Heterotrimeric GTP‐binding proteins: An expanding family of signal transducers

A. Spiegel, A. Spiegel, 1992, Medicinal research reviews.

Immunological Probes of the Structure, Function, and Expression of Heterotrimeric GTP-Binding Proteins

W. Simonds, T. L. Jones, A. Spiegel, 1992 .

The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.

F. Collins, W. Simonds, L. Weinstein, 2007, The Journal of clinical endocrinology and metabolism.

BRIEF REPORT The Parathyroid/Pituitary Variant of Multiple Endocrine Neoplasia Type 1 Usually Has Causes Other than p27 Kip1 Mutations

F. Collins, W. Simonds, L. Weinstein, 2007 .

Molecular Pathology of the MEN1 Gene

F. Collins, S. Libutti, M. Mullendore, 2004, Annals of the New York Academy of Sciences.

Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1.

S. Steinberg, M. Turner, M. Skarulis, 1997, Archives of dermatology.

Mutations of the Gs a-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis

E. Friedman, P. Gejman, L. Weinstein, 2022 .

High level expression of transfected G protein αi3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts

S. Hermouet, P. de Mazancourt, M. Farquhar, 1992 .

Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae.

J. Thorner, H. Dohlman, A. Spiegel, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

G. Milligan, M. Houslay, A. Spiegel, 1987, Nature.

Pseudohypoparathyroidism: deficiency of hormone receptor-adenylate cyclase coupling protein as a cause of hereditary hormone resistance.

A. Spiegel, M. Levine, 1982, Progress in clinical and biological research.

Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Cancer research.

A double negative: inhibition of hepatic Gi signaling improves glucose homeostasis.

A. Spiegel, 2018, The Journal of clinical investigation.

The membrane localization of the G protein alpha s subunit is not dependent on its TENIR sequence or effector domain.

M. Y. Degtyarev, T. L. Jones, A. Spiegel, 1994, Cellular signalling.

Differential isoprenylation of carboxy-terminal mutants of an inhibitory G-protein alpha-subunit: neither farnesylation nor geranylgeranylation is sufficient for membrane attachment.

P. Backlund, T. L. Jones, A. Spiegel, 1992, Biochemistry.

An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function.

R. Cerione, A. Spiegel, P. Goldsmith, 1988, The Journal of biological chemistry.

Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes.

K. Jakobs, P. Gierschik, A. Spiegel, 1987, European journal of biochemistry.

Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors.

G. Milligan, A. Spiegel, P. Goldsmith, 1988, Endocrinology.

The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene

F. Collins, J. Crabtree, S. Chandrasekharappa, 2003, Molecular and Cellular Biology.

Insulin-like growth factor I receptors in retinal rod outer segments.

Y. Zick, A. Spiegel, R. Sagi-Eisenberg, 1987, The Journal of biological chemistry.

Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1

F. Collins, T. Oda, S. Chandrasekharappa, 2000, Mammalian Genome.

G‐protein‐mediated Signal Transduction and Human Disorders

A. Spiegel, 2006 .

News From the NIH

A. Spiegel, 2000 .

Radiographic findings in recurrent parathyroid carcinoma.

J. Doppman, M. Brennan, A. Spiegel, 1982, Radiology.

Binding of 5'-guanylyl-imidodiphosphate to turkey erythrocyte membranes and effects on beta-adrenergic-activated adenylate cyclase.

A. Spiegel, G. Aurbach, 1974, The Journal of biological chemistry.

Expression of the calcium-sensing receptor in gastrinomas.

M. Raffeld, R. Jensen, A. Spiegel, 2000, The Journal of clinical endocrinology and metabolism.

Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.

M. Merino, E. Friedman, P. Gejman, 1991, The New England journal of medicine.

Inborn errors of signal transduction: Mutations in G proteins and G protein-coupled receptors as a cause of disease

A. Spiegel, 1997, Journal of Inherited Metabolic Disease.

The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gsα gene: site‐specific patterns and recurrent histological hallmarks

Bin Liu, A. Shenker, P. Bianco, 1999 .

3 Gas-Activating Mutations A Cause of Acromegaly, Thyroid Adenomas, Fibrous Dysplasia, and the McCune-Albright Syndrome

A. Spiegel, 1998 .

Gα s -Activating Mutations

A. Spiegel, 1998 .

Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.

A. Shenker, P. Bianco, P. Robey, 1997, The American journal of pathology.

G protein gene knockout hits the gut

A. Spiegel, 1995, Nature Genetics.

Mutations of the MEN1 tumor suppressor gene in pituitary tumors.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Cancer research.

Guanine nucleotides: key regulators of hormone receptor-adenylate cyclase interaction.

A. Spiegel, R. Downs, 1981, Endocrine reviews.

Future diagnostic and therapeutic trends in endocrine cancers.

S. Libutti, A. Spiegel, 2010, Seminars in oncology.

Signal transduction by guanine nucleotide binding proteins

A. Spiegel, Allen M. Spiegel, 1987, Molecular and Cellular Endocrinology.

Antibodies as Probes of G-Protein Structure and Function

W. Simonds, A. Spiegel, P. Goldsmith, 1990 .

Receptor-effector coupling by G-proteins: implications for neuronal plasticity.

A. Spiegel, 1990, Progress in brain research.

Identification of multiple Gi subtypes and a novel G protein in bovine kidney cortex.

B. Sacktor, A. Spiegel, K. Rossiter, 1989, Biochemical pharmacology.

Chapter 24. G-proteins as Receptor-Effector Couplers

A. Spiegel, 1988 .

Signal transduction by guanine nucleotide-binding proteins.

M. Brann, W. Simonds, A. Spiegel, 1988, Recent progress in hormone research.

Differential distribution of signal-transducing G-proteins in retina

C. Gerfen, G. Milligan, P. Gierschik, 1987, Brain Research.

Detection of multiple forms of Giα in HL60 cells

M. Brann, P. Gierschik, H. Malech, 1987 .

THE USE OF SPECIFIC ANTISERA TO STUDY THE DEVELOPMENTAL REGULATION OF GUANINE NUCLEOTIDE BINDING PROTEINS

G. Milligan, P. Gierschik, A. Spiegel, 1987 .

Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.

G. Milligan, F. McKenzie, A. Spiegel, 1988, The Biochemical journal.

GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini.

G. Milligan, P. Gierschik, A. Spiegel, 1987, Biochemical and biophysical research communications.

Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins.

G. Milligan, A. Spiegel, E. Saggerson, 1987, The Biochemical journal.

Reduced expression of multiple forms of the alpha subunit of the stimulatory GTP-binding protein in pseudohypoparathyroidism type Ia.

C. Bardin, A. Spiegel, P. Bray, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain.

G. Milligan, P. Gierschik, A. Spiegel, 1987, The Journal of biological chemistry.

Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.

M. Caron, R. Lefkowitz, L. Birnbaumer, 1986, The Journal of biological chemistry.

Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.

J. Falloon, G. Milligan, M. Pines, 1986, The Journal of biological chemistry.

Changes in the guanine nucleotide‐binding proteins, Gi and go, during differentiation of 3T3‐L1 cells

B. Morrow, G. Milligan, P. Gierschik, 1986, FEBS letters.

The β subunit of the guanine nucleotide regulatory proteins: Identification of its location on two‐dimesional gels of brain tissue and its regional and subcellular distribution in brain

D. Jacobowitz, G. Milligan, P. Gierschik, 1986 .

Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase.

P. Gierschik, A. Spiegel, 1985, Archives of biochemistry and biophysics.

Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems.

M. Caron, R. Lefkowitz, L. Birnbaumer, 1985, Biochemistry.

The tryptic and chymotryptic fragments of the β‐subunit of guanine nucleotide binding proteins in brain are identical to those of retinal transducin

M. Pines, P. Gierschik, A. Spiegel, 1985, FEBS letters.

Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism.

J. Gill, A. Spiegel, S. Marx, 1983, The Journal of clinical investigation.

Treatment of hyperparathyroidism by percutaneous embolization of a mediastinal adenoma.

J. Doppman, A. Spiegel, S. Marx, 1975, Radiology.

The effect of short term lithium administration on suppressibility of parathyroid hormone secretion by calcium in vivo.

M. Linnoila, A. Spiegel, S. Marx, 1984, The Journal of clinical endocrinology and metabolism.

Spontaneous Intracellular Calcium Oscillations and Gsα Subunit Expression are Inversely Correlated with Secretory Granule Content in Pituitary Cells

D. Cooper, N. Demaurex, W. Schlegel, 1992, Journal of neuroendocrinology.

Immunoelectron microscopic localization of photoreceptor-specific markers in the monkey retina.

G. Chader, I. Gery, G. Krishna, 1987, Current eye research.

Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein.

M. Caron, R. Lefkowitz, L. Birnbaumer, 1987, Biochemistry.

Hyperparathyroidism--a reversible cause of cimetidine-resistant gastric hypersecretion.

S. Peikin, D. McCarthy, A. Spiegel, 1979, British medical journal.

Reoperative parathyroid surgery for persistent hyperparathyroidism.

J. Doppman, E. Brown, M. Brennan, 1978, Surgery.

Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism.

B. Weintraub, A. Spiegel, S. Marx, 1982, The Journal of clinical endocrinology and metabolism.

Mutations in G proteins and G protein-coupled receptors in endocrine disease.

A. Spiegel, A. M. Spiegel, 1996, The Journal of clinical endocrinology and metabolism.

Fluoride stimulation of adenylate cyclase is dependent on the guanine nucleotide regulatory protein.

A. Spiegel, R. Downs, G. Aurbach, 1980, The Journal of biological chemistry.

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

R. Lefkowitz, L. Birnbaumer, J. Regan, 1986, The Journal of biological chemistry.

G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.

W. Simonds, N. Gautam, A. Spiegel, 1991, The Journal of biological chemistry.

Diagnosis of radiosensitive hypothalamic tumors without craniotomy: endocrine and neuroradiologic studies of intracranial atypical teratomas.

A. Ommaya, G. di Chiro, P. Gorden, 1976, Annals of internal medicine.

Receptor function and ion transport in turkey erythrocytes.

E. Brown, J. Gardner, A. Spiegel, 1976, Recent progress in hormone research.

CHAPTER 5 – Mechanism of Action of Hormones That Act at the Cell Surface

Simeon I. Taylor, R. Kulkarni, C. Carter-Su, 2011 .

Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region

B. Roe, M. Boguski, F. Collins, 1997, Human Genetics.

A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

B. Roe, M. Boguski, F. Collins, 1997, Genome research.

Membrane attachment of recombinant G-protein α-subunits in excess of βγ subunits in a eukaryotic expression system

M. Brann, W. Simonds, A. Spiegel, 1989 .

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

M. Caron, R. Lefkowitz, L. Birnbaumer, 1985, The Journal of biological chemistry.

Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

F. Collins, M. Erdos, S. Chandrasekharappa, 1999, Cell.

Genome-Wide Analysis of Menin Binding Provides Insights into MEN1 Tumorigenesis

Sean Davis, Francis S Collins, Peter C Scacheri, 2006, PLoS genetics.

Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas.

R. Jensen, I. Lubensky, A. Burns, 2000, The Journal of clinical endocrinology and metabolism.

Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Human molecular genetics.

Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis.

E. Gershon, E. Friedman, P. Gejman, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Human molecular genetics.

Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.

F. Collins, S. McWeeney, P. Scacheri, 2007, Neoplasia.

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

F. Collins, J. Weitzman, M. Yaniv, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The tumor suppressor protein menin interacts with NF-κB proteins and inhibits NF-κB-mediated transactivation

F. Collins, K. Bilimoria, S. Chandrasekharappa, 2001, Oncogene.

Introduction to G-Protein-Coupled Signal Transduction and Human Disease

A. Spiegel, 1998 .

Multiple endocrine neoplasia type 1: new clinical and basic findings

W. Simonds, M. Skarulis, A. Burns, 2001, Trends in Endocrinology & Metabolism.

Positional cloning of the gene for multiple endocrine neoplasia-type 1.

Y Wang, M S Boguski, B. Roe, 1997, Science.

Osteoblastic cells derived fronm isolated lesions of fibrous dysplasia contain activating somatic mutatuions of thje Gsα gene

P. Chanson, P. Marie, L. Weinstein, 1995 .

Osteoblastic cells derived from isolated lesions of fibrous dysplasia contain activating somatic mutations of the Gs alpha gene.

P. Chanson, P. Marie, L. Weinstein, 1995, Human molecular genetics.

Menin, the product of the MEN1 gene, is a nuclear protein.

F. Collins, S. Chandrasekharappa, S. Guru, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Guanine nucleotide binding proteins and signal transduction.

A. Spiegel, 1988, Vitamins and hormones.

Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.

S. Libutti, S. Hewitt, A. Spiegel, 2009, Cancer research.

Genetic mapping of the Gs-alpha subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis.

E. Gershon, P. Gejman, L. Weinstein, 1991, Genomics.

Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction.

L. Weinstein, A. Shenker, A. Spiegel, 1992, Endocrine reviews.

Effects of chemical and enzymatic modifications of glucagon on its activation of hepatic adenyl cyclase.

M. Bitensky, A. Spiegel, 1969, Endocrinology.

Multiple Endocrine Neoplasia Type 1 : Clinical and Genetic Topics Moderator :

F. Collins, L. Liotta, J. Doppman, 2009 .

Localization of parathyroid adenomas in patients who have undergone surgery. Part II. Invasive procedures.

J. Norton, T. Shawker, J. Doppman, 1987, Radiology.

Assessment of techniques for preoperative parathyroid gland localization in patients undergoing reoperation for hyperparathyroidism.

J. Doppman, M. Brennan, A. Spiegel, 1982, Surgery.

Parathyroid imaging after intraarterial injections of [75Se]selenomethionine.

J. Doppman, A. Jones, M. Brennan, 1981, The Journal of clinical endocrinology and metabolism.

Urinary cyclic 3',5'-adenosine monophosphate (cAMP): an index of the action of parathyroid hormone on the kidney.

E. Brown, A. Spiegel, S. Marx, 1980, Progress in biochemical pharmacology.

Differential diagnosis of brown tumor vs. cystic osteitis by arteriography and computed tomography.

J. Doppman, M. Brennan, A. Spiegel, 1979, Radiology.

The use of high-resolution ultrasound to locate parathyroid tumors during reoperations for primary hyperparathyroidism

Donald L. Miller, J. Norton, T. Shawker, 1987, World Journal of Surgery.

Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism.

J. Norton, T. Shawker, J. Doppman, 1994, Surgery.

Prospective evaluation of selective venous sampling for parathyroid hormone concentration in patients undergoing reoperations for primary hyperparathyroidism.

J. Norton, J. Doppman, D. Miller, 1993, Surgery.

Results of a multidisciplinary strategy for management of mediastinal parathyroid adenoma as a cause of persistent primary hyperparathyroidism.

J. Norton, J. Doppman, D. Miller, 1992, Annals of surgery.

Technetium-99m-sestamibi imaging before reoperation for primary hyperparathyroidism.

D. Fraker, M. Skarulis, A. Spiegel, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Aspiration of enlarged parathyroid glands for parathyroid hormone assay.

M. E. Brennan, J. Norton, J. Doppman, 1983, Radiology.

Hypocalcemic stimulation and nonselective venous sampling for localizing parathyroid adenomas: work in progress.

S. Libutti, J. Doppman, H. Alexander, 1998, Radiology.

The role of thyroid resection during reoperation for persistent or recurrent hyperparathyroidism.

S. Libutti, J. Doppman, D. Fraker, 1997, Surgery.

Parathyroid adenoma within the vagus nerve.

T. Shawker, J. Doppman, D. Fraker, 1994, AJR. American journal of roentgenology.

Angiographic ablation of parathyroid adenomas: lessons from a 10-year experience.

J. Norton, J. Doppman, D. Miller, 1987, Radiology.

Parathymic parathyroid: CT, US, and angiographic findings.

J. Norton, T. Shawker, J. Doppman, 1985, Radiology.

Angiographic ablation of parathyroid adenomas.

J. Doppman, E. Brown, M. Brennan, 1979, Radiology.

Undescended parathyroid adenoma: An important etiology for failed operations for primary hyperparathyroidism

J. Norton, T. Shawker, J. Doppman, 1990, World Journal of Surgery.

Intrathyroidal parathyroid adenoma or hyperplasia. An occasionally overlooked cause of surgical failure in primary hyperparathyroidism.

J. Doppman, A. Spiegel, S. Marx, 1975, JAMA.

Menin molecular interactions: insights into normal functions and tumorigenesis.

F. Collins, S. Libutti, B. Oliver, 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

D. Hanahan, F. Collins, T. Ried, 2003, Molecular and Cellular Biology.

Characterization of a MEN1 ortholog from Drosophila melanogaster.

F. Collins, B. Oliver, Y. Ip, 2001, Gene.

Maximal urine-concentrating ability: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.

A. Spiegel, S. Marx, M. Levine, 1981, The Journal of clinical endocrinology and metabolism.

The localization of abnormal mediastinal parathyroid glands.

J. Doppman, A. Broadus, A. Spiegel, 1975, Radiology.

Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation

A. Spiegel, Jianxin Hu, K. Ray, 2000, Endocrine.

Human Ca2+ Receptor Cysteine-rich Domain

A. Spiegel, Jianxin Hu, O. Hauache, 2000, The Journal of Biological Chemistry.

A Region in the Seven-transmembrane Domain of the Human Ca2+ Receptor Critical for Response to Ca2+*

Kenneth A Jacobson, K. Jacobson, Stuart J McLarnon, 2005, Journal of Biological Chemistry.

Expression of G protein alpha-subunits in bovine parathyroid.

A. Mithal, E. Brown, A. Spiegel, 1995, Endocrinology.

Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.

E. Brown, D. Gardner, A. Spiegel, 1978, The Journal of clinical endocrinology and metabolism.

Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2

R. Tsien, A. Harootunian, J. Feramisco, 1993, The Journal of cell biology.

Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction.

W. Simonds, A. Spiegel, T. Murakami, 1992, Biochemistry.

Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, The Journal of clinical endocrinology and metabolism.

An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome.

L. Weinstein, A. Shenker, A. Spiegel, 1994, The Journal of clinical endocrinology and metabolism.

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Cancer research.

Allelic loss from chromosome 11 in parathyroid tumors.

J. Norton, E. Friedman, P. Gejman, 1992, Cancer research.

Results of reoperation for persistent and recurrent hyperparathyroidism.

J. Doppman, M. Brennan, A. Spiegel, 1981, Annals of surgery.

Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability

F. Collins, K. Chin, J. Gray, 2004, Cancer Research.

Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion.

E. Brown, D. Gardner, A. Spiegel, 1980, Endocrinology.

Kinetic analysis of the rapid intraoperative parathyroid hormone assay in patients during operation for hyperparathyroidism.

S. Libutti, A. Remaley, H. Alexander, 1999, Surgery.

Autotransplantation of Cryopreserved Parathyroid Tissue in Man

J. Doppman, A. Spiegel, S. Marx, 1979, Annals of surgery.

Bidirectional transcriptional activity of PGK‐neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice

J. Crabtree, P. Scacheri, S. Chandrasekharappa, 2001, Genesis.

G proteins couple alpha-adrenergic and GABAb receptors to inhibition of peptide secretion from peripheral sensory neurons

A. Spiegel, G G Holz, R M Kream, 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Intraoperative measurements of urinary cyclic AMP to guide surgery for primary hyperparathyroidism.

M. Brennan, A. Spiegel, S. Marx, 1980, The New England journal of medicine.

Urinary cAMP excretion during surgery: an index of successful parathyroidectomy in patients with primary hyperparathyroidism.

E. Brown, M. Brennan, A. Spiegel, 1978, The Journal of clinical endocrinology and metabolism.

Intraoperative ultrasound and reoperative parathyroid surgery: An initial evaluation

J. Norton, T. Shawker, J. Doppman, 1986, World Journal of Surgery.

Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft.

J. Doppman, A. Spiegel, S. Marx, 1983, JAMA.

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.

F. Collins, L. Liotta, M. Emmert-Buck, 1996, Cancer research.

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.

F. Collins, M. Emmert-Buck, A. Vortmeyer, 1997, Cancer research.

Gland Size Is Associated With Changes in Gene Expression Profiles in Sporadic Parathyroid Adenomas

S. Libutti, H. Alexander, H. Alexander, 2004, Annals of Surgical Oncology.

Genetic abnormalities in sporadic parathyroid adenomas.

J. Norton, E. Friedman, A. Arnold, 1990, The Journal of clinical endocrinology and metabolism.

A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy.

P. Gejman, P. de Mazancourt, L. Weinstein, 1992, Genomics.

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.

J. Gutkind, S. Hermouet, A. Spiegel, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

W. Simonds, A. Spiegel, J. Codina, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Deficiency of hormone receptor-adenylate cyclase coupling protein: basis for hormone resistance in pseudohypoparathyroidism.

A. Spiegel, S. Marx, A. Moses, 1982, The American journal of physiology.

MEN1 gene analysis in sporadic adrenocortical neoplasms.

B. Allolio, A. Burns, A. Spiegel, 1999, The Journal of clinical endocrinology and metabolism.

Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants.

P. J. Steinbach, A. Spiegel, P. Goldsmith, 2001, The Journal of biological chemistry.

G Protein Defects in Signal Transduction

A. Spiegel, 2000, Hormone Research in Paediatrics.

Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells.

P. Bianco, P. Robey, M. Riminucci, 1998, The Journal of clinical investigation.

The gene for multiple endocrine neoplasia type 1: recent findings.

F. Collins, L. Liotta, M. Emmert-Buck, 1999, Bone.

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders*

M. Nesbit, R. Thakker, A. Hanyaloglu, 2016, The Journal of Biological Chemistry.

Identification of the Sites of N-Linked Glycosylation on the Human Calcium Receptor and Assessment of Their Role in Cell Surface Expression and Signal Transduction*

A. Spiegel, P. Goldsmith, K. Ray, 1998, The Journal of Biological Chemistry.

Sulfonylureas Amplify Cyclic 3′, 5′ AMP Mediated Hormone Action

A. Spiegel, J. Crawford, H. Bode, 1970, Pediatric Research.

Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.

A. Vortmeyer, R. Weil, C. Barlow, 1999, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Failure of ablation of a mediastinal parathyroid adenoma by repeated contrast staining.

J. Doppman, M. Brennan, A. Spiegel, 1981, Radiology.

Embolization of a mediastinal parathyroid adenoma.

J. Doppman, A. Spiegel, S. Marx, 1974, The Journal of clinical endocrinology and metabolism.

Human parathyroid autografts: comparison of function in vivo and in vitro.

E. Brown, M. Brennan, A. Broadus, 1979, The Journal of clinical endocrinology and metabolism.

Characterization of the Promoter of the Human Gi2 α-Subunit Gene

L. Weinstein, A. Spiegel, A. Carter, 1990 .

Deferred parathyroid autografts with cryopreserved tissue after reoperative parathyroid surgery.

M. Brennan, A. Spiegel, S. Marx, 1982, Archives of surgery.

Antibodies against synthetic peptides as probes of G protein structure and function.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Society of General Physiologists series.

The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No.

G. Milligan, P. Gierschik, A. Spiegel, 1986, FEBS letters.

Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.

F. Collins, L. Liotta, M. Emmert-Buck, 1999, Recent progress in hormone research.

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

M. Brann, W. Simonds, T. L. Jones, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Amino- and carboxy-terminal deletion mutants of Gs alpha are localized to the particulate fraction of transfected COS cells

T. L. Jones, A. Spiegel, Y. Juhnn, 1992, The Journal of cell biology.

Regulation of guanine nucleotide binding regulatory proteins in cultured adrenal cells by adrenocorticotropin and angiotensin-II.

A. Spiegel, J. Saez, M. Bégeot, 1991, Endocrinology.

Identification of the Cysteine Residues in the Amino-terminal Extracellular Domain of the Human Ca2+ Receptor Critical for Dimerization

A. Spiegel, P. Goldsmith, P J Steinbach, 1999, The Journal of Biological Chemistry.

Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins.

P. Gierschik, A. Spiegel, B. Eide, 1986, Biochemistry.

Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride.

A. Spiegel, R. Downs, G. Aurbach, 1982, Biochemical pharmacology.

The role of guanyl nucleotides in the expression on of catecholamine-responsive adenylate cyclase during maturation of the rat reticulocyte.

J. Bilezikian, A. Spiegel, G. Aurbach, 1977, Molecular pharmacology.

Identification and persistence of beta adrenergic receptors during maturation of the rat reticulocyte.

E. Brown, J. Bilezikian, A. Spiegel, 1977, Molecular pharmacology.

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937.

B. Strulovici, A. Spiegel, S. Daniel-Issakani, 1989, The Journal of biological chemistry.

Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene

F. Collins, W. Pavan, J. Crabtree, 1999, Mammalian Genome.

Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1

F. Collins, J. Ward, J. Crabtree, 2004, Mammalian Genome.

CHAPTER 6 – Immunologic Probes for Heterotrimeric GTP-Binding Proteins

A. Spiegel, 1990 .

Guanine Nucleotide Regulatory Proteins in Inflammatory and Immune Responses

A. Spiegel, 1988 .

'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise?

A. Spiegel, Allen M Spiegel, Meredith Hawkins, 2012, Health affairs.

High cervical intravagal hypercellular parathyroid gland as the etiology of severe persistent primary hyperparathyroidism.

T. Shawker, J. Doppman, D. Fraker, 1995, The American surgeon.

Computerized technetium/thallium scans and parathyroid reoperation.

J. Norton, J. Skibber, J. Reynolds, 1985, Surgery.

β-Arrestin--Not Just for G Protein-Coupled Receptors

A. Spiegel, 2003, Science.

Focus on hereditary endocrine neoplasia.

A. Spiegel, 2004, Cancer cell.

Management of primary parathyroid hyperplasia.

J. Doppman, E. Brown, O. Clark, 1976, The New England journal of medicine.

Separation of a guanine nucleotide regulatory unit from the adenylate cyclase complex with GTP affinity chromatography.

A. Spiegel, R. Downs, G. Aurbach, 1979, Journal of cyclic nucleotide research.

Myristoylation of an inhibitory GTP-binding protein a subunit is essential for its membrane attachment ( site-directed mutagenesis / immunoprecipitation / signal transduction / P 8-y subunits )

W. Simonds, T. L. Jones, A. Spiegel, 2022 .

Expression, Purification, and Biochemical Characterization of the Amino-terminal Extracellular Domain of the Human Calcium Receptor*

J. Shiloach, A. Spiegel, P. Goldsmith, 1999, The Journal of Biological Chemistry.

Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction

A. Spiegel, P. Goldsmith, K. Ray, 1998, FEBS letters.

GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells.

G. Milligan, L. Marshall, A. Spiegel, 1988, The Biochemical journal.

N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface.

C. Dunn, A. Spiegel, P. Goldsmith, 1997, Endocrinology.

Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.

R. Iyengar, M. Caron, A. Spiegel, 1990, The Journal of biological chemistry.

Carboxyl methylation and COOH-terminal processing of the brain G-protein gamma-subunit.

W. Simonds, P. Backlund, A. Spiegel, 1990, The Journal of biological chemistry.

Detection of alpha-transducin in retinal rods but not cones.

M. Nirenberg, P. Gierschik, A. Spiegel, 1986, Science.

Genetic interactions between Drosophila melanogaster menin and Jun/Fos.

F. Collins, B. Oliver, M. Parisi, 2006, Developmental biology.

Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.

T. Hökfelt, R. Cortės, M. Schalling, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The molecular basis of disorders caused by defects in G proteins.

A. Spiegel, 1997, Hormone research.

Human Ca2+ Receptor Extracellular Domain

A. Spiegel, Jianxin Hu, P. Goldsmith, 2001, The Journal of Biological Chemistry.

G proteins in cellular control

A. Spiegel, 1992, Current Biology.

Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.

W. Simonds, T. L. Jones, A. Spiegel, 1990, Biochemical Society symposium.

Guanosine 5′, α-β-methylene, triphosphate, a novel GTP analog, causes persistent activation of adenylate cyclase: Evidence against pyrophosphorylation mechanism

A. Spiegel, R. Downs, G. Aurbach, 1977 .

Baculovirus Expression and Purification of a Soluble, Mutant G-Protein α Subunit

T. L. Jones, A. Spiegel, C. Woodard, 1993 .

Prospective analysis of intraoperative and postoperative urinary cyclic adenosine 3',5'-monophosphate levels to predict outcome of patients undergoing reoperations for primary hyperparathyroidism.

J. Norton, A. Spiegel, S. Marx, 1988, Surgery.

Identification of G Protein α-Subunits in RINm5F Cells and Their Selective Interaction with Galanin Receptor

E. Van Obberghen, Y. Le Marchand-Brustel, M. Cormont, 1991, Diabetes.

Functional characterization of five V2 vasopressin receptor gene mutations

J. Wess, A. Spiegel, P. Goldsmith, 1996, Molecular and Cellular Endocrinology.

Commentary: new guidelines for NIH peer review: improving the system or undermining it?

A. Spiegel, 2010, Academic medicine : journal of the Association of American Medical Colleges.

CLINICAL ENDOCRINOLOGY & METABOLISM

S. Grundy, M. Fillyaw, J. Norton, 1992 .

Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.

J. Feramisco, J. Meinkoth, A. Spiegel, 1992, The Journal of biological chemistry.

Parathyroid tumor development involves deregulation of homeobox genes.

F. Collins, S. Libutti, S. Savage, 2008, Endocrine-related cancer.

Isoprenylation of an inhibitory G protein alpha subunit occurs only upon mutagenesis of the carboxyl terminus.

T. L. Jones, A. Spiegel, 1990, The Journal of biological chemistry.

Lithium does not inhibit the parathyroid hormone-mediated rise in urinary cyclic AMP and phosphate in humans.

D. Murphy, R. Gerner, A. Spiegel, 1976, Journal of Clinical Endocrinology and Metabolism.

Parathyroid aspiration directed by angiography: an alternative to venous sampling.

J. Norton, J. Doppman, A. Spiegel, 1984, Radiology.

Preoperative localization of abnormal parathyroid: neck massage versus arteriography and selective venous sampling.

J. Doppman, M. Brennan, D. Gardner, 1978, Annals of internal medicine.

Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma.

M. Greene, I. Magrath, A. Spiegel, 1978, The American journal of medicine.