D. Gearing

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Close proximity of the genes for leukemia inhibitory factor and oncostatin M.

E. Jeffery, V. Price, D. Gearing, 1993, Cytokine.

Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis.

J. Mattick, I. Barr, T. Littlejohn, 2001, Vaccine.

The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse.

D. Adler, C. Disteche, N. Copeland, 1992, Nature genetics.

The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

Daniel F. Schorderet, Nancy A. Jenkins, Neal G. Copeland, 1992, Nature Genetics.

Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells.

R. Hoffman, A. Tsukamoto, D. Gearing, 1996, Blood.

Expression cloning of a receptor for human granulocyte‐macrophage colony‐stimulating factor.

D. Gearing, N. Nicola, N. Gough, 1989, The EMBO journal.

Low-affinity placenta-derived receptors for human granulocyte-macrophage colony-stimulating factor can deliver a proliferative signal to murine hemopoietic cells.

D. Gearing, N. Nicola, D. Metcalf, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction

S. Ziegler, H. Baumann, T. Bird, 1993, Molecular and cellular biology.

The characterization, molecular cloning, and expression of a novel hematopoietic cell antigen from CD34+ human bone marrow cells.

O. Pourquié, R. Hoffman, A. Tsukamoto, 1997, Blood.

Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation.

G. Yu, J. Gutiérrez-Ramos, J. Gonzalo, 1999, Journal of immunology.

Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction

T. Bird, D. Gearing, B. Mosley, 1993 .

A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain

D. Gearing, Julie K. Allen, B. Lascelles, 2022, Frontiers in Veterinary Science.

Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus

S. Busfield, D. Gearing, E. Woolf, 1997, Molecular and cellular biology.

Yeast mitochondrial ATPase subunit 8, normally a mitochondrial gene product, expressed in vitro and imported back into the organelle.

P. Nagley, D. Gearing, 1986, The EMBO journal.

Leukemia Inhibitory Factor: Does the Cap Fit? a

D. Gearing, 1991, Annals of the New York Academy of Sciences.

Reconstitution of the response to leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in hepatoma cells.

S. Ziegler, S. Pajovic, H. Baumann, 1993, The Journal of biological chemistry.

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells

D. Friend, H. Baumann, D. Gearing, 1994, Molecular and cellular biology.

In Vitro and In Vivo Characterization of a Fully Felinized Therapeutic Anti‐Nerve Growth Factor Monoclonal Antibody for the Treatment of Pain in Cats

D. Gearing, B. Lascelles, M. Huebner, 2016, Journal of veterinary internal medicine.

A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain

D. Gearing, J. Innes, B. Lascelles, 2015, BMC Veterinary Research.

A fully caninised anti-NGF monoclonal antibody for pain relief in dogs

D. Gearing, A. Drew, R. P. Gearing, 2013, BMC Veterinary Research.

Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation.

E. Krebs, W. Schiemann, L. Graves, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

D. Gearing, D. Metcalf, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Leukaemia Inhibitory Factor or Related Factors Promote the Differentiation of Neuronal and Astrocytic Precursors within the Developing Murine Spinal Cord

L. Richards, T. Kilpatrick, P. Bartlett, 1996, The European journal of neuroscience.

Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

T. Willson, D. Gearing, M. Brown, 1990, The Journal of biological chemistry.

Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor.

S. Ziegler, D. Friend, D. Cosman, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Erratum: Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

J. Gutiérrez-Ramos, J. Gonzalo, J. Culpepper, 1997, Nature.

Identification of interleukin-1 and platelet-derived growth factor-B as major mitogens for the spindle cells of Kaposi's sarcoma: a combined in vitro and in vivo analysis.

P. Hofschneider, G. Raivich, D. Gearing, 1995, Oncogene.

LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells.

R. Williams, D. Hilton, T. Willson, 1989, Reproduction, fertility, and development.

Structural characterization of a murine myeloid leukaemia inhibitory factor.

D. Hilton, R. Simpson, E. Nice, 1988, European journal of biochemistry.

Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice.

D. Gearing, N. Nicola, D. Metcalf, 1990, Blood.

The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13.

K. Huebner, N. Copeland, D. Gilbert, 1993, Genomics.

Twisted gastrulation can function as a BMP antagonist

A. Brivanlou, Chenbei Chang, D. Gearing, 2001, Nature.

Leukemia inhibitory factor: a novel bone-active cytokine.

T. Martin, D. Hilton, J. Cornish, 1990, Endocrinology.

Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes.

S. Dower, D. Friend, T. Bird, 1994, The Journal of biological chemistry.

Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.

T. Vanden Bos, D. Cerretti, C. Kozlosky, 1993, Molecular immunology.

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor.

Comeau, D. Friend, C. Thut, 1992, Science.

Assembly of functional proton-translocating ATPase complex in yeast mitochondria with cytoplasmically synthesized subunit 8, a polypeptide normally encoded within the organelle.

P. Nagley, D. Gearing, R. Devenish, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The leukemia inhibitory factor and its receptor.

D. Gearing, 1993, Advances in immunology.

High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity.

Xue Yuan Pei, Adrian F Bristow, N. Gay, 2003, Biochemistry.

Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.

S. Busfield, J. Smutko, D. Gearing, 2000, Genomics.

Role of leukemia inhibitory factor and its receptor in mouse primordial germ cell growth.

L. Cheng, K. Schooley, P. Donovan, 1994, Development.

Leukemic burden in subpopulations of CD34+ cells isolated from the mobilized peripheral blood of alpha-interferon-resistant or -intolerant patients with chronic myeloid leukemia.

D. J. Van Den Berg, M. Wessman, D. Simonetti, 1996, Blood.

Functional and structural diversity of the human Dickkopf gene family.

K. Robison, S. Mccarthy, S. Sokol, 1999, Gene.

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

J. Gutiérrez-Ramos, J. Gonzalo, J. Culpepper, 1997, Nature.

Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6*

K. Kuropatwinski, H. Baumann, D. Gearing, 1997, The Journal of Biological Chemistry.

Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130.

C. Thut, V. Price, D. Cosman, 1991, The EMBO journal.

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

Donald Metcalf, Shirley Pease, Erwin F. Wagner, 1988, Nature.

Complete sequence of murine myeloid leukaemia inhibitory factor (LIF).

D. Gearing, N. Gough, J. A. King, 1988, Nucleic acids research.

Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.

D. Hilton, T. Willson, D. Gearing, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).

A. Kelso, D. Hilton, E. Nice, 1987, The EMBO journal.

Reconstitution of high affinity leukaemia inhibitory factor (LIF) receptors in haemopoietic cells transfected with the cloned human LIF receptor.

S. Ziegler, C. Thut, D. Gearing, 1992, Ciba Foundation symposium.

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

D. Cosman, D. Gearing, 1991, Cell.

STAT3 and STAT5B Are Targets of Two Different Signal Pathways Activated by Hematopoietin Receptors and Control Transcription via Separate Cytokine Response Elements (*)

H. Baumann, G. Fey, J. Ripperger, 1995, The Journal of Biological Chemistry.

Receptors for interleukin-3 (IL-3) and growth hormone mediate an IL-6-type transcriptional induction in the presence of JAK2 or STAT3.

J. Ripperger, H. Baumann, G. Fey, 1995, Blood.

The Action of Interleukin-2 Receptor Subunits Defines a New Type of Signaling Mechanism for Hematopoietin Receptors in Hepatic Cells and Fibroblasts (*)

S. Ziegler, J. Ihle, D. Tweardy, 1995, The Journal of Biological Chemistry.

Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.

J. Dick, Angel F. Lopez, H. Ramshaw, 2009, Cell stem cell.

Functional and biochemical association of Hck with the LIF/IL‐6 receptor signal transducing subunit gp130 in embryonic stem cells.

A. Dunn, D. Gearing, M. Ernst, 1994, The EMBO journal.

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

I. Reid, T. Martin, D. Hilton, 1990 .

A myelosclerotic syndrome in mice engrafted with cells producing high levels of leukemia inhibitory factor (LIF).

D. Gearing, D. Metcalf, 1989, Leukemia.

Localization of the human GM-CSF receptor gene to the XY pseudoautosomal region

G. Sutherland, D. Callen, M. Pritchard, 1990, Nature.

Production of Leukemia Inhibitory Factor in Escherichia coli by a Novel Procedure and Its Use in Maintaining Embryonic Stem Cells in Culture

R. Williams, S. Foote, T. Willson, 1989, Nature Biotechnology.

Schistosoma japonicum: monoclonal antibodies to the Mr 26,000 schistosome glutathione S-transferase (Sj26) in an assay for circulating antigen in infected individuals.

B. Hall, D. Gearing, W. Tiu, 1990, Experimental parasitology.

A Feline‐Specific Anti‐Nerve Growth Factor Antibody Improves Mobility in Cats with Degenerative Joint Disease–Associated Pain: A Pilot Proof of Concept Study

D. Gearing, B. Lascelles, M. Gruen, 2016, Journal of veterinary internal medicine.

Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF).

R. Williams, P. Braghetta, S. Pease, 1990, Developmental biology.

Comparison of factors which induce differentiation of the murine myeloid leukaemic cell line M1.

D. Gearing, 1989, Haematology and blood transfusion.

CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells.

J. Dick, Angel F. Lopez, H. Ramshaw, 2007 .

Fashioning FGFs from phage?

D. Gearing, N. Wrighton, 1999, Nature Biotechnology.

Enhanced suppression of human myeloid leukemic cell lines by combinations of IL‐6, LIF, GM‐CSF and G‐CSF

D. Gearing, D. Metcalf, T. Maekawa, 1990, International journal of cancer.

Mutagenesis of murine granulocyte/macrophage-colony-stimulating factor reveals critical residues near the N terminus.

D. Gearing, D. Metcalf, N. Gough, 1987, European journal of biochemistry.

Function of Hematopoietin Receptor Subunits in Hepatic Cells and Fibroblasts a

S. Ziegler, D. Tweardy, H. Baumann, 1995, Annals of the New York Academy of Sciences.

Separate Signaling Mechanisms Are Involved in the Control of STAT Protein Activation and Gene Regulation via the Interleukin 6 Response Element by the Box 3 Motif of gp130 (*)

H. Baumann, G. Fey, J. Ripperger, 1995, The Journal of Biological Chemistry.

Reprogrammed expression of subunit 9 of the mitochondrial ATPase complex of Saccharomyces cerevisiae. Expression in vitro from a chemically synthesized gene and import into isolated mitochondria.

P. Nagley, D. Gearing, L. B. Farrell, 1988, European journal of biochemistry.

Chemical synthesis of a mitochondrial gene designed for expression in the yeast nucleus.

P. Nagley, D. Gearing, G. Mcmullen, 1985, Biochemistry international.

Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells.

H. Baumann, D. Gearing, S. Ziegler, 1994, The Journal of biological chemistry.

Oncostatin M binds the high-affinity leukemia inhibitory factor receptor.

D. Gearing, A. Bruce, 1992, The New biologist.

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.

C. Ware, D. Liggitt, J. Peschon, 1995, Development.