T. Baasov

发表

Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells

O. Namy, L. Bidou, Olivier Bugaud, 2017, RNA biology.

Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

P. Huppke, H. Werner, J. Gärtner, 2010, Journal of Molecular Medicine.

New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism

R. Palmiter, V. Belakhov, T. Baasov, 2016, Proceedings of the National Academy of Sciences.

Crystal structure and snapshots along the reaction pathway of a family 51 α‐L‐arabinofuranosidase

Dietmar Schomburg, D. Schomburg, G. Shoham, 2003 .

Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples.

V. Belakhov, T. Baasov, Jeyakumar Kandasamy, 2013, Journal of pharmaceutical and biomedical analysis.

CC Stretching Frequencies in Model Compounds of the Protonated Retinal Schiff Base

M. Sheves, T. Baasov, 1984 .

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

J. Schacht, D. S. Pilch, V. Belakhov, 2009, Journal of medicinal chemistry.

When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.

T. Baasov, M. Shalev, 2014, MedChemComm.

Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations.

V. Belakhov, T. Baasov, Igor Nudelman, 2010, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics.

V. Belakhov, T. Baasov, S. Yaron, 2009, Journal of medicinal chemistry.

Methyl 2,3‐dideoxy‐2‐S‐methylmercurio‐2‐thio‐β‐d‐manno‐oct‐2‐ulopyranosonate‐(2,6)

V. Belakhov, T. Baasov, M. Botoshansky, 2002 .

The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse.

D. Bedwell, K. Keeling, Dan Wang, 2012, Molecular genetics and metabolism.

Crystallization and preliminary X-ray analysis of a family 51 glycoside hydrolase, the alpha-l-arabinofuranosidase from Geobacillus stearothermophilus T-6.

D. Schomburg, G. Shoham, Y. Shoham, 2003, Acta crystallographica. Section D, Biological crystallography.

The identification of the acid–base catalyst of α‐arabinofuranosidase from Geobacillus stearothermophilus T‐6, a family 51 glycoside hydrolase

G. Shoham, Y. Shoham, V. Belakhov, 2002, FEBS letters.

Detailed Kinetic Analysis and Identification of the Nucleophile in α-l-Arabinofuranosidase from Geobacillus stearothermophilus T-6, a Family 51 Glycoside Hydrolase*

G. Shoham, Y. Shoham, V. Belakhov, 2002, The Journal of Biological Chemistry.

Stereochemistry of family 52 glycosyl hydrolases: a β‐xylosidase from Bacillus stearothermophilus T‐6 is a retaining enzyme

G. Shoham, Y. Shoham, T. Bravman, 2001, FEBS letters.

Glutamic acid 160 is the acid‐base catalyst of β‐xylosidase from Bacillus stearothermophilus T‐6: a family 39 glycoside hydrolase

G. Shoham, Y. Shoham, A. Mechaly, 2001, FEBS letters.

Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.

J. Schacht, D. Bedwell, Liping Tang, 2014, American journal of respiratory cell and molecular biology.

A snapshot of enzyme catalysis using electrospray ionization mass spectrometry.

K. Anderson, C. Whitehouse, Zhili Li, 2003, Journal of the American Chemical Society.

The trans-Anethole Degradation Pathway in an Arthrobacter sp.*

U. Ravid, Y. Shoham, E. Shimoni, 2002, The Journal of Biological Chemistry.

Biotransformations of propenylbenzenes by an Arthrobacter sp. and its t-anethole blocked mutants.

U. Ravid, Y. Shoham, E. Shimoni, 2003, Journal of biotechnology.

Long-term nonsense suppression therapy moderates MPS I-H disease progression.

T. Schoeb, D. Bedwell, K. Keeling, 2014, Molecular genetics and metabolism.

Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations.

V. Belakhov, T. Baasov, E. Shulman, 2012, Journal of medicinal chemistry.

Erratum to: Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

P. Huppke, H. Werner, J. Gärtner, 2013, Journal of Molecular Medicine.

Ex Vivo Treatment with a Novel Synthetic Aminoglycoside NB54 in Primary Fibroblasts from Rett Syndrome Patients Suppresses MECP2 Nonsense Mutations

N. Amariglio, G. Rechavi, A. Simon, 2011, PloS one.

A synthetic pentasaccharide with GTPase activity.

M. Fridman, T. Baasov, J. Zhang, 2001, Organic letters.

Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression

D. Bedwell, K. Keeling, S. Velu, 2013, PloS one.

Repairing faulty genes by aminoglycosides: Identification of new pharmacophore with enhanced suppression of disease-causing nonsense mutations

V. Belakhov, T. Baasov, Jeyakumar Kandasamy, 2011 .

Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor.

Chi‐Huey Wong, M. Fridman, Lac V. Lee, 2005, Angewandte Chemie.

Aminoglycosides Affect Intracellular Salmonella enterica Serovars Typhimurium and Virchow

T. Baasov, S. Yaron, O. Menashe, 2008, Antimicrobial Agents and Chemotherapy.

Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54

Z. Bebők, D. Bedwell, E. Schwiebert, 2011, Journal of Molecular Medicine.

A Reciprocal Single Mutation Affects the Metal Requirement of 3-Deoxy-d-manno-2-octulosonate-8-phosphate (KDO8P) Synthases from Aquifex pyrophilus and Escherichia coli*

K. Anderson, N. Adir, Y. Shoham, 2004, Journal of Biological Chemistry.

Binding of the natural substrates and products to KDO8P synthase: 31P and 13C solution NMR characterization.

L. Kaustov, T. Baasov, A. Schmidt, 2003, Bioorganic chemistry.

Catalytic mechanism of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase. The use of synthetic analogues to probe the structure of the putative reaction intermediate.

V. Belakhov, T. Baasov, A. Kohen, 1993, European journal of biochemistry.

Mechanistic studies of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase from Escherichia coli.

T. Baasov, A. Kohen, A. Jakob, 1992, European journal of biochemistry.

Towards Catalytic Antibiotics: Redesign of Aminoglycosides To Catalytically Disable Bacterial Ribosomes

J. Trylska, T. Pieńko, V. Belakhov, 2019, Chembiochem : a European journal of chemical biology.

A combined chemical-enzymatic synthesis of a new phosphoramidate analogue of phosphoenolpyruvate

T. Baasov, S. Sheffer-Dee-Noor, 1993 .

Biochemical characterization and identification of catalytic residues in alpha-glucuronidase from Bacillus stearothermophilus T-6.

G. Shoham, Y. Shoham, T. Baasov, 2001, European journal of biochemistry.

Biochemical characterization and identification of the catalytic residues of a family 43 beta-D-xylosidase from Geobacillus stearothermophilus T-6.

D. Schomburg, G. Shoham, Y. Shoham, 2005, Biochemistry.

Towards the development of novel antibiotics: synthesis and evaluation of a mechanism-based inhibitor of Kdo8P synthase.

H. Faiger, S. Du, V. Belakhov, 1999, Bioorganic & medicinal chemistry.

Alteration of pKa of the bacteriorhodopsin protonated Schiff base. A study with model compounds

M. Sheves, T. Baasov, 1986 .

Insight into the catalytic mechanism of KDO8P synthase. Synthesis and evaluation of the isosteric phosphonate mimic of the putative cyclic intermediate

V. Belakhov, T. Baasov, S. Sheffer-Dee-Noor, 1993 .

Dynamic Intramolecular Cap for Preserving Metallodrug Integrity—A Case of Catalytic Fluoroquinolones

T. Pieńko, V. Belakhov, T. Baasov, 2022, Journal of medicinal chemistry.

Synthesis of novel phosphonate analogue of Kdo as a tool for the design of potent inhibitors for lipopolysaccharide biosynthesis

V. Belakhov, T. Baasov, S. Sheffer-Dee-Noor, 1994 .

Synthesis and evaluation of putative oxocarbenium intermediate mimic in the KDO8P synthase-catalyzed reaction as a tool for the design of potent inhibitors for lipopolysaccharide biosynthesis

S. Du, T. Baasov, Hana Tsipori, 1997 .

Programmable One‐Pot Oligosaccharide Synthesis.

Chi-Huey Wong, I. Ollmann, Chi‐Huey Wong, 1999 .

Synthesis and evaluation of a mechanism-based inhibitor of KDO8P synthase.

Y. Shoham, V. Belakhov, T. Baasov, 2002, Carbohydrate research.

Factors affecting the C = N stretching in protonated retinal Schiff base: a model study for bacteriorhodopsin and visual pigments.

M. Sheves, T. Baasov, N. Friedman, 1987, Biochemistry.

Cloning, expression, and biochemical characterization of 3-deoxy-d-manno-2-octulosonate-8-phosphate (KDO8P) synthase from the hyperthermophilic bacterium Aquifex pyrophilus

Y. Shoham, T. Baasov, E. Rabkin, 2003, Extremophiles.

Towards a new class of synthetic antibacterials acting on lipopolysaccharide biosynthesis

V. Belakhov, T. Baasov, 2000 .

Catalytic mechanism of KDO8P synthase: synthesis and evaluation of a putative reaction intermediate

Y. Benenson, F. D’Souza, T. Baasov, 1997 .

Catalytic mechanism of KDO8P synthase. Pre-steady-state kinetic analysis using rapid chemical quench flow methods

K. Anderson, P. Liang, T. Baasov, 1997 .

1-(Dihydroxyphosphynyl)vinyl phosphate: The phosphonate analogue of phosphoenolpyruvate is a pH-dependent substrate of Kdo8P synthase

Y. Benenson, V. Belakhov, T. Baasov, 1996 .

Towards the synthesis of the putative reaction intermediate in the Kdo8P synthase-catalyzed reaction. Synthesis and evaluation of 3-deoxy--manno-2-octulosonate-2-phosphate

V. Belakhov, T. Baasov, A. Kohen, 1994 .

Cross-utilization of β-galactosides and cellobiose in Geobacillus stearothermophilus

R. Salama, S. Lansky, G. Shoham, 2020, The Journal of Biological Chemistry.

Model compounds for the study of spectroscopic properties of visual pigments and bacteriorhodopsin

M. Sheves, T. Baasov, Mordechai Sheves, 1985 .

A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway.

Tami D. Lieberman, R. Kishony, T. Lieberman, 2016, Molecular biology and evolution.

One-pot synthesis of glucosamine oligosaccharides.

M. Fridman, T. Baasov, D. Solomon, 2002, Organic letters.

Factors affecting the rate of thermal isomerization of 13-cis-bacteriorhodopsin to all trans

M. Sheves, T. Baasov, 1984 .

C:C STRETCHING VIBRATIONAL FREQUENCIES IN THE MODEL COMPOUNDS OF PROTONATED SCHIFF BASES OF RETINAL

M. Sheves, T. Baasov, 1985 .

A blue shift of protonated retinal schiff base. A model study for bacteriorhodopsin

M. Sheves, T. Baasov, 1983 .

Family of thiomercuric derivatives of sugars: synthesis, fungicidal/herbicidal activity, and application to the X-ray structure determination of the corresponding enzymes.

G. Shoham, Y. Shoham, T. Bravman, 2000 .

Interactions between protonated retinal schiff base and various counter ions: A study by two‐dimensional NOE NMR spectroscopy

R. Ghirlando, M. Sheves, T. Baasov, 1987 .

Identification of the Catalytic Residues in Family 52 Glycoside Hydrolase, a β-Xylosidase from Geobacillus stearothermophilus T-6*

B. Henrissat, G. Shoham, Y. Shoham, 2003, Journal of Biological Chemistry.

On the Absorption Maxima of Protonated Retinal Schiff Bases. An Interaction with External Charges

M. Sheves, T. Baasov, 1985 .

Probing the binding site of bacteriorhodopsin with a fluorescent chromophore

M. Sheves, T. Baasov, 1987 .

Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives.

M. Fridman, V. Belakhov, T. Baasov, 2005, Bioorganic & medicinal chemistry.

A new class of branched aminoglycosides: pseudo-pentasaccharide derivatives of neomycin B.

M. Fridman, V. Belakhov, T. Baasov, 2003, Organic letters.

On the binding site of bacteriorhodopsin: a study with artificial pigments

M. Sheves, B. Ehrenberg, N. Friedman, 1984 .

ON THE BINDING SITE OF BACTERIORHODOPSIN. A STUDY WITH ARTIFICIAL PIGMENTS

M. Sheves, B. Ehrenberg, N. Friedman, 1984 .

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.

T. Baasov, Igor Nudelman, Mariana Hainrichson, 2008, Organic & biomolecular chemistry.

Structure-toxicity relationship of aminoglycosides: correlation of 2'-amine basicity with acute toxicity in pseudo-disaccharide scaffolds.

A. Mor, T. Baasov, S. Yaron, 2008, Bioorganic & medicinal chemistry.

Aminoglycosides : Redesign Strategies for Improved Antibiotics and Compounds for Treatment of Human Genetic Diseases

T. Baasov, Igor Nudelman, Jeyakumar Kandasamy, 2010 .

Combined Chemical‐Enzymatic Assembly of Aminoglycoside Derivatives with N‐1‐AHB Side Chain

T. Baasov, Igor Nudelman, Marina Cherniavsky, 2008 .

Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.

V. Belakhov, T. Baasov, M. Shavit, 2017, Bioorganic & medicinal chemistry.

Overexpression and Initial Characterization of the Chromosomal Aminoglycoside 3′-O-Phosphotransferase APH(3′)-IIb from Pseudomonas aeruginosa

T. Baasov, S. Yaron, Igor Nudelman, 2006, Antimicrobial Agents and Chemotherapy.

Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations.

T. Baasov, Igor Nudelman, T. Ben‐Yosef, 2006, Bioorganic & medicinal chemistry letters.

Post-transcriptionally Regulated Expression System in Human Xenogeneic Transplantation Models.

Y. Ron, J. Dougherty, Chiann-Chyi Chen, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations.

Narayana Murthy Sabbavarapu, V. Belakhov, T. Baasov, 2016, ACS medicinal chemistry letters.

Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics

J. Schacht, H. Rozenberg, N. Adir, 2015, Nucleic acids research.

Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity

J. Schacht, E. Meyron-Holtz, V. Belakhov, 2013, The Journal of Biological Chemistry.

In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome

Z. Ahmed, T. Baasov, Igor Nudelman, 2007, Human Genetics.

Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs)

U. Wolfrum, K. Nagel-Wolfrum, T. Baasov, 2016, BioDrugs.

Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites

E. Westhof, J. Kondo, D. S. Pilch, 2007, Chembiochem : a European journal of chemical biology.

Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives.

Narayana Murthy Sabbavarapu, J. Trylska, T. Pieńko, 2018, MedChemComm.

Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs)

U. Wolfrum, K. Nagel-Wolfrum, T. Baasov, 2016, BioDrugs.

Therapy strategies for Usher syndrome Type 1C in the retina.

U. Wolfrum, K. Nagel-Wolfrum, T. Baasov, 2014, Advances in experimental medicine and biology.

A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation

U. Wolfrum, N. Overlack, T. Goldmann, 2012, EMBO molecular medicine.

Beneficial read-through of a USH1C nonsense mutation by designed aminoglycoside NB30 in the retina.

U. Wolfrum, N. Overlack, T. Goldmann, 2010, Investigative ophthalmology & visual science.

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

T. Baasov, V. Pokrovskaya, 2010, Expert opinion on drug discovery.

An efficient chemical-enzymatic synthesis of 4-nitrophenyl β-xylobioside: a chromogenic substrate for xylanases

Y. Shoham, A. Mechaly, V. Belakhov, 1997 .

A new model for the stereoselective construction of the Kdo structure through a mechanism similar to that suggested for the enzyme Kdo8P synthase

S. Du, T. Baasov, Dorit Plat, 1996 .

Stereochemistry of the KDO8P synthase. An efficient synthesis of the 3-fluoro analogues of KDO8P

V. Belakhov, T. Baasov, A. Kohen, 1993 .

Crystal Structures of Geobacillus stearothermophilus α-Glucuronidase Complexed with Its Substrate and Products

V. Stojanoff, G. Shoham, Y. Shoham, 2004, Journal of Biological Chemistry.

Erratum to: Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

P. Huppke, H. Werner, J. Gärtner, 2013, Journal of Molecular Medicine.

Identification of the molecular attributes required for aminoglycoside activity against Leishmania

J. Kondo, N. Adir, C. Jaffe, 2013, Proceedings of the National Academy of Sciences.

Inhibition mode of a bisubstrate inhibitor of KDO8P synthase: a frequency-selective REDOR solid-state and solution NMR characterization.

L. Kaustov, Y. Shoham, V. Belakhov, 2003, Journal of the American Chemical Society.

Structural and mechanistic investigation of 3-deoxy-D-manno-octulosonate-8-phosphate synthase by solid-state REDOR NMR.

L. Kaustov, Y. Shoham, T. Baasov, 2000, Biochemistry.

Is the first enzyme of the shikimate pathway, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tyrosine sensitive), a copper metalloenzyme?

J. Knowles, T. Baasov, 1989, Journal of bacteriology.

Aminoglycoside-Induced Premature Stop Codon Read-Through of Mucopolysaccharidosis Type I Patient Q70X and W402X Mutations in Cultured Cells.

D. Brooks, L. Karageorgos, J. Hopwood, 2014, JIMD reports.

Preliminary crystallographic analysis of Xyn52B2, a GH52 β-D-xylosidase from Geobacillus stearothermophilus T6.

B. Manjasetty, N. Lavid, S. Lansky, 2014, Acta crystallographica. Section F, Structural biology communications.

pathway of a family 51 a - L -arabinofuranosidase

D. Schomburg, G. Shoham, Y. Shoham, 2022 .

Towards catalytic aminoglycoside: Probing the modification of kanamycin B at the 3′- and 4′-positions

T. Pieńko, V. Belakhov, T. Baasov, 2023, Tetrahedron.

Synthesis, Inhibition, and Acid-Catalyzed Hydrolysis Studies of Model Compounds of the Proposed Intermediate in the Kdo8P-Synthase-Catalyzed Reaction

T. Baasov, A. Kohen, 1995 .

Crystal structure and snapshots along the reaction pathway of a family 51 alpha-L-arabinofuranosidase.

Dietmar Schomburg, D. Schomburg, G. Shoham, 2003, The EMBO journal.

Direct Identification of Enzyme Active Site Residues by Solid-State REDOR NMR: Application to KDO8P Synthase

L. Kaustov, T. Baasov, A. Schmidt, 2000 .

Crystal structures of Escherichia coli KDO8P synthase complexes reveal the source of catalytic irreversibility.

N. Adir, V. Belakhov, T. Baasov, 2005, Journal of molecular biology.

Detailed kinetic analysis of a family 52 glycoside hydrolase: a beta-xylosidase from Geobacillus stearothermophilus.

B. Henrissat, G. Shoham, Y. Shoham, 2003, Biochemistry.

Toward Catalytic Antibiotics: Redesign of Fluoroquinolones to Catalytically Fragment Chromosomal DNA.

F. Glaser, V. Belakhov, T. Baasov, 2021, ACS infectious diseases.

Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases

T. Pieńko, V. Belakhov, T. Baasov, 2023, ACS Medicinal Chemistry Letters.

Photochemistry of thioanhydrides. Photofragmentation of -1,2-dihydrophthalic thioanhydrides

T. Baasov, B. Fuchs, 1982 .

Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor.

J. Friedman, N. Adir, Y. Shoham, 2001, Biochemistry.

Catalytic mechanism of Kdo8P synthase: transient kinetic studies and evaluation of a putative reaction intermediate.

Y. Benenson, F. D’Souza, K. Anderson, 1998, Biochemistry.

Biochemical characterization and identification of catalytic residues in α‐glucuronidase from Bacillus stearothermophilus T‐6

G. Shoham, Y. Shoham, T. Baasov, 2001 .

Overproduction and characterization of seleno-methionine xylanase T-6.

G. Shoham, Y. Shoham, A. Mechaly, 2000, Journal of biotechnology.

Anomeric specificity of 3-deoxy-D-manno-2-octulosonate 8-phosphate phosphatase from Escherichia coli

T. Baasov, A. Jakob, 1990 .

The use of (E)- and (Z)-phosphoenol-3-fluoropyruvate as mechanistic probes reveals significant differences between the active sites of KDO8P and DAHP synthases.

K. Anderson, C. Furdui, R. Woodard, 2005, Biochemistry.

Anomeric Specificity of 3-Deoxy-D-manno-2-octulosonate 8-Phosphate Phosphatase from Escherichia coli.

T. Baasov, A. Jakob, 1990 .

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.

T. Baasov, Igor Nudelman, Mariana Hainrichson, 2008, Organic and biomolecular chemistry.

Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54

D. Bedwell, E. Schwiebert, S. Rowe, 2011, Journal of Molecular Medicine.

Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells

O. Namy, L. Bidou, Olivier Bugaud, 2017, RNA biology.