C. Timperley

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Innovative technologies for chemical security

M. Zina, F. Trifiró, P. Ramasami, 2018, Chemistry International.

Fate of the chemical warfare agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX) on soil following accelerant-based fire and liquid decontamination

A. J. Webb, C. Timperley, M. R. Gravett, 2014, Analytical and Bioanalytical Chemistry.

Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents.

M. Zina, F. Trifiró, J. Forman, 2019, Toxicology.

Chapter 2 – Phosphonyl Compounds

C. Timperley, 2015 .

Analysis of chemical warfare agents III. Use of bis-nucleophiles in the trace level determination of phosgene and perfluoroisobutylene.

D. B. Cooper, C. Timperley, B. Muir, 2005, Journal of chromatography. A.

Analysis of chemical warfare agents. II. Use of thiols and statistical experimental design for the trace level determination of vesicant compounds in air samples.

D. B. Cooper, C. Timperley, B. Muir, 2005, Journal of chromatography. A.

Analysis of chemical warfare agents. I. Use of aliphatic thiols in the trace level determination of Lewisite compounds in complex matrices.

D. B. Cooper, C. Timperley, B. Muir, 2005, Journal of chromatography. A.

Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 3. On medical care and treatment of injuries from sulfur mustard.

Peter J. Hotchkiss, M. Ghanei, P. Hotchkiss, 2021, Toxicology.

Advice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide.

M. Zina, F. Trifiró, J. Forman, 2018, Talanta.

Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length.

J. Tattersall, C. Timperley, F. Worek, 2013, Chemico-biological interactions.

Determination of lewisite constituents in aqueous samples using hollow-fibre liquid-phase microextraction followed by gas chromatography-mass spectrometry

C. Timperley, F. B. Hopkins, J. Riches, 2014, Analytical and Bioanalytical Chemistry.

Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).

J. Tattersall, C. Timperley, F. Worek, 2012, Drug testing and analysis.

Is there a role for green and sustainable chemistry in chemical disarmament and nonproliferation?

J. Forman, C. Timperley, 2019, Current Opinion in Green and Sustainable Chemistry.

Metal-organic frameworks: Breaking bad chemicals down.

M. Rosseinsky, C. Timperley, Martin W. Smith, 2015, Nature materials.

Analysis of clothing and urine from Moscow theatre siege casualties reveals carfentanil and remifentanil use.

C. Timperley, R. Read, R. Black, 2012, Journal of analytical toxicology.

Fluorinated phosphorus compounds: Part 3. The synthesis of symmetrical and unsymmetrical fluoroalkyl phosphates

C. Timperley, I. Holden, I. J. Morton, 2000 .

Synthesis and anticholinesterase activity of some new fluorogenic analogues of organophosphorus nerve agents

Gareth R. Williams, Nicholas H Williams, C. Timperley, 2006 .

The steric and electronic effects of aliphatic fluoroalkyl groups

W. E. White, C. Timperley, 2003 .

Assessment of false transmitters as treatments for nerve agent poisoning.

C. Timperley, R. L. Williams, C. Lindsay, 2019, Toxicology letters.

Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro.

J. Tattersall, C. Timperley, F. Worek, 2012, Toxicology.

Evidence of VX nerve agent use from contaminated white mustard plants

A. J. Webb, M. Baker, C. Timperley, 2014, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

Detection of the organophosphorus nerve agent VX and its hydrolysis products in white mustard plants grown in contaminated soil

A. J. Webb, M. Baker, C. Timperley, 2013 .

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

C. Timperley, R. Banks, R. Haszeldine, 2011 .

Diels–Alder reactions of trifluoromethyl alkenes with 5-ethoxyoxazoles: synthesis of trifluoromethylated pyridine derivatives

G. Sandford, C. Timperley, Ian F. Wilson, 2004 .

Synthesis and μ-Opioid Activity of the Primary Metabolites of Carfentanil.

Tyler D. P. Goralski, C. Timperley, J. Myslinski, 2019, ACS Medicinal Chemistry Letters.

Chapter 1 – General Overview

J. Tattersall, C. Timperley, 2015 .

Ketene thioacetal derivatives from perfluoroisobutene (PFIB) and its 1,1-dichloro analogue

C. Timperley, 1999 .

Chapter 4 – Phosphoryl Compounds

P. Renard, C. Timperley, Catherine Gomez, 2015 .

Ketenes, Their Cumulene Analogs and Their S, Se, and Te Analogs

C. Timperley, 2005 .

Identification of iso- and n-propylphosphonates using liquid chromatography-tandem mass spectrometry and gas chromatography-Fourier transform infrared spectroscopy.

D. B. Cooper, Nicholas H Williams, C. Timperley, 2004, Journal of chromatography. A.

The synthesis and reactions of dialkyl fluoroalkyl phosphates

C. Timperley, I. J. Morton, Matthew J. Waters, 1999 .

The first isolable dialkyl iodophosphates

C. Timperley, Matthew J. Waters, 2001 .

Chapter 5 – Thiophosphoryl Compounds

C. Timperley, N. Cooper, 2015 .

Chapter 3 – Thiophosphonyl Compounds

C. Timperley, 2015 .

Fluorinated pyridine derivatives: Part 1. The synthesis of some mono- and bis-quaternary pyridine salts of potential use in the treatment of nerve agent poisoning

S. R. Turner, Simon R. Turner, J. Tattersall, 2005 .

1,1′-(Propane-1,3-diyl)bis(4-tert-butylpyridinium) di(methanesulfonate) protects guinea pigs from soman poisoning when used as part of a combined therapy

S. R. Turner, Simon R. Turner, J. Chad, 2012 .

Fluoroalkene chemistry: Part 1. Highly-toxic fluorobutenes and their mode of toxicity: reactions of perfluoroisobutene and polyfluorinated cyclobutenes with thiols

C. Timperley, 2004 .

Chapter 29 – Highly-toxic fluorine compounds

C. Timperley, 2000 .

Hydrolysis and Oxidation Products of the Chemical Warfare Agents 1,2-Bis[(2-chloroethyl)thio]ethane Q and 2,2′-Bis(2-chloroethylthio)diethyl Ether T

C. Timperley, R. Read, R. Black, 2003 .

Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents.

Gareth R. Williams, A. Fersht, A. Griffiths, 2006, Journal of medicinal chemistry.

A selected ion flow tube study of the reactions of OH− with a number of fully and partially halogenated methanes

C. Mayhew, R. Peverall, C. Timperley, 2004 .

Fluoroalkene Chemistry. Part 3. Reactions of Arylthiols with Perfluoroisobutene, Perfluoropropene and Chlorotrifluoroethene.

C. Timperley, J. A. Greenall, Matthew J. Waters, 2006 .

Fluoroalkene chemistry: Part 3. Reactions of arylthiols with perfluoroisobutene, perfluoropropene and chlorotrifluoroethene

C. Timperley, J. A. Greenall, Matthew J. Waters, 2006 .

Fluorinated phosphorus compounds: Part 5. The boiling points of fluoroalkyl phosphoryl compounds

C. Timperley, Matthew J. Waters, 2001 .

Fluorinated phosphorus compounds: Part 1. The synthesis and reactions of some fluoroalkyl phosphoryl compounds

C. Timperley, M. Bird, J. Broderick, 2000 .

Fragmentations and reactions of some isotopically labelled dimethyl methyl phosphono and trimethyl phosphoro thiolates and thionates studied by electrospray ionisation ion trap mass spectrometry

J. D. Barr, F. Ferrante, C. Timperley, 2005 .

Fluorinated phosphorus compounds: Part 6. The synthesis of bis(fluoroalkyl) phosphites and bis(fluoroalkyl) phosphorohalidates

Robert E. Arbon, C. Timperley, Matthew J. Waters, 2002 .

Fluorinated phosphorus compounds: Part 7. The reactions of bis(fluoroalkyl) phosphorochloridates with nitrogen nucleophiles

C. Timperley, Matthew J. Waters, Sally A. Saunders, 2002 .

Chemical Disarmament in a Technologically Evolving World

J. Forman, C. Timperley, 2018 .

Production of ES1 plasma carboxylesterase knockout mice for toxicity studies.

Gareth R. Williams, E. Duysen, O. Lockridge, 2011, Chemical research in toxicology.

Fluoroalkene chemistry: Part 2. Reactions of thiols with some toxic 1,2-dichlorinated polyfluorocycloalkenes

C. Timperley, 2004 .

Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on isotopically labelled chemicals and stereoisomers in relation to the Chemical Weapons Convention

M. Zina, F. Trifiró, P. Ramasami, 2018, Pure and Applied Chemistry.

Fluoroalkene Chemistry. Part 2. Reactions of Thiols with Some Toxic 1,2-Dichlorinated Polyfluorocycloalkenes.

C. Timperley, 2004 .

Fragmentations and reactions of the organophosphate insecticide Diazinon and its oxygen analog Diazoxon studied by electrospray ionization ion trap mass spectrometry

J. D. Barr, F. Ferrante, C. Timperley, 2005, Journal of the American Society for Mass Spectrometry.

3-Quinuclidinyl-α-methoxydiphenylacetate: a multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning.

J. Tattersall, C. Timperley, C. Lindsay, 2020, Toxicology letters.

Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.

S. R. Turner, J. Chad, J. Tattersall, 2011, Toxicology letters.

Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs).

J. Tattersall, C. Timperley, F. Worek, 2011, Toxicology letters.

Bis(fluoroalkyl)acrylic and methacrylic phosphate monomers, their polymers and some of their properties

Robert E. Arbon, C. Willis, C. Timperley, 2003 .

Toxicity and medical countermeasure studies on the organophosphorus nerve agents VM and VX

C. Timperley, J. Jenner, C. Dalton, 2015, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

Material and methods ( a ) Synthesis of 14 C VM and 14 C VX

C. Timperley, J. Jenner, C. Dalton, 2015 .

Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice

J. Tattersall, C. Timperley, J. Kassa, 2022, Toxics.

Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice – a comparison with oxime-based treatment

J. Tattersall, C. Timperley, J. Kassa, 2020, Toxicology mechanisms and methods.

Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.

J. Tattersall, C. Timperley, J. Kassa, 2018, Toxicology.

Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice

J. Tattersall, C. Timperley, J. Kassa, 2018, Basic & clinical pharmacology & toxicology.

Painful chemistry! From barbecue smoke to riot control

C. Timperley, F. B. Hopkins, J. Riches, 2017 .

Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation

C. Timperley, J. Riches, C. Lindsay, 2015, Royal Society Open Science.

Organophosphorus chemistry. Part 1. The synthesis of alkyl methylphosphonic acids

C. Timperley, R. Black, M. Bird, 2001 .

Fluorinated phosphorus compounds: Part 10. Bis(fluoroalkyl) S-alkyl phosphorothiolates and tris(fluoroalkyl) phosphorothionates

C. Timperley, Matthew J. Waters, S. Kirkpatrick, 2005 .

Fluorinated phosphorus compounds: Part 2. The synthesis of some bis(fluoroalkyl) alkylphosphonates

C. Timperley, J. Broderick, I. Holden, 2000 .

Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.

Gareth R. Williams, C. Timperley, F. Worek, 2008, Biochemistry.

Isotopically Labelled Phosphorus Compounds: Some Deuterated Methyl and Ethyl Derivatives

C. Timperley, J. Harrison, P. Watts, 2006 .

Solid-Phase Synthesis of Some Alkyl Hydrogen Methylphosphonates

C. Timperley, R. Read, R. Black, 2003 .

Fluorinated Phosphorus Compounds. Part 10. Bis(fluoroalkyl) S-Alkyl Phosphorothiolates and Tris(fluoroalkyl) Phosphorothionates.

C. Timperley, Matthew J. Waters, S. Kirkpatrick, 2005 .

Fluorinated phosphorus compounds: Part 11. The reactions of some fluorinated amines with dialkyl and bis(fluoroalkyl) phosphorochloridates

C. Timperley, Matthew J. Waters, 2005 .

The Synthesis and Properties of Some Fluorinated Dialkyl Phosphoramidates

C. Timperley, Matthew J. Waters, 2002 .

Fluorinated phosphorus compounds: Part 4. A lack of anticholinesterase activity for four tris(fluoroalkyl) phosphates

C. Timperley, D. Sellers, Matthew J. Waters, 2001 .

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines

S. R. Turner, Simon R. Turner, J. Chad, 2015, PloS one.

Chemistry and diplomacy

J. Forman, C. Timperley, Siqing Sun, 2018, Pure and Applied Chemistry.

Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.

Cerys Docx, J. Tattersall, C. Timperley, 2016, Toxicology letters.

α-Conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor

Brian O. Smith, C. Timperley, Astrid Knuhtsen, 2019, Chemical Science.

CHAPTER 8:Chemical Defence Against Fentanyls

Christopher M. Timperley, Christopher D. Lindsay, James R. Riches, 2016 .

Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on riot control agents in connection to the Chemical Weapons Convention

M. Zina, F. Trifiró, P. Ramasami, 2018, RSC advances.

Evaluation of the benefit of the bispyridinium compound MB327 for the antidotal treatment of nerve agent-poisoned mice

J. Tattersall, M. Pohanka, C. Timperley, 2016, Toxicology mechanisms and methods.

Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant.

A. Fersht, A. Griffiths, C. Timperley, 2011, Protein engineering, design & selection : PEDS.

Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters.

Andrew D Griffiths, A. Fersht, A. Griffiths, 2011, Protein engineering, design & selection : PEDS.

μ‐Conotoxin KIIIA peptidomimetics that block human voltage‐gated sodium channels

Brian O. Smith, C. Timperley, Astrid Knuhtsen, 2020, Peptide Science.

M. Zina, F. Trifiró, P. Ramasami, 2018, Pure and Applied Chemistry.

Reply to “Comment on ‘Nomenclature, Chemical Abstracts Service Numbers, Isomer Enumeration, Ring Strain, and Stereochemistry: What Does Any of This Have to Do with an International Chemical Disarmament and Nonproliferation Treaty?’”

J. Forman, C. Timperley, 2020 .

Nomenclature, Chemical Abstracts Service Numbers, Isomer Enumeration, Ring Strain, and Stereochemistry: What Does Any of This Have to Do with an International Chemical Disarmament and Nonproliferation Treaty?

Giovanna. F. M. Pontes, J. Forman, C. Timperley, 2020, Journal of Chemical Education.

Investigative science and technology supporting the Organization for the Prohibition of Chemical Weapons (OPCW)

J. Forman, C. Timperley, V. Borrett, 2018, Australian Journal of Forensic Sciences.

Fragmentation and reactions of two isomeric O-alkyl S-(2-dialkylamino)ethyl methylphosphonothiolates studied by electrospray ionization/ion trap mass spectrometry

C. Timperley, A. Bell, P. Watts, 2001, Journal of the American Society for Mass Spectrometry.

Structure–pulmonary toxicity/retention relationships of inhaled fluorocyclobutenes

C. Timperley, D. G. Upshall, S. Patel, 1999, Journal of applied toxicology : JAT.

Chemical Safety and Security in a Rapidly Changing World

J. Forman, C. Timperley, A. Hay, 2016 .

Fragmentations and reactions of protonated O,O-dimethyl ethylphosphonate and some isotopomers produced by electrospray ionisation in an ion trap mass spectrometer

F. Ferrante, S. Hall, V. Mikhailov, 2008 .

Chemical analysis of bleach and hydroxide-based solutions after decontamination of the chemical warfare agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX)

C. Timperley, M. R. Gravett, F. B. Hopkins, 2014, Analytical and Bioanalytical Chemistry.

Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR.

P. Biggin, T. Piggot, J. Tattersall, 2021, Toxicology letters.

The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives.

C. Timperley, F. Nachon, J. Dias, 2024, Chemico-biological interactions.