J. Rowlands

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A 21st century roadmap for human health risk assessment

M. Dellarco, Samuel M. Cohen, A. Boobis, 2014, Critical reviews in toxicology.

Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

T. Starr, M. van den Berg, D. Schrenk, 2014, Critical reviews in toxicology.

A Model for Aryl Hydrocarbon Receptor-Activated Gene Expression Shows Potency and Efficacy Changes and Predicts Squelching Due to Competition for Transcription Co-Activators

R. Budinsky, T. Simon, J. Rowlands, 2015, PloS one.

Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges

A. Dombkowski, J. Rowlands, Alan A. Dombkowski, 2011 .

An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity--proof of concept.

Richard A Becker, Grace Patlewicz, J Craig Rowlands, 2015, Regulatory toxicology and pharmacology : RTP.

An Evaluation of Single Nucleotide Polymorphisms in the Human Heat Shock Protein 90 kDa Alpha and Beta Isoforms

J. Urban, R. Budinsky, J. Rowlands, 2012 .

Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice.

T. Zacharewski, E. Dere, L. Burgoon, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Altered mammary gland differentiation and progesterone receptor expression in rats fed soy and whey proteins.

M. Ronis, T. Badger, J. Rowlands, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Estimates of cancer potency of 2,3,4,7,8-pentachlorodibenzofuran using both nonlinear and linear approaches.

C. Kirman, R. Budinsky, L. Aylward, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.

T. Zacharewski, Andrea W Lee, L. Burgoon, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice.

T. Zacharewski, E. Dere, L. Burgoon, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

Russell S. Thomas, R. Budinsky, A. Nyska, 2016, Journal of applied toxicology : JAT.

2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the aryl hydrocarbon receptor.

M. Stevens, T. Bradshaw, R. Bazzi, 2009, Toxicology and applied pharmacology.

Biochemical and Molecular Action of Nutrients Altered Expression and Glucocorticoid-Inducibility of Hepatic CYP 3 A and CYP 2 B Enzymes in Male Rats Fed Diets Containing Soy Protein Isolate 1

M. Ronis, T. Badger, J. Rowlands, 1999 .

Altered expression and glucocorticoid-inducibility of hepatic CYP3A and CYP2B enzymes in male rats fed diets containing soy protein isolate.

M. Ronis, T. Badger, J. Rowlands, 1999, The Journal of nutrition.

Inducibility of hepatic CYP1A enzymes by 3-methylcholanthrene and isosafrole differs in male rats fed diets containing casein, soy protein isolate or whey from conception to adulthood.

M. Ronis, T. Badger, J. Rowlands, 2001, The Journal of nutrition.

Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro.

M. Berhow, T. Badger, J. Rowlands, 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Single nucleotide polymorphisms in the human aryl hydrocarbon receptor nuclear translocator (ARNT) gene.

J. Urban, R. Budinsky, J. Rowlands, 2011, Drug metabolism and pharmacokinetics.

Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis

Bethany B. Parks, Russell S. Thomas, J. Rowlands, 2015, Hepatology.

Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells

T. Badger, J. Rowlands, L. He, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Russell S. Thomas, N. Kaminski, R. Budinsky, 2016, Toxicology.

Anomalous structure-activity relationships of 13-homo-13-oxarotenoids and 13-homo-13-oxadehyrorotenoids.

J. Casida, J. Rowlands, N. Fang, 1997, Chemical research in toxicology.

An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor-interacting protein (AIP) gene.

J. Urban, R. Budinsky, J. Rowlands, 2011, Drug metabolism and pharmacokinetics.

Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.

J. Gustafsson, I. McEwan, J. Rowlands, 1996, Molecular pharmacology.

Screening-Level Risk Assessment for Styrene-Acrylonitrile (SAN) Trimer Detected in Soil and Groundwater

C. Kirman, M. Gargas, J. Rowlands, 2012, Journal of toxicology and environmental health. Part A.

The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events

Alan R. Boobis, Ted W. Simon, S. Stoney Simons, 2014, Critical reviews in toxicology.

Aryl hydrocarbon receptor-mediated signal transduction.

J. Gustafsson, J. Rowlands, Jan-Åke Gustafsson, 1997, Critical reviews in toxicology.

Determining the Safety of Bioengineered Microorganisms Bioengineered microorganisms have a history of safe use in the food industry thanks to a well-developed risk-assessment process

J. C. Rowlands, J. Rowlands, 2002 .

Application of Evolving Computational and Biological Platforms for Chemical Safety Assessment

D. M. Wilson, P. J. Spencer, R. S. Settivari, 2017 .

Chronic intragastric infusion of ethanol-containing diets induces CYP3A9 while decreasing CYP3A2 in male rats.

H. Strobel, M. Ronis, T. Badger, 2000, The Journal of pharmacology and experimental therapeutics.

Use and validation of HT/HC assays to support 21st century toxicity evaluations.

Richard A Becker, Ted Simon, Katy O Goyak, 2013, Regulatory toxicology and pharmacology : RTP.

Determining the safety of bioengineered microorganisms

J. Rowlands, 2002 .

The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor.

Richard A Becker, Grace Patlewicz, J Craig Rowlands, 2015, Regulatory toxicology and pharmacology : RTP.

Adverse outcome pathways: From research to regulation scientific workshop report.

David Allen, Stephen W. Edwards, Sharon Munn, 2016, Regulatory toxicology and pharmacology : RTP.

The health consequences of early soy consumption.

M. Ronis, T. Badger, J. Rowlands, 2002, The Journal of nutrition.

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

Russell S. Thomas, R. Budinsky, J. Rowlands, 2013, Toxicology and applied pharmacology.

A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes.

Michael B. Black, Chad M Thompson, J Craig Rowlands, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Michael B. Black, J Craig Rowlands, Robert A Budinsky, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Risk assessment in the 21st century: Roadmap and matrix

Angelo Moretto, Nancy G Doerrer, Richard D Phillips, 2014, Critical reviews in toxicology.

Derivation of Soil Clean-Up Levels for 2,3,7,8-Tetrachloro-dibenzo-p-dioxin (TCDD) Toxicity Equivalence (TEQD/F) in Soil Through Deterministic and Probabilistic Risk Assessment of Exposure and Toxicity

Ted W. Simon, Chris Kirman, Robert A. Budinsky, 2011 .

A pilot study of oral bioavailability of dioxins and furans from contaminated soils: Impact of differential hepatic enzyme activity and species differences.

J. Giesy, S. Casteel, R. Budinsky, 2008, Chemosphere.

Endocrine disruption: historical perspectives and its impact on the future of toxicology testing.

Mary Sue Marty, Edward W Carney, J. Rowlands, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

FutureTox: building the road for 21st century toxicology and risk assessment practices.

J Craig Rowlands, James S Bus, Miriam Sander, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

Melvin E. Andersen, Harvey J. Clewell, Russell S. Thomas, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats.

Ling He, M. Ronis, T. Badger, 2001, The Journal of nutrition.

Nutrition and Cancer Soy and Whey Proteins Downregulate DMBA-Induced Liver and Mammary Gland CYP 1 Expression in Female Rats 1

Ling He, M. Ronis, T. Badger, 2001 .

Fused mesoionic heterocyclic compounds are a new class of aryl hydrocarbon receptor (AhR) agonist of exceptional potency.

M. Rose, R. Bazzi, D. Bell, 2012, Toxicology.

AH receptor agonist activity in human blood measured with a cell-based bioassay: Evidence for naturally occurring AH receptor ligands in vivo

J Craig Rowlands, Mark A Harris, Robert A Budinsky, 2008, Journal of Exposure Science and Environmental Epidemiology.

Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

R. Budinsky, S. Ferguson, T. Simon, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanism-based common reactivity pattern (COREPA) modelling of aryl hydrocarbon receptor binding affinity

J C Rowlands, O Mekenyan, M. Denison, 2010, SAR and QSAR in environmental research.

Sex ratio of the offspring of Sprague-Dawley rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally in a three-generation study.

R. Budinsky, L. Aylward, J. Rowlands, 2006, Toxicology and applied pharmacology.

Human dioxin receptor chimera transactivation in a yeast model system and studies on receptor agonists and antagonists.

J. Gustafsson, J. Rowlands, 1995, Pharmacology & toxicology.

Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics.

Lesa L Aylward, Ted Simon, J Craig Rowlands, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells.

J. Casida, J. Rowlands, J. Craig Rowlands, 1998, Pharmacology & toxicology.

Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context.

G. Balboni, M. Denison, M. Rose, 2012, Toxicology.

Genes involved in the induction of liver growth by peroxisome proliferators

T. Gant, S. Avery, A. Aboobaker, 2014 .

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes.

Richard A Becker, Grace Patlewicz, J Craig Rowlands, 2015, Regulatory toxicology and pharmacology : RTP.

Fourth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease The Health Consequences of Early Soy Consumption 1 , 2

M. Ronis, T. Badger, J. Rowlands, 2002 .

Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former Michigan trichlorophenol and pentachlorophenol workers

R. Budinsky, C. Burns, J. Rowlands, 2007, Journal of Exposure Science and Environmental Epidemiology.

Developing scientific confidence in HTS-derived prediction models: lessons learned from an endocrine case study.

Richard A Becker, Louis Anthony Cox, Katy O Goyak, 2014, Regulatory toxicology and pharmacology : RTP.

Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

R. Budinsky, T. Simon, J. Rowlands, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity--proof of concept.

G. Patlewicz, R. Becker, T. Simon, 2015, Regulatory toxicology and pharmacology : RTP.

Animal Studies Repository Animal Studies Repository 11-2013 Incorporating New Technologies Into Toxicity Testing and Risk Assessment : Moving From 21 st Century Vision to a Data-Driven Framework

I. Cote, L. Flowers, J. Rowlands, 2019 .