R. Boyce

发表

Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth)

A. Bendele, S. Fossey, B. Bolon, 2016, Journal of toxicologic pathology.

The Conneulor: unbiased estimation of connectivity using physical disectors under projection.

J R Nyengaard, R W Boyce, J. Nyengaard, 1993, Bone.

Recommendations for the Evaluation of Pathology Data in Nonclinical Safety Biomarker Qualification Studies

K. Pandher, R. Boyce, T. Zabka, 2011, Toxicologic pathology.

BACKGROUND INFORMATION TO SUPPORT BEST PRACTICES IN THE HISTOPATHOLOGY EVALUATION OF NONCLINICAL SAFETY BIOMARKER QUALIFICATION STUDIES Role of Bias in Biomarker Evaluation

K. Pandher, R. Boyce, T. Zabka, 2011 .

Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow

Viviana Gradinaru, Alon Greenbaum, Tatyana Dobreva, 2017, Science Translational Medicine.

Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats

Yudong D. He, P. Nioi, H. Hamadeh, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The effects of risedronate on canine cancellous bone remodeling: Three‐dimensional kinetic reconstruction of the remodeling site

R. Boyce, R. Boyce, E. Eriksen, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Preliminary Comparison of Quantity, Quality, and Microarray Performance of RNA Extracted From Formalin-fixed, Paraffin-embedded, and Unfixed Frozen Tissue Samples

R. Boyce, M. Scicchitano, Roberta A. Thomas, 2006, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Sustained Modeling‐Based Bone Formation During Adulthood in Cynomolgus Monkeys May Contribute to Continuous BMD Gains With Denosumab

P. Kostenuik, R. Baron, D. Dempster, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin

Yudong D. He, Troy E. Barger, S. Elliott, 2014, Toxicologic pathology.

Genetic and atherosclerotic plaque immunohistochemical analyses do not associate reduced sclerostin expression with cardiovascular events

James R. Staley, G. Pasterkamp, J. Staley, 2020, medRxiv.

Contrasting effects of parathyroid hormone and insulin‐like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis

R. Boyce, M. Jankowsky, S. D'souza, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Sequential histomorphometric changes in cancellous bone from ovariohysterectomized dogs

J. Bevan, R. Boyce, M. Jankowsky, 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys

Susan Y. Smith, S. Boyd, I. Pyrah, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reproductive toxicity of denosumab in cynomolgus monkeys.

D. Branstetter, I. Pyrah, R. Boyce, 2013, Reproductive toxicology.

In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-&ggr; Agonist Rosiglitazone

W. Bao, T. Yue, Jun Chen, 2001, Circulation.

Yudong D. He, Troy E. Barger, S. Elliott, 2014, Toxicologic pathology.

Evaluation of Sinclair Miniature Swine as an Osteopenia Model

C. Reddy, R. Boyce, C. Paddock, 1996 .

Antiresorptive drugs and trabecular bone turnover: Validation and testing of a computer model

J. Bevan, R. Boyce, M. E. Lacy, 1994, Calcified Tissue International.

Application of Histopathology and Bone Histomorphometry for Understanding Test Article-Related Bone Changes and Assessing Potential Bone Liabilities

R. Erben, R. Boyce, J. Jolette, 2017 .

Modeling‐Based Bone Formation After 2 Months of Romosozumab Treatment: Results From the FRAME Clinical Trial

Jacques P. Brown, R. Chapurlat, P. Chavassieux, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Resorption is not essential for the stimulation of bone growth by hPTH‐(1‐34) in rats in vivo

R. Boyce, J. Hock, L. Raisz, 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Histogenesis of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.

R. Boyce, S. Weisbrode, 1985, Bone.

Systemic Administration of Acidic Fibroblast Growth Factor (FGF‐1) Prevents Bone Loss and Increases New Bone Formation in Ovariectomized Rats

G. Mundy, B. Boyce, I. Garrett, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Activation of Peroxisome Proliferator–Activated Receptor- (cid:1) Protects the Heart From Ischemia/Reperfusion Injury

W. Bao, R. Mirabile, T. Yue, 2003 .

Activation of Peroxisome Proliferator–Activated Receptor-&agr; Protects the Heart From Ischemia/Reperfusion Injury

W. Bao, R. Mirabile, T. Yue, 2003, Circulation.

Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury.

W. Bao, R. Mirabile, R. Willette, 2004, Cardiovascular research.

/ Reperfusion Injury Protects the Heart From α Activated Receptor-− Activation of Peroxisome Proliferator

Jian-qi, W. Bao, R. Mirabile, 2003 .

p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 2. Improved Renal Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging

S. Nerurkar, R. Mirabile, R. Willette, 2003, Journal of Pharmacology and Experimental Therapeutics.

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

M. Stolina, N. Chinookoswong, M. Véniant, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

FGF 21 is not a major mediator for bone homeostasis or metabolic actions of PPAR and PPAR agonists † Running Title : FGF 21 on bone and actions of PPAR PPAR

M. Stolina, N. Chinookoswong, M. Véniant, 2016 .

Ultrastructural development of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.

R. Boyce, S. Weisbrode, O. Kindig, 1985, Bone.

Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.

I. Pyrah, R. Boyce, G. Chellman, 2014, Bone.

Topic of Histopathology Blinding in Nonclinical Safety Biomarker Qualification Studies

K. Pandher, R. Boyce, T. Zabka, 2010, Toxicologic pathology.

OPG‐Fc but Not Zoledronic Acid Discontinuation Reverses Osteonecrosis of the Jaws (ONJ) in Mice

S. Dry, P. Kostenuik, R. Boyce, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Society of Toxicologic Pathology Position Paper: Review Series: Assessment of Circulating Hormones in Nonclinical Toxicity Studies: General Concepts and Considerations

C. Wood, T. Rosol, M. Gilbert, 2012, Toxicologic pathology.

Bone Therapeutics: Safety Considerations, Session Summary

R. Boyce, C. Jerome, 2017, Toxicologic pathology.

Target Gene Localization Using Laser-Capture Microdissection and Real-Time Reverse Transcription-Polymerase Chain Reaction Analysis

L. Tierney, R. Boyce, M. Scicchitano, 2005 .

p38 MAPK Inhibition Reduces Aortic Ultrasmall Superparamagnetic Iron Oxide Uptake in a Mouse Model of Atherosclerosis: MRI Assessment

R. Mirabile, R. Willette, R. Boyce, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study.

Susan Y. Smith, P. Mann, I. Pyrah, 2016, Regulatory toxicology and pharmacology : RTP.

Histologic and Immunocytochemical Characterization of Canine Distemper-associated Metaphyseal Bone Lesions in Young Dogs Following Experimental Infection

M. Axthelm, W. Baumgärtner, R. Boyce, 1995, Veterinary pathology.

Local Effects Following Single and Repeat Intra-Articular Injections of Triamcinolone Acetonide Extended-Release: Results from Three Nonclinical Toxicity Studies in Dogs

V. Strand, R. Boyce, N. Bodick, 2018, Rheumatology and Therapy.

Novel Vascular Lesions in Mice Given a Non-Peptide Vitronectin Receptor Antagonist

R. Mirabile, S. Rehm, R. Boyce, 2007, Toxicologic pathology (Print).

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

B F Boyce, T. Yoneda, G. Mundy, 1995, Cancer research.

Effects of p38 MAP Kinase Inhibitors on the Differentiation and Maturation of Erythroid Progenitors

L. Schwartz, L. Tierney, R. Boyce, 2008, Toxicologic pathology.

An essential role for ectodomain shedding in mammalian development.

David C. Lee, S. Sunnarborg, W. Russell, 1998, Science.

Cloning, expression, and initial characterization of a novel cytokine-like gene family.

Michael A. Briggs, G. Rose, B. Wolf, 2002, Genomics.

Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans

James R. Staley, G. Pasterkamp, C. Vangjeli, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.

Yudong D. He, C. Afshari, P. Nioi, 2016, Bone.

Protein Extraction of Formalin-fixed, Paraffin-embedded Tissue Enables Robust Proteomic Profiles by Mass Spectrometry

Heath C. Thomas, R. Boyce, M. Scicchitano, 2009, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Inhibition of ALK5 Signaling Induces Physeal Dysplasia in Rats

R. Mirabile, N. Laping, R. Boyce, 2007, Toxicologic pathology.

Clinically Relevant Doses of Sclerostin Antibody Do Not Induce Osteonecrosis of the Jaw (ONJ) in Rats with Experimental Periodontitis

S. Dry, M. Stolina, R. Boyce, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effects of sclerostin antibodies in animal models of osteoporosis.

R. Boyce, H. Ke, M. Ominsky, 2017, Bone.

Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats.

M. Stolina, I. Pyrah, R. Boyce, 2015, Bone.

Role of p38 in regulation of hematopoiesis: effect of p38 inhibition on cytokine production and transcription factor activity in human bone marrow stromal cells.

L. Schwartz, L. Tierney, Heath C. Thomas, 2008, Blood cells, molecules & diseases.

Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.

Yudong D. He, L. D. Ward, M. Guillot, 2020, Regulatory toxicology and pharmacology : RTP.

Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats

R. Hu, I. Pyrah, R. Boyce, 2018, Bone reports.

Bone‐Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment

Jacques P. Brown, A. Grauer, R. Chapurlat, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection.

M. Axthelm, W. Baumgärtner, R. Boyce, 1995, Veterinary microbiology.

Stereological Solutions for Common Quantitative Endpoints in Neurotoxicology

H. Gundersen, R. Boyce, L. Lyck, 2011 .

Efficacy and Safety of FX201, a Novel Intra-Articular IL-1Ra Gene Therapy for Osteoarthritis Treatment, in a Rat Model

R. Boyce, N. Bodick, Agathe Bédard, 2021, Human gene therapy.

Effects of Food Restriction on Testis and Accessory Sex Glands in Maturing Rats

S. Rehm, R. Boyce, D. Stanislaus, 2008, Toxicologic pathology.

Design-based Stereology

Rogely Waite Boyce, Karl-Anton Dorph-Petersen, Lise Lyck, 2010, Toxicologic pathology.

Transcriptional Profiling of Laser Capture Microdissected Rat Arterial Elements: Fenoldopam-induced Vascular Toxicity as a Model System

R. Mirabile, L. Schwartz, Heath C. Thomas, 2008, Toxicologic pathology.

NE-58095: a diphosphonate which prevents bone erosion and preserves joint architecture in experimental arthritis.

R. Boyce, M. Francis, K. Hovancik, 1989, International journal of tissue reactions.

Effects of intermittent hPTH(1–34) alone and in combination with 1,25(OH)2d3 or risedronate on endosteal bone remodeling in canine cancellous and cortical bone

R. Boyce, E. Eriksen, M. Jankowsky, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Evaluation of the skeletal effects of combined mild dietary calcium restriction and ovariectomy in sinclair S‐1 minipigs: A pilot study

L. Mosekilde, R. Boyce, C. Danielsen, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Kinetic reconstruction reveals time-dependent effects of romosozumab on bone formation and osteoblast function in vertebral cancellous and cortical bone in cynomolgus monkeys.

R. Boyce, M. Ominsky, Q. Niu, 2017, Bone.

Unbiased estimation of vertebral trabecular connectivity in calcium-restricted ovariectomized minipigs.

H J Gundersen, R W Boyce, H. Gundersen, 1995, Bone.

Direct stereological estimation of three-dimensional connectivity in rat vertebrae: effect of estrogen, etidronate and risedronate following ovariectomy.

H J Gundersen, R W Boyce, H. Gundersen, 1995, Bone.

Stochastic simulation of vertebral trabecular bone remodeling.

E Mosekilde, R W Boyce, J S Thomsen, 1994, Bone.

854 SGN-B7H4V, a novel, investigational vedotin antibody-drug conjugate directed to the T cell checkpoint ligand B7-H4, shows promising activity in preclinical models

P. Treuting, R. Boyce, Jason P. Schrum, 2021, Journal for ImmunoTherapy of Cancer.

Extensive modeling-based bone formation after 2 months of romosozumab treatment: Results from the FRAME clinical trial

Jacques P. Brown, R. Chapurlat, P. Chavassieux, 2020 .

Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody

I. Pyrah, R. Boyce, M. Ominsky, 2018, Bone reports.

Stereological Principles and Sampling Procedures for Toxicologic Pathologists

Hans Jørgen G. Gundersen, Rosanna C. Mirabile, Danielle L. Brown, 2013 .

Validation of wall thickness estimates obtained with polarized light microscopy using multiple fluorochrome labels: correlation with erosion depth estimates obtained by lamellar counting.

R. Boyce, C. Paddock, E. Eriksen, 1995, Bone.

Automation of Nonisotopic In Situ Hybridization

L. Schwartz, L. Tierney, R. Boyce, 2003 .

Cloning, expression, and pharmacological characterization of a novel human histamine receptor.

C. M. Davenport, H. Sarau, R. Ames, 2001, Molecular pharmacology.

Effects of p38 MAP Kinase Inhibitors on the Differentiation and Maturation of Erythroid Progenitors

L. Schwartz, L. Tierney, R. Boyce, 2008, Toxicologic pathology (Print).

Direct stereological estimation of 3-D connectivity density in human iliac cancellous bone: the effect of age and sex

H. Gundersen, L. Mosekilde, R. Boyce, 1994 .

Reconstruction of Remodeling units reveals positive effects after 2 and 12 months of Romosozumab treatment.

R. Boyce, M. Oates, Donald Betah, 2024, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inhibition of both sclerostin and DKK1 results in novel skull findings in the rat and non-human primate that is not observed with inhibition of sclerostin alone.

R. Boyce, M. Felx, Jean Guy Bienvenu, 2023, Bone.