A. Leask

Andrew Leask, A. Leask, David J. Abraham, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cell–matrix interactions governing skin repair: matricellular proteins as diverse modulators of cell function

D. Hamilton, John T. Walker, A. Leask, 2015 .

Targeting the extracellular matrix: matricellular proteins regulate cell-extracellular matrix communication within distinct niches of the intervertebral disc.

C. Séguin, A. Leask, Jake Bedore, 2014, Matrix biology : journal of the International Society for Matrix Biology.

Conditional β1‐integrin‐deficient mice display impaired pancreatic β cell function

S. Liu, Shangxin Liu, A. Leask, 2011, The Journal of pathology.

Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.

D. Abraham, C. Denton, A. Leask, 2004, The Journal of investigative dermatology.

Connective Tissue Growth Factor Gene Regulation

D. Abraham, A. Holmes, A. Leask, 2003, The Journal of Biological Chemistry.

CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling*

S. Sa, A. Leask, C. Black, 2001, The Journal of Biological Chemistry.

CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload.

M. Brans, M. Vos, T. V. van Veen, 2015, Journal of molecular and cellular cardiology.

miR-218 regulates focal adhesion kinase–dependent TGFβ signaling in fibroblasts

A. Leask, D. Carter, Fen Guo, 2014, Molecular biology of the cell.

Conjunction junction, what's the function? CCN proteins as targets in fibrosis and cancers.

A. Leask, 2020, American journal of physiology. Cell physiology.

The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts

S. Sa, D. Abraham, A. Holmes, 2001, Molecular pathology : MP.

N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma.

D. Abraham, C. Denton, A. Leask, 2005, QJM : monthly journal of the Association of Physicians.

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients.

D. Abraham, A. Holmes, G. Martin, 2001, The Journal of clinical investigation.

Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2-Dependent Mechanism in Polycystic Kidney Disease.

J. Calvet, D. Wallace, T. Fields, 2020, Journal of the American Society of Nephrology : JASN.

Constitutive Connective Tissue Growth Factor Expression in Scleroderma Fibroblasts Is Dependent on Sp1*

D. Abraham, C. Denton, A. Holmes, 2003, Journal of Biological Chemistry.

Lefty Contributes to the Remodeling of Extracellular Matrix by Inhibition of Connective Tissue Growth Factor and Collagen mRNA Expression and Increased Proteolytic Activity in a Fibrosarcoma Model*

Hao Xu, J. Mason, A. Leask, 2002, The Journal of Biological Chemistry.

Monitoring Collagen Synthesis in Fibroblasts Using Fluorescently Labeled tRNA Pairs

B. Cooperman, Dvir Dahary, D. O'Gorman, 2014, Journal of cellular physiology.

Activation of Key Profibrotic Mechanisms in Transgenic Fibroblasts Expressing Kinase-deficient Type II Transforming Growth Factor-β Receptor (TβRIIΔk)*

D. Abraham, C. Denton, E. Renzoni, 2005, Journal of Biological Chemistry.

TGF-b signaling in cartilage homeostasis and osteoarthritis.

A. Philip, George Bou-Gharios, A. Leask, 2012, Frontiers in bioscience.

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

Satoshi O. Suzuki, K. Shin‐ya, K. Nakao, 2015, Proceedings of the National Academy of Sciences.

Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis.

A. Leask, 2004, The Keio journal of medicine.

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

A. Leask, X. Shi-wen, R. Stratton, 2017, PloS one.

Integrin β1: A Mechanosignaling Sensor Essential for Connective Tissue Deposition by Fibroblasts.

A. Leask, 2013, Advances in wound care.

CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts?

A. Leask, 2013, Journal of Cell Communication and Signaling.

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.

M. Baron, D. Abraham, C. Denton, 2012, Rheumatology.

Integrin β1 is required for dermal homeostasis.

Shangxin Liu, A. Leask, 2013, The Journal of investigative dermatology.

Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

A. Didangelos, J. Saklatvala, A. Leask, 2018, Annals of the rheumatic diseases.

Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism

Yunliang Chen, D. Abraham, C. Denton, 2011, Fibrogenesis & tissue repair.

Tumor Necrosis Factor α Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-β in Normal and Scleroderma Fibroblasts*

S. Sa, D. Abraham, A. Leask, 2000, The Journal of Biological Chemistry.

Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

D. Pennington, R. D. du Bois, D. Abraham, 2000, Experimental cell research.

CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.

S. Sa, R. Goldschmeding, D. Abraham, 2002, Kidney international.

Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling

A. Leask, J. Rockel, S. Bernier, 2009, Arthritis research & therapy.

RESULTS The Ability of CCN 2 to Bind to the Cell Surface of Adult Human Dermal Fibroblasts Is

Yunliang Chen, K. Lyons, J. Pearson, 2004 .

CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.

Yunliang Chen, K. Lyons, J. Pearson, 2004, Molecular biology of the cell.

Thrombospondin 1 in hypoxia-conditioned media blocks the growth of human microvascular endothelial cells and is increased in systemic sclerosis tissues

D. Abraham, A. Leask, R. Stratton, 2011, Fibrogenesis & tissue repair.

The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.

Saptarsi M. Haldar, A. Leask, Mukesh K. Jain, 2006, Journal of molecular and cellular cardiology.

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling

J. Molkentin, J. V. van Berlo, J. Rabinowitz, 2015, Molecular and Cellular Biology.

Genetic analysis of CTGF as an effector of TGFβ signaling and cardiac

J. Molkentin, J. Rabinowitz, A. Leask, 2015 .

Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?

R. Goldschmeding, A. Leask, I. Blom, 2002, Matrix biology : journal of the International Society for Matrix Biology.

Curcumin prevents and reverses murine cardiac hypertrophy.

M. Fukuoka, A. Ghosh, L. Kirshenbaum, 2008, The Journal of clinical investigation.

The hard problem: Mechanotransduction perpetuates the myofibroblast phenotype in scleroderma fibrosis

A. Leask, 2021, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis

D. Abraham, A. Holmes, A. Leask, 2002, Current rheumatology reports.

Loss of protein kinase Cϵ results in impaired cutaneous wound closure and myofibroblast function

Yunliang Chen, D. Abraham, C. Denton, 2008, Journal of Cell Science.

Expression of Amino- and Carboxyl-terminal γ- and α-Tubulin Mutants in Cultured Epithelial Cells*

T. Stearns, A. Leask, 1998, The Journal of Biological Chemistry.

Synaptically coupled central nervous system neurons lack centrosomal gamma-tubulin.

T. Stearns, K. Obrietan, A. Leask, 1997, Neuroscience letters.

Synaptically coupled central nervous system neurons lack centrosomal γ-tubulin

T. Stearns, K. Obrietan, A. Leask, 1997, Neuroscience Letters.

Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts.

Yunliang Chen, S. Parapuram, D. Abraham, 2009, Arthritis and rheumatism.

FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.

Yunliang Chen, Shiwen Xu, D. Abraham, 2007, Molecular biology of the cell.

Do drugs that target mTOR generate CCN2-mediated fibrogenic side effects?

A. Leask, 2019, Journal of Cell Communication and Signaling.

Src kinase inhibition promotes the chondrocyte phenotype

A. Leask, F. Beier, A. Woods, 2007, Arthritis research & therapy.

The role of endothelin-1 signaling in the fibrosis observed in systemic sclerosis.

A. Leask, 2011, Pharmacological research.

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation.

M. Kapoor, D. Abraham, P. Carreira, 2012, Arthritis and rheumatism.

Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma

A. Leask, 2012, The open rheumatology journal.

CCN2 is necessary for the function of mouse embryonic fibroblasts.

Yunliang Chen, K. Lyons, D. Abraham, 2007, Experimental cell research.

The Contribution of Peroxisome Proliferator-Activated Receptor Gamma to Cutaneous Wound Healing.

A. Leask, 2013, Advances in wound care.

Possible strategies for anti-fibrotic drug intervention in scleroderma

A. Leask, 2011, Journal of Cell Communication and Signaling.

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.

D. Abraham, C. Denton, A. Leask, 2010, Rheumatology.

Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.

M. Kapoor, D. Abraham, C. Denton, 2009, Arthritis and rheumatism.

Skin Progenitor Cells Contribute to Bleomycin‐Induced Skin Fibrosis

Y. Hérault, G. Pavlovic, Shangxin Liu, 2014, Arthritis & rheumatology.

Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment

A. Leask, 2010, Fibrogenesis & tissue repair.

Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma

A. Leask, 2009, Journal of Cell Communication and Signaling.

Connective tissue growth factor is induced in bleomycin-induced skin scleroderma

Shangxin Liu, A. Leask, R. Taghavi, 2009, Journal of Cell Communication and Signaling.

Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.

R. D. du Bois, D. Abraham, C. Denton, 2007, Arthritis and rheumatism.

Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.

Yunliang Chen, D. Abraham, C. Denton, 2006, Arthritis and rheumatism.

5Z-7-Oxozeanol Inhibits the Effects of TGFβ1 on Human Gingival Fibroblasts

A. Leask, D. Carter, H. Kuk, 2015, PloS one.

CCN1: a novel target for pancreatic cancer

A. Leask, 2011, Journal of Cell Communication and Signaling.

Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts

A. Leask, B. Perbal, Alexander Peidl, 2019, PloS one.

ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts

A. Leask, K. Thompson, Hannah Murphy-Marshman, 2014, Journal of Cell Communication and Signaling.

B cell block: is rituximab a new possible treatment for systemic sclerosis?

A. Leask, 2010, Journal of Cell Communication and Signaling.

Targeting the jagged/notch pathway: a new treatment for fibrosis?

A. Leask, 2010, Journal of cell communication and signaling.

ALK5 Inhibition Blocks TGFβ-induced CCN2 Expression in Gingival Fibroblasts

D. Hamilton, A. Leask, K. Thompson, 2010, Journal of dental research.

Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2

A. Leask, 2009, Journal of Cell Communication and Signaling.

The skinny on CCN2

A. Leask, 2008, Journal of Cell Communication and Signaling.

The Starbuck stops here: it’s a Smad world

A. Leask, 2008, Journal of Cell Communication and Signaling.

Ceramide inhibits CCN2 expression in fibroblasts

S. Parapuram, A. Leask, J. Greenspoon, 2008, Journal of Cell Communication and Signaling.

Fibroblast adhesion results in the induction of a matrix remodeling gene expression program.

D. Abraham, A. Leask, X. Shi-wen, 2008, Matrix biology : journal of the International Society for Matrix Biology.

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Yunliang Chen, A. Pitsillides, D. Abraham, 2008, Arthritis and rheumatism.

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.

Yunliang Chen, D. Abraham, E. Renzoni, 2005, The American journal of pathology.

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

S. Parapuram, D. Abraham, A. Leask, 2009, Journal of Cell Communication and Signaling.

Endothelin receptor selectivity: evidence from in vitro and pre‐clinical models of scleroderma

A. Leask, C. Fonseca, X. Shiwen, 2009, European journal of clinical investigation.

CCN2/decorin interactions: a novel approach to combating fibrosis?

A. Leask, 2011, Journal of Cell Communication and Signaling.

Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes

K. Ghoshal, S. Jacob, A. Balasubramanian, 2012, PloS one.

Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells

Shaoqiong Chen, A. Leask, D. Brigstock, 2008, Journal of Cell Communication and Signaling.

A sticky situation: CCN1 promotes both proliferation and apoptosis of cancer cells

A. Leask, 2009, Journal of Cell Communication and Signaling.

Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

Yunliang Chen, R. D. du Bois, J. Pearson, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Sonic advance: CCN1 regulates sonic hedgehog in pancreatic cancer

A. Leask, 2013, Journal of Cell Communication and Signaling.

All in the CCN family: essential matricellular signaling modulators emerge from the bunker

Andrew Leask, D. Abraham, A. Leask, 2006, Journal of Cell Science.

Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma.

S. Gruber, D. Holdsworth, C. Norley, 2018, Matrix biology : journal of the International Society for Matrix Biology.

Studying the CCN Proteins in Fibrosis.

A. Leask, K. Thompson, J. Hutchenreuther, 2017, Methods in molecular biology.

CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair

A. Leask, M. Tsang, 2015, Journal of Cell Communication and Signaling.

CCN2 expression by fibroblasts is not required for cutaneous tissue repair

Shangxin Liu, A. Leask, K. Thompson, 2014, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

CCN2 modulates hair follicle cycling in mice

Shangxin Liu, A. Leask, 2013, Molecular biology of the cell.

CCN6: a novel method of aTAKing cancer

A. Leask, 2013, Journal of Cell Communication and Signaling.

CCN2 expression and localization in melanoma cells

W. Sha, A. Leask, 2011, Journal of Cell Communication and Signaling.

Mechanical Tension Increases CCN2/CTGF Expression and Proliferation in Gingival Fibroblasts via a TGFβ-Dependent Mechanism

A. Leask, D. Carter, Fen Guo, 2011, PloS one.

CCN2 is not required for skin development

Shangxin Liu, A. Leask, 2011, Journal of Cell Communication and Signaling.

CCN6 (WISP3): a new anti-cancer therapy?

A. Leask, 2010, Journal of Cell Communication and Signaling.

When there’s smoke there’s.....CCN2

A. Leask, 2010, Journal of Cell Communication and Signaling.

Yin and Yang Part Deux: CCN5 inhibits the pro-fibrotic effects of CCN2

A. Leask, 2010, Journal of Cell Communication and Signaling.

It’s a knockout: CCN3 suppresses neointimal thickening

A. Leask, 2010, Journal of Cell Communication and Signaling.

YANG PART DEUX CCN 5 INHIBITS THE PRO-FIBROTIC EFFECTS OF CCN 2

A. Leask, 2010 .

Getting to the heart of the matter: CCN2 plays a role in cardiomyocyte hypertrophy

A. Leask, 2009, Journal of Cell Communication and Signaling.

What’s in an intron? CCN1 mRNA splicing in cancer

A. Leask, 2009, Journal of Cell Communication and Signaling.

Pericytes display increased CCN2 expression upon culturing

D. Abraham, C. Denton, V. Rajkumar, 2009, Journal of Cell Communication and Signaling.

Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes.

A. Leask, J. Rockel, S. McLean, 2009, Osteoarthritis and cartilage.

Hijacking ZIP codes: posttanscriptional regulation of CCN2 by nucleophosmin

A. Leask, 2009, Journal of Cell Communication and Signaling.

CCN 3 INHIBITS THE PRO-FIBROTIC EFFECTS OF CCN 2

A. Leask, 2009 .

Focal Adhesion Kinase/Src Suppresses Early Chondrogenesis

K. Lyons, M. Kapoor, Shangxin Liu, 2008, Journal of Biological Chemistry.

CCN3: A novel function in vivo

A. Leask, 2007, Journal of Cell Communication and Signaling.

Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK

A. Leask, Melissa Pickles, 2007, Journal of Cell Communication and Signaling.

Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome.

P. Segarini, A. Leask, Y. Chen, 2001, Experimental cell research.

Connective tissue growth factor and integrin αvβ6: A new pair of regulators critical for ductular reaction and biliary fibrosis in mice

E. Scott, P. Weinreb, S. Violette, 2015, Hepatology.

Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor.

S. French, A. Leask, D. Brigstock, 2011, Journal of hepatology.

A sticky wicket: Overexpression of integrin alpha 11 is sufficient for cardiac fibrosis

A. Leask, 2018, Acta physiologica.

Focal Adhesion Kinase: A Key Mediator of Transforming Growth Factor Beta Signaling in Fibroblasts.

A. Leask, 2013, Advances in wound care.

Integrin β1 is required for maintenance of vascular tone in postnatal mice

Shangxin Liu, A. Leask, 2012, Journal of Cell Communication and Signaling.

Integrin β1 is necessary for the maintenance of corneal structural integrity.

S. Parapuram, Shangxin Liu, A. Leask, 2011, Investigative ophthalmology & visual science.

CCN2: a bona fide target for anti-fibrotic drug intervention

A. Leask, 2011, Journal of Cell Communication and Signaling.

Inflammatory microenvironment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts.

D. Hamilton, A. Leask, T. Forbes, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model.

M. Kapoor, D. Abraham, C. Denton, 2009, Arthritis and rheumatism.

Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of Ccn2

D. Abraham, George Bou-Gharios, A. Leask, 2020, Disease Models & Mechanisms.

Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of CCN2

D. Abraham, George Bou-Gharios, A. Leask, 2020, bioRxiv.

When there’s smoke there’s…scleroderma: evidence that patients with scleroderma should stop smoking

A. Leask, 2011, Journal of Cell Communication and Signaling.

GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.

J. Woodgett, M. Kapoor, D. Abraham, 2008, The Journal of clinical investigation.

Fixing a hole: CCN2 closes chronic wounds

A. Leask, 2015, Journal of Cell Communication and Signaling.

Gingival Fibroblasts Display Reduced Adhesion and Spreading on Extracellular Matrix: A Possible Basis for Scarless Tissue Repair?

A. Leask, D. Carter, Fen Guo, 2011, PloS one.

Matrix remodeling in systemic sclerosis

A. Leask, 2015, Seminars in Immunopathology.

CCN3: stopping that achy, breaky aorta

A. Leask, 2017, Journal of Cell Communication and Signaling.

Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2.

S. Parapuram, Shangxin Liu, A. Leask, 2013, Arthritis and rheumatism.

Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts

A. Leask, X. Shi-wen, R. Stratton, 2021, Journal of Cell Communication and Signaling.

Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism.

S. Parapuram, Shangxin Liu, A. Leask, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Loss of protein kinase C&egr; results in impaired cutaneous wound closure and myofibroblast function

Yunliang Chen, D. Abraham, C. Denton, 2014, Journal of Cell Science.

Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes.

A. Leask, J. Rockel, Matthew W. Grol, 2009, Matrix biology : journal of the International Society for Matrix Biology.

Egr-ly awaiting a “personalized medicine” approach to treat scleroderma

A. Leask, 2012, Journal of Cell Communication and Signaling.

Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus

C. Séguin, A. Leask, Jake Bedore, 2016, Journal of Cell Communication and Signaling.

CCN3: a novel anti-fibrotic treatment in end-stage renal disease?

A. Leask, 2012, Journal of Cell Communication and Signaling.

A NOVEL ANTI-FIBROTIC TREATMENT IN END-STAGE RENAL DISEASE ?

A. Leask, 2012 .

Periostin and CCN2 Scaffolds Promote the Wound Healing Response in the Skin of Diabetic Mice.

M. Drangova, J. Dunmore-Buyze, D. Hamilton, 2019, Tissue engineering. Part A.

Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

Arjun Deb, M. Rojas, M. Willis, 2012, The EMBO journal.

CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis

B. Hinz, Yizhi Xiao, W. Siqueira, 2019, Matrix biology plus.

The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology.

D. Abraham, A. Leask, 2003, Biochemistry and cell biology = Biochimie et biologie cellulaire.

TAK1 is required for dermal wound healing and homeostasis.

A. Leask, D. Carter, Fen Guo, 2013, The Journal of investigative dermatology.

TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma

S. Parapuram, C. Hutnik, M. Motolko, 2017, Scientific Reports.

Potential Therapeutic Targets for Cardiac Fibrosis: TGF&bgr;, Angiotensin, Endothelin, CCN2, and PDGF, Partners in Fibroblast Activation

A. Leask, 2010, Circulation research.

The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment

E. Drobetsky, A. Leask, C. Gerarduzzi, 2020, Cancer Research.

TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma

S. Parapuram, C. Hutnik, M. Motolko, 2017, Scientific Reports.

Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2.

C. Séguin, W. Sha, Shangxin Liu, 2013, Arthritis and rheumatism.

A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors.

A. Leask, 2019, Seminars in cell & developmental biology.

Eureka! Ets a target for fibrosis!

A. Leask, 2011, Journal of Cell Communication and Signaling.

CCN2 is required for bleomycin-induced skin fibrosis in mice.

D. Abraham, Shangxin Liu, A. Leask, 2011, Arthritis and rheumatism.

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

D. Abraham, C. Denton, A. Holmes, 2009, Arthritis and rheumatism.

The induction of CCN2 by TGFβ1 involves Ets-1

Andrew Leask, A. Leask, J. Rockel, 2006, Arthritis research & therapy.

Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK*

R. D. du Bois, J. Pearson, D. Abraham, 2004, Journal of Biological Chemistry.

Prostacyclin derivatives prevent the fibrotic response to TGFβ2 by inhibiting the Ras/MEK/ERK pathway

D. Abraham, V. Rajkumar, A. Leask, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Targeting the TGFbeta, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma.

A. Leask, 2008, Cellular signalling.

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair

D. Hamilton, Shiwen Xu, J. Guan, 2012, Journal of Cell Science.

Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes

M. Köbel, G. Lajoie, Guihua Zhang, 2021, Neoplasia.

Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes

M. Köbel, G. Lajoie, Guihua Zhang, 2020, bioRxiv.

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis.

D. Abraham, A. Leask, X. Shi-wen, 2008, Cytokine & growth factor reviews.

Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex

D. Geschwind, M. Sahin, A. Leask, 2017, The Journal of experimental medicine.

Insights into Fibroblast Plasticity: CCN2 Is Required for Activation of Cancer-Associated Fibroblasts in a Murine Model of Melanoma.

L. Postovit, Krista M. Vincent, A. Leask, 2019, The American journal of pathology.

Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer.

D. Abraham, C. Denton, D. Aden, 2008, Rheumatology.

Signaling in fibrosis: targeting the TGF beta, endothelin-1 and CCN2 axis in scleroderma.

A. Leask, 2009, Frontiers in bioscience.

Why target the tumor stroma in melanoma?

A. Leask, J. Hutchenreuther, 2018, Journal of Cell Communication and Signaling.

Expression of integrin β1 by fibroblasts is required for tissue repair in vivo

D. Abraham, C. Denton, T. Krieg, 2010, Journal of Cell Science.

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

A. Leask, K. Makino, M. Trojanowska, 2017, Arthritis Research & Therapy.

Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors

R. D. du Bois, J. Pearson, D. Abraham, 2006, Molecular and Cellular Biology.

Conditional knockout of CTGF affects corneal wound healing.

E. Scott, B. Petersen, G. Schultz, 2014, Investigative ophthalmology & visual science.

Andrew Leask CCN 2 , and PDGF , Partners in Fibroblast Activation , Angiotensin , Endothelin , β Potential Therapeutic Targets for Cardiac Fibrosis : TGF

A. Leask, 2010 .

TGFβ, cardiac fibroblasts, and the fibrotic response

A. Leask, 2007 .

Scar wars: is TGFβ the phantom menace in scleroderma?

A. Leask, 2006, Arthritis research & therapy.

Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis.

D. Abraham, C. Denton, A. Leask, 2010, The Journal of investigative dermatology.

CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis.

L. Postovit, Krista M. Vincent, A. Leask, 2015, The Journal of investigative dermatology.

CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts*

Yunliang Chen, K. Lyons, J. Pearson, 2006, Journal of Biological Chemistry.

β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function

Shangxin Liu, A. Leask, Rennian Wang, 2013, Laboratory Investigation.

Emerging targets for the treatment of scleroderma

A. Leask, 2012, Expert opinion on emerging drugs.

Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

Yunliang Chen, D. Pennington, D. Abraham, 2002 .

Genetic manipulation of CCN2/CTGF unveils cell‐specific ECM‐remodeling effects in injured skeletal muscle

A. Leask, Federica Accornero, Jennifer Petrosino, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Rac1 expression by fibroblasts is required for tissue repair in vivo.

M. Kapoor, Shangxin Liu, A. Leask, 2009, The American journal of pathology.

Will o’ the wisp: CCN4 as a novel molecular target in osteoarthritis

A. Leask, 2011, Journal of Cell Communication and Signaling.

Connective tissue growth factor promoter activity in normal and wounded skin

S. Parapuram, M. Kapoor, Shangxin Liu, 2008, Fibrogenesis & tissue repair.

A tale of two orgins: do myofibroblasts originate from different sources in wound healing and fibrosis?

A. Leask, J. Hutchenreuther, 2016, Cell and Tissue Research.

TGFbeta, cardiac fibroblasts, and the fibrotic response.

A. Leask, 2007, Cardiovascular research.

CCN2 YAPs at cancer

A. Leask, 2008, Journal of Cell Communication and Signaling.

Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice.

M. Glogauer, M. Kapoor, D. Abraham, 2008, Arthritis and rheumatism.

Tumor-Associated Fibrosis Impairs the Response to Immunotherapy.

A. Leask, Angha Naik, 2023, Matrix biology : journal of the International Society for Matrix Biology.

ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts

A. Leask, K. Thompson, Hannah Murphy-Marshman, 2014, Journal of Cell Communication and Signaling.

CCN2: a mechanosignaling sensor modulating integrin-dependent connective tissue remodeling in fibroblasts?

A. Leask, 2013, Journal of Cell Communication and Signaling.

CCN2 in Skin Fibrosis.

A. Leask, 2017, Methods in molecular biology.

CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair

A. Leask, M. Tsang, 2015, Journal of Cell Communication and Signaling.

Fixing a hole: CCN2 closes chronic wounds

A. Leask, 2015, Journal of Cell Communication and Signaling.

Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function

A. Leask, M. Nystoriak, Matthew A. Nystoriak, 2022, Matrix biology : journal of the International Society for Matrix Biology.

CCN2: a novel, specific and valid target for anti-fibrotic drug intervention

A. Leask, 2013, Expert opinion on therapeutic targets.

Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-β2 in fibroblasts. Vol. 278 (2003) 13008–13015

D. Abraham, A. Holmes, A. Leask, 2005 .

CCN6: a novel method of aTAKing cancer

A. Leask, 2013, Journal of Cell Communication and Signaling.

Breathe, breathe in the air: the anti-CCN2 antibody pamrevlumab (FG-3019) completes a successful phase II clinical trial for idiopathic pulmonary fibrosis

A. Leask, 2019, Journal of cell communication and signaling.

Modeling the microenvironment special issue

A. Leask, 2022, Journal of cell communication and signaling.

Mithramycin reduces expression of fibro‐proliferative mRNAs in human gingival fibroblasts

A. Leask, S. Liu, K. Thompson, 2011, Cell proliferation.

Tripterygium wilfordii derivative celastrol, a YAP inhibitor, has antifibrotic effects in systemic sclerosis

John Nguyen, J. Biernaskie, A. Leask, 2023, Annals of the Rheumatic Diseases.

Yin and Yang revisited: CCN3 as an anti-fibrotic therapeutic?

A. Leask, 2015, Journal of Cell Communication and Signaling.

Slow train coming: an anti-CCN2 strategy reverses a model of chronic overuse muscle fibrosis

A. Leask, 2020, Journal of Cell Communication and Signaling.

GSK-3b in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1– dependent mechanism

J. Woodgett, M. Kapoor, D. Abraham, 2018 .

CTGF(CCN2) is essential for fibroblast function

K. Lyons, D. Abraham, A. Leask, 2006 .

Matrix remodeling in systemic sclerosis

A. Leask, 2015, Seminars in Immunopathology.

Toward personalized medicine in scleroderma: classification of scleroderma patients into stable "inflammatory" and "fibrotic" subgroups.

A. Leask, 2012, The Journal of investigative dermatology.

COVID-19: is fibrosis the killer?

A. Leask, 2020, Journal of Cell Communication and Signaling.

HIJACKING ZIPCODES : POSTTANSCRIPTIONAL REGULATION OF CCN 2 BY NUCLEOPHOSIN

A. Leask, 2008 .

Sticking it to Scleroderma: Potential Therapies Blocking Elevated Adhesive and Contractile Signaling

A. Leask, 2010 .

Matrix Contraction by Dermal Fibroblasts Requires Transforming Growth Factor-β/Activin-Linked Kinase 5, Heparan Sulfate-Containing Proteoglycans, and MEK/ERK

Yunliang Chen, D. Abraham, E. Renzoni, 2005 .

Why target the tumor stroma in melanoma?

A. Leask, J. Hutchenreuther, 2017, Journal of cell communication and signaling.

Potential Therapeutic Targets for Cardiac Fibrosis: TGF&bgr;, Angiotensin, Endothelin, CCN2, and PDGF, Partners in Fibroblast Activation

A. Leask, 2010, Circulation research.

Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data

C. Greenwood, M. Hudson, Yixiao Zeng, 2023, Clinical Epigenetics.

Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor.

S. French, A. Leask, D. Brigstock, 2011, Journal of hepatology.

Egr-ly awaiting a “personalized medicine” approach to treat scleroderma

A. Leask, 2012, Journal of Cell Communication and Signaling.

CCN3: a novel anti-fibrotic treatment in end-stage renal disease?

A. Leask, 2012, Journal of Cell Communication and Signaling.

Yin and Yang revisited: CCN3 as an anti-fibrotic therapeutic?

A. Leask, 2015, Journal of Cell Communication and Signaling.

Loss of PPARγ expression by fibroblasts enhances dermal wound closure

M. Baron, W. Sha, A. Leask, 2012, Fibrogenesis & tissue repair.

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair

D. Hamilton, Shiwen Xu, J. Guan, 2012, Journal of Cell Science.

CCN2: a bona fide target for anti-fibrotic drug intervention

A. Leask, 2011, Journal of Cell Communication and Signaling.

Fibroblast adhesion results in the induction of a matrix remodeling gene expression program.

D. Abraham, A. Leask, D. Carter, 2008, Matrix biology : journal of the International Society for Matrix Biology.

Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.

D. Abraham, C. Denton, A. Leask, 2004, The Journal of investigative dermatology.

Skin Progenitor Cells Contribute to Bleomycin‐Induced Skin Fibrosis

Y. Hérault, G. Pavlovic, Shangxin Liu, 2014, Arthritis & rheumatology.

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.

M. Baron, D. Abraham, C. Denton, 2012, Rheumatology.

MEK/ERK inhibitors: proof-of-concept studies in lung fibrosis

A. Leask, 2012, Journal of Cell Communication and Signaling.

Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2.

S. Parapuram, Shangxin Liu, A. Leask, 2013, Arthritis and rheumatism.

Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism.

S. Parapuram, Shangxin Liu, A. Leask, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Conditional β1‐integrin‐deficient mice display impaired pancreatic β cell function

Shangxin Liu, A. Leask, Rennian Wang, 2011, The Journal of pathology.

Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element

Shaoqiong Chen, A. Leask, 2009, Journal of Cell Communication and Signaling.

Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

Arjun Deb, M. Rojas, M. Willis, 2012, The EMBO journal.

Activation of latent TGFβ by αvβ1 integrin: of potential importance in myofibroblast activation in fibrosis

A. Leask, J. Hutchenreuther, 2014, Journal of Cell Communication and Signaling.

Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts.

A. Leask, D. J. Abraham, X. Shiwen, 2000, The Journal of biological chemistry.

CCN6: a modulator of breast cancer progression

A. Leask, 2016, Journal of Cell Communication and Signaling.

CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload.

M. Brans, M. Vos, T. V. van Veen, 2015, Journal of molecular and cellular cardiology.

Getting to the heart of the matter: new insights into cardiac fibrosis.

A. Leask, 2015, Circulation research.

Abstract 1219: The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.

Saptarsi M. Haldar, A. Leask, Baiqiu Wang, 2006 .

Sonic advance: CCN1 regulates sonic hedgehog in pancreatic cancer

A. Leask, 2012, Journal of Cell Communication and Signaling.

What a long, strange trip it’s been

A. Leask, 2020, Journal of Cell Communication and Signaling.