S. Marx

F. Collins, S. Libutti, W. Simonds, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reoperation for hyperparathyroidism in multiple endocrine neoplasia type 1.

S. Libutti, J. Norton, D. Fraker, 2001, Surgery.

Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1

J. Norton, J. Menczel, A. Spiegel, 1991, Clinical endocrinology.

Familial hypocalciuric hypercalcemia.

S. Marx, 1980, The New England journal of medicine.

Familial hypocalciuric hypercalcemia: recognition among patients referred after unsuccessful parathyroid exploration.

J. Doppman, E. Brown, M. Brennan, 1980, Annals of internal medicine.

Cloned endothelial cells from fetal bovine bone.

M. Brandi, K. Sakaguchi, E. Streeten, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Probability of Positive Genetic Testing Results in Patients with Family History of Primary Hyperparathyroidism.

W. Simonds, E. Kebebew, A. Tirosh, 2018, Journal of the American College of Surgeons.

Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure

W. Simonds, E. Kebebew, S. Marx, 2018, Surgery.

Hyperparathyroid genes: sequences reveal answers and questions.

S. Marx, 2011, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

Secretory dysfunction in parathyroid cells from a neonate with severe primary hyperparathyroidism.

D. A. Gillis, E. Brown, D. Cole, 1986, The Journal of clinical endocrinology and metabolism.

Clinical review 109: Contrasting paradigms for hereditary hyperfunction of endocrine cells.

S. Marx, 1999, Journal of Clinical Endocrinology and Metabolism.

Familial Hypocalciuric Hypercalcemia as an Atypical Form of Primary Hyperparathyroidism

S. Marx, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Family studies in patients with primary parathyroid hyperplasia.

E. Brown, A. Spiegel, S. Marx, 1977, The American journal of medicine.

Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype.

E. Brown, M. Brandi, G. Hendy, 1994, The Journal of clinical investigation.

Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

J. Seidman, E. Brown, C. Seidman, 1995, Pediatric Nephrology.

Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families

L. Liotta, M. Emmert-Buck, I. Lubensky, 1998, Human mutation.

FGF-23 is elevated by chronic hyperphosphatemia.

M. Econs, M. Collins, S. Marx, 2004, The Journal of clinical endocrinology and metabolism.

Progression of uremic hyperparathyroidism involves allelic loss on chromosome 11.

M. Brandi, C. Bordi, A. Amorosi, 1993, The Journal of clinical endocrinology and metabolism.

Hyperparathyroidism-Jaw Tumor Syndrome: Results of surgical management

W. Simonds, E. Kebebew, S. Marx, 2014 .

Localisation of mesenchymal tumours by somatostatin receptor imaging

N. Watts, A. Civelek, E. Streeten, 2002, The Lancet.

Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells.

J. Doppman, E. Brown, M. Brennan, 1979, The American journal of medicine.

Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia.

E. Brown, M. Brennan, D. Gardner, 1978, The Journal of clinical endocrinology and metabolism.

Gene expression profile analysis of pituitary adenomas developed by HMGA transgenic mice ”

J. Herman, I. Pastan, M. Gottesman, 2007 .

Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism.

W. Travis, J. Doppman, D. Fraker, 1991, Annals of surgery.

Localization and operative management of undescended parathyroid adenomas in patients with persistent primary hyperparathyroidism.

J. Norton, T. Shawker, J. Doppman, 1994, Surgery.

Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism.

E. Brown, M. Brennan, A. Broadus, 1979, The Journal of clinical endocrinology and metabolism.

Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.

E. Brown, D. Gardner, A. Spiegel, 1980, The Journal of clinical endocrinology and metabolism.

Neonatal primary hyperparathyroidism with autosomal dominant inheritance.

E. Brown, A. Spiegel, S. Marx, 1977, The Journal of pediatrics.

A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma.

J. Norton, T. Shawker, J. Doppman, 1996, Annals of surgery.

Familial hypocalciuric hypercalcemia. Mild expression of the gene in heterozygotes and severe expression in homozygotes.

S. Marx, D. Fraser, D. Fraser, 1985, The American journal of medicine.

Questions and Controversies About Parathyroid Pathophysiology in Children With Multiple Endocrine Neoplasia Type 1

S. Marx, D. Lourenço, 2018, Front. Endocrinol..

PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex

J. Bertherat, W. Farrell, R. Clayton, 2002, Journal of medical genetics.

Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma.

J. Doppman, E. Brown, M. Brennan, 1978, The New England journal of medicine.

Identification and characterization of JunD missense mutants that lack menin binding

F. Collins, S. Chandrasekharappa, A. Hickman, 2000, Oncogene.

Imaging to Detect Early Endocrine Cancers

W. Simonds, S. Marx, 2006 .

Immunocytology on microwave-fixed cells reveals rapid and agonist-specific changes in subcellular accumulation patterns for cAMP or cGMP.

S. Marx, J. Barsony, J. Bársony, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Normal intrauterine development of the fetus of a woman receiving extraordinarily high doses of 1,25-dihydroxyvitamin D3.

H. DeLuca, S. Marx, A. Hamstra, 1980, The Journal of clinical endocrinology and metabolism.

Benign breast dysplasia causing hypercalcemia.

S. Marx, W. Umiker, R. Zusman, 1977, The Journal of clinical endocrinology and metabolism.

Absent intestinal response to calciferols in hereditary resistance to 1,25-dihydroxyvitamin D: documentation and effective therapy with high dose intravenous calcium infusions.

M. Brandi, A. Yergey, N. Vieira, 1988, The Journal of clinical endocrinology and metabolism.

Hereditary resistance to 1,25-dihydroxyvitamin D: clinical and radiological improvement during high-dose oral calcium therapy.

S. Marx, H. Harfi, N. Woodhouse, 1986, Hormone research.

Radioimmunoassay for the middle region of human parathyroid hormone: comparison of two radioiodinated synthetic peptides.

S. Marx, M. Sharp, 1985, Clinica chimica acta; international journal of clinical chemistry.

Increased basic fibroblast growth factor in plasma from multiple endocrine neoplasia type 1: relation to pituitary tumor.

M. Brandi, S. Marx, H. Friesen, 1993, The Journal of clinical endocrinology and metabolism.

Receptor-positive hereditary resistance to 1,25-dihydroxyvitamin D: chromatography of hormone-receptor complexes on deoxyribonucleic acid-cellulose shows two classes of mutation.

U. Liberman, S. Marx, C. Eil, 1986, The Journal of clinical endocrinology and metabolism.

CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2

John P. Bilezikian, Rajesh V. Thakker, Bruce A.J. Ponder, 2001 .

Children with MEN1 gene mutations may present first (and at a young age) with Cushing disease

Maria Belen Bonella, C. Stratakis, M. Lodish, 2018, Clinical endocrinology.

Multiple angiofibromas and collagenomas in a 45-year-old man with recurrent nephrolithiasis, fatigue, and vision loss.

M. Turner, S. Marx, E. Cowen, 2009, Journal of the American Academy of Dermatology.

The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.

F. Collins, W. Simonds, L. Weinstein, 2007, The Journal of clinical endocrinology and metabolism.

BRIEF REPORT The Parathyroid/Pituitary Variant of Multiple Endocrine Neoplasia Type 1 Usually Has Causes Other than p27 Kip1 Mutations

F. Collins, W. Simonds, L. Weinstein, 2007 .

Multiple endocrine neoplasia type 1 variant with frequent prolactinoma and rare gastrinoma.

R. Jensen, G. Hobbs, W. Simonds, 2004, The Journal of clinical endocrinology and metabolism.

Molecular Pathology of the MEN1 Gene

F. Collins, S. Libutti, M. Mullendore, 2004, Annals of the New York Academy of Sciences.

Aggressive pituitary tumors in MEN1: do they refute the two-hit model of tumorigenesis?

L. Nieman, S. Marx, 2002, The Journal of clinical endocrinology and metabolism.

Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1.

S. Steinberg, M. Turner, M. Skarulis, 1997, Archives of dermatology.

Rapid accumulation of cyclic GMP near activated vitamin D receptors.

S. Marx, J. Barsony, J. Bársony, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Familial Hyperparathyroidism: Mild Hypercalcemia in at Least Nine Members of a Kindred

J. Bilezikian, S. Wells, S. Marx, 1973 .

INTERACTION BETWEEN THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR AND PDK 1 AS POTENTIAL THERAPEUTIC TARGET IN NEOPLASTIC CELLS ”

J. Herman, I. Pastan, M. Gottesman, 2007 .

Vitamin D-dependent Rickets Type 11 Defective Induction of 25-Hydroxyvitamin D3-24-Hydroxylase by 1,25-Dihydroxyvitamin D3 in Cultured Skin Fibroblasts

U. Liberman, S. Marx, R. Downs, 2013 .

Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Cancer research.

Cutaneous tumors in patients with multiple endocrine neoplasia type 1 show allelic deletion of the MEN1 gene.

A. Vortmeyer, M. Turner, M. Skarulis, 1998, The Journal of investigative dermatology.

The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene

F. Collins, J. Crabtree, S. Chandrasekharappa, 2003, Molecular and Cellular Biology.

Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1

F. Collins, T. Oda, S. Chandrasekharappa, 2000, Mammalian Genome.

Clinical Endocrinology 6 Metabolism Editor-in-chief: Delbert A. Fisher

R. Rubin, J. Flier, M. Schambelan, 2022 .

Menin Immunoreactivity in Secretory Granules of Human Pancreatic Islet Cells

M. Emmert-Buck, S. Libutti, M. Raffeld, 2014, Applied immunohistochemistry & molecular morphology : AIMM.

Radiographic findings in recurrent parathyroid carcinoma.

J. Doppman, M. Brennan, A. Spiegel, 1982, Radiology.

Effects of Mutant Gene Dosage on Phenotype

J. Seidman, E. Brown, C. Seidman, 2016 .

Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia.

J. Seidman, E. Brown, M. Brandi, 1995, American journal of human genetics.

Mutations of the MEN1 tumor suppressor gene in pituitary tumors.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Cancer research.

Low affinity of the receptor for 1α, 25‐dihydroxyvitamin D3 in the marmoset, a new world monkey

U. Liberman, S. Marx, D. de Grange, 1985 .

Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism

W. Simonds, E. Kebebew, L. Weinstein, 2016, Annals of Surgical Oncology.

Vitamin D-dependent rickets type II. Defective induction of 25-hydroxyvitamin D3-24-hydroxylase by 1,25-dihydroxyvitamin D3 in cultured skin fibroblasts.

U. Liberman, S. Marx, R. Downs, 1985, The Journal of clinical investigation.

Mapping the gene for hereditary hyperparathyroidism and prolactinoma (MEN1Burin) to chromosome 11q: evidence for a founder effect in patients from Newfoundland.

E. Petty, S. Marx, A. Bale, 1994, American journal of human genetics.

Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism.

J. Gill, A. Spiegel, S. Marx, 1983, The Journal of clinical investigation.

Multiple leiomyomas of the esophagus, lung, and uterus in multiple endocrine neoplasia type 1.

A. Vortmeyer, I. Lubensky, M. Skarulis, 2001, The American journal of pathology.

Treatment of hyperparathyroidism by percutaneous embolization of a mediastinal adenoma.

J. Doppman, A. Spiegel, S. Marx, 1975, Radiology.

The effect of short term lithium administration on suppressibility of parathyroid hormone secretion by calcium in vivo.

M. Linnoila, A. Spiegel, S. Marx, 1984, The Journal of clinical endocrinology and metabolism.

Multiple Endocrine Neoplasia – Introduction

C. Stratakis, S. Marx, C. Stratakis, 2005, Journal of internal medicine.

Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

J. Seidman, E. Brown, C. Seidman, 1993, Cell.

Multiple endocrine neoplasias in the era of translational medicine.

C. Stratakis, S. Marx, 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3.

U. Liberman, J. Pike, S. Marx, 1990, Molecular endocrinology.

Hyperparathyroidism--a reversible cause of cimetidine-resistant gastric hypersecretion.

S. Peikin, D. McCarthy, A. Spiegel, 1979, British medical journal.

Demonstration of parathyroid adenomas by retrograde thyroid venography.

J. Doppman, S. Marx, A. Ketcham, 1972, Radiology.

Reoperative parathyroid surgery for persistent hyperparathyroidism.

J. Doppman, E. Brown, M. Brennan, 1978, Surgery.

Primary hyperparathyroidism. Preoperative tumor localization and differentiation between adenoma and hyperplasia.

J. Doppman, S. Wells, J. Potts, 1972, The New England journal of medicine.

Antibodies cytotoxic to bovine parathyroid cells in autoimmune hypoparathyroidism.

A. Fattorossi, R. Quarto, M. Brandi, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism.

B. Weintraub, A. Spiegel, S. Marx, 1982, The Journal of clinical endocrinology and metabolism.

CHAPTER 35 – Multiple Endocrine Neoplasia Type 1

S. Marx, 2001 .

Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia.

W. Simonds, G. Hendy, S. Marx, 2005, Human molecular genetics.

Overexpression of the human vitamin D3 receptor in mammalian cells using recombinant adenovirus vectors.

G. Hager, J. Pike, S. Marx, 1991, Molecular endocrinology.

Evolution of Our Understanding of the Hyperparathyroid Syndromes: A Historical Perspective

D. Goltzman, S. Marx, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Results of heterotopic parathyroid autotransplantation: a 13-year experience.

A. Feldman, S. Libutti, J. Norton, 1999, Surgery.

Somatic mutation of the MEN1 gene in parathyroid tumours

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Nature Genetics.

Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region

B. Roe, M. Boguski, F. Collins, 1997, Human Genetics.

A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

B. Roe, M. Boguski, F. Collins, 1997, Genome research.

Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain

R. Adelstein, A. Burns, S. Marx, 2003, Oncogene.

Doctorate Program in Molecular Oncology and Endocrinology

J. Herman, I. Pastan, M. Gottesman, 2006 .

Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

F. Collins, M. Erdos, S. Chandrasekharappa, 1999, Cell.

Genome-Wide Analysis of Menin Binding Provides Insights into MEN1 Tumorigenesis

Sean Davis, Francis S Collins, Peter C Scacheri, 2006, PLoS genetics.

Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas.

R. Jensen, I. Lubensky, A. Burns, 2000, The Journal of clinical endocrinology and metabolism.

Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Human molecular genetics.

Hereditary hormone excess: genes, molecular pathways, and syndromes.

W. Simonds, S. Marx, 2005, Endocrine reviews.

MINISYMPOSIUM MEN & VHL

M. Emmert-Buck, J. Doppman, I. Lubensky, 1998 .

CHAPTER 41 – Multiple Endocrine Neoplasia

S. Wells, C. Philpott, S. Marx, 2011 .

Molecular genetics of multiple endocrine neoplasia types 1 and 2

S. Marx, 2005, Nature Reviews Cancer.

The MEN1 Gene and Pituitary Tumours

S. Marx, S. Agarwal, A. Ozawa, 2009, Hormone Research in Paediatrics.

Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Human molecular genetics.

Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.

F. Collins, S. McWeeney, P. Scacheri, 2007, Neoplasia.

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

F. Collins, J. Weitzman, M. Yaniv, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The tumor suppressor protein menin interacts with NF-κB proteins and inhibits NF-κB-mediated transactivation

F. Collins, K. Bilimoria, S. Chandrasekharappa, 2001, Oncogene.

Multiple Endocrine Neoplasia Type 1: Clinical and Genetic Topics

L. Liotta, M. Skarulis, S. Marx, 1998, Annals of Internal Medicine.

Long-term remission of disseminated parathyroid cancer following immunotherapy

E. Friedman, W. Simonds, A. Bradwell, 2019, Endocrine.

Familial multiple endocrine neoplasia type 1 Mutation of a tumor suppressor gene

S. Marx, 1989, Trends in Endocrinology & Metabolism.

Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome.

J. Carpten, C. Robbins, W. Simonds, 2004, The Journal of clinical endocrinology and metabolism.

HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome

J. Carpten, E. Gillanders, J. Trent, 2002, Nature Genetics.

Multiple endocrine neoplasia type 1: new clinical and basic findings

W. Simonds, M. Skarulis, A. Burns, 2001, Trends in Endocrinology & Metabolism.

Comparative genomic hybridization analysis of human parathyroid tumors.

E. Schröck, T. Ried, C. Heffess, 1998, Cancer genetics and cytogenetics.

Positional cloning of the gene for multiple endocrine neoplasia-type 1.

Y Wang, M S Boguski, B. Roe, 1997, Science.

The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.

S. Zaman, Yan Wang, S. Chandrasekharappa, 2011, Cancer research.

Menin, the product of the MEN1 gene, is a nuclear protein.

F. Collins, S. Chandrasekharappa, S. Guru, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.

S. Libutti, S. Hewitt, A. Spiegel, 2009, Cancer research.

Multiple Endocrine Neoplasia Type 1 : Clinical and Genetic Topics Moderator :

F. Collins, L. Liotta, J. Doppman, 2009 .

Localization of parathyroid adenomas in patients who have undergone surgery. Part II. Invasive procedures.

J. Norton, T. Shawker, J. Doppman, 1987, Radiology.

Assessment of techniques for preoperative parathyroid gland localization in patients undergoing reoperation for hyperparathyroidism.

J. Doppman, M. Brennan, A. Spiegel, 1982, Surgery.

Parathyroid imaging after intraarterial injections of [75Se]selenomethionine.

J. Doppman, A. Jones, M. Brennan, 1981, The Journal of clinical endocrinology and metabolism.

???Familial Multiple Endocrine Adenoma???Peptic Ulcer Complex???: A Classic in Medicine

S. Marx, 1991 .

1 , 25-Dihydroxyvitamin D 3 Receptors and Resistance : Implications in Rickets , Osteomalacia , and Other Conditions

S. Marx, 2006 .

Tissue‐selective 1,25‐dihydroxyvitamin D3 resistance: Novel applications of calciferols

S. Marx, J. Barsony, Julia Barsony, 1988, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Urinary cyclic 3',5'-adenosine monophosphate (cAMP): an index of the action of parathyroid hormone on the kidney.

E. Brown, A. Spiegel, S. Marx, 1980, Progress in biochemical pharmacology.

Differential diagnosis of brown tumor vs. cystic osteitis by arteriography and computed tomography.

J. Doppman, M. Brennan, A. Spiegel, 1979, Radiology.

The use of high-resolution ultrasound to locate parathyroid tumors during reoperations for primary hyperparathyroidism

Donald L. Miller, J. Norton, T. Shawker, 1987, World Journal of Surgery.

Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism.

J. Norton, T. Shawker, J. Doppman, 1994, Surgery.

Prospective evaluation of selective venous sampling for parathyroid hormone concentration in patients undergoing reoperations for primary hyperparathyroidism.

J. Norton, J. Doppman, D. Miller, 1993, Surgery.

Results of a multidisciplinary strategy for management of mediastinal parathyroid adenoma as a cause of persistent primary hyperparathyroidism.

J. Norton, J. Doppman, D. Miller, 1992, Annals of surgery.

Technetium-99m-sestamibi imaging before reoperation for primary hyperparathyroidism.

D. Fraker, M. Skarulis, A. Spiegel, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Aspiration of enlarged parathyroid glands for parathyroid hormone assay.

M. E. Brennan, J. Norton, J. Doppman, 1983, Radiology.

Hypocalcemic stimulation and nonselective venous sampling for localizing parathyroid adenomas: work in progress.

S. Libutti, J. Doppman, H. Alexander, 1998, Radiology.

The role of thyroid resection during reoperation for persistent or recurrent hyperparathyroidism.

S. Libutti, J. Doppman, D. Fraker, 1997, Surgery.

Angiographic ablation of parathyroid adenomas: lessons from a 10-year experience.

J. Norton, J. Doppman, D. Miller, 1987, Radiology.

Parathymic parathyroid: CT, US, and angiographic findings.

J. Norton, T. Shawker, J. Doppman, 1985, Radiology.

Angiographic ablation of parathyroid adenomas.

J. Doppman, E. Brown, M. Brennan, 1979, Radiology.

Undescended parathyroid adenoma: An important etiology for failed operations for primary hyperparathyroidism

J. Norton, T. Shawker, J. Doppman, 1990, World Journal of Surgery.

The blood supply of mediastinal parathyroid adenomas.

J. Doppman, M. Brennan, S. Marx, 1977, Annals of surgery.

Preoperative Localization of Hyperfunctioning Parathyroid Tissue: Radioimmunoassay of Parathyroid Hormone in Plasma from Selectively Catheterized Thyroid Veins

J. Doppman, A. Ketcham, J. Bilezikian, 1973, Annals of surgery.

Intrathyroidal parathyroid adenoma or hyperplasia. An occasionally overlooked cause of surgical failure in primary hyperparathyroidism.

J. Doppman, A. Spiegel, S. Marx, 1975, JAMA.

Menin molecular interactions: insights into normal functions and tumorigenesis.

F. Collins, S. Libutti, B. Oliver, 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

D. Hanahan, F. Collins, T. Ried, 2003, Molecular and Cellular Biology.

Characterization of a MEN1 ortholog from Drosophila melanogaster.

F. Collins, B. Oliver, Y. Ip, 2001, Gene.

Neonatal Severe Hyperparathyroidism: Novel Insights from Calcium, PTH, and the CASR Gene.

S. Marx, N. Sinaii, 2019, The Journal of clinical endocrinology and metabolism.

New Concepts About Familial Isolated Hyperparathyroidism.

S. Marx, 2019, The Journal of clinical endocrinology and metabolism.

Familial Primary Hyperparathyroidism (Including MEN, FHH, and HPT‐JT)

A. Arnold, S. Marx, 2013 .

Familial Isolated Hyperparathyroidism: Clinical and Genetic Characteristics of 36 Kindreds

W. Simonds, G. Hendy, M. Skarulis, 2002, Medicine.

Maximal urine-concentrating ability: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.

A. Spiegel, S. Marx, M. Levine, 1981, The Journal of clinical endocrinology and metabolism.

The parathyroid glands in familial hypocalciuric hypercalcemia.

U. Thorgeirsson, S. Marx, J. Costa, 1981, Human pathology.

Calcium sensing comes full circle

S. Marx, 1995, Nature Genetics.

The localization of abnormal mediastinal parathyroid glands.

J. Doppman, A. Broadus, A. Spiegel, 1975, Radiology.

Hyperplasia in glands with hormone excess.

S. Marx, 2016, Endocrine-related cancer.

Role of preoperative localization and intraoperative localization maneuvers including intraoperative PTH assay determination for patients with persistent or recurrent hyperparathyroidism.

P. Choyke, H. Alexander, Clara C. Chen, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Calcimimetic Use in Familial Hypocalciuric Hypercalcemia—A Perspective in Endocrinology

S. Marx, 2017, The Journal of clinical endocrinology and metabolism.

Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.

E. Brown, D. Gardner, A. Spiegel, 1978, The Journal of clinical endocrinology and metabolism.

Parathyroid venous sampling.

J. Doppman, S. Wells, S. Marx, 1972, Radiology.

The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3

W. Simonds, S. Marx, S. Agarwal, 2008, Molecular Cancer.

Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, The Journal of clinical endocrinology and metabolism.

Chapter 58 – Multiple Endocrine Neoplasia Type 1

M. Brandi, C. Bordi, S. Marx, 2002 .

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.

F. Collins, L. Liotta, M. Emmert-Buck, 1997, Cancer research.

Allelic loss from chromosome 11 in parathyroid tumors.

J. Norton, E. Friedman, P. Gejman, 1992, Cancer research.

Results of reoperation for persistent and recurrent hyperparathyroidism.

J. Doppman, M. Brennan, A. Spiegel, 1981, Annals of surgery.

Germline mutation landscape of multiple endocrine neoplasia type 1 using full gene next-generation sequencing.

S. Marx, A. Lerário, A. Jorge, 2018, European journal of endocrinology.

Recent Topics Around Multiple Endocrine Neoplasia Type 1

S. Marx, 2018, The Journal of clinical endocrinology and metabolism.

Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability

F. Collins, K. Chin, J. Gray, 2004, Cancer Research.

Familial multiple endocrine neoplasia type I.

K. Sakaguchi, M. Brandi, S. Marx, 1988, Nihon Naibunpi Gakkai zasshi.

Kinetic analysis of the rapid intraoperative parathyroid hormone assay in patients during operation for hyperparathyroidism.

S. Libutti, A. Remaley, H. Alexander, 1999, Surgery.

Sleeping parathyroid tumor: rapid hyperfunction after removal of the dominant tumor.

S. Libutti, W. Simonds, A. Remaley, 2012, The Journal of clinical endocrinology and metabolism.

Utility of rapid intraoperative parathyroid hormone assay to predict severe postoperative hypocalcemia after reoperation for hyperparathyroidism.

S. Libutti, D. Venzon, W. Simonds, 2002, Surgery.

Autotransplantation of Cryopreserved Parathyroid Tissue in Man

J. Doppman, A. Spiegel, S. Marx, 1979, Annals of surgery.

Bidirectional transcriptional activity of PGK‐neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice

J. Crabtree, P. Scacheri, S. Chandrasekharappa, 2001, Genesis.

Intraoperative measurements of urinary cyclic AMP to guide surgery for primary hyperparathyroidism.

M. Brennan, A. Spiegel, S. Marx, 1980, The New England journal of medicine.

Urinary cAMP excretion during surgery: an index of successful parathyroidectomy in patients with primary hyperparathyroidism.

E. Brown, M. Brennan, A. Spiegel, 1978, The Journal of clinical endocrinology and metabolism.

New insights into primary hyperparathyroidism.

S. Marx, 1984, Hospital practice.

Intraoperative ultrasound and reoperative parathyroid surgery: An initial evaluation

J. Norton, T. Shawker, J. Doppman, 1986, World Journal of Surgery.

Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft.

J. Doppman, A. Spiegel, S. Marx, 1983, JAMA.

Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gsα, and Gi2α genes in isolated familial acromegaly

S. Marx, M. Levine, S. Agarwal, 2001 .

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.

F. Collins, L. Liotta, M. Emmert-Buck, 1996, Cancer research.

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.

F. Collins, M. Emmert-Buck, A. Vortmeyer, 1997, Cancer research.

Mutation-targeted therapy with sunitinib or everolimus in patients with advanced low-grade or intermediate-grade neuroendocrine tumours of the gastrointestinal tract and pancreas with or without cytoreductive surgery: protocol for a phase II clinical trial

P. Meltzer, S. Steinberg, Jianhua Yao, 2015, BMJ Open.

Gland Size Is Associated With Changes in Gene Expression Profiles in Sporadic Parathyroid Adenomas

S. Libutti, H. Alexander, H. Alexander, 2004, Annals of Surgical Oncology.

Genetic abnormalities in sporadic parathyroid adenomas.

J. Norton, E. Friedman, A. Arnold, 1990, The Journal of clinical endocrinology and metabolism.

Genetic defects in primary hyperparathyroidism.

S. Marx, 1988, The New England journal of medicine.

Multiple Endocrine Neoplasia Type I: Assessment of Laboratory Tests to Screen for the Gene in a Large Kindred

A. Vinik, R. Santen, J. Mills, 1986, Medicine.

Deficiency of hormone receptor-adenylate cyclase coupling protein: basis for hormone resistance in pseudohypoparathyroidism.

A. Spiegel, S. Marx, A. Moses, 1982, The American journal of physiology.

MEN 1 Gene Analysis in Sporadic Adrenocortical Neoplasms *

B. Allolio, A. Burns, A. Spiegel, 1998 .

Anti-endothelial cell antibodies: detection and characterization in sera from patients with autoimmune hypoparathyroidism.

A. Fattorossi, M. Brandi, K. Sakaguchi, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The gene for multiple endocrine neoplasia type 1: recent findings.

F. Collins, L. Liotta, M. Emmert-Buck, 1999, Bone.

Multiplicity of hormone-secreting tumors: common themes about cause, expression, and management.

S. Marx, 2013, The Journal of clinical endocrinology and metabolism.

PARATHYROID FUNCTION AFTER PARATHYROIDECTOMY: EVALUATION BY MEASUREMENT OF URINARY cAMP

S. Marx, R. Downs, E. M. Brown, 1981, Clinical endocrinology.

Selective expression of a normal action of the 1,25-dihydroxyvitamin D3 receptor in human skin fibroblasts with hereditary severe defects in multiple actions of that receptor.

U. Liberman, S. Marx, J. Barsony, 1989, The Journal of clinical investigation.

Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.

A. Vortmeyer, R. Weil, C. Barlow, 1999, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Mutations in CDKN2C (p18) and CDKN2D (p19) may cause sporadic parathyroid adenoma.

Ziqiang Yuan, Thomas Gluick, S. Libutti, 2013, Endocrine-related cancer.

Germline AIP, MEN1, PRKAR1A, CDKN1B (p27Kip1) and CDKN2C (p18INK4c) gene mutations in a large cohort of pediatric patients with pituitary adenomas occurring in isolation or with associated syndromic features

V. Bours, C. Stratakis, A. Horvath, 2008 .

Allelic Loss in Pituitary Tumors in Patients with Multiple Endocrine Neoplasia Syndrome Type 1

A. Vortmeyer, R. Weil, Steve Huang, 2005 .

11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.

A. Vortmeyer, R. Weil, E. Oldfield, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

High prevalence of chronic kidney disease in patients with multiple endocrine neoplasia type 1 and improved kidney function after parathyroidectomy

W. Simonds, E. Kebebew, L. Weinstein, 2019, Surgery.

Failure of ablation of a mediastinal parathyroid adenoma by repeated contrast staining.

J. Doppman, M. Brennan, A. Spiegel, 1981, Radiology.

Embolization of a mediastinal parathyroid adenoma.

J. Doppman, A. Spiegel, S. Marx, 1974, The Journal of clinical endocrinology and metabolism.

Mitogenic activity on parathyroid cells in plasma from members of a large kindred with multiple endocrine neoplasia type 1.

K. Sakaguchi, M. Brandi, K. Sakaguchi, 1988, The Journal of clinical endocrinology and metabolism.

Human parathyroid autografts: comparison of function in vivo and in vitro.

E. Brown, M. Brennan, A. Broadus, 1979, The Journal of clinical endocrinology and metabolism.

Deferred parathyroid autografts with cryopreserved tissue after reoperative parathyroid surgery.

M. Brennan, A. Spiegel, S. Marx, 1982, Archives of surgery.

Inhibitory effects of tumor necrosis factor-α and interferon-γ on deoxyribonucleic acid and collagen synthesis by rat osteosarcoma cells (ROS 17/2.8)

S. Marx, M. Nanes, W. Mckoy, 1989 .

Endocannabinoids as emerging suppressors of angiogenesis and breast tumor growth and metastatic spreading ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Total body retention of orally administered 47-calcium in primary hyperparathyroidism.

S. Marx, L. Mallette, G. Aurbach, 1975, The Journal of clinical endocrinology and metabolism.

The effect of the bicarbonate anion on serum ionized calcium concentration in vitro.

S. Marx, G. Aurbach, M. Sharp, 1984, The Journal of laboratory and clinical medicine.

Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.

F. Collins, L. Liotta, M. Emmert-Buck, 1999, Recent progress in hormone research.

HORMONES AND OTHER FACTORS REGULATING CALCIUM METABOLISM

H. Keutmann, J. Potts, J. Heersche, 1971, Annals of the New York Academy of Sciences.

Mouse Embryo Fibroblasts Lacking the Tumor Suppressor Menin Show Altered Expression of Extracellular Matrix Protein Genes

F. Collins, Yidong Chen, A. Elkahloun, 2007, Molecular Cancer Research.

A patient with MEN1 typical features and MEN2-like features.

W. Simonds, L. Weinstein, S. Marx, 2016, International journal of endocrine oncology.

Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene

F. Collins, W. Pavan, J. Crabtree, 1999, Mammalian Genome.

Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1

F. Collins, J. Ward, J. Crabtree, 2004, Mammalian Genome.

Structure, synthesis, and mechanism of action of parathyroid hormone.

H. Keutmann, J. Potts, S. Marx, 1972, Recent progress in hormone research.

Persistent Primary Hyperparathyroidism Caused by Adenomas Identified in Pharyngeal or Adjacent Structures

S. Libutti, J. Doppman, H. Alexander, 2003, World Journal of Surgery.

High cervical intravagal hypercellular parathyroid gland as the etiology of severe persistent primary hyperparathyroidism.

T. Shawker, J. Doppman, D. Fraker, 1995, The American surgeon.

Computerized technetium/thallium scans and parathyroid reoperation.

J. Norton, J. Skibber, J. Reynolds, 1985, Surgery.

Comparison of Vitamin D Receptor ( VDR ) Content by lmmunocytology with 9 A 7 Antibody and by Calcitriol High A ~ inity Binding Capacity from Competitive Binding Studies with [ zH ] Calcitriol in Various Cell Lines

J. Pike, S. Marx, H. Deluca, 2002 .

Vitamin D-dependency rickets type II: truncated vitamin D receptor in three kindreds

H. DeLuca, S. Marx, H. Goto, 1993, Molecular and Cellular Endocrinology.

9 – Familial hypocalciuric hypercalcemia

S. Marx, Stephen J. Marx, 1982 .

Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Management of primary parathyroid hyperplasia.

J. Doppman, E. Brown, O. Clark, 1976, The New England journal of medicine.

ABO(H) cell surface antigens in parathyroid adenoma and hyperplasia.

M. Brennan, E. Woltering, S. Marx, 1981, Surgery.

VITAMIN D DEPENDENT RICKETS TYPE 11 (DD11) WITH ALO PECIA. TREATMENT WITH MEGA DOSES OF 1, 25(OH)2 D3 OVERCOMES AFFINITY DEFECT IN RECEPTOR FOR 1,25(OH)2 D

U. Liberman, S. Marx, S. Yasumura, 1984, Pediatric Research.

Inhibitory effects of tumor necrosis factor-alpha and interferon-gamma on deoxyribonucleic acid and collagen synthesis by rat osteosarcoma cells (ROS 17/2.8).

S. Marx, M. Nanes, W. Mckoy, 1989, Endocrinology.

Genetic interactions between Drosophila melanogaster menin and Jun/Fos.

F. Collins, B. Oliver, M. Parisi, 2006, Developmental biology.

Use of a highly polymorphic locus on human chromosome Hq13 discloses allelic loss in parathyroid tissues from uremic patients

G. Evans, M. Brandi, A. Amorosi, 1992 .

Docetaxel in adjuvant therapy of breast cancer : results of the TAXIT 216 multicenter phase III trial ”

J. Herman, I. Pastan, M. Gottesman, 2008 .

Circumscribing or periadenomal vessel: a helpful angiographic finding in certain islet cell and parathyroid adenomas.

J. Doppman, M. Brennan, C. R. Kahn, 1981, AJR. American journal of roentgenology.

A pulsed-field gel electrophoresis (PFGE) map of twelve loci on chromosome 11q11-q13.

E. Petty, A. Arnold, S. Marx, 1993, Genomics.

Prospective analysis of intraoperative and postoperative urinary cyclic adenosine 3',5'-monophosphate levels to predict outcome of patients undergoing reoperations for primary hyperparathyroidism.

J. Norton, A. Spiegel, S. Marx, 1988, Surgery.

Rapid effects of insulin on cyclic GMP location in an intact protozoan

L. Kőhidai, J. Roth, S. Marx, 1992, Experientia.

Arteriographic localization of parathyroid adenoma in the presence of lingual thyroid.

J. Doppman, M. Brennan, S. Marx, 1981, AJR. American journal of roentgenology.

Ongoing protein synthesis needed for 1,25‐(OH)2D3‐mediated rapid increase of cyclic GMP in human skin fibroblasts

S. Marx, J. Barsony, 1988, FEBS letters.

Association between neuroendocrine tumors biomarkers and primary tumor site and disease type based on total 68Ga-DOTATATE-Avid tumor volume measurements.

P. Herscovitch, E. Kebebew, A. Tirosh, 2017, European journal of endocrinology.

Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1.

Y. Nakamura, K. Sakaguchi, E. Friedman, 1989, The New England journal of medicine.

CLINICAL ENDOCRINOLOGY & METABOLISM

S. Grundy, M. Fillyaw, J. Norton, 1992 .

CHAPTER 41 – Multiple Endocrine Neoplasia

S. Wells, S. Marx, 2011 .

Occurrence of multiple endocrine neoplasia type 1 (MEN-1) gene mutations in patients with zollinger-ellison syndrome (ZES)

R. Jensen, A. Burns, S. Marx, 1998 .

Dermatoglyphic and radiographic findings in a mother and daughter with pseudohypoparathyroidism

S. Marx, B. White, 1978, Clinical genetics.

Molecular and Cellular Pathobiology The Tumor Suppressor ProteinMenin Inhibits AKT Activation by Regulating Its Cellular Localization

S. Zaman, Yan Wang, S. Chandrasekharappa, 2011 .

Parathyroid tumor development involves deregulation of homeobox genes.

F. Collins, S. Libutti, S. Savage, 2008, Endocrine-related cancer.

Fibroblast Growth Factor–like Autoantibodies in Plasma from Patients with Multiple Endocrine Neoplasia Type 1 and Prolactinoma

S. Marx, S. Thakker-Varia, J. Eng, 1997, Annals of the New York Academy of Sciences.

Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states.

S. Marx, S. Agarwal, C. Mateo, 2009, The Journal of clinical endocrinology and metabolism.

Guidelines for diagnosis and therapy of MEN type 1 and type 2.

J. Bilezikian, M. Brandi, R. Thakker, 2001, The Journal of clinical endocrinology and metabolism.

Parathyroid aspiration directed by angiography: an alternative to venous sampling.

J. Norton, J. Doppman, A. Spiegel, 1984, Radiology.

Preoperative localization of abnormal parathyroid: neck massage versus arteriography and selective venous sampling.

J. Doppman, M. Brennan, D. Gardner, 1978, Annals of internal medicine.

Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma.

M. Greene, I. Magrath, A. Spiegel, 1978, The American journal of medicine.

1200 MANIFESTATIONS OF 1,25-HYDROXYVITAMIN D RECEPTORS WITH ABNORMALLY LOW HORMONE AFFINITY: COMPARISON OF TWO KINDREDS

S. Marx, L. Finberg, F. Greig, 1985, Pediatric Research.

Resistance to 1,25(OH)2D: Association with heterogeneous defects in cultured skin fibroblasts

U. Liberman, S. Marx, C. Eil, 1983 .

Primary hyperparathyroidism. Preoperative tumor localization and differentiation between adenoma and hyperplasia.

J. Doppman, S. Wells, J. Potts, 1972, The New England journal of medicine.

Hypoparathyroidism: a possible cause of rickets.

G. Chrousos, S. Marx, O. Pescovitz, 1985, The Journal of pediatrics.