C. Burrows

发表

Unzipping of A-Form DNA-RNA, A-Form DNA-PNA, and B-Form DNA-DNA in the α-Hemolysin Nanopore.

Rukshan T. Perera, H. White, A. M. Fleming, 2016, Biophysical journal.

Base Flipping within the α-Hemolysin Latch Allows Single-Molecule Identification of Mismatches in DNA.

H. White, A. M. Fleming, C. Burrows, 2016, Journal of the American Chemical Society.

α-Hemolysin nanopore studies reveal strong interactions between biogenic polyamines and DNA hairpins

A. M. Fleming, C. Burrows, Yun Ding, 2016, Microchimica Acta.

Internal vs Fishhook Hairpin DNA: Unzipping Locations and Mechanisms in the α-Hemolysin Nanopore

H. White, A. M. Fleming, C. Burrows, 2014, The journal of physical chemistry. B.

Interactions of the human telomere sequence with the nanocavity of the α-hemolysin ion channel reveal structure-dependent electrical signatures for hybrid folds.

A. M. Fleming, C. Burrows, Na An, 2013, Journal of the American Chemical Society.

Crown ether–electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules

H. White, A. M. Fleming, C. Burrows, 2012, Proceedings of the National Academy of Sciences.

Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases.

J. Bond, M. Dizdaroglu, P. Jaruga, 2009, DNA repair.

The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo.

William L. Neeley, S. Tannenbaum, J. Essigmann, 2003, Biochemistry.

Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.

R. Dukor, A. M. Fleming, C. Burrows, 2013, Journal of the American Chemical Society.

Targeting the DNA cleavage activity of copper phenanthroline and clip-phen to A.T tracts via linkage to a poly-N-methylpyrrole.

C. Burrows, B. Meunier, M. Pitié, 2000, Bioconjugate chemistry.

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

A. M. Fleming, C. Burrows, S. Wallace, 2015, Nucleic acids research.

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

A. M. Fleming, C. Burrows, S. Wallace, 2015, Nucleic acids research.

Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.

A. M. Fleming, C. Burrows, Omar R. Alshykhly, 2015, Chemical research in toxicology.

Electronic structure of DNA--unique properties of 8-oxoguanosine.

R. Naaman, A. M. Fleming, C. Burrows, 2009, Journal of the American Chemical Society.

Ultrafast excited-state dynamics and vibrational cooling of 8-oxo-7,8-dihydro-2'-deoxyguanosine in D2O.

S. Matsika, Zhen Lu, B. Kohler, 2013, The journal of physical chemistry. A.

Single-Molecule Analysis of Thymine Dimer-Containing G-Quadruplexes Formed from the Human Telomere Sequence

Anna H. Wolna, A. M. Fleming, C. Burrows, 2014, Biochemistry.

8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves.

C. Burrows, P. Beal, A. Kannan, 2011, Journal of the American Chemical Society.

Oxidative Nucleobase Modifications Leading to Strand Scission.

C. Burrows, J. Muller, 1998 .

Alkene Epoxidation Using Ni(II) Complexes of Chiral Cyclams

T. Wagler, C. Burrows, J. F. Kinneary, 1988 .

Mechanistic studies of alkene epoxidation catalyzed by nickel(II) cyclam complexes. Oxygen-18 labeling and substituent effects.

C. Burrows, J. Albert, J. F. Kinneary, 1988, Journal of the American Chemical Society.

Catalysis of alkene oxidation by nickel salen complexes using NaOCl under phase-transfer conditions

C. Burrows, H. Yoon, 1988 .

Metallodrug complexes that mediate DNA and lipid damage via sulfite autoxidation: copper(II) famotidine and iron(III) bis(salicyglycine)

C. Burrows, J. Muller, 1998 .

Metal-mediated oxidation of guanines in DNA and RNA: a comparison of cobalt(II), nickel(II) and copper(II) complexes

S. Rokita, C. Burrows, J. Muller, 1996 .

Interplay of guanine oxidation and G-quadruplex folding in gene promoters.

A. M. Fleming, C. Burrows, A. Fleming, 2019, Journal of the American Chemical Society.

Nickel Complexes as Antioxidants. Inhibition of Aldehyde Autoxidation by Nickel(II) Tetraazamacrocycles.

J. Valentine, C. Burrows, B. Ahn, 1996, Inorganic chemistry.

Oxidative DNA damage from sulfite autoxidation catalyzed by manganese(III)

C. Burrows, J. Muller, R. Jameton, 2002 .

Oxidatively induced DNA-protein cross-linking between single-stranded binding protein and oligodeoxynucleotides containing 8-oxo-7,8-dihydro-2'-deoxyguanosine.

C. Burrows, J. Muller, Mark E Johansen, 2005, Biochemistry.

DNA Cleavage vs. Cross-Linking Using Nickel Peptides

S. Rokita, R. Hickerson, C. Burrows, 1999 .

DNA Damage from Sulfite Autoxidation Catalyzed by a Nickel(II) Peptide

R. Hickerson, C. Burrows, J. Muller, 1997 .

DNA and RNA Modification Promoted by [Co(H2O)6]Cl2 and KHSO5: Guanine Selectivity, Temperature Dependence, and Mechanism

S. Rokita, P. Zheng, C. Burrows, 1996 .

Binding of AP Endonuclease-1 to G-Quadruplex DNA Depends on the N-Terminal Domain, Mg2+, and Ionic Strength

C. Burrows, A. Fleming, Shereen A. Howpay Manage, 2021, bioRxiv.

Chemistry of ROS-mediated oxidation to the guanine base in DNA and its biological consequences

C. Burrows, A. Fleming, 2021, International journal of radiation biology.

On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics.

C. Burrows, A. Fleming, 2020, Chemical Society reviews.

Iron Fenton oxidation of 2'-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical.

C. Burrows, A. Fleming, 2020, Chemical communications.

Oxidative Modification of Guanine in a Potential Z-DNA-Forming Sequence of a Gene Promoter Impacts Gene Expression.

C. Burrows, Yun Ding, Judy Zhu, 2019, Chemical research in toxicology.

Structure and potential mutagenicity of new hydantoin products from guanosine and 8-oxo-7,8-dihydroguanine oxidation by transition metals.

M. Leipold, C. Burrows, S. David, 2002, Environmental health perspectives.

Location dependence of the transcriptional response of a potential G-quadruplex in gene promoters under oxidative stress

C. Burrows, Yun Ding, Judy Zhu, 2019, Nucleic acids research.

Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin.

C. Burrows, A. Orendt, Omar R. Alshykhly, 2015, Tetrahedron letters.

Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch.

H. White, C. Burrows, Yun Ding, 2017, Biochemistry.

Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.

Xiaobei Zhao, C. Burrows, S. David, 2010, Biochemistry.

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

C. Burrows, S. Wallace, Jia Zhou, 2015, Nucleic acids research.

Copper/H2O2-mediated oxidation of 2'-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts.

C. Burrows, J. Muller, Yi Liao, 2011, The Journal of organic chemistry.

Characterization of 2'-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts.

C. Burrows, J. Muller, A. Fleming, 2011, Organic & biomolecular chemistry.

Colocalization of m6A and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine N6-Methylation

C. Burrows, N. Nguyen, A. Fleming, 2019, ACS central science.

Photorepair of cyclobutane pyrimidine dimers by 8‐oxopurine nucleosides

C. Burrows, K. Nguyen, 2012 .

A prebiotic role for 8-oxoguanosine as a flavin mimic in pyrimidine dimer photorepair.

C. Burrows, K. Nguyen, 2011, Journal of the American Chemical Society.

Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.

C. Burrows, J. Muller, Xin Chen, 2013, New journal of chemistry = Nouveau journal de chimie.

In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase.

Xiaobei Zhao, C. Burrows, S. David, 2007, Biochemistry.

Synthesis of an optically active C-funtiopnalized cyclam: (S)-5-(hydroxymethyl)-1,4,8,11-tetra-azacyclotetradecane and itws nickel(II) complex

T. Wagler, C. Burrows, 1987 .

Synthesis of all optically active spermine macrocycle, (S)-6-(hydroxymethyl)-1,5,10,14-tetraazacyclooctadecane, and its complexation to ATP

C. Burrows, J. Marecek, 1986 .

Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions.

C. Burrows, Yun Ding, Judy Zhu, 2018, Biochemistry.

Pseudouridine and N1-Methylpseudouridine Display pH-Independent Reaction Rates with Bisulfite Yielding Ribose Adducts.

C. Burrows, A. Fleming, Songjun Xiao, 2022, Organic letters.

Potential G-Quadruplex Forming Sequences and N6-Methyladenosine Colocalize at Human Pre-mRNA Intron Splice Sites

C. Burrows, Manuel Jara-Espejo, A. Fleming, 2020, bioRxiv.

8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.

C. Burrows, A. Fleming, 2017, Organic & biomolecular chemistry.

Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing.

C. Burrows, J. Muller, Adrienne C. Dlouhy, 2012, Journal of the American Chemical Society.

The pH-dependent role of superoxide in riboflavin-catalyzed photooxidation of 8-oxo-7,8-dihydroguanosine.

C. Burrows, J. Muller, W. Luo, 2001, Organic letters.

Characterization of hydantoin products from one-electron oxidation of 8-oxo-7,8-dihydroguanosine in a nucleoside model.

C. Burrows, J. Muller, E. M. Rachlin, 2001, Chemical research in toxicology.

Hydroxylation, Epoxidation, and DNA Cleavage Reactions Mediated by the Biomimetic Mn-TMPyP/O2/Sulfite Oxidation System†

C. Burrows, J. Muller, B. Meunier, 1999 .

Gel electrophoretic detection of 7,8-dihydro-8-oxoguanine and 7, 8-dihydro-8-oxoadenine via oxidation by Ir (IV).

R. Hickerson, C. Burrows, J. Muller, 1998, Nucleic acids research.

Formation of trans-3-hydroxy-4-phenylbutyrolactone from trans-styrylacetic acid and aqueous KHSO5

C. Burrows, J. D. Horn, 1999 .

Fluorophore‐mediated photooxidation of the guanine heterocycle

C. Burrows, A. Fleming, Song Xiao, 2022, Journal of Physical Organic Chemistry.

Effect of the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin on proofreading by Escherichia coli DNA polymerase I (Klenow fragment) in different sequence contexts.

C. Burrows, O. Kornyushyna, 2003, Biochemistry.

In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment).

C. Burrows, J. Muller, O. Kornyushyna, 2002, Biochemistry.

Removal of hydantoin products of 8-oxoguanine oxidation by the Escherichia coli DNA repair enzyme, FPG.

M. Leipold, C. Burrows, S. David, 2000, Biochemistry.

G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.

C. Burrows, A. Fleming, 2013, Chemical research in toxicology.

Spermine participates in oxidative damage of guanosine and 8-oxoguanosine leading to deoxyribosylurea formation.

C. Burrows, J. Muller, Mandy E Hosford, 2004, Journal of the American Chemical Society.

Formation of 13C-, 15N-, and 18O-labeled guanidinohydantoin from guanosine oxidation with singlet oxygen. Implications for structure and mechanism.

Roger A. Jones, C. Burrows, J. Muller, 2003, Journal of the American Chemical Society.

Recognition and removal of oxidized guanines in duplex DNA by the base excision repair enzymes hOGG1, yOGG1, and yOGG2.

M. Leipold, C. Burrows, S. David, 2003, Biochemistry.

Mechanism-Based DNA−Protein Cross-Linking of MutY via Oxidation of 8-Oxoguanosine

C. L. Chepanoske, R. Hickerson, C. Burrows, 1999 .

Identification of the Major Product of Guanine Oxidation in DNA by Ozone.

C. Burrows, A. Fleming, Michael B. Chabot, 2022, Chemical research in toxicology.

Oxidation of 9-β-d-ribofuranosyl uric acid by one-electron oxidants versus singlet oxygen and its implications for the oxidation of 8-oxo-7,8-dihydroguanosine

C. Burrows, J. Muller, K. Nguyen, 2011 .

Synthesis of a chiral dioxo-cyclam derived from L-phenylalanine and its application to olefin oxidation chemistry

T. Wagler, C. Burrows, 1988 .

The Fifth Domain in the G-Quadruplex-Forming Sequence of the Human NEIL3 Promoter Locks DNA Folding in Response to Oxidative Damage.

C. Burrows, Carla A Omaga, A. Fleming, 2018, Biochemistry.

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function?

C. Burrows, S. Wallace, Jia Zhou, 2015, ACS central science.

Mechanism of two-electron oxidation of deoxyguanosine 5'-monophosphate by a platinum(IV) complex.

Sunhee Choi, C. Burrows, J. Muller, 2004, Journal of the American Chemical Society.

Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel.

H. White, C. Burrows, Na An, 2012, Chemical communications.

Insights into the 5-Carboxamido-5-Formamido-2-Iminohydantoin Structural Isomerization Equilibria.

C. Burrows, A. Fleming, Michael B. Chabot, 2022, The Journal of organic chemistry.

Detection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanopore

Rukshan T. Perera, H. White, C. Burrows, 2015, Nanotechnology.

The RAD17 Promoter Sequence Contains a Potential Tail-Dependent G-Quadruplex That Downregulates Gene Expression upon Oxidative Modification.

C. Burrows, Judy Zhu, A. Fleming, 2018, ACS chemical biology.

Oxidative Modification of the Potential G-Quadruplex Sequence in the PCNA Gene Promoter Can Turn on Transcription.

C. Burrows, S. Redstone, A. Fleming, 2019, Chemical research in toxicology.

Alkene aziridination and epoxidation catalyzed by chiral metal salen complexes

C. Burrows, K. O'connor, Shiow‐Jyi Wey, 1992 .

Case studies on potential G-quadruplex-forming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomes

C. Burrows, Yun Ding, A. Fleming, 2018, Scientific Reports.

Synthesis and conformational studies of a new host system based on cholic acid

C. Burrows, R. A. Sauter, 1987 .

Temperature and electrolyte optimization of the α-hemolysin latch sensing zone for detection of base modification in double-stranded DNA.

H. White, C. Burrows, Robert P. Johnson, 2014, Biophysical journal.

DNA modification promoted by water-soluble nickel(II) salen complexes: a switch to DNA alkylation.

S. Rokita, S. Paikoff, C. Burrows, 1994, Journal of inorganic biochemistry.

Synthesis of an Optically Active Spermine Macrocycle, (S)-6-(Hydroxymethyl)-1,5,10,14-tetraazacyclooctadecane, and Its Complexation to ATP.

C. Burrows, J. Marecek, 1987 .

Optically active difunctionalized dioxocyclam macrocycles: ligands for nickel-catalyzed oxidation of alkenes

T. Wagler, C. Burrows, Yuan-Qing Fang, 1989 .

An exploration of mechanisms for the transformation of 8-oxoguanine to guanidinohydantoin and spiroiminodihydantoin by density functional theory.

Barbara H. Munk, H. Schlegel, C. Burrows, 2008, Journal of the American Chemical Society.

Synthesis of Site-Specific Crown Ether Adducts to DNA Abasic Sites: 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and 2'-Deoxycytidine.

C. Burrows, Na An, Yi Liao, 2019, Methods in molecular biology.

Nickel(III)‐Promoted DNA Cleavage with Ambient Dioxygen

S. Rokita, C. Burrows, Chien-Chung Cheng, 1993 .

Oxidative Nucleobase Modifications Leading to Strand Scission.

C. Burrows, J. Muller, 1998, Chemical reviews.

Preparation and structural characterization of dicopper(II) and dinickel(II) imidazolate-bridged macrocyclic Schiff base complexes

C. Burrows, Marie-Thérèse Youinou, Carol A. Salata, 1991 .

Recognition of Guanine Structure in Nucleic Acids by Nickel Complexes

S. Rokita, C. Burrows, 1994 .

Nickel- and cobalt-dependent oxidation and crosslinking of proteins.

S. Rokita, C. Burrows, 2001, Metal ions in biological systems.

Mechanisms of DNA cleavage by copper complexes of 3-clip-phen and of its conjugate with a distamycin analogue.

C. Burrows, B. Meunier, C J Burrows, 2000, Nucleic acids research.

FORMATION OF DNA ADDUCTS USING NICKEL(II) COMPLEXES OF REDOX-ACTIVE LIGANDS : A COMPARISON OF SALEN AND PEPTIDE COMPLEXES

S. Rokita, S. Paikoff, C. Burrows, 1999 .

Nickel-catalyzed oxidations: from hydrocarbons to DNA.

S. Rokita, C. Burrows, J. Muller, 1996, Acta chemica Scandinavica.

Substituent effects on the aliphatic Claisen rearrangement. 1. Synthesis and rearrangement of cyano-substituted allyl vinyl ethers

C. Burrows, B. K. Carpenter, 1981 .

5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA Contexts

C. Burrows, Omar R. Alshykhly, A. Fleming, 2015, The Journal of organic chemistry.

Rates of Chemical Cleavage of DNA and RNA Oligomers Containing Guanine Oxidation Products

C. Burrows, J. Muller, Judy Zhu, 2015, Chemical research in toxicology.

High turnover rates in pH-dependent alkene epoxidation using NaOCl and square-planar nickel(II) catalysts

T. Wagler, C. Burrows, H. Yoon, 1990 .

Template)2 synthesis of a dinucleating macrocyclic ligand and crystal structure of its dicopper(II) imidazolate complex

C. Burrows, Marie-Thérèse Youinou, Carol A. Salata, 1989 .

The Cys-Xaa-His metal-binding motif: {N} versus {S} coordination and nickel-mediated formation of cysteinyl sulfinic acid

D. Goldenberg, G. Bulaj, C. Burrows, 2003, JBIC Journal of Biological Inorganic Chemistry.

Dioxygen chemistry of nickel(II) dioxopentaazamacrocyclic complexes : Substituent and medium effects

S. Rokita, C. Burrows, Chien-Chung Cheng, 1996 .

Synthesis and structure of a semi-rigid dinucleating macrocycle containing the 2,6-bis(thiomethyl)pyridine unit and reactions of its copper(II) complex

C. Burrows, D. Engen, Carol A. Salata, 1988 .

Complexation of ATP to a Synthetic [15]-N3 Macrocyclic Polyammonium Receptor

C. Burrows, J. Marecek, P. Fischer, 1988 .

Substituent effects on the aliphatic Claisen rearrangements. 2. Theoretical analysis

C. Burrows, B. K. Carpenter, 1981 .

Macrocyclic nickel complexes in DNA recognition and oxidation

S. Rokita, C. Burrows, J. Muller, 1993 .

NICKEL-BASED PROBES OF NUCLEIC ACID STRUCTURE BIND TO GUANINE N7 BUT DO NOT PERTURB A DYNAMIC EQUILIBRIUM OF EXTRAHELICAL GUANINE RESIDUES

S. Rokita, C. Burrows, N. Tang, 1998 .

Conformation-specific detection of guanine in DNA: ends, mismatches, bulges and loops

S. Rokita, C. Burrows, Xiaoying Chen, 1992 .

DNA modification: Intrinsic selectivity of nickel(II) complexes

S. Rokita, C. Burrows, Xiaoying Chen, 1991 .

Preparation of primary vicinal diamines from amino acid esters and crystal structure of a chiral nickel salen complex

C. Burrows, K. O'connor, Wey Shiow-Jyi, 1993 .

Synthesis of a metallopeptide-PNA conjugate and its oxidative cross-linking to a DNA target.

A. Stemmler, C. Burrows, O. Kornyushyna, 2005, Bioconjugate chemistry.

Optically Active Difunctionalized Dioxocyclam Macrocycles: Ligands for Nickel-Catalyzed Oxidation of Alkenes.

T. Wagler, C. Burrows, Yuan-Qing Fang, 1989 .

Synthesis of novel macrobicyclic polyfunctional cryptands

J. Behr, J. Lehn, C. Burrows, 1985 .

Hydrophobic vs coulombic interactions in the binding of steroidal polyamines to DNA

C. Burrows, J. Muller, M. Ng, 1996 .

Structural effects in novel steroidal polyamine-DNA binding

H. Hsieh, C. Burrows, J. Muller, 1994 .

Synthesis and DNA binding properties of C3-, C12-, and C24-substituted amino-steroids derived from bile acids.

H. Hsieh, C. Burrows, J. Muller, 1995, Bioorganic & medicinal chemistry.

Ligand effects associated with the intrinsic selectivity of DNA oxidation promoted by nickel(II) macrocyclic complexes

S. Rokita, C. Burrows, J. Muller, 1992 .

DESIGN OF CHOLIC ACID MACROCYCLES AS HOSTS FOR MOLECULAR RECOGNITION OF MONOSACCHARIDES

C. Burrows, C. Venanzi, S. M. Evans, 1995 .

Design of cholic acid hosts for molecular recognition of monosaccharides using systematic conformational searching

C. Burrows, C. Venanzi, S. M. Evans, 1994 .

THE SAL-XH MOTIF FOR METAL-MEDIATED OXIDATIVE DNA-PEPTIDE CROSS-LINKING

A. Stemmler, C. Burrows, 1999 .

A primer extension assay for modification of guanine by Ni(II) complexes.

S. Rokita, S. Woodson, C. Burrows, 1993, Nucleic acids research.

RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair–π and CH–π interactions

Dong Wang, Jun Xu, Juntaek Oh, 2020, Proceedings of the National Academy of Sciences.

Nanopore sequencing for N1-methylpseudouridine in RNA reveals sequence-dependent discrimination of the modified nucleotide triphosphate during transcription

C. Burrows, A. Fleming, 2022, bioRxiv.

Effect of Oxidative Damage on Charge and Spin Transport in DNA.

R. Naaman, C. Burrows, C. Fontanesi, 2018, Journal of the American Chemical Society.

Reactivity of Bulged Bases in Duplex DNA with Redox-active Nickel and Cobalt Complexes

C. Burrows, J. Muller, Jingjing Cai, 2002 .

Progress toward artificial metalloenzymes: New ligands for transition metal ions and neutral molecules

T. Wagler, C. Burrows, J. Albert, 1989 .

Characterization of spiroiminodihydantoin as a product of one-electron oxidation of 8-Oxo-7,8-dihydroguanosine.

C. Burrows, J. Muller, C J Burrows, 2000, Organic letters.

Chemical modification of siRNA bases to probe and enhance RNA interference.

C. Burrows, P. Beal, A. Kannan, 2011, The Journal of organic chemistry.

Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

C. Burrows, P. Beal, Rachel Valenzuela, 2012, Journal of the American Chemical Society.

Bromination of pyrimidines using bromide and monoperoxysulfate: A competition study between cytidine, uridine and thymidine

C. Burrows, S. Ross, 1997 .

Formation of tricyclic [4.3.3.0] adducts between 8-oxoguanosine and tyrosine under conditions of oxidative DNA-protein cross-linking.

C. Burrows, J. Muller, Xiaoyun Xu, 2008, Journal of the American Chemical Society.

DNA-protein cross-links between guanine and lysine depend on the mechanism of oxidation for formation of C5 vs C8 guanosine adducts.

Cynthia J Burrows, C. Burrows, J. Muller, 2008, Journal of the American Chemical Society.

Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq.

C. Burrows, Yun Ding, A. Fleming, 2017, Journal of the American Chemical Society.

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair

C. Burrows, Yun Ding, A. Fleming, 2016, Proceedings of the National Academy of Sciences.

Nanopore Detection of 8-Oxoguanine in the Human Telomere Repeat Sequence

H. White, C. Burrows, Na An, 2015, ACS nano.

Kinetics of T3-DNA Ligase-Catalyzed Phosphodiester Bond Formation Measured Using the α-Hemolysin Nanopore.

Jan Riedl, H. White, C. Burrows, 2016, ACS nano.

Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family

Cynthia J. Burrows, C. Burrows, Yun Ding, 2016, ACS infectious diseases.

Case studies on potential G-quadruplex-forming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomes

C. Burrows, Yun Ding, A. Fleming, 2018, Scientific Reports.

Promoters vs. telomeres: AP-endonuclease 1 interactions with abasic sites in G-quadruplex folds depend on topology

C. Burrows, Judy Zhu, A. Fleming, 2023, RSC chemical biology.

Oxidative stress-mediated epigenetic regulation by G-quadruplexes

C. Burrows, A. Fleming, 2021, NAR cancer.

Characterization of G-Quadruplexes in Chlamydomonas reinhardtii and the Effects of Polyamine and Magnesium Cations on Structure and Stability.

C. Burrows, A. Fleming, Jingwei Ma, 2018, Biochemistry.

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.

B. Dalhus, M. Bjørås, L. Luna, 2013, DNA repair.

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

M. Bjørås, V. Rolseth, L. Luna, 2011, Proceedings of the National Academy of Sciences.

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

Xiaobei Zhao, J. Bond, M. Dizdaroglu, 2010, Proceedings of the National Academy of Sciences.

Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine.

C. Burrows, J. Muller, V. Duarte, 1999, Nucleic acids research.

Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters

C. Burrows, R. A. Rogers, A. Fleming, 2018, ACS omega.

Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers.

C. Burrows, A. Fleming, Anton Alenko, 2017, Biochemistry.

γ-Hemolysin Nanopore Is Sensitive to Guanine-to-Inosine Substitutions in Double-Stranded DNA at the Single-Molecule Level.

H. White, C. Burrows, H. Ren, 2018, Journal of the American Chemical Society.

Differentiation of G:C vs A:T and G:C vs G:mC Base Pairs in the Latch Zone of α-Hemolysin.

H. White, C. Burrows, Yun Ding, 2015, ACS nano.

Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel.

Anna H. Wolna, H. White, C. Burrows, 2013, Israel journal of chemistry.

Nanopore detection of 8-oxo-7,8-dihydro-2'-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site.

H. White, C. Burrows, Na An, 2010, Journal of the American Chemical Society.

Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution

Bradley R. Cairns, Vahid Khoddami, Cynthia J. Burrows, 2019, Proceedings of the National Academy of Sciences.

Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore.

Cynthia J Burrows, Henry S White, H. White, 2012, Journal of the American Chemical Society.

A nickel complex cleaves uridine in folded RNA structures: application to E. coli tmRNA and related engineered molecules.

J. F. Atkins, R. Gesteland, B. Felden, 1998, Journal of molecular biology.

8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On–Off Switch for Transcription

C. Burrows, Yun Ding, Judy Zhu, 2017, ACS chemical biology.

Structural destabilization of DNA duplexes containing single-base lesions investigated by nanopore measurements.

H. White, C. Burrows, Yun Ding, 2013, Biochemistry.

Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin.

S. Doublié, P. Aller, C. Burrows, 2010, Biochemistry.

Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.

B. Van Houten, C. Burrows, S. David, 2013, Journal of the American Chemical Society.

Mechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions.

Barbara H. Munk, H. Schlegel, C. Burrows, 2009, Chemical research in toxicology.

Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus.

Xiaobei Zhao, C. Burrows, Michael R. Newton, 2007, DNA repair.

Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1.

Xiaobei Zhao, C. Burrows, S. David, 2008, Biochemistry.

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

Xiaobei Zhao, J. Bond, M. Dizdaroglu, 2010, DNA repair.

Effect of an Electrolyte Cation on Detecting DNA Damage with the Latch Constriction of α-Hemolysin

H. White, C. Burrows, Robert P. Johnson, 2014, The journal of physical chemistry letters.

Single-molecule investigation of G-quadruplex folds of the human telomere sequence in a protein nanocavity

Cynthia J. Burrows, C. Burrows, Na An, 2014, Proceedings of the National Academy of Sciences.

Single-molecule detection of a guanine(C8) - thymine(N3) cross-link using ion channel recording.

Anna H. Wolna, C. Burrows, A. Fleming, 2014, Journal of physical organic chemistry.

Base-excision repair activity of uracil-DNA glycosylase monitored using the latch zone of α-hemolysin.

H. White, C. Burrows, Robert P. Johnson, 2013, Journal of the American Chemical Society.

Structural elucidation of bisulfite adducts to pseudouridine that result in deletion signatures during reverse transcription of RNA.

C. Burrows, J. Kitt, A. Orendt, 2019, Journal of the American Chemical Society.

Dynamics of a DNA Mismatch Site Held in Confinement Discriminate Epigenetic Modifications of Cytosine.

Rukshan T. Perera, H. White, C. Burrows, 2017, Journal of the American Chemical Society.

Human Telomere G-Quadruplexes with Five Repeats Accommodate 8-Oxo-7,8-dihydroguanine by Looping out the DNA Damage.

C. Burrows, Na An, A. Fleming, 2016, ACS chemical biology.

Formation and processing of DNA damage substrates for the hNEIL enzymes☆

C. Burrows, A. Fleming, 2017, Free radical biology & medicine.

Exploration of mechanisms for the transformation of 8-hydroxy guanine radical to FAPyG by density functional theory.

Barbara H. Munk, H. Schlegel, C. Burrows, 2007, Chemical research in toxicology.

Photoinduced Electron Transfer in DNA: Charge Shift Dynamics Between 8-Oxo-Guanine Anion and Adenine.

R. Improta, B. Kohler, Yuyuan Zhang, 2015, The journal of physical chemistry. B.

8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis.

C. Burrows, A. Fleming, 2017, DNA repair.

Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli.

R. Lloyd, S. Mitra, C. Burrows, 2001, Nucleic acids research.

pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion.

C. Burrows, A. Orendt, Judy Zhu, 2016, The Journal of organic chemistry.

Neil3 and NEIL1 DNA Glycosylases Remove Oxidative Damages from Quadruplex DNA and Exhibit Preferences for Lesions in the Telomeric Sequence Context*

C. Burrows, S. Wallace, Jia Zhou, 2013, The Journal of Biological Chemistry.

Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli Fpg.

C. Burrows, S. David, J. Muller, 2007, Biochemistry.

Comparison of Transition Metal-Mediated Oxidation Reactions of Guanine in Nucleoside and Single-Stranded Oligodeoxynucleotide Contexts.

C. Burrows, J. Muller, Mark A. Schallenberger, 2011, Inorganica chimica acta.

A highly sensitive probe for guanine N7 in folded structures of RNA: application to tRNA(Phe) and Tetrahymena group I intron.

S. Rokita, S. Woodson, X. Chen, 1993, Biochemistry.

Computational Study of Oxidation of Guanine by Singlet Oxygen (1 Δg ) and Formation of Guanine:Lysine Cross-Links.

Barbara H. Munk, H. Schlegel, Bishnu Thapa, 2017, Chemistry.

4n-1 Is a "Sweet Spot" in DNA i-Motif Folding of 2'-Deoxycytidine Homopolymers.

C. Burrows, Yun Ding, Judy Zhu, 2017, Journal of the American Chemical Society.

Spirodi(iminohydantoin) Products from Oxidation of 2′-Deoxyguanosine in the Presence of NH4Cl in Nucleoside and Oligodeoxynucleotide Contexts

C. Burrows, J. Muller, Judy Zhu, 2014, The Journal of organic chemistry.

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

Sylvie Doublié, Cynthia J. Burrows, S. Doublié, 2014, Biochemistry.

Cytosine-specific chemical probing of DNA using bromide and monoperoxysulfate.

C. Burrows, S. Ross, 1996, Nucleic acids research.

Surviving an Oxygen Atmosphere: DNA Damage and Repair.

Cynthia J Burrows, C. Burrows, 2009, ACS symposium series. American Chemical Society.

Sequence and Stacking Dependence of 8-Oxoguanine Oxidation: Comparison of One-Electron vs Singlet Oxygen Mechanisms

James G. Muller, Robyn P. Hickerson, Cynthia J. Burrows, 1999 .

Sequencing of DNA Lesions Facilitated by Site-Specific Excision via Base Excision Repair DNA Glycosylases Yielding Ligatable Gaps.

Jan Riedl, C. Burrows, A. Fleming, 2016, Journal of the American Chemical Society.

Identification of DNA lesions using a third base pair for amplification and nanopore sequencing

Jan Riedl, C. Burrows, Yun Ding, 2015, Nature Communications.

UV-Induced Proton-Coupled Electron Transfer in Cyclic DNA Miniduplexes.

B. Kohler, Yuyuan Zhang, C. Burrows, 2016, Journal of the American Chemical Society.

Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide

R. Improta, B. Kohler, Yuyuan Zhang, 2014, Proceedings of the National Academy of Sciences.

Whence flavins? Redox-active ribonucleotides link metabolism and genome repair to the RNA world.

C. Burrows, K. Nguyen, 2012, Accounts of chemical research.

Computational Study of the Radical Mediated Mechanism of the Formation of C8, C5, and C4 Guanine:Lysine Adducts in the Presence of the Benzophenone Photosensitizer.

Barbara H. Munk, H. Schlegel, Bishnu Thapa, 2016, Chemical research in toxicology.

Human NEIL3 Gene Expression Regulated by Epigenetic-Like Oxidative DNA Modification

C. Burrows, Judy Zhu, A. Fleming, 2019, Journal of the American Chemical Society.

Cysteine Oxidation to Sulfenic Acid in APE1 Aids G-Quadruplex Binding While Compromising DNA Repair.

C. Burrows, A. Fleming, Shereen A. Howpay Manage, 2022, ACS chemical biology.

Riboflavin Stabilizes Abasic, Oxidized G-Quadruplex Structures

T. Cheatham, R. Galindo-Murillo, C. Burrows, 2022, Biochemistry.

Bis(N‐methylsalicylaldimine)nickel

C. Burrows, Shiow‐Jyi Wey, 2001 .

Computational Study of the Formation of C8, C5 and C4 Guanine:Lysine Adducts via Oxidation of Guanine by Sulfate Radical Anion.

Barbara H. Munk, H. Schlegel, Bishnu Thapa, 2019, The journal of physical chemistry. A.

DNA modifications walk a fine line between epigenetics and mutagenesis

C. Burrows, A. Fleming, 2023, Nature Reviews Molecular Cell Biology.

Nickel complexes as probes of guanine sites in nucleic acid folding.

S. Rokita, C. Burrows, 1996, Metal ions in biological systems.

Sequence-specific single-molecule analysis of 8-oxo-7,8-dihydroguanine lesions in DNA based on unzipping kinetics of complementary probes in ion channel recordings.

H. White, C. Burrows, Na An, 2011, Journal of the American Chemical Society.

The Role of Electrons’ Spin in DNA Oxidative Damage Recognition

R. Naaman, Qirong Zhu, T. Das, 2022, SSRN Electronic Journal.

Nanopore Dwell Time Analysis Permits Sequencing and Conformational Assignment of Pseudouridine in SARS-CoV-2

C. Burrows, A. Fleming, Shereen A. Howpay Manage, 2021, bioRxiv.

Mechanistic Information on the Redox Cycling of Nickel(II/III) Complexes in the Presence of Sulfur Oxides and Oxygen. Correlation with DNA Damage Experiments.

I. Grgić, C. Burrows, R. van Eldik, 1999, Inorganic chemistry.

Energetics of base flipping at a DNA mismatch site confined at the latch constriction of α-hemolysin.

Rukshan T. Perera, H. White, C. Burrows, 2016, Faraday discussions.

Sequencing for oxidative DNA damage at single-nucleotide resolution with click-code-seq v2.0.

C. Burrows, A. Fleming, Songjun Xiao, 2023, Chemical Communications.

Impact of DNA Oxidation on Toxicology: From Quantification to Genomics.

Junzhou Wu, S. Sturla, C. Burrows, 2019, Chemical research in toxicology.

Prebiotic chemistry: Ribozyme takes its vitamins.

C. Burrows, 2013, Nature chemistry.

Synthesis of N2-alkyl-8-oxo-7,8-dihydro-2'-deoxyguanosine derivatives and effects of these modifications on RNA duplex stability.

C. Burrows, A. Kannan, 2011, The Journal of organic chemistry.

Hysteresis in poly‐2′‐deoxycytidine i‐motif folding is impacted by the method of analysis as well as loop and stem lengths

C. Burrows, R. A. Rogers, A. Fleming, 2020, Biopolymers.

Direct Nanopore Sequencing for the 17 RNA Modification Types in 36 Locations in the E. coli Ribosome Enables Monitoring of Stress-Dependent Changes

C. Burrows, V. Bandarian, A. Fleming, 2023, ACS chemical biology.

Nanopore sequencing for the 17 modification types in 36 locations in E. coli ribosomal RNA enables monitoring of stress-dependent changes

C. Burrows, A. Fleming, Songjun Xiao, 2023, bioRxiv.

NEIL3 promoter G-quadruplex with oxidatively modified bases shows magnesium-dependent folding that stalls polymerase bypass.

C. Burrows, A. Fleming, Carla A. Omaga, 2023, Biochimie.

Computational Study of Oxidation of Guanine by Singlet Oxygen (1 Δg ) and Formation of Guanine:Lysine Cross-Links.

Barbara H. Munk, Bishnu Thapa, C. Burrows, 2017, Chemistry.

Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

C. Burrows, P. Beal, Rachel Valenzuela, 2012, Journal of the American Chemical Society.

Effect of Oxidative Damage on Charge and Spin Transport in DNA

R. Naaman, C. Burrows, V. S. Poonia, 2018 .

Dynamics of a DNA Mismatch Site Held in Confinement Discriminate Epigenetic Modifications of Cytosine.

Rukshan T. Perera, H. White, C. Burrows, 2017, Journal of the American Chemical Society.

Unfolding Kinetics of the Human Telomere i-Motif Under a 10 pN Force Imposed by the α-Hemolysin Nanopore Identify Transient Folded-State Lifetimes at Physiological pH

C. Burrows, Yun Ding, Lidong He, 2015, Journal of the American Chemical Society.

Bisulfite and Nanopore Sequencing for Pseudouridine in RNA.

C. Burrows, A. Fleming, 2023, Accounts of chemical research.

Sequence-specific single-molecule analysis of 8-oxo-7,8-dihydroguanine lesions in DNA based on unzipping kinetics of complementary probes in ion channel recordings.

H. White, C. Burrows, Na An, 2011, Journal of the American Chemical Society.

Chemical modification of siRNA bases to probe and enhance RNA interference.

C. Burrows, P. Beal, A. Kannan, 2011, The Journal of organic chemistry.

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair

C. Burrows, Yun Ding, A. Fleming, 2016, Proceedings of the National Academy of Sciences.

Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin.

S. Doublié, P. Aller, C. Burrows, 2010, Biochemistry.

Differentiation of G:C vs A:T and G:C vs G:mC Base Pairs in the Latch Zone of α-Hemolysin.

H. White, C. Burrows, Yun Ding, 2015, ACS nano.

Temperature and electrolyte optimization of the α-hemolysin latch sensing zone for detection of base modification in double-stranded DNA.

H. White, C. Burrows, Robert P. Johnson, 2014, Biophysical journal.

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

Xiaobei Zhao, J. Bond, M. Dizdaroglu, 2010, DNA repair.

Human NEIL3 Gene Expression Regulated by Epigenetic-Like Oxidative DNA Modification

C. Burrows, Judy Zhu, A. Fleming, 2019, Journal of the American Chemical Society.

Advantages and challenges associated with bisulfite-assisted nanopore direct RNA sequencing for modifications

C. Burrows, Judy Zhu, A. Fleming, 2023, RSC chemical biology.

Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch.

H. White, C. Burrows, Yun Ding, 2017, Biochemistry.

CO2 protects cells from iron-Fenton oxidative DNA damage in E. coli and humans

C. Burrows, A. Fleming, Justin C. Dingman, 2024, bioRxiv.